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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SIPA1 6494 Signal-induced proliferation-associated gene 1  11SPA1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22990111   2012Cell line : HT 115,Caco 2

Source : European Collection for Animal Cell Culture (ECACC, Porton Down, Salisbury, UK).

Sample Type : CRC tumor and normal tissue

No. of Sample : 94 colorectal cancer tissues 80 normal tissues

Stage : -

real time RT-PCR) and immunohistochemistryUp-regulation-SIPA1 is up-regulated in colorectal cancer. This suggests that SIPA1 plays diverse roles during disease progression as has contrasting effects on growth and motility of colorectal cancer cells.


Gene Details



Chromosome: 11; NC_000011.9 (65405578..65418391)

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Gene Type protein coding
Gene Family -
Description The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11q13
Start 65638107  
End 65650930  
Strand +  
Gene Sequence

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Length 12824  
OMIM ID 602180   
HGNC ID HGNC:10885   
Unigene ID Hs.530477    
Ensembl ID ENSG00000213445   
PharmGKB ID -   

mRNA Information


mRNA ID NM_006747.3
Exon join(1..76,2725..3494,4144..4271,4357..4533,6849..7023, 7748..7851,8115..8272,8350..8959,9278..9552,11156..11374, 11455..11566,11651..11759,11844..11945,12032..12086, 12295..12373,12463..12814)  
mRNA Sequence

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Length 3513  



CDS Information


   
Locationjoin(2816..3494,4144..4271,4357..4533,6849..7023, 7748..7851,8115..8272,8350..8959,9278..9552,11156..11374, 11455..11566,11651..11759,11844..11945,12032..12086, 12295..12373,12463..12609)
CDS Sequence

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CCDS ID CCDS8108.1



Protein Information


      
Protein IDNP_006738.3
Protein NameSignal-induced proliferation-associated gene 1
Molecular Wt. (Da)112018
Protein Sequence

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Length 1042  
Uniprot IDP20815
Ensembl Protein ID ENSP00000222982  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation74;-
SPhosphorylation74;-
SPhosphorylation867;-
SPhosphorylation867;-
SPhosphorylation870;-
SPhosphorylation870;-
TPhosphorylation875;-
TPhosphorylation875;-
SPhosphorylation53
SPhosphorylation53
SPhosphorylation55
SPhosphorylation55
TPhosphorylation64
SPhosphorylation67
TPhosphorylation64
SPhosphorylation67
SPhosphorylation839
SPhosphorylation839
SPhosphorylation884
SPhosphorylation884
TPhosphorylation323
TPhosphorylation323
SPhosphorylation559
SPhosphorylation559
SPhosphorylation664
SPhosphorylation680
TPhosphorylation685
SPhosphorylation664
SPhosphorylation680
TPhosphorylation685
SPhosphorylation817
SPhosphorylation817
TPhosphorylation962
TPhosphorylation962

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Leukocyte transendothelial migration hsa04670
Rap1 signaling pathway hsa04015


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00992685-759  PDZ_signaling
cl00117685-759  PDZ superfamily
pfam02145350-539  Rap_GAP
cl03466350-539  Rap_GAP superfamily
pfam00595687-759  PDZ
smart00228684-762  PDZ
pfam03980943-1010  Nnf1
cl04354943-1010  Nnf1 superfamily
cd00988695-767  PDZ_CTP_protease
pfam13094963-1041  CENP-Q
cl22438963-1041  TMF_TATA_bd superfamily
pfam09755924-1041  DUF2046
pfam12795964-1040  MscS_porin
pfam01576925-1042  Myosin_tail_1
COG1196905-1027  Smc
pfam13949918-1013  ALIX_LYPXL_bnd
PHA0337831-114  PHA03378
COG1196973-1027  Smc
PHA0324735-201  PHA03247


Ontology Information


   
HPRD ID5939
Molecular ClassGTPase activating protein
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO