CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
TDG	6996	thymine-DNA glycosylase	12

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24532795	2014	Cell line : - Source : Nanfang Hospital in China Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	RT-PCR, Chromatin immunoprecepetation	Up-regulation	-	TDG warrants consideration as a potential biomarker for CRC and as a target for CRC treatment. In CRC patients, TDG levels were significantly higher in tumor tissues than in the adjacent normal tissues.

Gene Details

Chromosome 12 - NC_000012.12 (103965815..103988878)
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Gene Type	protein coding
Gene Family
Description	The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Chromosome	12
Location	12q24.1
Start	103965815
End	103988878
Strand	+
Gene Sequence	>gi\|568815586:103965815-103988878 Homo sapiens chromosome 12, GRCh38.p2 Primary Assembly GATTTGGCTCCGAGGAGGCGGAAGTGCAGCACAGAAAGGGGGTCCGTGGGGGACGGTAGAAGCCTGGAGG AGGAGCTTGAGTCCAGCCACTGTCTGGGTACTGCCAGCCATCGGGCCCAGGTCTCTGGGGTTGTCTTACC GCAGTGAGTACCACGCGGTACTACAGAGACCGGCTGCCCGTGTGCCCGGCAGGTGGAGCCGCCCGCATCA GCGGCCTCGGGGAATGGAAGCGGAGAACGCGGGCAGGTAATACCGGGGCCAGCGCCGCCCCTCCCTTGCG CCCCTCACTGCTGGGCAGGCTGGCTGGCGCGCGCGCGCGCACGCAGGGGTCTTTTAAATCCCGGCCGGAA TACAAAGGCCGGGGCCGCGCGTGCGCACTGTGGCCTGGTCGGCCTTTCCTTCCCTGGCTGCGGCGGTGGT GGTGGAGGTCGGGGCTGCTCTGAGGGTTACCTGGTGCACCTGGACCCTTCTTTGGTTCCCCGCGATAACC AGTTGACTATAAAATATATTAGTAAGCATTCAGCAGTCTTTGGTTAATGTGTCTTTCTGGATGCCATTCT TGGCTAGAAGGGTTTTCCGTCACCCTCCATTACCACGCAGAGAGCTGTAAAGATGAGTGTCGAACATTTC CAGCTCCAGGAGTTTTCATTTTAAAGTTGGTTGATTTGTTGCGGCTTCCCCCCACCCCAAAGGCCTACTG AAAGCAACTTTAAGGGTCACGGGTTAGATAATTTTGTTGTGGGCATATGTATACACTCTCGAGTAGTCAA TCTAAAAATGACCTTTGAGTTTTCCAGTGGCCTTGGGGACGATCTTAAGAATCCGTTTTTAAAAAGTCCT TTGGGGGAGTCAAGAGAAAAATTTGCAAAAGCAGGAGATTTAGGGACTTGAACTCCTGGCGGAAGACTAA ATTTTTAAAAAATGGATATGGTGACAGTTTTTTAAAAGATAAAGAGTGATGATTTACATTGAAATTAAAA GGAAAAAAACCTATGCCTAATGAAGAATTATCCTGACTCTCAGTGGCTAATGGGAGCTGAATTTAGGCAA TACAAGGGACTTATATGGGCCTGTTCATGTCTGTAAAGTTGGCATGTCTGGAATCTGATTCTGACATGCC GAGAATTGGTGTTACATGAAAGGGCACACTAACCAAAATAAATTAGAGCTTAGGAAAAGAGATATATGTA GACAAAGTGTGGACTTTATCTTGACTTTGTGGATCAAGTCCTGGAATAAATTACTCCACTTCTTTCCCAG AAGAACTTTACAAATAAGAGAATTCACCAGAATTTGTGGAAATCTCTCTCTCATAACCTCACTTAAGAGC AGAATTGAAACTTGGGCCAAGAATAAATTACACATTGTAAGACTTTATTCAGGGTCTTACAGCAAAATAG TAGGACTTCAATACACTGTTTAGCTCAAAGCTGTGATATGTCGGCCTGACTTCATCCAAAAGGCTATAGA CCAGATTTTATTTTGCCTTGAAAAGCTTTCACCTTCAGGAACTGTGGAAAATTCTGTGTAATCTTCTGAA ATGACTCAGACCCCAGGTAATCCTTAAGAGAGTAGTTCTCTGTCACCCTTGACTGTGCTAATCAAGAAAT GTAATGTGGGATGTGAAAAAAAATAAATTTACTTTTTTTTTTTTTTTTTTTGAGACAGAGCCTTGCTCTG TTGCCCAGGCTGGAGTGCAGTGGCGGATCTTGGCTCACTGCAACCTCCATCACCCGGGTTCAAGCGATTC TCCCGCTGCAGCCTCCCAAGTAGCTGGGATTACAGGCACCTGCCACCAGGCCTGGCTAATTTTTGTATTT TTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCTTGCCCTCAAGTGATCCACCTG CCTCGGCCTCCCAAAGTGCTAGGATTACAAATGTGAGCCACCGGGCCCAGCCGACTTTTTTAGAAGACTA ATTTCAGATATTCAAAGAAGAAAATTCAAATTCCATGAATACAGACTTTTTTTTTTGTTTTTTTTTTTTT TTGAGACAGAGTTTCACTCTGTTGCCCAAGATGGAGTACAGTGGTGCGATCACCGTTCACTGCAACCTCT GCTTCCCGAGTTTAAGCGATTCTCATGCCTCAGCCTCCCAAGCATCTGGGACTACAGGTACCCAACACCA CGCCCAGCTAATTTTTTGTATATTTAGCAGAGACGAGGTTTCACCATTTTGGCCAGGCGGGTCTTGAACT CCTGGCTTCAAGTGATCACTTTGGCCTCCCAAAGTGCTGGGATTACAAGCATGAGCCAAAGCGCCCAGCC TAGACTTTATTTCAATGGCAAAATAGTTCAGGAGTCTTAGAAAGTGCTTACAGTCAATCAACCAGAGAGG AATAAAGGAGGAATTTTCTAAGGGTACTGGGGAGTTTCCCGTGACCTCAGGCGTGAAAAAGACATTTACC GAAGATGGAAAATAGGATGCCAAATCAAAAGTAACTGGAAGAGAGTAGCATGGACCACTAAGAATACCAA CAGGAAAGATTAACCCTTGCATGAGAGTAGACTTTATAGAAATGTTAAGGAGACCAGGAAGGACTGTTTT GGTTAGATGTTGACAACAAGAAGAATAAAAAAGATTTGGGTTTTCTCCCCAGTCTACTGGCATGGTGGCA GCAGACAACAGAACACCTAAGTACTTTGTTCTGATTTGGATTTTACATCTCCTATGTTAGCAAAATGATT GTCTGACTGGAAATGGCAGAATGAATATCTGTAAGACTTAAAGCTCAAGACCAGTGAAGGCATTTAGGAG AAGTTTCAGGTGTTCTAACAGAATCATATGCCTTGGCCTGCGTGTGTTGTGTTTCAAGGGAGAGGCCAGA TTAAAGCAGTGTTAGAGGATTTGTAGCAAATGTAAGGGACCTGGAAATAAACACGTGGGTTCCTGTTCTT CCAGAGGTGGAGTCTGTCCTCTGTTGACATTGATCCTGAACAAAATTTTTACTTAATCAATGGTTACTGA GCATTTTTAAAAGAAACTAATTGACCGGGCACAGTGGCTGACGCCTGTAATCCCAGCACTTTGGGAGGCC AAGGCAAGTGGATCACCTGAAGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTA CTAAAAATACAAAATTAGCTGGGCATGGTGGCATAACTAGTGACCACTACACTACAGTATCAGTTCAGAA AGAAAGCAAGACCTATACTAGACAGGCAGCATCAGAAGGATGCTGGCAGGAGGTACCTACAGTAGTCATT ATTATAGCAAATTTATTATATACCAGGTACTGTTTTGGATGTTTTACATAGGCCAACTAGCTTAATGCTC CTAACCAATTATTAGGTACTATTCCCATTTTACAGATGTGGAAGCATGGGCATAAAGAGATTAAGGAACT TGCCCACAGAGCTAGTAAATGGGAGAGCTGAAATTTGAATCCAGATGACCTAGCTTCAAAGTCTGCTTCT CTAGCTAGCAAATGTGCTTTACTGCCTCTCTTAGTGAGCAAGATGGAGATGGACTGATGGCAATCCAGTT AGGTGAAATAAAAACCTGACTTACTACTGAAAGAATCAGGCAGACTGAAGAGAGGTCTGTACTTATATGC CATGTATCTCTATCCCTAACTTTGTTCCTTTCAGTACCTTAACGTCAGGGTGCTGATGGCATGGTGATAA AATTTGTGAGTGACCCAAGCCTGGGAGGAATTTGTGGAATTAACTGATTGATTTAATCAGAGTCCAGATA AATCCTGACTGACTGGAATGGTGAATCATCTTTTACAAAGAAGAGGCACAATCCTATACTCAGCTGCAGA AAAATCAGTGATAAAGTGTGGAATGAGGGAGAAGTGATACAAGGACAGTGTTCGTTGATGGGAAACTCAG TGTGAATCAACAGTATAATGTGGGTGCCAGTATAGCTAGTGTCATGGGTTCTGCAGTTTGTCTCCAAAAT GAGCAAGTTGGTAGCCCTGCTCATTTTCGGGCTGATGAGGCTTTATCTGGAGTTTTGTTTGATTCCGAGC ACCAAAAAATGAAGAAATTTGAAATCATACTACATGAGGAATTATACTATTTGAGGAATACTGTATGAGG ACTGGCTTATTCTAAATCTTTATATTTACAGTTTCTAGTAGACTGTACATATGGTGAATACACAGACCTC CATCTAGCAATACCAAATGGAATAATAGTTATGGTGCTATCGCATCATAATTTACATAACCAGACCCCTT TAGTTGAGCATTTGGATTATTTAGCCTTGTTCATTATTTTGTAAGTATTCAGTATGGTATATGCTTTTTT TAAGTGAAGATAATAAAATGTATTTAGAAAATAGCAACTTAGGCTGGGTGCAGTGGCTCACACCTGTAAT CCCAGCACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGACCAGAAGTTCAAGACTAGCCTGGGCAACA TAGTGAAGCCCCATCTCTACAAAAAATTTAAAATTTAGCCAGGCATAGATGCATGTACCTGTAGTCCCAG CTGCTCAGGAGACTGAGGTGAGAGGATTGTCTGAGCCCAGGTGTGTGTGGTTACTGTGAGCTATGATAGC ACCACTGCACTCCAGCCTGGGTGGCAGCCAGACCCTGTCTCTTAAAAAAGAAAAAAGCAACTTAAATCCC TAAAATAGTGTAAAATAATTGAAGATAAAAGAAGTTGGAGTCATTAATTTTAGAGAAAACCTTAAAAATT TAGTTTTTTGAAATACAGCAAATCTAGCTAGGCATGGTGGTGTGTGCCTGTAGTCCTAGCTACTCAGGAG GCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTGGAGGCTGCAGCCAACTATGATCATGCCACTGCACT CCAGCATGGGTGACAGAGTGAGACCCCATCTCTTAAAAAAAAAATAATTAAAAAAATAAAAAAATAGCAA ATCTGAATTAACTGGACTTCTTAATGAACTCTATGCGTGGAGTGTGTGTATGTGTGTTTTGAGAAAGACT ATCAGAAAATATAGTCGACCTTCCATATCTATGGATTCTGCATCTAAGAATTCAACCAACTGTGGATTGA AATTATTTGGGAAAAAAAAAGACAAATAACAACATTAAAAAATGATACAGATAAAAAGAATGCAGGATGA CAGCTACTTACATAGCATTTACATTGTATTAGGTATTATAAATAATGTAAAGATTATCTAAAGTATATGG GAGGATCTGCATAGGTTATATACAAATACTATGCCATTTTATATCAAGCGACTTGAGCATCCTTAGATAT TGGTGTCTGTGAGGGGTTCTACAACCAGTCCCCCATGTATGCAAAACTAGGTACATACCACAGTCCATTT TTAGAAAGATTGATTAGTAACTAAAGGATGACTGTACACAATTCATCAGTTCCAGGCAGCTATAAGAAAA CAATCTAGCCGGACACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGGAAGCTAAGGCGGGCAGATCG TGAGGTCAGGAGTTTGACACCAGCCTGACCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATT AGCCCGGTGTAGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGA GGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCT CAAAAACCAAACAAACAAAAAACAACAGAAAAACAATCTATGAGCGCTGCAGTTCAACAGAAGGTAAGTG CAAATGGAGGCTAGCAGAGAAAAAGGGGTAAACAGGAAAATGAGGGAGAGTGAGAGGTAGTGAAGAATAT TTGAGACTAAGATAAATGATGGGGGAAGAAAAGTGAACGAAGAGAAATAAAATCAATCGTGCTTGTAAGT TTAACATCAGGAAGTTATACAAAGTAGAAAGTCTTTGGGGTCTGTTTTGAGTCTAGACAGATCTAGTCCT ATTTCCTATACATTGTCCACATATGTAGAAATCACTGAATCTAATTCCTCATTTTCATGGTGAGGGAATG GATACCCCGAGAGGATAAATGACTAAATGCTCTTTGTTACTGTCCTTCTCATAGAGTTATTGCTCAGAAA CATTGCAGAGTTCTGGATTATAAAGTAGCAACGATCATTATGCATACACAAATGTATTTAAGAAATATCC TCACACTGAGGTTGAAACAGGTTTATGCTGCTTATACATTTAGTTGTTATTATAATAGAAGATAAAATTA TCCAGAACCCCCCTTTTTTTTTTAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGTACGAT CTTGGCTTACTGCAGCCTCCGCCTCCCTAGTTCAAGCAATTCTCCTGCCTCAGCCTTCCCTGTATTTAGG ATTACAGGCGCATGCCACGACGCCTGACTAAGTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTG GCCAGGCCGGTCTCGAACTCCTAACCTCGTGATCCAACCCCCTCGGCCTCCCAAAGTGCTGGGATTACAG GCGTGAGCCACTGTTTCCGGCCAGTTATCCAGAACTGTTTAGTTAACTAGCATTCAAGTTTATGAAGATT TTTGTGTAGATGTAATGCTTGCTTCTGCCAAGGAATAAGAATGTTGTAATCCACCATCTTTTATTCTGGC TTTTAGGCAGCTGTTGAGGTAAACAAACTAAGTTTAATGCTCGAAGATAGTGTATTCCTCAGAACTAACA CATTTGATTTTCCATAGGTTTATTTTCCTTTACCTGTTCTAATTTAACTTTTTGTAAAATGCCACAGTCC ATTTTTAGAAAGATTAAGGGATATTTCATTATTATAGATAAGTTTCTAGGTTTCTTTCAAACTTGATATA CCTAATATAAAAGTTCAGATTATTTTTCCTCTTTATTTTTCACTTTTTATTCAGCCAACTGTGATTTCTA GAATTTTGATTTTCAGCTTCTGAACCCCAGAATTTCTGAAGATGATTAATGACCTCCGACTATACTAAAA GTTTTGAAAAATTTTTTTAAAGTAAAGAATCCTGTTGTAATGTGAACGGTGTCTCCCTAATTTATGTATT TTCAGTTTGCATTTTCATGAAGTGCTCAAAATGGGACATGTGAAATTCTGAGAGTAGTAGTAAGAAACAT GGGAGAGTGGTAGGTAGATTGCCTTCCTGACCATGTGACAGAGTAAAAACACGTTTCATACATTTTTTTT TTTTTTTGAGACGGAGTTTCGCTCTTGTTGTCCAGGCTGGAGTGCAATGGCATCATCTCGGCTCACCACA ACCTCCACCTCCTGGGTTCAAGCGATTCTCCTACCTCAGCATCCTGAACTAGCTGGGATTACAGGCATGC GCCACCACACCCAGCTAATTTTGTGTTTTTAGTAGAGACAGGGTTTCTGCATGTTGGTCGGGCTGGTCTT GAACTCCTGACCTCAGGTGATCCGCCCGCCTTGACCTCCCAAAGCGCCGAGATTACAGGCGTGAGCCACT GCACCCAGCCACATCTCATGCATTCTTTTGCTCGCTCATTTATTGTCACCATATGCCTTTGTTTCTATAT ATTCAAGCTAAATCAAGGTGCTATTAGAATCTCGGGAAGCTGCCGCTGACCACAGTCAGAACTTGCAGTT TCTTTAGTTAGAATTGCCATAGGACCACTGCTCAAGACTTCCAGATCTAACCTAGCCATATCCAACTCAT CATTAGAATATTTAAATCATGAATGTTGAACAACCAATATTTTAACAATTTATTGCATAGAGCTACTAAT AATATTAAATAAAACTATGGAAAAAAAGGACATTTTACTTTGTGCCAGGTATGCTTCTAAGCATAGTTCT ACATCTTAACTTCTAGTCCCTGTCTACATATTTTCCCTTATGTGTAGCCTTAGTTATACTATTTTGTATT CTTTTCTGTTTTAAAATATATATAAACTCTTTCCTGTTCTTTTACATAAGATAAATAAACTTAATTTTTT AGCTGCATAGTATTTTCTCATGTTAATGTATTGTAGTTTACTAAGTCATAACTTTATTTTTATTTAATTT GTGAACAATAAAAGAAATAAAACTCTTATGATACAGGTTAATCTCTTTCTCACTCATTCTTAATCTTTGC TTTACCAACCTACCCTTAAAGATAGCTGGAAGTGGAAATGCCTCTCCAGTGGTTTGTCCATTGGGATTGG GCTTCTGTTTATCTTGAGCTGCCAACATTTAGCCCAGCCGCTGGGGGTGGTCTGTTATCCTTTGTTTCCC CAGGCCATTTAAGCTTATCCAGGAAATGCTTTAGTTTGCCTTTTTTTTTTCCTGTTAACCATTTTATTGA GATATGATTTACATACTACATAGTTCATCCATTTAAAGTGTACTCATTTGCCCTCTTTTGTTGTTGTTGT TGTTGTTATTGAGGCAGAGTCTCGTTCTGTCCCCCAGGCTGGGGTGCAGCAGTGTGATCATCGCTCACTG TAACCTTGAACTCCTAGACTCAGGCAATCCTCCTGCCTCACCCTCCTGAGCAGCTGGGGCTGTCAGCATG TACCACCATGCCCAGCTAATGTTTTAAAATTTTTTTGTGGAGGTGGCGATCTTGCTATATTGCCCCGGCC ACTCTTGAATTCCTGGCCTCAAGTGATCCTCCCGCCTTGCCCTCCCAAAGCACTAGGATTACAGACATAA GCCACCGTGCCTGGCCTCATTTCCCTTTTTAATCTGCTTTCTGAGCTTCCTGTTCTCTTTCAATGAATAT CATAGAGAATGAAAACTGATTAGTATAGTATCTTGCAGTAGAAAACATGACTTTCGCTGGGCGCGGTGGC TCATGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCGCGAGGTCAGGAGATTGAGACCAT CCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATATAAAAAAAAATTAGCTGGGTGTGGTGGTGGG GGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTG CAGTGAGCCAAGATCGCGCCACCACACTCCAGCCTGGGCGACAGGGCGAGACTCCGTCTCAAAAAAAAAA AAAAAAAAAGAAAAAGAAAAAGAAAACATGACTTTCCTCTCCAAATAGTAAAGCAAACTTTTCCATTTTA TTTTCTACTGTTTTTCTTCTCCTGCCTATTTAATGGCATTATTTGGCATTTGCTGTAACTTGAGTTTCAT CAAATATGTGTTTACTTCTCTGGTTTTATGCTAACAGCAACACCATGAGATAGTGGTTTAAGGCCATGAG AAGTATTTTTTTTAATTGTTTTCTTTGAAAGCCCACATTGTTTCCTTTGAACAGAATACTTTGAACAAAA TTTAAATCGTGTTCAGAAGAGAGGTTTAGAGGTTTTTTCCTTCATAAATTCAACACATGTTTACAAAATA TCCATTTCATGTTTCTCTTTAGTGACTGAATCTATTTTGTGTTGCTGTTTCAGAATGCCATAGACTGGGC AATTAATAAACAGTAGAGGTTTTTTTGGCTCCTACTTCTGGAGCCTGGGAAGTCCAAGATGGAGGGGCTA CATCTGATGAGGGGCTTCTTGCTGCGTCATAAAATGGCAGAAGGAATCACACAGTGAGGCAGCACTTGTG ACAGAGAGATAGGAAAGGGAGTTGAACTCATCCACTCATCGTGTTATCAGGAACCCTCTCCTGTGATAAT AGCATTAACCCACTCCTGAAGGCAGAGCCCTCCTCTTGACCTAATCACCATTTTTTTTTTCTTTTGAGAC AGAATCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTACAATCTCAGCTCACTTAAACCTCCACCTTCC AGGCTCAAACAGTTCTCCTGCCTCAGCCTCCCAAGTATCTGGGACTTCAGGTGCATGCCACTGTGCCCGG CTAATTTTTATATTTTTAGTAGAGGCGGGGTTTTGCCATGTTGGTCAGGCTGGTTATAAACTCCTGACCT CAGGTGATCTACCCTCCTCGGCCTCCCAAAGTGCTGGGTTTACAGGTGTGAGCCACTGTGCCCGGCCTTG TCACCTCATAAAGGTCCTACCTCTCAACACTTGCATTGGGGATTTAGTTTTCAACACGTGAACTTTGGGG GACACATTCAAACCATAGCAGTGGCAAAAAAAAAAAGCCCTAGCCCCAACAAAACAAAAATACCACCATC AATAAAAATCAAATATAGGCCTGGGTGCAGTGGCTCACATCTGTAATCCTAGCACTTGGGGAAACTGAGA TGGGCAGATCTCTTGAGCTCAGAAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTAGACAAA AATTACAAAAATTAGCCAGGCATTGGGGCTCGCTCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGA GGATCACTTGAGATCTCCCACCTCAGAAGTAACAGTGAACCAAGATCACACTACTGCACTCCAACCTGGG TGACAGAGGGAGACCCTGTCTCCCCACACACACACACACACACACACACACAAACTAATGAAAAAATAAG TAAACAGGCAAATAAAAATAAACTAAAAGAGAATCTTAATTAGATTGGAGGGGATCTTCAGGTGATTAAA TACTGAAGGAAAGTAGGGGCACAAATTGTATTTGGGGACATCTTAACCCTGTATGGGTTGATAGACCTTT CAAGTCTGTCTACTAGAAAACTCCCTCAAATCTTATTTCAGAGAAAGTATGGGCTGACTTGACAGGACTG ATCAGTTTTATCAGTGACACATCTTATCATTTAAACAGTGCAAGAGTTAATGGTTGGTTATTAAGCACTC AGTAAAGGTTGGTGAACATGTACATACAGGACTAGATCTCTCCTCTGTAATCCACTCTAAATAAATACTT CAGTCTGGTTACAAAATACTTAATACTGTACTGAAGATTTTTGTACAGCTGATCATTTGGATTTACATTT GGGTAATTTTATCATTACATCTCATGCTTCATTATTCTTTCAGCTATTCCCTTCAGCAAGCTCAAGCTTT TTATACGTTTCCATTTCAACAACTGATGGCTGAAGCTCCTAATATGGCAGTTGTGAATGAACAGCAAATG CCAGAAGAAGTTCCAGCCCCAGCTCCTGCTCAGGAACCAGTGCAAGGTAGTTTCACCATGAGAGCTTAGA AAGTTCAACATCGGATCAGCCAGCTTATTTGAGAAAGGGTTTCATGGTGAATTTTAGCTCTATTTTAGTG TTAAAAAGTCAAATCCACTTTTTAAGTACTTAGTATGTGCTAAGCACTGATAGGTTCTGGGGAATAAAAG AACATGGGTCCTGCCCAAAAATATCTCATAATCTAGTAGAGAAAAGTAATAAGTAAATACACGTTACAGC TCAGCACAGTTTGTAGTGAAGAGGGGCATAGAATGAATGCCCTGAAAGCTTATGGGGTTGGCTTCTAACT CAGACTGATGGCTCAGAGGCTGCTTCCCAGAGCAGAGAAATAACACCAGGGCTCTGAAACTCCAACAATG TGGAGGCTTCATCCCGATAAAGATCAGAGTAGGGACATGTCCAGGCTGAGGGAGCTATACAGGCTGGGTA CAGACACACACAAGCATGGCATGGCCAGAAACAGAGCAATTCTGTGTCCTTGGAGTCTGGGATATAACAA GGAAATGGTGAGAGGTGAGGCTGGATGGGGACAGTTGAAACTTGTTTTTTAATCCCAAAGAATTTATATT CTATCATGAAGGCAATAGGGAGCTGTTGAGAGAATGTAAGCAAGGGATGACTTACTTGACTGGTGCTTTA CAAATTAGCCTGGAAATATTAGAGAAGATAGATTGGTTGGTAGACAACAAGTCGGAACTTGGAGGCAGGC CGGGCACAGTGGCTCATACCTGTAATCCCTGCACTTTGGAAGGCTGAGGCGGGTAGATCACCTGAGGTCA GGAGTTCATGACCAGCCTGGCGAACATGGCAAAACCCTGCCTCACACAAATTAGCCGGGCATGGTGGCGC ACACCTGTGATTCCAGCTACTGGGGAGGCTGAGGCACGAGAATTGCTTGAATCCTGGAGGCGGAGGCTGA GAGGCTGCAGTGAGCCAAGATTGCACCACTGCACTCCAGCTGGGCAATAGTGCGAGACTCTGTCTCAAAA ACAAAAACAAAAACAAAAACAAAAACAAAACTTGGAGTCAAGGAGTGGATTAGATGGATTAGAGACACTG TTTGAATAATCTAGGGGAGCACTGAGGAGGACCTGAAGGGGTGGAGAAAGAATTAGGAAACACTTAGGAG GTAGAATTACCTAGCCATGGCTAATGGGTTTCATGTGTTTGGGGGGAGCATGGCAGGATAGTGGGGGAGA AAGGGGAGTCCAGAAGTAACTACCAGGTTTCTGGCATTGGCATTTGGTTGGAGGAGGTGCCACTCACCAA GACAGAGAATTAGAAGAAAATAATAGGTTCCAGGGGTGGGAGAGTGGTTGGAGAGAAGTTAATGATTTTC TCCAGTGTAACAGTATTTTATGAGAAATGTGCTCAGGGTTTTGGTTTATGATTGCAGGAACACATCTAAT AACTCTGCCTCCGCATTAGGACTTCCCCAGCTACATGCCAGTGATGGTGGATCTGTTGGCATAGGGAGTG GCTAAGACAATGTGAGGCAGAAGAGAGGAGGGACTGACTGCCTGTATCCTGCGAGGCTTGATTGGGGAAA CGCCAAAGAGGAGTAGAATAGGGTAGAAGCCTGAGTAGTTAGGAGAAATGTTAAATAATTAAGGGTAAGA AAATCAGGGCTTCCTGTTGGGTAACTATAGGTCAGTGGTTTTCAATCAAGGGTGATTTTGCCCTCCCAAG GGACATTTGACATTGTCTGAAGACACTTTTGATGATCAAGACTGGCAGGTTACTACTGGCATCTAGTGGG TAGAGATCAGGGGTGCTATTAAACATTCTGTAATGTGCAGTACAGCCACCCACAACAAAAAATTATGCAA CCTAAAATGTCAATAGTGTGGAGGCTGAGAAACTGCTTTACGTCCTGAGGTTGGATCCCTCCTCTTGCCT TTTGAAAAATACTGCCAGCCCAGAGATGTCATCCTGGGCACCCCTAAATTCCCCTCTTCAACTATGTATG GAACAGAATATACACCTCATCTCTAAAACAAGCCCACAAGCCATTGTGTTTTTCTTTTTTCTTTCTTTTT TTTTTTTGGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAATGCAGAGGCATGATCTCAGCTCACTGCAAC CTCCACCTCTTGGGTTCAAGCAATTCTCCTGCCTCAGCTTCCCGAGTAGTTGGAATTACAGGTGCACGAC ACCATGCCTGGCTAATTTTTGTATTTTTAGTAAAGACGGGGGTTTCACCATGTTGGCCAGGCTGGTCTTG AACTCCTGACGTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACCA TACCTGGCCCATTTGTGGTTTTCTACTGGGGAAGTTGAGTTAAAATGTTTCCCTTCCTTCCTGTTTCTCT ATTTTTCTGTTCTTATTTAATTATTTATGTATTTACATTTAGAATTTATATAAAATGATATGTAGATACT TTGTATCCTTGAGGAGGTTAAGATGCCAAGTAATACTGTGTCGAAAATAATAGTCTATGATTATTCTTCC CACGAACAGCTAGCAGGGGAAGGAGAGTGGCATGGGGGGTTGCACGAACCCAGTTCTAGGGAGAAAGAAA GGGAAGATATTGCAGAGGAGACTCATGTTGGGACTGTAAGAGCTTAATTTTGGGGAGACAGGTACAAAAG GTGCTAGTTGGGTAACTTTTCTGGGAAAGCTGCTAAAGTTTCTAAGTTAAGATTTTCTGCATTTCTGGAA ATTATTTGTATTTCAGAGGCTCCAAAAGGAAGAAAAAGAAAACCCAGAACAACAGAACCAAAACAACCAG TGGAACCCAAAAAACCTGTTGAGTCAAAAAAATCTGGCAAGTCTGCAAAATCAAAAGAAAAACAAGAAAA AATTACAGACACATTTAAAGTAAAAAGAAAAGTAGACCGTTTTAATGGTGTTTCAGAAGCTGAACTTCTG ACCAAGACTCTCCCCGATATTTTGACCTTCAATCTGGACATTGTCATTGTAAGATCTTTGTCCTCGTTGG ATTTTATAAGTAGTATTGGGGGATCAGCTTTACTTAACAGTTGTCCTTGCAAATAGCATTTTGCTGAAAA GGACCATTTCTAAGAATCCTTTTGGTGGTAAATGGTGTCAGCTTCATGAGGTTGTGTTATATGAGAGTGT TTAAGAGGGTGGGCTCCAAATTTAGACTGTCTGGGTTCAAATCCTGTCACAAGTATAATCTTGGATAAGT CTTATTAACCTTTCTAAACACCGGTTTTCTCATTGATAAACCAGGGGTGATAATACCACCCCCCGATAGG GTTGCAAGTAAATGAGAGAATCCATGTGAATCACTTCAACTGAATGATGCCTGTGGAGACCTGATACATG GCAGCACTAATTTTAAGCTCTTATTTTTCTCAGTAACTGTAAGAAACATCAGCATGTGAACAATTGTGTA GGTGATGTGGAGCGAGCTTCTTGTTGAAAGTTGAGAATCAGAATTGTGGCTGGACATGGGCTCAGATTGA TTGTTCCAGGACCTGTCTTTCCAGACTCAAAGCAGCCCAGTTGGTGAGGGTGCGAGGCCTGGGATCATAA AGGAGTCAAACTGGTTTTTTAAAATAACAGCAAAACTTTTAAAATAAAGAAAATCTCTTTCCCATATATG AAATACTTTGTTCAGATCAAGAGTAGTAATTGATAAATGATATTGCTTATGATGCTGAATTAAATTTGTA TTTTAATCAACTCAATTTTGTCCACCACTCCTCCATAGAAACGCTAAGGCTTAGGTCCTGCTTTTTAAGA TGAAATGTCTAATTGTTTTGTTTTATAGATTGGCATAAACCCGGGACTAATGGCTGCTTACAAAGGGCAT CATTACCCTGGACCTGGAAACCATTTTTGTAAGTGGTTACCTTTTAAATTAATTTACTTTTAAATTAGGT ATCTTTGTTAACAGGTTTTTTCAGAAAAACCAATTGTGTTTTTAAAAAGAAAGAGACTGTAAATACACAT TCGTGTTTCATGTTCTGTGTGTGTGTCTGTACGTGAAAATAAGAGAGTTTGAAATGATATGTTACTGTTA ACATTTTAGTCTATGAGAATGGAGGGATGTGAATAAGAGTACTTTCTCTTTTGTTTGAATTGTTTCTAAT GAGTTGTACTACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTTTTGCGCAGACTG GAGTGCAATGGCGCGATCTCGGCTCACCACAATCTCCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAG CCTCCCTAGTAGCTGGGATTACAGGCATGTACCACCACGCCTGGTTAATTTTGTATTTTTAGTAGAGACG GGGTGTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGGCCTCAGGTGATCTGCCCACCTCAGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCTACAACGCCCAGCCAAGTTGTATTACTTTTTAAAAATGATTTTT TAAAAGTTGTTATCTATAGGCATAGTAACGATAGTATAGTACATCTTTGTGGCAGTGCAGACATAATACT AACTTTCCCAGATTTCTGGTGATTATTTTCTAGCAGAGCATAAAATAGTAGTAAAGACTCATATTTTTAG AGTAAGTTTTAAAACCAAGTGTTGGCTGGATCTGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGC CAAAGCAGGAGGATCACTTGAGGCCAGGAGTTTGAGACTAGCCTGTACAACATACCAAGATCTCATTTCT ACAAAAAAATAAATAAAAAATTAGCTGAGTGCTGTGGTGCACACCTGTAGTTCCAGCTACTACGGAGGCT GGGTTGGGAAAATTGCTTGAGCCTGAGAGGTTGAGGCTGCAGTTAGCCATAATTACTCCACTGCACTCCA GCCTAGGTGACAGAACTAGACCCTGTATCACAAAAACAAACAAGAAAACAAACAAAAAACAAGCGTAACT ACTGTTGCATTGCCTTCTCTATATAAGTTGTCTTGTATATAAATCATCTTATTTTATACTGCCTAATAGA TCAGTGTATGCAGTATACGCTCAGGAAATTGATTATCTAATAGTAACATTCAAAACATTTAGGGCAACTG ATAGTAATGTGGTTTTGGAACTAATAATAACATATTGTCCCTATTATTTTAAAAAATTCCTTTTTAAGGG AAGTTTGGACTTTTGACTTTCTTCACTGTCAAGGTGTTTGAATGTTGTTAGTCTAGTGCTGTATGTTTAC GTGTGAGGTGGTGGTATCACCAATTGTAAAGCAAAATAGTCTCAAAGTTTCCTAAACTGAGTTGCTATAT ATTCTTGGGCAGGCATTTGCCTCAACCCCCTGTGAAAAGGAGATAATAATAGTATCTTGCAAGATAATTA TGATGATTAAATCCAAGCGCTGTGGCTCACACCTGTAATCCCAGCAATTTTGGAGGCTGAGGTGGGAAGA TCACTTGAGCCCAGGAATTCAAGACCAGCCTGGGCAACATGGTGAAACCCTGTCTACAAACAATACAAAA ATTAGCTGGGCGTGGTGGTGTGCATCTGGGGTTCCAGCCACTCAGGAGGCTGAAGTGGGAGGATTGCTTG AGCCTCGGTGGTCGAGGCTGCACTGAGCCATGATCGTGCCACTACACTCTAGCCTGGGTGACAGAGCGAG ACCCTGTCTAAAAAAAAATAAATAACTGAATTTTCATTTTACAGGGAAGTGTTTGTTTATGTCAGGGCTC AGTGAGGTCCAGCTGAACCATATGGATGATCACACTCTACCAGGGAAGTATGGTATTGGATTTACCAACA TGGTGGAAAGGACCACGCCCGGCAGCAAAGATCTCTCCAGGTAAGTACACAGCATTTGCTTTTATGGGTT GGAACCTTGAGTATGCTGGTGCCCCAAATATTCTAGGAACATCATATGTATCTAGTTCAAGCTGAGCTCA ACAAATGTACAATATGCTCTTTCATTGAAAGCTGTCTGAATTTAGCATATTATAAATATTGTCATATTTA TATTTTTGACTACTTTTTAATTCAATTTTAGTAAAGAATTTCGTGAAGGAGGACGTATTCTAGTACAGAA ATTACAGAAATATCAGCCACGAATAGCAGTGTTTAATGGAAAATGTAAGATTTACTTTTAAATTTTTTTT TTCTTTGCTAACATTATGGGCAATGTAAATATGTTTGTATTTCATTTTAGGTATTTATGAAATTTTTAGT AAAGAAGTTTTTGGAGTAAAGGTTAAGAACTTGGAATTTGGGCTTCAGCCCCATAAGATTCCAGACACAG AAACTGTAAGTCCCTAAAATTGAATTTGTAAATCAGCTAAATGTGAATTTTTTTCTAGATAATTTCCTTA TTTGTCCTATCCATTGTGATTTATACCATGCAAAACAATTACACTGTATTTTGTTGAATAATACCTATAC ATCAGCTTTAACTAATAGTTGTAAATTAATTCAAATACTATTAGGGTTTATTAGAAAGAAAAACATTTGT CAGCTAAATGTCTTGATGTTGTTATTCAGTGAAAATATTGAGAGGAACTGGCTCATATACTACATTCAGA ATACATTTAATGGCATGTAGTTGTCAAATTCAAATGGTTTAGCCCTCGTACTGTTGTGAAACAAACATGG AAACACAGACATGATCCTGATTAGGAAAACCAGTTGCCCCATTTATATATCTTAGCTCAACTTCATTTTA GAGCCATATAAATAATACAACCCAGACAAGCCTCCAGCCAACCTAACTGGCATTCAATACTGTTGTCTTA TACACAAAGTCATCATGAAATAACAGTGTTTTTCAAATTGTCCTCTCTACAGAGCTTCTGCAGGCATTTG GTTCCAATTTTGCTTCTTAGTTTTAGGTTTTATTTACAACTTTTAAAGAACAACACAGTGCACAGATTTA CATGTTGTATATACAACATCTTAACTGATGGAGAAGCTAATTTGCTGCCAGGTTTTTGTGGAAACCTAAA AATGTTTCTGCCACCTAAATATATTTAAATTTCTCCTTTAAAATTGTTTTTGTTCATAATTTCTTATAAA TATGCAATTGATGAGTTTTATTATAGCATTGGTTTTTGCTTAAATAAAGGCCCACCTTTGTCTGCTTGGT TAAAATGGTACAAATTCACTACCTGTAGTGAATTGTAGAGAAATTCCTGTAGAGTACTGTGTCATTCTCT GTTACATGCCATTTGGAGGCCGGGCGTGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGC AGGCGGATCACCTGAGGTTAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCCACTAAA AAATACAAAAATTAGCCAGGCATGGTGGCATGCGCTGTAATCCCAGCTACGTAGGAGGCTGAGGCAGAAG AATCGCTTGAACCCAGGAGGCAGCTCATTAGGCGGAGGCTCATTATTTTTCACTTCCTGACTTGGTAATA AGTCAGTATTACAAATTCAACCTTAAAAGCAACTACTTTTATTGATTTTTACATATATTTATATGTAGTT AAGTATCAAGTTATTAACCCAAATAAAGACAAATATTCTAATCTCAATGAGTGAATTCAATAGAATTATA AGATTTCTGAAATTATAAAATGTTGTGATTCTAGCTCTGCTATGTTATGCCATCATCCAGTGCAAGATGT GCTCAGTTTCCTCGAGCCCAAGACAAAGTTCATTACTACATAAAACTGAAGGACTTAAGAGATCAGTTGA AAGGCATTGAACGAAATATGGACGTTCAAGAGGTGCAATATACATTTGACCTACAGCTTGCCCAAGGTAT GTTACTGTCCTCATTCCTTTTATTCATTTTGTGTGTGTATATATACACATATATACTTACATATATATAC ACATATACATATATACATATACACATATACATATGTGTGCACATATATGCACACGTGTATATATACATGT GTATATATACATATATACACATAAGTATGTATGTCTATATACATATATGTGTGTATACACTTGTGTGCGT ATACATATGTGTGTGTCTATATATAGACACATACACACACACACACACACACACACACACACACACACAC ACACATTACAGAAAGTATCTTATGGATTTAAAAGCAGGAAAAAAGAAAACAATTATATTCGCAGCCAGAG TGCTCTGATAATGAATATTAGTCACTGTTAAAATCTCCTTTTACCAAGGTCTTCCCTCTACTCTGGCACT TCTGCAGATAATTCACCTGCAGAGTGCCAGAGCAGAGGGATGTAAGAAATATTGTACCCTACGTAAAGTT GAATGTAAGCGGTTTTTACAGTTCTTATGTGTTTATTTAGTACATGCTATAAGTTTAAAAGATTAATAGA GATGTATCTCAGTGTATATGAATATTCAAGAAAAAGAATTGTTCATGATTTCTGAATAAAGCTACTTTTA AAATTGTTGTACAAAATCAGATTTAAATCCTTTTTACCTTCCTCACAGAGGATGCAAAGAAGATGGCTGT TAAGGAAGAAAAATATGATCCAGGTTATGAGGCAGCATATGGTGGTGCTTACGGAGAAAATCCATGCAGC AGTGAACCTTGTGGCTTCTCTTCAAATGGGCTAAGTATGGTTCCCTCCACATGTGTATTCCTTTCAAAGA CGGTTTGGTCAGGATTGGGGGGAAAATTTTAATAGAAGGAGAGTAAATTATTGAAGAATGGGAATGATAA TATGAAATTTTATTTAGTGACTAATAGTGAAAAATTGATGGTTATTTCACGTTGAATTACACAGACTTTT ACAGTACATTTTCTTTTTTGTTTGTTTGTTTTTGAGACAGATTCTCGCTGTGTCACCCAGGCTAGAGTGC AGTGGCTCGATCTTGGCTCACTGCAAGCTCCCCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCC GAGTAGCTGGGACTACAGGCATCCGCCACGATGCCTGGCTAATTTTTTTTGTATTTTTAATAGAGACAGG GTTTCACCGTGTTAGCCAGGTTGGTCTCGATCTCCTGACCTCGTGATCTGCCCACCTTGGCCTCCAAAAG TGCTGGGATTACAGGCATGAGCCACCGCACCCGGCCTACAGTGCATTTTCTTTAAGTCATGAACTCTAGG CCATCCTAGTTGCATTTTCCTCCTTTAATAACAAATGAGTCCTGTATCTGAAGAACAGAAACTTAACAGT TGTATTCCGGAAGCTTGCTTAACTATTTTAATAATAATTCTCCTTCACTAGACTGTTAAAATCTCCTACT TTGATCATTTAAAACTTCCAGGCCGGGCATGGTGGTTCACGCCTGTAATCCCAGCAGTTTGAGAGGCTGA GGTGGGTGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACT AAAATATACAAAAATTAGCATGGTGGCAGGTATAATCCTAGCTACTTGGGAGGCTGAGGCAGGAGTATCA TTATATATAATATATATGCCTCTCCTCGATCCCGGGAGGCAGAGGCTGTAGTGAGCCGAAATCACACCAC TGGACTCCAGCCTGGGTGACAGAATGAGACACCGTCTCAAAAAGAAAAAAAAAAACTTCAAATAAGCTGA TACGGTGGCTCACACCTGTAATCCCAGTGCTTTGAGAGGCTAGGATGGGAGGATCACTCAAGCCCAGGAG TTTGAGGCTGCAAAGAGCTGTGATCATGCCACTGCATTCCAGCCTGGGCGATAGAGTAAGACCCAGTCTC TACTTTAAAAAAAGCAAATATTTCTAAATGGCATAAACTAACTTTGTTTTTCTTTTCTGGCAGTTGAGAG CGTGGAGTTAAGAGGAGAATCAGCTTTCAGTGGCATTCCTAATGGGCAGTGGATGACCCAGTCATTTACA GACCAAATTCCTTCCTTTAGTAATCACTGTGGAACACAAGAACAGGAAGAAGAAAGCCATGCTTAAGAAT GGTGCTTCTCAGCTCTGCTTAAATGCTGCAGTTTTAATGCAGTTGTCAACAAGTAGAACCTCAGTTTGCT AACTGAAGTGTTTTATTAGTATTTTACTCTAGTGGTGTAATTGTAATGTAGAACAGTTGTGTGGTAGTGT GAACCGTATGAACCTAAGTAGTTTGGAAGAAAAAGTAGGGTTTTTGTATACTAGCTTTTGTATTTGAATT AATTATCATTCCAGCTTTTTATATACTATATTTCATTTATGAAGAAATTGATTTTCTTTTGGGAGTCACT TTTAATCTGTAATTTTAAAATACAAGTCTGAATATTTATAGTTGATTCTTAACTGCATAAACCTAGATAT ACCATTATCCCTTTTATACCTAAGAAGGGCATGCTAATAATTACCACTGTCAAAGAGGCAAAGGTGTTGA TTTTTGTATATGAAGTTAAGCCTCAGTGGAGTCTCATTTGTTAGTTTTTAGTGGTAACTAAGGGTAAACT CAGGGTTCCCTGAGCTATATGCACACTCAGACCTCTTTGCTTTACCAGTGGTGTTTGTGAGTTGCTCAGT AGTAAAAACTGGCCCTTACCTGACAGAGCCCTGGCTTTGACCTGCTCAGCCCTGTGTGTTAATCCTCTAG TAGCCAATTAACTACTCTGGGGTGGCAGGTTCCAGAGAATGCAGTAGACCTTTTGCCACTCATCTGTGTT TTACTTGAGACATGTAAATATGATAGGGAAGGAACTGAATTTCTCCATTCATATTTATAACCATTCTAGT TTTATCTTCCTTGGCTTTAAGAGTGTGCCATGGAAAGTGATAAGAAATGAACTTCTAGGCTAAGCAAAAA GATGCTGGAGATATTTGATACTCTCATTTAAACTGGTGCTTTATGTACATGAGATGTACTAAAATAAGTA ATATAGAATTTTTCTTGCTAGGTAAATCCAGTAAGCCAATAATTTTAAAGATTCTTTATCTGCATCATTG CTGTTTGTTACTATAAATTAAATGAACCTCATGGAAAGGTTGAGGTGTATACCTTTGTGATTTTCTAATG AGTTTTCCATGGTGCTACAAATAATCCAGACTACCAGGTCTGGTAGATATTAAAGCTGGGTACTAAGAAA TGTTATTTGCATCCTCTCAGTTACTCCTGAATATTCTGATTTCATACGTACCCAGGGAGCATGCTGTTTT GTCAATCAATATAAAATATTTATGAGGTCTCCCCCACCCCCAGGAGGTTATATGATTGCTCTTCTCTTTA TAATAAGAGAAACAAATTCTTATTGTGAATCTTAACATGCTTTTTAGCTGTGGCTATGATGGATTTTATT TTTTCCTAGGTCAAGCTGTGTAAAAGTCATTTATGTTATTTAAATGATGTACTGTACTGCTGTTTACATG GACGTTTTGTGCGGGTGCTTTGAAGTGCCTTGCATCAGGGATTAGGAGCAATTAAATTATTTTTTCACGG GACTGTGTAAAGCATGTAACTAGGTATTGCTTTGGTATATAACTATTGTAGCTTTACAAGAGATTGTTTT ATTTGAATGGGGAAAATACCCTTTAAATTATGACGGACATCCACTAGAGATGGGTTTGAGGATTTTCCAA GCGTGTAATAATGATGTTTTTCCTAACATGACAGATGAGTAGTAAATGTTGATATATCCTATACATGACA GTGTGAGACTTTTTCATTAAATAATATTGAAAGATTTTAAAATTCATTTGAAAGTCTGATGGCTTTTACA ATAAAAGATATTAAGAATTGTTATCCTTAACTTA Download Select all
Length	23064
OMIM ID	601423
HGNC ID	HGNC:11700
Unigene ID	Hs.584809
Ensembl ID	ENSG00000139372
PharmGKB ID	-

mRNA Information

mRNA ID	NM_003211.4
Exon	join(1..246,11104..11246,14017..14258,15079..15148, 16985..17120,17322..17404,17481..17575,18935..19106, 19789..19914,21134..23064)
mRNA Sequence	>6996 GATTTGGCTCCGAGGAGGCGGAAGTGCAGCACAGAAAGGGGGTCCGTGGGGGACGGTAGAAGCC TGGAGGAGGAGCTTGAGTCCAGCCACTGTCTGGGTACTGCCAGCCATCGGGCCCAGGTCTCTGG GGTTGTCTTACCGCAGTGAGTACCACGCGGTACTACAGAGACCGGCTGCCCGTGTGCCCGGCAG GTGGAGCCGCCCGCATCAGCGGCCTCGGGGAATGGAAGCGGAGAACGCGGGCAGCTATTCCCTT CAGCAAGCTCAAGCTTTTTATACGTTTCCATTTCAACAACTGATGGCTGAAGCTCCTAATATGG CAGTTGTGAATGAACAGCAAATGCCAGAAGAAGTTCCAGCCCCAGCTCCTGCTCAGGAACCAGT GCAAGAGGCTCCAAAAGGAAGAAAAAGAAAACCCAGAACAACAGAACCAAAACAACCAGTGGAA CCCAAAAAACCTGTTGAGTCAAAAAAATCTGGCAAGTCTGCAAAATCAAAAGAAAAACAAGAAA AAATTACAGACACATTTAAAGTAAAAAGAAAAGTAGACCGTTTTAATGGTGTTTCAGAAGCTGA ACTTCTGACCAAGACTCTCCCCGATATTTTGACCTTCAATCTGGACATTGTCATTATTGGCATA AACCCGGGACTAATGGCTGCTTACAAAGGGCATCATTACCCTGGACCTGGAAACCATTTTTGGA AGTGTTTGTTTATGTCAGGGCTCAGTGAGGTCCAGCTGAACCATATGGATGATCACACTCTACC AGGGAAGTATGGTATTGGATTTACCAACATGGTGGAAAGGACCACGCCCGGCAGCAAAGATCTC TCCAGTAAAGAATTTCGTGAAGGAGGACGTATTCTAGTACAGAAATTACAGAAATATCAGCCAC GAATAGCAGTGTTTAATGGAAAATGTATTTATGAAATTTTTAGTAAAGAAGTTTTTGGAGTAAA GGTTAAGAACTTGGAATTTGGGCTTCAGCCCCATAAGATTCCAGACACAGAAACTCTCTGCTAT GTTATGCCATCATCCAGTGCAAGATGTGCTCAGTTTCCTCGAGCCCAAGACAAAGTTCATTACT ACATAAAACTGAAGGACTTAAGAGATCAGTTGAAAGGCATTGAACGAAATATGGACGTTCAAGA GGTGCAATATACATTTGACCTACAGCTTGCCCAAGAGGATGCAAAGAAGATGGCTGTTAAGGAA GAAAAATATGATCCAGGTTATGAGGCAGCATATGGTGGTGCTTACGGAGAAAATCCATGCAGCA GTGAACCTTGTGGCTTCTCTTCAAATGGGCTAATTGAGAGCGTGGAGTTAAGAGGAGAATCAGC TTTCAGTGGCATTCCTAATGGGCAGTGGATGACCCAGTCATTTACAGACCAAATTCCTTCCTTT AGTAATCACTGTGGAACACAAGAACAGGAAGAAGAAAGCCATGCTTAAGAATGGTGCTTCTCAG CTCTGCTTAAATGCTGCAGTTTTAATGCAGTTGTCAACAAGTAGAACCTCAGTTTGCTAACTGA AGTGTTTTATTAGTATTTTACTCTAGTGGTGTAATTGTAATGTAGAACAGTTGTGTGGTAGTGT GAACCGTATGAACCTAAGTAGTTTGGAAGAAAAAGTAGGGTTTTTGTATACTAGCTTTTGTATT TGAATTAATTATCATTCCAGCTTTTTATATACTATATTTCATTTATGAAGAAATTGATTTTCTT TTGGGAGTCACTTTTAATCTGTAATTTTAAAATACAAGTCTGAATATTTATAGTTGATTCTTAA CTGCATAAACCTAGATATACCATTATCCCTTTTATACCTAAGAAGGGCATGCTAATAATTACCA CTGTCAAAGAGGCAAAGGTGTTGATTTTTGTATATGAAGTTAAGCCTCAGTGGAGTCTCATTTG TTAGTTTTTAGTGGTAACTAAGGGTAAACTCAGGGTTCCCTGAGCTATATGCACACTCAGACCT CTTTGCTTTACCAGTGGTGTTTGTGAGTTGCTCAGTAGTAAAAACTGGCCCTTACCTGACAGAG CCCTGGCTTTGACCTGCTCAGCCCTGTGTGTTAATCCTCTAGTAGCCAATTAACTACTCTGGGG TGGCAGGTTCCAGAGAATGCAGTAGACCTTTTGCCACTCATCTGTGTTTTACTTGAGACATGTA AATATGATAGGGAAGGAACTGAATTTCTCCATTCATATTTATAACCATTCTAGTTTTATCTTCC TTGGCTTTAAGAGTGTGCCATGGAAAGTGATAAGAAATGAACTTCTAGGCTAAGCAAAAAGATG CTGGAGATATTTGATACTCTCATTTAAACTGGTGCTTTATGTACATGAGATGTACTAAAATAAG TAATATAGAATTTTTCTTGCTAGGTAAATCCAGTAAGCCAATAATTTTAAAGATTCTTTATCTG CATCATTGCTGTTTGTTACTATAAATTAAATGAACCTCATGGAAAGGTTGAGGTGTATACCTTT GTGATTTTCTAATGAGTTTTCCATGGTGCTACAAATAATCCAGACTACCAGGTCTGGTAGATAT TAAAGCTGGGTACTAAGAAATGTTATTTGCATCCTCTCAGTTACTCCTGAATATTCTGATTTCA TACGTACCCAGGGAGCATGCTGTTTTGTCAATCAATATAAAATATTTATGAGGTCTCCCCCACC CCCAGGAGGTTATATGATTGCTCTTCTCTTTATAATAAGAGAAACAAATTCTTATTGTGAATCT TAACATGCTTTTTAGCTGTGGCTATGATGGATTTTATTTTTTCCTAGGTCAAGCTGTGTAAAAG TCATTTATGTTATTTAAATGATGTACTGTACTGCTGTTTACATGGACGTTTTGTGCGGGTGCTT TGAAGTGCCTTGCATCAGGGATTAGGAGCAATTAAATTATTTTTTCACGGGACTGTGTAAAGCA TGTAACTAGGTATTGCTTTGGTATATAACTATTGTAGCTTTACAAGAGATTGTTTTATTTGAAT GGGGAAAATACCCTTTAAATTATGACGGACATCCACTAGAGATGGGTTTGAGGATTTTCCAAGC GTGTAATAATGATGTTTTTCCTAACATGACAGATGAGTAGTAAATGTTGATATATCCTATACAT GACAGTGTGAGACTTTTTCATTAAATAATATTGAAAGATTTTAAAATTCATTTGAAAGTCTGAT GGCTTTTACAATAAAAGATATTAAGAATTGTTATCCTTAACTTAAAAAAAA Download Select all
Length	3251

CDS Information

Location	join(224..246,11104..11246,14017..14258,15079..15148, 16985..17120,17322..17404,17481..17575,18935..19106, 19789..19914,21134..21276)
CDS Sequence	>lcl\|NM_003211.4_cds_NP_003202.3_1 [gene=TDG] [protein=G/T mismatch-specific thymine DNA glycosylase] [protein_id=NP_003202.3] [location=224..1456] ATGGAAGCGGAGAACGCGGGCAGCTATTCCCTTCAGCAAGCTCAAGCTTTTTATACGTTTCCATTTCAAC AACTGATGGCTGAAGCTCCTAATATGGCAGTTGTGAATGAACAGCAAATGCCAGAAGAAGTTCCAGCCCC AGCTCCTGCTCAGGAACCAGTGCAAGAGGCTCCAAAAGGAAGAAAAAGAAAACCCAGAACAACAGAACCA AAACAACCAGTGGAACCCAAAAAACCTGTTGAGTCAAAAAAATCTGGCAAGTCTGCAAAATCAAAAGAAA AACAAGAAAAAATTACAGACACATTTAAAGTAAAAAGAAAAGTAGACCGTTTTAATGGTGTTTCAGAAGC TGAACTTCTGACCAAGACTCTCCCCGATATTTTGACCTTCAATCTGGACATTGTCATTATTGGCATAAAC CCGGGACTAATGGCTGCTTACAAAGGGCATCATTACCCTGGACCTGGAAACCATTTTTGGAAGTGTTTGT TTATGTCAGGGCTCAGTGAGGTCCAGCTGAACCATATGGATGATCACACTCTACCAGGGAAGTATGGTAT TGGATTTACCAACATGGTGGAAAGGACCACGCCCGGCAGCAAAGATCTCTCCAGTAAAGAATTTCGTGAA GGAGGACGTATTCTAGTACAGAAATTACAGAAATATCAGCCACGAATAGCAGTGTTTAATGGAAAATGTA TTTATGAAATTTTTAGTAAAGAAGTTTTTGGAGTAAAGGTTAAGAACTTGGAATTTGGGCTTCAGCCCCA TAAGATTCCAGACACAGAAACTCTCTGCTATGTTATGCCATCATCCAGTGCAAGATGTGCTCAGTTTCCT CGAGCCCAAGACAAAGTTCATTACTACATAAAACTGAAGGACTTAAGAGATCAGTTGAAAGGCATTGAAC GAAATATGGACGTTCAAGAGGTGCAATATACATTTGACCTACAGCTTGCCCAAGAGGATGCAAAGAAGAT GGCTGTTAAGGAAGAAAAATATGATCCAGGTTATGAGGCAGCATATGGTGGTGCTTACGGAGAAAATCCA TGCAGCAGTGAACCTTGTGGCTTCTCTTCAAATGGGCTAATTGAGAGCGTGGAGTTAAGAGGAGAATCAG CTTTCAGTGGCATTCCTAATGGGCAGTGGATGACCCAGTCATTTACAGACCAAATTCCTTCCTTTAGTAA TCACTGTGGAACACAAGAACAGGAAGAAGAAAGCCATGCTTAA Download Select all
CCDS ID	CCDS9095.1

Protein Information

Protein ID	NP_003202.3
Protein Name	thymine-DNA glycosylase
Molecular Wt. (Da)	45922
Protein Sequence	>6996 MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRK PRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDIL TFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNM VERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQP HKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLA QEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWM TQSFTDQIPSFSNHCGTQEQEEESHA Download Select all
Length	410
Uniprot ID	P05019
Ensembl Protein ID	ENSP00000302665

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Acetylation	59
K	Acetylation	83
K	Acetylation	84
K	Acetylation	87

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1387	CREBBP	2534	NP_004371.2	in vitro;in vivo;yeast 2-hybrid	11864601
2099	ESR1	589	NP_000116.2	in vitro;in vivo;yeast 2-hybrid	12874288
3725	JUN	1302	NP_002219.1	in vivo;yeast 2-hybrid	1631061
4089	SMAD4	2995	NP_005350.1	yeast 2-hybrid	15231748
5371	PML	23	NP_150241.2	in vitro;in vivo	15569683
6256	RXRA	1577	NP_002948.1	in vitro;in vivo	12874288
7080	NKX2-1	2798	NP_001073136.1	in vitro;yeast 2-hybrid	11438542
7508	XPC	2046	NP_004619.3	in vitro;yeast 2-hybrid	12505994
7919	BAT1	805	NP_004631.1	yeast 2-hybrid	14667819
79753	SNIP1	6999	NP_078976.2	yeast 2-hybrid	15231748

Pathway Information

Pathway Name	Pathway ID
Base excision repair	hsa03410

Structure Information

PDB ID	1WYW
Resolution	2.1
Method	X-RAY DIFFRACTION
Chains	A
Molecule	G/T mismatch-specific thymine DNA glycosylase
Model	View

Domain Information

ID	Location	Description
cd10028	124-294	UDG_F2_MUG
cl00483	124-294	UDG_like superfamily
TIGR00584	2-329	mug
PRK10201	126-273	PRK10201
pfam03167	131-293	UDG
COG3663	124-283	Mug
smart00987	131-244	UreE_C
smart00986	131-285	UDG
cd09593	134-232	UDG_like
TIGR04274	124-163	hypoxanDNAglyco
COG0810	Jun-81	TonB

Ontology Information

HPRD ID	928
Molecular Class	DNA repair protein
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO