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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLC1A5 6510 Solute carrier family 1 (neutral amino acid transporter), member 5  19R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21531130   2011Cell line : -

Source : Japan

Sample Type : CRC tumor and normal tissue

No. of Sample : 113 patients primary CRC

Stage : -

Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles using the HumaUp-regulation--

12529963   2002Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 63 CRC patient samples

Stage : -

Western blotting, Immunohistochemistry and Kaplan-Meier methodUp-regulation-Patient survival decreased with increased percentage of ASCT2-positive cancer cells and ASCT2(SLC1A5) is expressed in a significant number of CRC, and that ASCT2 expression is associated with aggressive biological behavior.

22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation4.5-


Gene Details



Chromosome: 19; NC_000019.9 (47278140..47291842, complement)

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Gene Type protein coding
Gene Family Solute carriers
Description The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]  
Chromosome 19
Location 19q13.3
Start 46759698  
End 46788649  
Strand -  
Gene Sequence

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Length 28952  
OMIM ID 109190   
HGNC ID HGNC:10943   
Unigene ID Hs.631582    
Ensembl ID ENSG00000105281   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005259167.3
Exon join(1..1250,4091..4133,4506..4553,6101..6267,9742..9975, 11245..11439,11541..11675,28255..28952)  
mRNA Sequence

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Length 2873  



CDS Information


   
Locationjoin(685..1250,4091..4133,4506..4553,6101..6267, 9742..9975,11245..11439,11541..11675,28255..28276)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005619.1
Protein NameSolute carrier family 1 (neutral amino acid transporter), member 5
Molecular Wt. (Da)56467
Protein Sequence

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Length 541  
Uniprot IDP22680
Ensembl Protein ID ENSP00000301645  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation535;-
TPhosphorylation494
SPhosphorylation503
TPhosphorylation532
NGlycosylation212
NGlycosylation163
SPhosphorylation493
YPhosphorylation524
SPhosphorylation9
SPhosphorylation539
SPhosphorylation198

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
79735TBC1D1715471NP_078958.1yeast 2-hybrid16169070   


Pathway Information


            
Pathway Name Pathway ID
Central carbon metabolism in cancer hsa05230
Protein digestion and absorption hsa04974


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00375106-485  SDF
cl00573106-485  SDF superfamily
COG1301106-497  GltP
PRK01663106-463  PRK01663
COG1823106-484  TcyP
PRK11283106-507  gltP
PRK13027106-463  PRK13027
COG3633230-477  SstT
PRK13628230-439  PRK13628
PRK14695230-477  PRK14695


Ontology Information


   
HPRD ID2031
Molecular ClassMembrane transport protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q15758DB00174L-AsparagineSmallMoleculeDrug
Q15758DB00130L-GlutamineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO