Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SIPA1 | 6494 | Signal-induced proliferation-associated gene 1  | 11 | SPA1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22990111    | 2012 | Cell line : HT 115,Caco 2 Source : European Collection for Animal Cell Culture (ECACC, Porton Down, Salisbury, UK). Sample Type : CRC tumor and normal tissue No. of Sample : 94 colorectal cancer tissues 80 normal tissues Stage : - | real time RT-PCR) and immunohistochemistry | Up-regulation | - | SIPA1 is up-regulated in colorectal cancer. This suggests that SIPA1 plays diverse roles during disease progression as has contrasting effects on growth and motility of colorectal cancer cells. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]   | Chromosome | 11 |
| Location | 11q13 |
| Start | 65638107   |
| End | 65650930   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 12824   |
| OMIM ID | 602180    |
| HGNC ID | HGNC:10885    |
| Unigene ID | Hs.530477     |
| Ensembl ID | ENSG00000213445    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_006747.3 |
|---|---|
| Exon | join(1..76,2725..3494,4144..4271,4357..4533,6849..7023, 7748..7851,8115..8272,8350..8959,9278..9552,11156..11374, 11455..11566,11651..11759,11844..11945,12032..12086, 12295..12373,12463..12814)   | mRNA Sequence |    Download   Select all |
| Length | 3513   |
CDS Information
| Location | join(2816..3494,4144..4271,4357..4533,6849..7023, 7748..7851,8115..8272,8350..8959,9278..9552,11156..11374, 11455..11566,11651..11759,11844..11945,12032..12086, 12295..12373,12463..12609) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8108.1 |    
Protein Information
| Protein ID | NP_006738.3 |
|---|---|
| Protein Name | Signal-induced proliferation-associated gene 1 |
| Molecular Wt. (Da) | 112018 |
| Protein Sequence |    Download   Select all |
| Length | 1042   |
| Uniprot ID | P20815 |    
| Ensembl Protein ID | ENSP00000222982   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 74;- |
| S | Phosphorylation | 74;- |
| S | Phosphorylation | 867;- |
| S | Phosphorylation | 867;- |
| S | Phosphorylation | 870;- |
| S | Phosphorylation | 870;- |
| T | Phosphorylation | 875;- |
| T | Phosphorylation | 875;- |
| S | Phosphorylation | 53 |
| S | Phosphorylation | 53 |
| S | Phosphorylation | 55 |
| S | Phosphorylation | 55 |
| T | Phosphorylation | 64 |
| S | Phosphorylation | 67 |
| T | Phosphorylation | 64 |
| S | Phosphorylation | 67 |
| S | Phosphorylation | 839 |
| S | Phosphorylation | 839 |
| S | Phosphorylation | 884 |
| S | Phosphorylation | 884 |
| T | Phosphorylation | 323 |
| T | Phosphorylation | 323 |
| S | Phosphorylation | 559 |
| S | Phosphorylation | 559 |
| S | Phosphorylation | 664 |
| S | Phosphorylation | 680 |
| T | Phosphorylation | 685 |
| S | Phosphorylation | 664 |
| S | Phosphorylation | 680 |
| T | Phosphorylation | 685 |
| S | Phosphorylation | 817 |
| S | Phosphorylation | 817 |
| T | Phosphorylation | 962 |
| T | Phosphorylation | 962 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Leukocyte transendothelial migration |    hsa04670 |    
| Rap1 signaling pathway |    hsa04015 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00992 | 685-759  | PDZ_signaling |
| cl00117 | 685-759  | PDZ superfamily |
| pfam02145 | 350-539  | Rap_GAP |
| cl03466 | 350-539  | Rap_GAP superfamily |
| pfam00595 | 687-759  | PDZ |
| smart00228 | 684-762  | PDZ |
| pfam03980 | 943-1010  | Nnf1 |
| cl04354 | 943-1010  | Nnf1 superfamily |
| cd00988 | 695-767  | PDZ_CTP_protease |
| pfam13094 | 963-1041  | CENP-Q |
| cl22438 | 963-1041  | TMF_TATA_bd superfamily |
| pfam09755 | 924-1041  | DUF2046 |
| pfam12795 | 964-1040  | MscS_porin |
| pfam01576 | 925-1042  | Myosin_tail_1 |
| COG1196 | 905-1027  | Smc |
| pfam13949 | 918-1013  | ALIX_LYPXL_bnd |
| PHA03378 | 31-114  | PHA03378 |
| COG1196 | 973-1027  | Smc |
| PHA03247 | 35-201  | PHA03247 |
Ontology Information
| HPRD ID | 5939 |    
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
