Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC1A5 | 6510 | Solute carrier family 1 (neutral amino acid transporter), member 5  | 19 | R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130    | 2011 | Cell line : - Source : Japan Sample Type : CRC tumor and normal tissue No. of Sample : 113 patients primary CRC Stage : - | Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles using the Huma | Up-regulation | - | - |
| 12529963    | 2002 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 63 CRC patient samples Stage : - | Western blotting, Immunohistochemistry and Kaplan-Meier method | Up-regulation | - | Patient survival decreased with increased percentage of ASCT2-positive cancer cells and ASCT2(SLC1A5) is expressed in a significant number of CRC, and that ASCT2 expression is associated with aggressive biological behavior. |
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 4.5 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]   | Chromosome | 19 |
| Location | 19q13.3 |
| Start | 46759698   |
| End | 46788649   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 28952   |
| OMIM ID | 109190    |
| HGNC ID | HGNC:10943    |
| Unigene ID | Hs.631582     |
| Ensembl ID | ENSG00000105281    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005259167.3 |
|---|---|
| Exon | join(1..1250,4091..4133,4506..4553,6101..6267,9742..9975, 11245..11439,11541..11675,28255..28952)   | mRNA Sequence |    Download   Select all |
| Length | 2873   |
CDS Information
| Location | join(685..1250,4091..4133,4506..4553,6101..6267, 9742..9975,11245..11439,11541..11675,28255..28276) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_005619.1 |
|---|---|
| Protein Name | Solute carrier family 1 (neutral amino acid transporter), member 5 |
| Molecular Wt. (Da) | 56467 |
| Protein Sequence |    Download   Select all |
| Length | 541   |
| Uniprot ID | P22680 |    
| Ensembl Protein ID | ENSP00000301645   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 535;- |
| T | Phosphorylation | 494 |
| S | Phosphorylation | 503 |
| T | Phosphorylation | 532 |
| N | Glycosylation | 212 |
| N | Glycosylation | 163 |
| S | Phosphorylation | 493 |
| Y | Phosphorylation | 524 |
| S | Phosphorylation | 9 |
| S | Phosphorylation | 539 |
| S | Phosphorylation | 198 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 79735 |    TBC1D17 |    15471 |    NP_078958.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Central carbon metabolism in cancer |    hsa05230 |    
| Protein digestion and absorption |    hsa04974 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00375 | 106-485  | SDF |
| cl00573 | 106-485  | SDF superfamily |
| COG1301 | 106-497  | GltP |
| PRK01663 | 106-463  | PRK01663 |
| COG1823 | 106-484  | TcyP |
| PRK11283 | 106-507  | gltP |
| PRK13027 | 106-463  | PRK13027 |
| COG3633 | 230-477  | SstT |
| PRK13628 | 230-439  | PRK13628 |
| PRK14695 | 230-477  | PRK14695 |
Ontology Information
| HPRD ID | 2031 |    
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q15758 | DB00174 | L-Asparagine | SmallMoleculeDrug |
| Q15758 | DB00130 | L-Glutamine | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
