CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SPARC	6678	Secreted protein, acidic, cysteine-rich (osteonectin)	5	ON

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
17397030	2007	Cell line : DLD 1, HCT 8, HCT 116, LOVO, HT 29 Source : ATTC or the Korean Cell Line Bank (KCLB). Sample Type : CRC tumor and normal tissue No. of Sample : 20 Stage : -	Methylation specific PCR,Western blot analysis, Immunohistochemistry, real time RT-PCR	Methylation	-	Epigenetic gene silencing of SPARC is frequent in colon cancers, and that inactivation of SPARC is related to rapid progression of colon cancers. Methylation status of the CpG island of SPARC in 7 colon cancer cell lines and in 20 test set of colon cancer tissues were found.
18458674	2008	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 10 CRC tissue sample and 5 normal tissue Stage : -	DNA bisulfite sequencing, methylation-specific PCR, RT-PCR, Chromatin immunoprecipitation assay .	Methylation	-	Therapeutic utility of employing demethylating agents 5-Aza-2'deoxycytidine to improve response through augmentation of SPARC expression.
22939997	2012	Cell line : DLD 1, HCT 8, HCT 116, LOVO and HT 29 Source : ATCC, Korean Cell Line Bank and Tissue from Department of Pathology at Yonsei University, Seoul, Korea and Gastrointestinal Tumor Working Group Tissue Bank at Yonsei University Medical Center (Seoul, Korea). Sample Type : CRC tumor and normal tissue No. of Sample : 312 CRC tissue sample Stage : -	DNA bisulfite sequencing, methylation-specific PCR and Combined bisulfate restriction analysis (COBR	Methylation	-	SPARC is commonly dysregulated in GI malignancies. Inhibition of DNA methylation can reverse the silencing of SPARC.
21818290	2011	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 120 paired normal and stage I-IV CRCs. Stage : TNM Stag I-IV	Tissue microarray	Up-regulation	-	High SPARC and FOXP3 are associated with better disease outcome in stage II CRC and may be prognostic indicators of CSS. SPARC and FOXP3 expression were significantly greater in CRC than normal colon. SPARC expression was initially assessed in 120 paired normal and stage I-IV CRCs.

Gene Details

Chromosome: 5; NC_000005.9 (151040657..151066615, complement)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]
Chromosome	5
Location	5q31.3-q32
Start	151661096
End	151687054
Strand	-
Gene Sequence	>gi\|568815593:c151687054-151661096 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly GGGAGAAGGAGGAGGCCGGGGGAAGGAGGAGACAGGAGGAGGAGGGACCACGGGGTGGAGGGGAGATAGA CCCAGCCCAGAGCTCTGAGTGGTTTCCTGTTGCCTGTCTCTAAACCCCTCCACATTCCCGCGGTCCTTCA GACTGCCCGGAGAGCGCGCTCTGCCTGCCGCCTGCCTGCCTGCCACTGAGGTATGTGTGACCCCCGCCCA GCCTTTCCCTTCTATAGTTGCACCAACCCCGACACCCCCGTTCACGCCGTCAGCTCGTGTGCAAGGGAGG GAAGCTCTGCTGAGGATGCGCCTCTCCTCCCGGCTCCATCACGGCTCCCCTTAAGAGCATGGCCCTCGGT CCTGTCTGCCTGTTGCTTTTCAGAAGGTGGACTCACTGTGTAACTTTGTCTTCCCTTACAGGTTTACAGA AAATAATCTCACTATGTCTTCGGGGGAGCATTTTCTCACTCTCTGTTTTTCTCTGTGTCTGTCTCTGGTT TCAGAGGCTGCCTGCCTGTCCTCTTTGCTCCCTTTGCAAATGTGGCAGCCTCCTCCTTTCCTGGGAATCT GATCCCATCACAGCTGCCACAGGGACCTGGCCAGCAACCGGAGTCTGTCCTCCAGATCTCGGTCAGGGGT TCTGTTTTCCAAAAGGGACTTTGCACGAACAATCAGTTGATCTCTGAAAGGCAAAGGGGGAGGCTTCACC ATTAATCCACACCTCTGGGAAGCCTTCTGTTTTCCTCTAATTCTCCTCACTCCCAAACACCACCTTCCGT CCCCCCAATACACAAATTTCAGCACCATTCTGCCTGAAATGGCACCATCACAACCTCAGTCTTGGGTTAG GTGTTGTTCCTGTCCTGAGTTCCTTGGGATGGTAAACACAGGCAGTAGCCCTTAGTTTATCTAGATCTGA AAACCCAGACATCAGATATCGTCAACCAAGACATGGGTGTAATGGGAGGTGGAGTGTGCTGGGGGAGATA TTCTCAGAAGGGGGAAAGGGGGAAGGGAAGAGGGAGAGAATTCCAGGGTCCCCTTCCGTAATCCACCCAA GACTAGTGTCCAGCCTGTCAGGGTGTCAGTTCTTCTTCAGACAAATCCACTACCTTTCTTCGCCGCCACT GGCTCCGTGAACTGGCTGTCAAGTGGACTTCCTTAGGGAAAGGGACTCCAAGGACTCCAAGGGAAGGGGG GCACTGGGATGAGTTATGTCTTCCAGGATTCCCAGTCTGCCCAAAAGGGAACAGAGAGGCATGCATTTTC CTCAGGAAAGGACAGCATTTTTTTCATTAGAGAAAATGTTTTCTCTAGTAATGCTTTAGAGTTAAATTTC TATACGCCCCAAGTGCTGGTGGTTTAGTGAGAAGCAAAGCAGAAGTAGGACACAGGCTTCGGGCATGCAT TTTATGTGTGATCTTAGGTAAGTGTCTCCCCTGGATTTAGTGCCCCATCTGTAATGAAAGAAGGCTGAAA CTGAAGGCTCTTTGGGGTGCTTTGTGTCCTCTAAAATATTCAAAGGAAGATTTCTTAACCAGGGTCTATG GAGTGGTCTTTGAATGGGCCTCAAGCCATCTCTAAGCCCCTAAAAATTGTATGCACTGTGTGTGTGTGTG TGTGTGTGTGTGTGTGTGTGTGAGAGAGAGAGGGAGAGAGAGAGAGAGAGAGGATGAATATGGGTGGTCA CAGCTTTCAGCTTTAAGATATTCTCAAATGGATTAGAGGGCATGACGTGGGGATGGAGTGAGGACTGGTA ACAAATGTGTGTATTTGCTGGAGGATGAAGCCTTCTGAAAAGGGAGTGGTTGAGGAAAGAGAGAGTTAAC TCTCAGCTATCAGCTGCCACATCGACATAGCCTAGAGCAAAGAGGGGGAGGGAGGAGAAGAAGGGGGTTG CCTGGAGAAGGAATCAACTTTTGAAACTTTCTCCAAGTCCCACCCACCAGAAGGCTCTTCTCTGCCTGAC TCACTCTCCGAGGAATGCGAGTTGCCACGGTAACCTTTTTTTCAGGGTCTCTGCCTGCTGGCTGGAGGGG ACCCTTGAAACCCTCTAAGAACATCAGTCTGAACGTACCCCACCCCCAAATTCAAGGCCTGCAGCAAATT CTAGGCCCTGCCCTTGTGATCTCTCAGGATTCCGGGGAAGCCTTGGGCCATGATAATCTCCTTGCAAGGG TGTTTGAAGACCTGGGTTTTAGCTCTGGCTGTGCCCTGAAGGTACCATTTGACCTTGAACTAATACTTCT TTCTGGGCCCCATTCCCTCTACAGTTAAAGAACAGTAACAGCAGCCACCTCTAGGGGGTAGATAGTGTGT AGAAGAAATGGGATAATGCACAGGGAAGCACTTTGCGAATTGTGGCATTCCCTCATAATGCAAAGGGTTT TAGAACTGATGGATTAAAGGCATCCAAAGACCTAGTGAAATCATTCTCAGCTTTTTTTTTTTTTTTTTTT CCTGGCAGCTCCATCATCTTGGGGTTTGTATAGAACTTTCCTTTACTAGAAGTACTGACAGGAAAAATTT TAAAATCATAATATTGTTTATCTTCATTTTGATTTGGGGAACTTCTTGTGTATTTCCCAAGACTGTTGTG CCCTCTATGTAGGAAAAGCATTGGCCAAGGGTGAAAAAAAAAAAAAAAAGTGTGTTCTAACTCCCAGTGC CTGACATTGGGAAAGACACTTCCTCTCTTGAGGCTGCAGTTTCCCAAACTGTTAAATAGAGTTTCTAAGC TAGATGATTTCCCAGGCACCCTTCTAACTCTGAAGTCCTATAAACCTAAATCCCAGATACCGCTTTTATT CAAAGGAATAGCTTGCCTGCATTTTTAACACCGCCTTACTGCACCCCCAGTTGAAAAGAAAACAAGAAAA GATGGGCTAGGGGATCTTGAGTTGCATAACCATCATGCTGTAATCCTTATCCATCTGTAGAGATTTGTCA ATCAACAGTGTGGCTGGGGTTTGCTATTCATGAGAGCAGCTTTCCTTGCTGAAAACAAGCTATAAATAAG AAAGAATGGTGAAGGAAAGGAAAGAGCTGAGGATGTGAGGTAAACAGTAGAATATTTGGCTTTTGAAGTT GTTTATGTAGGTAGATAAATATGCAGAGATAAACAGGGACAGGTACAAACCCATAGGGATGAAGAGTATA AACATCGATTTCATCAACAGGCACCCACTGGCTCAGCTAAAAATAAGTGCCTCATTACAGGAGCAGACAC AGAAAGTCATTCACTCACACACCTCTTCCTGGATGACAATGATTTACAGACAAGTTCCAGGAATATATCT CAATGAATGTGAAAATTCTGACCCTCGCCTATTACAGGCTGAAACAGACAGATGCTAAGTCAGGCTGTAT GTAACTTACACAGACATGCCATCAGGTATACAAACACACACCGCCACTTGCAGCCACACATGGATGGATG TGCACAGTCAAACATATGCACAGTCAAACATAATATGGATCATGACAATGAGACAGACGTGTAACCTACA TTTATCACCAACCACCTCTATGTCTCAGAGAGAGAGAAACTGAGGCTCAGGAAGAGAAAATAACTCACTG GAGGTCACATAGCAAGCTGGCGTCTGAGCCAAACTTCCACGTGTTTGGAGCCATTTTGATATTCACCTTG CCTTCCCCCCCAATCCCCATTTGTTCAGTTTGGAAACACACTTATGCACACAAGCCCCATGGATACTAAG TGGTGAGCAGCACTTTGTCTCTCCCGTTGGCTGGCCTGCAATGCCTATTCCAGCCCACGTGGCTTTGTCA TTAGGCCCAAAGGCCCTGCATGATGTGCCTGTAGGCGGCTGCTCCCTTGCTTCTAGCTGGCTCCCTCCCA AACGTCAGTTTCAAAGGAGAGAAGGGAAAACCAGCCTTGAGCTTTCAGCAACCCTGAGGACCTTGTTTCT ACAGCACAGACCCTGATGCCTCCCTCCCTCCCTCCCTCCCTCCCAACCTCAATCCTGAACCCAGGGACAG CTGGGCTGTGCAGGGCCAGGGCCAGCAAGTAGTGACTTGACGGAATTATTTAGAGAAACAGCCTCTCCTC AACTGGCAGCTTAGACAGGAAATCATCTCTGCTCTCACCCATCAAGCTATAGAACTTTATGTCTGCAAGG AAAACATGAACATAGACAACAATTGTTGTCAGAGCTGGTTTCTTTCAGAAACTTGGTATTAACTTCTCTC ATCTGGGGATCACTCTGGGTCATCTTGATGTTAGTCATGGCATTAGGATTTCAGACCTATCAGATAAAAA AAGCAAAGCAAACATCTGGATGTTTTTGAACATCTGGAAATTTGGCTTAGACACCAGCTTGCCGTGTGAC CTCCAGTGAGGTATTTTCCTTCTCTAAGCCTCAATTTCTCTACCTCTACAATAAGAGGCAGCACACAGAG GTTTCATGTGGCCTGACAACATCACTAATTCATCGGTAGTGGCTGTCAGAAGAACTGTGTTCAGGATTCT GATGACTCTCTAAGCTTTAGGAGAAGAGGTCAAGCGATTGATTAGTAATGTCTGCCACATGTGCAGGAGG GGTAGGTGGAGGCCACGTGTTTGTCACATATGCCACATATTTGCTATCTTTGGGATCTCGGAGGCTTTTC CAGATGCAATAGCCTGGACACTTTGATGTTATTTCTCATCCTTTCATTTGTGGTCACCACAATGCAGCAG CGGTGCCCTAGAGGGAGCCAAGGATGAAGCCTGAAGCTCCACCCCAGCCTCTGCTAGCCACAGTGAAATG TGGCATCTCAGATGTCTTTATGGAATCTCGGGCTGATTCCAGCCCCAAACTCTGGAGCCACCTCTGAGTT GCCCCAGAAGCTCTCCAGTCCTAAGTTTTAGCTACCACACCTTAAAAGTTTCCTTTAGCGTCTTTCCTTC CAGCAGGAAATAGAAGTGGAAGCAGGGAGTCAAGGGGCAAGTGGAGAGAGGTAAGGCTCTAAAAAGCTTC TGCCCAAGTTGATCCGGAAAATCAGAGCTGAAAAGAACCTAAAGGACCACCTTGCCTAAGGGTTCCATAT TGTGTTCCTAGGAGAAAGTACAGATGTTCCAAGGTATCTTAGGGAATGTCCCTGTGTGTAGGACTCCCAC TCCTCAGCTCCACTCCACTTTTATCTGCTTTTCTTTTTTGTGGATTTTTTTGAGAGGGAGTTTCACTCTT GTTGCCCAGGCGAGAGTGCAATGGCACAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGAC TCTCCTGCCTCAGCCTCCCGAGTTGCTGGGATTTTAGGCGCCCGCCACCATGCCCGGCTAATTTTTTGTA TTTTTAGTAGAGACGGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTGCTGACCTCAGGTGATCTAC CCTCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATTGCGCCCAGCCTGCTCTTGTTTTTTA ATTTCACACTTATTGATTAACTAGATAATACTCATTCACATGGTTCAGTACATGCTAAAAGATTTCAGCT GTTTGAAATATCGGACTCTGCAGAAGACTTCATTGAAATAAAGGATTTTCTGGCTTACATAATTTTGAGC ACTGACCTTATACAGACAAGCTGGGGGTGTTAGTTCTGGAGAGCAGAGGAGACTCCCCTGAATTCGCACA GTGAGCTGGGAGACATGCTGACTTGCTCTCAGCTCTCCTGACTTCCACGTCATGAGGCCACCTCTGAGCT GCTGTGTCTGCTCCCAGGGGTGTGAGCAGGAGTGCCATTGTAGCTGCATGTGGCCACCTCTCTGGCCTGC CTGGCTCGGTCCCCATGTCAGCAGACCCCAGGCTCCTTCCGAGTCCCAACTCCCTGGAGGGCCTGGCTCT TGGCTTCCTTTATTAGCCTCTAGGCTTGTTTTCCTCTCTTTGGGCTTGTTTACCAGCAACATGTGTTTTT GGAGCCCTTGTTTCCAAGCCAAATAGTGAGAGTGAGATGCTTGGCTGGTATCAGCTGCCCAAGTAAGAGG CCAGCCCTGGGCCTGGTCTTCGTCACTGTATCCTCTGGAGGCTGGACTTACCCAGACCAACAGGGGCAAT ATGTCCTTTGTTCCACCCAAACACCCCTTTCTCCCTGGGCTTATAAAGCACTGGAATTTTGCACTGAATT CTTTCGGGGGATGGAGATTCTGGGAACCTCGGACTTTATAAGATGCTCTTCCCAACGACAACATTGCTTA CCTCTTTATTTGGATTCTCTTGTGTAAATCACCCATGAGCCTTTAAAGATTGGTATGTTATTGTTTCCAT TTTACACATTGGGGAACAAATTGAGGCCCCAAGAGGTAAAGTTGATTTCTAAAGGTCATACAATTACTAA GTGGTGAGCCAGGATTTGAACCTGTATATTCTGGCTCCAGAGCCTATGAGCTTACCTTTATGCTATACTG CCTCATAGTTTATTATCACTCTGTCTACCATGGTAGCCACTAGCCACATGTGGCTATTTAGATTTAAGTT GATTAAAATAGATGGGCATGGTGGCTCACGCCTATAATCCCACCTCTTTGGGAGGCTGAGGCGGGCGGAT GGCTTGAGGTCAGGAGTTCGAGACCAGCCTGGGCAACATAATGAAGCCCCATCTCTACAAAAAAGAAAAG AAAAGAAAAATTCGCTGGGTGTAGTCACAAGTGCCTGTGATCTCAGCTACTCGGGAGGCTGAGATGGGAG AATCACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCAACCACACTCCAGTCTGGGTG ACAGAGGGAGACCGTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGATGTTTTCCACTATTCTCTAT TGCAGTATTTCAACAAGGTATGGGTTAAGTAAGATATTTTGGATTGGCCTCAGTCCTTTTGCATAAAATT TTTAAATAAAAAAATTGGTTAAAATGAAATACAATTTAAAACTCAGTTCTTCATTTGCACTGGCAACATT TCAAGCATTCAGTAACCACTTGTAACCAGTAGCTATCATAGTGGACCACGTAGATATAGAATGTGTTCAT CATCTTGGGAAGTCCTGTTGGGTTGCATTACTCCATAAGTTCTTTCCACCCAAATAAGATTTAATGATGG CAACTCAGTTTCTTTGCTTCACATCCTAAGTCTATCATTCTGAGACCCACAGTCCATGATTCTATGATTC TGAGGTATCCCCCCTGTTCTAACGTTCAGTGGCTTTTTAACGTCCAAGGAGAGCCCAAAGGAGGCCCTTT ATGTTTTGAGGGACAAACCTGGGGGCTGGCTGTACTTTTCCATCCTCAGAGTCTTTCCAGAGAGAGAAGT GACCTCAGCTTCAGGTCCTGCTGGCAGCCAAGGACGGGTTTTCAGCAGTCTCCAGAGCAAATAAAGGCAA AAGGAAGGGACTCGATGTACGGAACAGGAGGCAGTGGCGGCTGGGAGGGGGCTAAAACTGTCTGCATTTG ATGGCCACCATGCCAAGGGAAATATGCCTTCTCTTCCTCCCCTGGCCCTGGGCATTTTCCTTCCCAGGAA CTCAGGCCAGTTCAAGGCCCAACTGAGCCCCATTCAGGTGACCACCTGGGAGCGGGTAGCTGCCAAGGGA AATAGTGTGCAGAGGTAGAGACATACCAGTGGTGGGGTAGGGTTGCACGGGTTCTCACCCTAGCCCTGCC ACCCAGTCACTCACTCACTGCTGTTAGCCGTTGGCAGTTTTCTCCTTTCCTCTAGGCCTTGGTCTTCTCA TCTGTACTATTGGGCAGAAATATGTGACTTGAGCCCCCAGTGGGGTGCTGGATTATGAAAACACCCTGAA AATGATAAATGTATGCATCATCACAGACTAAAGAAATACAAAGGAGGGAGTTTTTGTTTAATATTGGTCA TTTATATGAAGGGAATTTAAATTTTCGCCAGGCACGCTACACCTAGGTTTGATTGGCAAAGGATCACAGC TGTGAGTTCTGAATGCTGGGGTTTGATACTGTGTTCTGACCTTGCTGGGGTGACTGTTATACTCCATTAG CTTTGCAGGATGGACACAGGGCTCTTTGGTCAGTGGTAGTTTAGAGAGCCTCAGAGAGGTATCTCGTGGG GAGGCAGGGAGATGGCTGTGCATCTGGAATAGTTCAGCCGCTTCCCTTCCCTCCCATCTCATCATCTGGG GGAAAAGTGCTCTTGGACTGGTGGTGTAGCACCGGGTGCTGGGCAGGACCCAGATTTTGTGTTTGTGTTT ACAGTTTTCTTCCAAAACTTTTAAGGTGTATTCCAAGATTTTGCGTTCTGTTCTTAACAGTCTCTCTGCA TTTCTCCCCCACTCCCACTTGTCTGAGCGTAATTCCTATTAGGCTCACCCCAACTCCATGAGTGAGAACG CTTGCCTATTTGGAGAGGGCCTGAATTGTTGCATGACTTTGGACAAGTGCTTCCTCCCTCTCAACCTCAG ATTCCCCATTAGGACAGTGGGACTAAGAACCCTTCCATGCCTGTCTGCCTACTTCCCAGCATTGTCAGAA GGCTCTAGGAGACAGTGTTATGTGACAGTGCTTTAGAAACTATGAAGCAGCACTATAAGACTTAGAGTTA TTTTTCTCTTCTGGCTGCAACAGCAGGGATGGGGGTGGCAGGGAGGGTGAGTGTGCAGCTGGAAAAGGAA TTCAGGAAGATGAGGAGGCAGGACAGACAGAAGAGCCGCCCAGCGAAACCTTCCCCTGGTCACAGAGGGG AGCGCGGTTACTCTGCTCATATGAAGGACGCAGACTCAGGGAAATGTCTGTCTTCCTGTCTTTCTAATCT GAAGCTTACTACATTTCCAGTCCTAGCTGGGCTATTTCTTCAATAACATGACTTCCCTGTCATTATAGCT CAGACAGGGTAACTTTTTGTTTTGTTTTGTTTTAGCTGCTATTTCACTTTGATCCTTCAACCTCAAACTA TCTCAGACAAGTCCTTCCTTGATGTTTTCTTTTCTGTTCCATTTGTCCCAAGCCACATGCAGGAGTTATT TATCTTGCGTCTTCCAAAAGGGGAAGCAAGAAGGGAGATTTTTCCACTTAAGCCTGGGGAACAAGTGAAC AACTGTGTGAGGGGAGGAACATTCCACAAGCTGCCTCAAAAGGGAAGACTAGACTCCTCTGGAAGTTGGG GTTATTGTGAAGCAATACCAAACCCCCAGGTCCTTTACATTTCTGTTAGTTTTACTTCATTCACTCTGTG CAATAGGGGGTGAGGTTTTGTGTCTCTTTAAGCCCAAGAAAGGACCATTATGAAGTGGGCTCTTCCTCTG CCTGTTTCTGCTTCCCAAATGCTATAGTACAAGTGAAGACATATGATCCCAGAGGAGACCATATGTGTCA AGACCAGAATGTGCTTGGGGTGTCTTAAGAGCATTTTAAGGACCGAGGCTGCCACTTCAAAGTTCACCTA GTCTACCCATTTCAATTGATAGATGGGGGAACCAAGGTCTAGAGAGACCAAAAGACTTGATACTACTGTG GTAGAACAAGACCCCCTGGCATTTAATTTCAAGCTGAGTATTTTTCTCCATGATGCCGGGTTACCTCCCA CCACCATTTGGTCAGTTGAGAAGTCTTGGAAGAAATAAGGGATGATGAGCCTGACAGGGAGGTTTTGGGA GAAGAAAGAGGGAAGACATGGCCACTGTTGCTCCTGATGGAAGGTTATTTGTGGGTAGAGAGAGCAGGTT TGTTCTTTGTGGCTGCAGGGGAGATGGGGTAGACAGATCAGAAAGTTTGAGGGAGGCACATTTAGATCAG TAAAAGAAAGAACTTTCTAAAGTCACTTGAGAATGAAAAGCCATTTAGTTAGTGCAAGAAATGAAATGTC TCCACCACAGAGCCTCTGTTAGGAATAGCATTTTAGTTTTGAATCCTCAGAGGAGATACTGCTCCAAAAT CCCTTATAGTCATGAGAGTATTAGAGTCTAGAGCTTGGCATTTAGAGAATGAGGCCTTAACAGTTACCAG AACAGAGGTATTTTCTAGATCTCAGCTAACATCCCCTCTGCAACACATGGAAGCATCTGGATGGTTTCCG TACAGGACCTAAAGAAGTGCTGTCTCTTCTGGGTAGAATGGAGAAAAATGTGGCCACCCTCAAGTTTCCA TGGGTTACATTCCAAGACTATTGTTCTTTGTTTTAGAATGTGGATCTCATTGTCCCAAACTGGCAAGAAG TTCCTGCCTATTAACTTCTCCCATTGCAGAGGGAGTAGGAAGGAGGGGGAGGAGGCGACAGAGGAGGAAG AGGAGAGATTGGGTTTAGGGAAAAAAATAATTTTAGAATATCAGGGATTGAAGGGACCTTGAAGATGATC TGGTTTGGCATTGCCCAAACTTAACTAGTTAGCCCATCACCTTAGTTGAATCACTTTGCAAAAACTTTAA TAAATGTATTACAAAAGCAGATTTTATATCACTACCATAAATGGAAAAAACTCTGTGTACCTTTGTCATA AATAGAAGGAAACTGTAAAAACAAACACATAAAAAAAACAAAACAACTTGATTCAGTTCCAGCTGGATAT AACTTCCTGTGGAAGCTCTGAGCTGGAGGCTTATTCTCTTTTTGTTAAAAAAGGAGATAGATGAGTATAA AGGAGGTGTTTAAGACATCTTGGCACCAAACTGAGACTTTCTTCTCATATAAGCAGAATTGAAAGAATAT TAAATGGAACCAACCTCCTCATGTTTTTCACTATCATTTAACTTGTACCATCTAACATTATCTTGCACAT ATCAGGAATTCAGAAGGAAATCTCCATAAGGAAGTCTCACCCTCACTGAACTCTCAATCTCTCCTCCCCA TAGGGTTCCCAGCACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCC CCTGTAAGTACCTAAATATCATGTCTTCTTGTTTTCATTCCTACCGCTAGCACCAGGGGTTCTGAGCCTG CCAGCCCTGGATGCTGAAAGGGAACAGGGACTTCCCCATTTCAAGTTAGTGGTCTTTTTTTTTTCTTAAG TTAGGAAGCTCGGGATAAAAACTGGGATGAGGACCATTGGGTGGAGGTATCAGAGAAGAGAGAGTTCCAT GTAATGTTAGATAAACTTCTTAGTAGTCAGAGCCTCCCAGCAATGAACTAGGATTGCTTTAGAAGGAAAT GACCTCTTTGTCATATGAGGAATTCAAGCAGGCAGGAGACAGGATGTGGGGGATTTCTGGTAGGGGTGGT ATTAGAAGAGATTCAAGCTATAGAGAGAGGAATGTGTTGGCTTCTGAAACAGTGAGGGTTGTTTGGTTGT AAGCAACAGTTCAATCTGACTAAATTGGGGAAGGAGGGGAAGATACAGAGGTAGATTATAATATTAAAGG CCTTGGGGAGGACTGGAAAAGGGCAGCTCTAGGCTTTGGGAGTTAAGAACTAATGGACAGTCTCTGAGAT ATTGCTGTCTGAATGAATCAACTCCAGCAATTTTCACATCTTGAGAGAATGTGCCAAGAAGGTTTTTATA AATTCAAAAAATGAGAGCCAATCTGGCTGAGCTTGGGTCCTGAGCCAGCTTCTTGGCCAGGTGAGAGTGG GGCCCCTTGATTGACAGACAGTTCCTCGAAGCATTGCATGCAGGGACAGGAGTAGTTATCCACAGCTCAT CTGGAAGCCTTCACAAGGAGAGGAGGAAGAAACAGGGCAGGCAAAAAGTGCAATTTCTTTCAACCTGTGA TCCCCTCATCCTCTGTTTACTAAGAAGTGGGAGTGATGGCAGACCCTGGCAATCTTGATCAGGCTGGTAG ATGGAGGCAAAAGTTTCTCAAAGTTGGCATTAAGTTTTGAAGCAGCTCCAGCCAGCTAAGGGCCTCAAAG TTGTGTGTTTTCTTGCTTCCTCCTACTCCAAGTTGAAATGGCAAGAAAAATTGCCTAATAATACTACTAA TAATATCACACTGTGAGGAAGATGATGACATCTGTTAAAATTCACAGTGTCATCCCCTCTGGATGTCAAT TTTCCTATCTGTAAAGTGAAAGAATTGGTCTGGATCAGTGATTTTCAGACTTTATAAGAATTCAAAGCAG CAGAAATACTTTTCCAAGCTAAATCTTAGGTAGACACCTAGGATATAAAATATATAAAATGGGAGCTGCT TGAGTGTTCCACGGTGCTCACATGACTGGCTTCTTCTTTGTTCTGTCCCTCACCATGGCAGTCCATGAGG CACAACTTTGGGGATCTCCAGTAAGCTGCTCTCCAAGCTCCCCTAGCCTGTATCCGAGGCCACAGGCACT TTGGAGGTGAAGCTGGCCTTATTCCTGACCCCTCTGAACGCTACTTTCTCTTTCCAACAGCAGCAAGAAG CCCTGCCTGATGAGACAGAGGTGGTGGAAGAAACTGTGGCAGAGGTGACTGAGGTATGTGGGCAGTGACC GCAGCCCCTTAGCCCCTCTCTACCTGTATCTGTGCCCTGAGAAATTAGGGCGGATGCTGTGGGTCTCAAT GCTAGAGTGGGGCATTCGTCTCCCTGTACACACATAGCATAGATGCAAACCCTGAGTATATCCCACATCC TGACACACTCCTGAATGCTTCCCAAACCTTCAACGGAACCCTACGTTTGGGGACCAGGACCTTAAAATTT TTGTTTTTTAAGCTATGCAACAGTTGTTCTTCCATGATTACCCACAGTTTTTGCAAACGTAAAACAGAGG AGGCCGGGTGCGGTGGCTCATGCCTGTAATCCCTGTAATCCTTTGGGAGGCCGAGGCAGGCAATTCACGA GGTCAGGAGTTCAAGACCAGTGTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAG CTGGGCGTGGTGGCGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGTAGGAGAATCGCTTGAACCC GGGAGGTGGAGGTTGCAGTTAGCCAAGATCTCGCCACTGTACTCTACCCTGGGCGACAGCATGAGACTCC ATCTCAAAAACAAACAAACAAACAAGCACACACACACACACACACACACACACACACACACACACACAGA GGAAAGGGGAGATGCTTGGGTGTGGCTGGCAGGGGTGGAGGCTTGACACCCTCTTGTGAACATAGATCTC AGTCAATTTAGAAAGTTTACTTTGCCAAGGTTAAGAATGTGCCTGTGACACAGCCTCAGGAAGTTCTGAG ACATGTGTCCAAGGTGGTCGGGAGTACAGTTTGCTTTCATACATTTTAGGGAGACACGAGACTTCAATCA ACATGTCTAAATTGTGCATTGGTTGAGTTCGCTAAGGCAAGACAACTTGAGAAGTGAGGGCTTCCAGGTT AGAAGTAGATAAGAGACAAATGGTTGCATTCCTTTGAGTCCTTGATCAGCCTTCCCCTGAATACACAATT TAATCTGGCTCAGTGAATCTGCATTTTTACATAAACAATAGGGGAGAGGAAGCAATCAGATAAGCGTTTG TCTCAGGTGAGCCTCAGAGGGATGACTGCATAGAATAGGAGGCAGGTTTGTCCTATGCAGTTCTCAGCTT GACTTTTCCCCTTAGCTTAGTGATTTTGGGGTCCAAGGTATATTTTCCTTTCACACTCTCTTTCCCTAAC ACCCCTGGTGACCTCTAAGGCAGCTCAACAGAATCCCAGGCATACTGCAAAACACAGCAGGCCTATAGAT TAAATCTGGATTCCCAACCCTGCGTTTGTGCTTTCTGTGACCTGGAACCCTTCAGCTACCCTTATGGGTC TGGGATGGGAGTGGGGCCATTTCACCCATTCTTCTCCCTCAATTCCAGGTATCTGTGGGAGCTAATCCTG TCCAGGTGGAAGTAGGAGAATTTGATGATGGTGCAGAGGAAACCGAAGAGGAGGTGGTGGCGGAAAGTAT GTCCCTTCCCTGTAACTTGGCACATCCAAGCTGCCCTTGGCTGCCTGGGCCTGGGGCACGAGGACAGCCT ACATGAGGCTCCTTCCAGCAGAAATGCAGGGTGGGGTCCTCAGTGGGCTATGAAGGAAACACGGCTTTGA CTTAACAAGTGGGAAACTGTGGCACTCAGTCCCCTGGGATCTGGGCAAGATCGGTTTCCAGGCCATCCAT GTGTGTGGTAGGAAGGAGAGTTCTCCAGCTGGAAATGGGCTTCTCCCCTCATAGCTCTTTGCCCTGAGTC CAAAGCTGAGTTTCCCAGTCCCACGGAGGTCGCTGATCACATCTGGTCACCGAAATCTCCCATTGCTTCT GTATCAGCCCGTGCCCCACAGAGAAGTAGAACTGAGAGAAGAGATCAGGAACTTGCACACTCATAAGCTC ATTCTATTTCACACAGTCCAAGGAAACGAGGTCCTGAGGAAATGCAACCTGACATAATCCGTACCATGCT ATCCATGCGTTAGTGCCCTGGGAGAGAAATGACCTAGGGGCTCTGGCTCCAGCCCTAGGTGCAAAGCATT TGTACTCAAGGGGTTAAGAGCAAGGACTTTGGAAGCGGTCCAACCAAGCTTTGAACCTAGGCTTCTCCAC GCCAGCTTGCTTAGCATCTCGGAGCCTCAGTTTCTCATCTCTCATATGGGGCTGATGAAGATGGCAGACC CTTGTCCCAGGGCTGCCGGGAAGTTTTCAGACAAGCTGAGTAGGCATCCGCTAAAGGATTATTAAAACAC CCAAAATAAAGCATTGCGAGGAAAAGGCCACATTAAGCTCTCATCCTGAGGGGATAGCTAATGGTATTTG ATCTAGCTGGGCACAGGGTTTCTGTTGAACAGAGGGACATCTACTGAGTCATGTTCCTTCCCGCCTCCAC GCCCACCTCATCCGGTGTTTACCAGGCTCTATTGTCCAGCATGGACTTTGAGGCTCTTCTCCCTTTTCCT TTACTGCCACTTAAGTCTGTTTTGTTGGGCCTCAGCTCCCTGGCTCAGTGTCAACAGCTGACTTTCTAAG CCATTCTAGAAAGCTTATTCTGGAATCCAGAAATGCCCCACTGTGATTGTTCAATGGAGACCCAGGAACA CAATGGTTGCTTCAATCTTCAGGAAAGCCATATGGTATCTAGTGTTTCTGGGTCCCAGACTGAGCCTCCA GCCCCCCAGAAGTGCCTGACCTCTATCTCAAGCTAAACCTCTAATCCCCAGGCTGAACCAGCTGCTGCCC TAAATGTTGACTGTGAGGCTCAGTGCAAGAGCAGGCAGGACTCAGGGCTGTCCAAAGCCCAGAGTGGGGG CCACAGTCAAGGACTGTCAGCCCTGAGATCTGTCCAGGTAGGATGGGGGTGGATGTGCTAGTCCAGGTGA TGCTAACTCCCTTGTCTTTCTGCCCTACAGATCCCTGCCAGAACCACCACTGCAAACACGGCAAGGTGTG CGAGCTGGATGAGAACAACACCCCCATGTGCGTGTGCCAGGACCCCACCAGCTGCCCAGCCCCCATTGGC GAGTTTGAGAAGGTGAGGGCTGAGAGACAGGGGCAGGGGGAAGGGATTGGGCACTTCGGAATACAGGATG TCTGCTCAGGAAACTGTTGGCTTGGTGGTTCTATGGGGCAGTGCCAGTCTCAGAAGTCCCCTTGCTAGAC CTAGTCCCAGCAGGAAAGAGGGGATGAGTCAGAGTGCTCTGCCTGGCACTGGATCTTTTCAGCAACCAGC AAGACTTTAAACAGCACCATCAGGTTCCAAGCCCTGTGCCAGACTCTTAGAGCTAAGAGTATAACAGCAT CAGCAAAGAATCAGGTCCAAAAATACGGGTTCTGGGGCCAAACTGAAGGTTGACTTCAAACCTCATCTCC ATCACTTATTAGGTGTGAGATTTAAGCTAAGTTGCCGAACCTTTTCAGGTCTCAGTTTTCTCACATCCAA AGAGAGGATAAAAATAGTCCTTAACTCATAGATCTGTTGTGGAGATGTGTCAGAAATGTTTGGTACATAA CAAGTATCCAATAAATGCTACTTAATTTTAAATTATCTCTCAAATATGTCCCTTCTCTCCAATAGGATCC ATCCATCCGTCCAAGTAAATATTTTTTGAGTGCCTGCTCCTGCCTACCATCATGCTAGTGGCAGTCTAGC TCATGGCAGCAAATCTAGGGCCAGCACTATTCCTACAGCCTCCCATCTGGCTTCTCCATCTTCAGTTTCT CCAGAGACTACATAGCCTCTGGGCTCCACATTTTAATATCATTGTTAACATTTTCCTCCTCCTCACCCCT CCCCACTCCCAGTGCCCAGTCACCAGTGCCCATCAGTTCTCCCTCTGCAGTGACATATAAGCTATACTAA ATAAGTACGGACAGGATGTTCAACACAGGCTCCCCTCCTCCTAACACAGCTACTTACGGCCACTGCATGT CCAGCCCTCAACATCTCTGCTTGGCCACCCCTATGTTCAGAGATCGACTAGGACTCCATTGGCTCAGCAT ACAGTTGTACTCACACCTAAGGTTTAGTACAGCGACATATTCAGGATATACAGCTGGATCGTAAGGGAAA AAGACACTAGCAGAGTCTGGAGGAATCTGGGTGGAGACTGACTGACTCCCAAGAGGGGTCATCAGAGTGC ATTCTTACCCCAGCTACAAAGAGGCAGCCACATGTGAGTGATGTTTCTTTCCAGGGAAGTTCATTAGAGA CTCAGCACCCAAAGTTTTAATTGGAGGCTGGTCACATAGGTACCCTTTGCCTAGCATGCACCAGAATTTC ACACTTCCAGAAGGAAAGCAGATGTTCAGCATAAACCAGATTGTTTGTACAAACAGTCCAGGCATAGCGA GCCACTCTTATCAGTTAGGGAAAGATTTACAACAGTGCAGAGAACTGTTTCCCAGCTAAGTTCCCAGACA CCAGCCACAGGCTGACCTTACAAGCAGGCCTTTTCTAAGGATAACAATTCCAGGCCTGCTATGTTAACTC TTCTTTGAACACTCTTGTTTCTCTCCCATTCCTGTCTTTAACTTTCTCTTCAAATATCTTCCAGGATTTT TTTCCCTATATCTCAGAACTGACTCAGTCATGCCTCTGCTCAGAGACCATCGATGGCTCTCAGCCTGGGC TGAGCATTGACCTGGGAACCCAAAAAGTGGATTTGTGGCCCAGCCCTATCACTAACTCACTATATGACCT CAGGCTAATGACATTCCTTGCTTAACCCTCAGTGTCCCCATCTCTGAAATGGACAAGGATATTGGTATCA GCGAAGGGCTTTGGGAATGAAGGAGGGGGTACTCTGTGCTTTGCCAACAGGTGTGCAGCAATGACAACAA GACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAG CTCCACCTGGACTACATCGGGCCTTGCAAATGTGAGTGTCCTTGGGCCCTTCCAGACTCCTGTCTTGGGG AGAGAGCTCTGAGCTGGCACTGATGCTGTCTCTGCCACCCCCATGCTGGGTGATCTTGGGCAAATCTCTC TCCCTTTCTGAGTCTCGGCATCCCCATTTATAAAATGAGGTAATTGTCTATGAGTTGGCTCCTCTCAACT CTGAGTTCAGGGCACTTTCTGGGGAAGGACTGAGCGATTATGGAAGGTCAACATCAGGGAAGATTTCTGG AGTCTCTCACTAGCATCTGAGACAACTGCATTTCATTTCTCTAATGAGGAAGAATTTCTTCTCTCAGGCT AAGTTGAATCTTTCTTGCTTCAACACTGTAAAGCAAAAATGATGTTTGACCTGGGCCTACAAAATATTTT GAAAATATCTGATTTTGAATGCTTTAAAATAAGGGCATGCCTGTCGGTTTGCTTTGGGCCCTGTTACTTG GTACTGTCATATCTTCACCCTTTTACTCCATTACATTCCTATCTGCCCTCCGAAGAGAGAGGATAAGCAC CCTCTTCTGGAAACCTGGGAGTCAGTTGTCTGGGGAGGGATGCCAGGGTGTGGTCTGATCTTTGGTTAGT GACCCCAGCTGCAAACTCAGTGGGGCCAAGTGCCTTGTTCAGTATCCTCCCTATCATGGGAGACCCCCAA GACCACACCTGCTCCCCCTCCAAGGCAACATCCACACTGTGGGTCTTGTGTATTCTGGCACCCGATGGCA ATGAGGAGAGCCACTCACCTACCTCAGGTGTACAGGGTGCAGAAAAGTATGTAGGGGGTGGGAAACAAAG TTCTCCTCGTGGGACCCCAGGTATGAAATTGAGAAGGTACAGAGTAGAAAAGGAGGGTTGGGGGAAGAAG CATGGGTAGGAAGTCCCTGGGCAGCAAGACTAGAGAGCCTGTCTTAAGGAGTCTTTATGAAGTGGCTTTG CTTTCCCTGAGGCATGTTGCCCACTCACTTCAACTCCTAAGGTTTTTATCACCAGATATTCTCTCCCAGA CCCCAGCTGATGATGAAGGTAGCCTCACAGAGGGGACTTTCCCTGGTTCAATGATGAGGGAAGAACAGAC CCCTAAGCCCCCAGGTGACCACACTGCCCTGGATGCTGGATGAGGCTCTGACATTGTGGCCTTGAGCAAG TCCCTTCTCTCCATGCTGACCTCTAATAAGTCCAGTACAAAGTGTGAACCTGGGTCAGGCGCGGTGGCTC ACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGTAGGGAGGATCACTTGAGCTCAGGAGTTCGAGACCAG TCTGGGCAACGTGGCAAAACCTTGTCTCTGGAAAATATACAAAAATTAGCTGGGTATGGTGGCATGTGCC TGTAGTCCCAGCTACTCAGGAGGCTGAGGAGGGAGGATTGGTTGAGTCCAGGAGGCTGAGGCTGCAGTGA GCCGTGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACCCTGTCTAAAAAAAAAAAAAAGAA GAAAAAAAGAAAAAAGAAAAGAAAAGGAAAAGAAAAGTGTGGACTTGGATGAAATCTTCAGGTCCAACAT TTGGGATTCTAAGTTCCAAAGACCAGGTTGGAATCATTTCTAAGAAGGTTCTGGTGGTTACACATTCCTG AGTCCTCTACTCCCCACTCCCTGCCAAGCTGGGCCTGTGGATAGATGTGATCCCTCAGCCTCCCAGCTTC AAACACCTGCCAGTGGTTGACGTGAACAACATGGGCTCAGTCTCAGCTAGGATCACACCCAAAGCCCAGC ACCCAGTAAGGTGCAGGAGCCATCCATTTCCCTGAGCAGAGCAGATTAGGCTGAGGAAAGCAGCAGCCAT GCCTTTGCACAATGCATTTCTAGGGCATTCTTCCCACACATAATCTCCTCTGCTCATTGTCCTGTGAAGA AACTGTGGCCTGGAGAGGTTGAGCCACTGTGCCAAGGCCACCAATGCAGGTGGTATGTGGGTGGGTGGGG GCCTGGGGTGGGGAGCACGGCCCAGGCAGGGTCTGTGCTGACCGCCCTTGTGTTTGGAACCTAGACATCC CCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGT CACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCTGCGGGTAAGTGGTCTC TCTGGCCTTGCTGGCCCCGTGCTGGTGAAGATCCAGTCCCATTCCTAGAACTGGGCCCCCAGCTGCAGGG CGGCATCCTGCTCCGGAGCGTGCATTTACCCCTGAGCACCAGGACACGTACTTCTCTTCCTGCCTTTGGA GGCTGTGGTGCACATTAACATCTTAGAGGCTCTGAGAAGTCCTGCAGCAGAGACCTGCTCCCTTTGCTTA ACCTAACGTTAAACAAAAGAGACACAAACAGCCCTATTCCTTTTTCCTTTGGAGTCTGTGGATCTTAAGC TTTAATGAGCATATTAACTACCCCAAGAAGCTGATAAAATGCAGATTCCTTGGCCCCATCTCAGGCCACT GAAACAGTGTCTCTAGAAAGCAAGGCCCAGGAAGCTGCATTCTAAATACTCCCCAGGTGATTTATGTTTA TTTTATTTTTTTGAGGCAAAGTCTCACTCTGTTGCCAGGCTGGAGTGCAGTGGTGCGATCTCGGTTCACT GCAACCTCCACCTCCTGGGTTCAAGTGATTCCCCTGCCTCAGCCTCCTGAGTAGCTGGGACTGCAGGCAT GCTACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCACTGTGTTGGCCAGGCTGGTCT CAAAACTCCTGGCCTCAGGTGATCTGCCTGCCTCAGCCTCCCAAAGCGCTGGGATTACAGGTGTGAGTGT GTGCCCGGCCTTCGCCAGGTGATTTTGATGTGGGTAGCTATATGGAGAATTCTTTGAGGTCATCCCAGGC TTCTATTTTTGTGAATGAGATGCTAGTACCCATCTATGACACCTCCCTCCCCTCGCTGTGAGCTTTGGTC TGGCTAGTCTCTGCCTGCTCTGGCCTTCTGGGAGGGGTGGGAGGGCCCGACTGGTCCAGACAATCTCCAT GGACCTCTTGTCACACACAGTCTCTACTCCCTCAGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGA GGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCT GTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTAAGACCCCAGACCCTAGAGTGAAC AGAGCTCAAGGCTGGCAGGTGCACTAGCTATGGCCAGAAAGCCTCTCAGCAGCCTATACTGCTCCAAGCC CTGGCATCCACAGTTTGCCTGGGGATTGGAGCAGAAGGATGAGGCATCTGGAGAAAAGATGTGGACCTGG GACAAAGAAACCGATAAGACACTCTCATGCTGAGGTGAAAGTCAGTAGGAGCTCAAAATAGCTCCATAAT CCTGCAAGTACTAGGCGTGGATATCTGGATAATGAAGGAGTGTGAATTAAGAAGGAGTACCAGGCTCCAA GGGGTGGCAGGGGACAAGGTTGGGTCAGCCACACGCCCCCTGTCCTTCAGCAGAACATCCAGGGGCAGAG CAGCCACCTGGCACTGTCTAAGCCCCCTCCTAAGGCTCAGCCCCAATAGGGCCCAACTGACCCTGGAAGT TATCCAAAAAAGCCTGTCTATTTTGCAAGCCCCCAGTTTGAGGGCTCTTGTCCCTTGTCCAAACGAGTTA TGAGGCCCTGTGCAACTGCACTGCCGAACAGGCAGGCAGCTGGCCAGTTAGCAAATGCTTATGGAGTGTG CATTTTGTGCCCTGCACTATTCTAGGCAGGGGATTGAACAGCAGTCAGAGCTGGCATGGTCCTTGCCCTC ATGGACTTATACTCTGTTCATAACCTGTCACTACCTTCTGAACTTCTCTTGTGGTGATGAAGTGAGAGCC CCTGCTCAGCCTCAGATGGAGCAAGCTACACCTGCACCTTCCCAGAGTGGTTTTTTCTTCGTCCTTGGGT TGTGGAAGCAGAGCATCACACAGAGGGGAAAGGAAGGGCTGCCCTACTCACATACTCAGGGAACTTCCTC TCTAGGATGTTCACCCCTCGCTCTTTGTCCAGCCTGTGTGCCTGGAGTCTGCCAACCCTGCCAGTGATCC TGAGGGCTGGGGTCTCCTGGGCTCTGGGAATCTCCCGGCCACTTCTCTCCCAGGCTTTTGCCATGGCTGG GATCCAACTGAGTCACTCATTATGGCAGGGAGGGGAAAAGTCAAAGGGGAACATCTGGAGCTCAGGCAAA GCAATTTGATCCCACTGCAACAGAGGGCCTGGAGGGAGGCTTTCAGATGGGGTGCAAGAACAGCACATCT GGGAAAGGGGTCCAGCTTGGGCAAGGGGACCCGCTTCCTCCTCCTCCCATCCCAGGGCTGTAGGTGACCT TGCCTGCATCCCTGCCCCTCCCTGGGCCTCAGTTTTCCACCAGTACAATGAAGGGGAGGAGAATGTTCCT ATCAGTTCAAACATTGTGTGATTTCTTTGGTGAGCTGGGTGGGGCTGCGAGGTCTAGAGGTTAAGAAGAC AACTGGAGTCACATTGTTCCCTGGAGATCCTTTGTGGATCTTTAGGGACAAGTAGTTGGGGGCTCTGGGA AACAAAGAAAAAAATTATACACATGCTCTGGAGTCTAAGGCCAGCAGGGAGAATAGGGAGGGAGGACAGT GGGAGAGACATCCAAAGGGCCTCCCTCTCAGACATTACAGGATACACAAGCAAAGCTCTATGAAGATGGT TAGAGCTCCCGTTGACCCTCACTGCCAATCCCAGTCCCTTTCCACATTCCTCCCCAGAAGGCAGCACTGT CACCAGATTGGTGTGTCATTTTTAGACCCTTTACTAGGCATTTATAGATGTATAAATGTGTGTCCATAGA CAATATACAGTGCTGTGTCATGCTAGATTTTGATCTACCCATAGCAGAAGTGCTGAATTTTGATTTTAAG TTTCTGTGTCCCCAGTTCTCAGCCAATTAGGAAACAATCAAATACACCAAACAGACCTTTGTTTTTGAGA CCCTGAAACCTTAGAGCTGGAAGGGCCGTTAGTAATTATGGCCATCTCCTCCTCTTTGCTGGAAGGAGAA ACTGAGGTTCCGAATGGTGCACTGCTGTTCTCTGAGTCTCAGAGCAGTCAGTGGCAGAGCTAGGGGTAGA CCTGGGATTCTGGCTTTTTGTCCTGCTTTAAATATCCTTTCCTCCATGCTCTGGGGCAGGCTAACTCCCC GGTTGCCTCCCAAGGCTGGGTGTGGAGCTTTTCCATGCCTCAGGCCCTCCCCTGCCTCCTTCCCTGCAGG TACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCT TTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCAT CAAGCAGAGTGAGTGTCTGAACAAAGAAGCAAGGGGCATGGGCAGAAACACTGCTCCCAGGGTGCTGGGT TGTCATCCCCCCACTCTCCGCTCTCTTGGTCTGTCTGTTGTCTGTCCTCTCTGCCTGTCTCTGCTCTCTC TGCCTATTTGACTCCTGTCTCTTGGGCGTCTTCCTGATCCTTCTCTGTCCATCCAACTGTCCCTCTCTCT TTCCCTTCCTCAAGCGTTAGCACTCACCCGTGCTAAACACTATTTTGGGAACTGGCAGGCACACAGAGAG GAAACAGGAAGTGTAACTTGGCAGCGTGTGTAAGAGACAGGGACAGGCCAGAGACAGAGAGAGCGAGATT CCTCCGTCACTGACTTCCTGGGTGACCTTGCATGGCCACCTAGACCCCTGCCCCTGGGGATGGGTGGGAG TCCACTGACTCCTTGGGAAGTGCGTTATCATCGACACAGCCTTATTTTTAACCGTGCTCTTTTCTTGCTT TGCAGAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAA CCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGT GCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTC TTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGT AGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATT GCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATT TCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGA CACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCAC CAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAG ACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTA GGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGG GCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTC AGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATC GGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTC CCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAA CTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTG AAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGT GTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACA CAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTT ATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAAC CCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATT CATTCATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGG GGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTA GATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCAT GAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCAC ATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAA CATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTT TCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAA AGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGA GAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCT CTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGT GTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGA ATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCA TTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGC AGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAA TACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCAGAGAACTATCATGGAAAA Download Select all
Length	25959
OMIM ID	182120
HGNC ID	HGNC:11219
Unigene ID	Hs.111779
Ensembl ID	ENSG00000113140
PharmGKB ID	PA36055

mRNA Information

mRNA ID	NM_003118.3
Exon	join(1..190,10854..10923,12381..12443,13839..13926, 15361..15482,17271..17391,19455..19588,20546..20694, 22820..22968,23456..25959)
mRNA Sequence	>6678 GGGAGAAGGAGGAGGCCGGGGGAAGGAGGAGACAGGAGGAGGAGGGACCACGGGGTGGAGGGGA GATAGACCCAGCCCAGAGCTCTGAGTGGTTTCCTGTTGCCTGTCTCTAAACCCCTCCACATTCC CGCGGTCCTTCAGACTGCCCGGAGAGCGCGCTCTGCCTGCCGCCTGCCTGCCTGCCACTGAGGG TTCCCAGCACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGC CCCTCAGCAAGAAGCCCTGCCTGATGAGACAGAGGTGGTGGAAGAAACTGTGGCAGAGGTGACT GAGGTATCTGTGGGAGCTAATCCTGTCCAGGTGGAAGTAGGAGAATTTGATGATGGTGCAGAGG AAACCGAAGAGGAGGTGGTGGCGGAAAATCCCTGCCAGAACCACCACTGCAAACACGGCAAGGT GTGCGAGCTGGATGAGAACAACACCCCCATGTGCGTGTGCCAGGACCCCACCAGCTGCCCAGCC CCCATTGGCGAGTTTGAGAAGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACT TCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCCACCTGGACTACAT CGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGCATG CGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGA CTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGA CCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTA CACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGG CTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGA CCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAG GATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAAC CCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGAC AAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAG ACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATT TTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCT GGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAA TACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCC AGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGG ACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGA GGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCC CAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTT CAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTC TCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTT CAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTG GTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCT TTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTC GGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAA TCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACT TAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACAC AAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTA TGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTT CCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTAC CACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTC ATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGA CACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACA TTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGG AGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACG GCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCA GCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCT ATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTC TAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGT ATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCA ATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGT TAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACA CAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAG CCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCAT TGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAG TAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACA TAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCAGAGAACTATCAT GGAAAAAAAAAAAAAAAAAA Download Select all
Length	3604

CDS Information

Location	join(10867..10923,12381..12443,13839..13926,15361..15482, 17271..17391,19455..19588,20546..20694,22820..22968, 23456..23484)
CDS Sequence	>lcl\|NM_003118.3_cds_NP_003109.1_1 [gene=SPARC] [protein=SPARC precursor] [protein_id=NP_003109.1] [location=204..1115] ATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAGCAAGAAGCCC TGCCTGATGAGACAGAGGTGGTGGAAGAAACTGTGGCAGAGGTGACTGAGGTATCTGTGGGAGCTAATCC TGTCCAGGTGGAAGTAGGAGAATTTGATGATGGTGCAGAGGAAACCGAAGAGGAGGTGGTGGCGGAAAAT CCCTGCCAGAACCACCACTGCAAACACGGCAAGGTGTGCGAGCTGGATGAGAACAACACCCCCATGTGCG TGTGCCAGGACCCCACCAGCTGCCCAGCCCCCATTGGCGAGTTTGAGAAGGTGTGCAGCAATGACAACAA GACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAG CTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCC CCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCT TCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGAC CACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGC AGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGC TCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTAC ATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCT AA Download Select all
CCDS ID	CCDS4318.1

Protein Information

Protein ID	NP_003109.1
Protein Name	Secreted protein, acidic, cysteine-rich (osteonectin)
Molecular Wt. (Da)	32698
Protein Sequence	>6678 MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEE EVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFAT KCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQ KLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLR APLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI Download Select all
Length	303
Uniprot ID	Q16643
Ensembl Protein ID	ENSP00000292385

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Disulfide Bridge	101;123
C	Disulfide Bridge	112;149
N	Glycosylation	116
C	Disulfide Bridge	273;289
C	Disulfide Bridge	72;83
C	Disulfide Bridge	77;93
N	Glycosylation	88
C	Disulfide Bridge	95;130
R	Proteolytic Cleavage	195
Q	Proteolytic Cleavage	20
C	Disulfide Bridge	155;265

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1277	COL1A1	362	NP_000079.2	in vitro	7034958
1278	COL1A2	363	NP_000080.2	in vitro	7034958
1280	COL2A1	361	NP_001835.3	in vitro	2745554
1281	COL3A1	365	NP_000081.1	in vitro	2745554
1305	COL13A1	383	NP_005194.3	in vitro	11956183
2335	FN1	626	NP_997647.1	in vitro	2745554
3339	HSPG2	804	NP_005520.4	in vitro	2745554
5154	PDGFA	1424	NP_002598.4	in vitro	1311092
5327	PLAT	1419	NP_000921.1	in vitro	2745554
5340	PLG	1417	NP_000292.1	in vitro	27 455 547 982 919
6383	SDC2	803	NP_002989.2	in vitro	2745554

Pathway Information

No matching records could be found.

Structure Information

PDB ID	1BMO
Resolution	3.1
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	BM-40
Model	View

Domain Information

ID	Location	Description
cd00252	154-301	SPARC_EC
cl22905	154-301	SPARC_EC superfamily
cd01328	71-152	FSL_SPARC
cl00097	71-152	KAZAL_FS superfamily
pfam10591	153-289	SPARC_Ca_bdg
pfam00050	95-149	Kazal_1
pfam09289	72-93	FOLN
cl23022	72-93	FOLN superfamily
smart00274	71-94	FOLN
cl23052	71-94	FOLN superfamily
smart00280	98-149	KAZAL
pfam07648	101-149	Kazal_2
cd00104	101-149	KAZAL_FS

Ontology Information

HPRD ID	145
Molecular Class	Secreted polypeptide
Molecular Function	Carboxy-lyase activity (GO:0016831)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO