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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ZEB1 6935 zinc finger E-box binding homeobox 1  10BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a, FECD6 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23420790   2013Cell line : -

Source : First Department of General Surgery, the Affiliated Hospital of North Sichuan Medical College, China

Sample Type : CRC tumor and normal tissue

No. of Sample : 92 patients primary CRC

Stage : -

real time RT-PCRUp-regulation-Data indicate the potential of ZEB1 as a novel prognostic biomarkerfor CRC.

the relative expression levels of ZEB1 were significantly higher in CRC tissues compared to the normal adjacent mucosa and higher expression of ZEB1 correlated with liver metastasis


Gene Details



Chromosome 10 - NC_000010.11(31318783..31529814)

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Gene Type protein coding
Gene Family Zinc fingers, C2H2-type, "Homeoboxes / ZF class"
Description This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[  
Chromosome 10
Location 10p11.22
Start 31318783  
End 31529814  
Strand +  
Gene Sequence

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Length 211032  
OMIM ID 189909   
HGNC ID HGNC:11642   
Unigene ID Hs.124503   
Ensembl ID ENSG00000148516   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011519645.1
Exon join(1..351,54236..54391,68342..68484,68938..69016, 142255..142455,176994..177056,183566..183727, 191891..192093,195821..195926,201344..203154, 205151..205331,207890..211032)  
mRNA Sequence

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Length 6278  



CDS Information


   
Locationjoin(453..510,142255..142455,176994..177056, 183566..183727,191891..192093,195821..195926, 201344..203154,205151..205331,207890..208482)
CDS Sequence

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CCDS ID CCDS53505.1



Protein Information


      
Protein IDNP_001121600.1
Protein Namezinc finger E-box binding homeobox 1
Molecular Wt. (Da)121954
Protein Sequence

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Length 1108  
Uniprot IDP01579
Ensembl Protein ID ENSP00000229135  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation679
SPhosphorylation33;-
SPhosphorylation31;-
SPhosphorylation312
SPhosphorylation317
SPhosphorylation322
SPhosphorylation313
SPhosphorylation315
SPhosphorylation319
SPhosphorylation646
SPhosphorylation693
TPhosphorylation702
SPhosphorylation706
SPhosphorylation701
SPhosphorylation583
SPhosphorylation704
SPhosphorylation700
SPhosphorylation673
SPhosphorylation642
SPhosphorylation645

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vitro12743039   


Pathway Information


            
Pathway Name Pathway ID
MicroRNAs in cancer hsa05206
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00086581-629  homeodomain
cl00084581-629  homeodomain superfamily
pfam13465946-971  zf-H2C2_2
cl22375946-971  zf-H2C2_2 superfamily
pfam13465254-277  zf-H2C2_2
cl22375254-277  zf-H2C2_2 superfamily
smart00389593-629  HOX
pfam13465918-943  zf-H2C2_2
cl22375918-943  zf-H2C2_2 superfamily
pfam00096240-262  zf-C2H2
cl23491240-262  zf-C2H2 superfamily
pfam00046581-629  Homeobox
smart00355240-262  ZnF_C2H2
cl18194240-262  ZnF_C2H2 superfamily
pfam00096932-954  zf-C2H2
cl23491932-954  zf-C2H2 superfamily
pfam13894240-262  zf-C2H2_4
cl20498240-262  zf-C2H2_4 superfamily
smart00355932-954  ZnF_C2H2
cl18194932-954  ZnF_C2H2 superfamily
COG527127-197  MDN1
COG5048929-982  COG5048


Ontology Information


   
HPRD ID939
Molecular ClassTranscription factor
Molecular FunctionGrowth factor activity (GO:0008083); Receptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO