Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ZEB1 | 6935 | zinc finger E-box binding homeobox 1  | 10 | BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a, FECD6  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23420790    | 2013 | Cell line : - Source : First Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, China Sample Type : CRC tumor and normal tissue No. of Sample : 92 patients primary CRC Stage : - | real time RT-PCR | Up-regulation | - | Data indicate the potential of ZEB1 as a novel prognostic biomarkerfor CRC. the relative expression levels of ZEB1 were significantly higher in CRC tissues compared to the normal adjacent mucosa and higher expression of ZEB1 correlated with liver metastasis |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type, "Homeoboxes / ZF class" |
| Description | This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[   |
| Chromosome | 10 |
| Location | 10p11.22 |
| Start | 31318783   |
| End | 31529814   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 211032   |
| OMIM ID | 189909    |
| HGNC ID | HGNC:11642    |
| Unigene ID | Hs.124503    |
| Ensembl ID | ENSG00000148516    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011519645.1 |
|---|---|
| Exon | join(1..351,54236..54391,68342..68484,68938..69016, 142255..142455,176994..177056,183566..183727, 191891..192093,195821..195926,201344..203154, 205151..205331,207890..211032)   | mRNA Sequence |    Download   Select all |
| Length | 6278   |
CDS Information
| Location | join(453..510,142255..142455,176994..177056, 183566..183727,191891..192093,195821..195926, 201344..203154,205151..205331,207890..208482) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS53505.1 |    
Protein Information
| Protein ID | NP_001121600.1 |
|---|---|
| Protein Name | zinc finger E-box binding homeobox 1 |
| Molecular Wt. (Da) | 121954 |
| Protein Sequence |    Download   Select all |
| Length | 1108   |
| Uniprot ID | P01579 |    
| Ensembl Protein ID | ENSP00000229135   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 679 |
| S | Phosphorylation | 33;- |
| S | Phosphorylation | 31;- |
| S | Phosphorylation | 312 |
| S | Phosphorylation | 317 |
| S | Phosphorylation | 322 |
| S | Phosphorylation | 313 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 319 |
| S | Phosphorylation | 646 |
| S | Phosphorylation | 693 |
| T | Phosphorylation | 702 |
| S | Phosphorylation | 706 |
| S | Phosphorylation | 701 |
| S | Phosphorylation | 583 |
| S | Phosphorylation | 704 |
| S | Phosphorylation | 700 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 642 |
| S | Phosphorylation | 645 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 |    EP300 |    4078 |    NP_001420.2 |    in vitro |    12743039    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer |    hsa05206 |    
| Transcriptional misregulation in cancer |    hsa05202 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 581-629  | homeodomain |
| cl00084 | 581-629  | homeodomain superfamily |
| pfam13465 | 946-971  | zf-H2C2_2 |
| cl22375 | 946-971  | zf-H2C2_2 superfamily |
| pfam13465 | 254-277  | zf-H2C2_2 |
| cl22375 | 254-277  | zf-H2C2_2 superfamily |
| smart00389 | 593-629  | HOX |
| pfam13465 | 918-943  | zf-H2C2_2 |
| cl22375 | 918-943  | zf-H2C2_2 superfamily |
| pfam00096 | 240-262  | zf-C2H2 |
| cl23491 | 240-262  | zf-C2H2 superfamily |
| pfam00046 | 581-629  | Homeobox |
| smart00355 | 240-262  | ZnF_C2H2 |
| cl18194 | 240-262  | ZnF_C2H2 superfamily |
| pfam00096 | 932-954  | zf-C2H2 |
| cl23491 | 932-954  | zf-C2H2 superfamily |
| pfam13894 | 240-262  | zf-C2H2_4 |
| cl20498 | 240-262  | zf-C2H2_4 superfamily |
| smart00355 | 932-954  | ZnF_C2H2 |
| cl18194 | 932-954  | ZnF_C2H2 superfamily |
| COG5271 | 27-197  | MDN1 |
| COG5048 | 929-982  | COG5048 |
Ontology Information
| HPRD ID | 939 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Growth factor activity (GO:0008083); Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
