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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BUB1B 701 BUB1 mitotic checkpoint serine/threonine kinase B  15BUBR1, MAD3L, Bub1A, SSK1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18699967   2008Cell line : -

Source : Departments of Surgery at three Norwegian regional hospitals (Ullev�l University Hospital, Asker and B�rum County Hospital and Vestfold County Hospital, T�nsberg, Norway).

Sample Type : CRC tumor and normal tissue

No. of Sample : 67

Stage : -

Immunohistochemistry , flow cytometry, comparative genomic hybridizationDown-regulation-A significant reduction of�BUB1B�level was detected in aneuploid compared to diploid�colorectal�cancers.


Gene Details



NC_000015.9 (40453210..40513337)

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Gene Type protein coding
Gene Family -
Description This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q15
Start 40453210  
End 40513337  
Strand +  
Gene Sequence

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Length 60128  
OMIM ID 602860   
HGNC ID HGNC:1149   
Unigene ID Hs.513645   
Ensembl ID ENSG00000156970   
PharmGKB ID PA82   

mRNA Information


mRNA ID NM_001211.5
Exon join(1..247,4045..4188,9054..9113,9529..9673,15469..15665, 22706..22875,24157..24371,24543..24634,35537..35766, 38607..38719,39236..39351,39923..39972,41397..41457, 41581..41686,45176..45450,47629..47762,48627..48767, 49102..49202,51491..51640,52324..52466,56488..56659, 57448..57554,59556..60128)  
mRNA Sequence

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Length 3749  



CDS Information


   
Location213..3365
CDS Sequence

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CCDS ID CCDS10053.1



Protein Information


      
Protein IDNP_001202.4
Protein NameBUB1 mitotic checkpoint serine/threonine kinase B
Molecular Wt. (Da)119387
Protein Sequence

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Length 1050  
Uniprot IDP00156
Ensembl Protein ID ENSP00000354554  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1042;-
SPhosphorylation435
SPhosphorylation670
SPhosphorylation1043
SPhosphorylation543
TPhosphorylation434

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
162AP1B12541NP_001118.3yeast 2-hybrid12419313   
163AP2B13015AAH06201.1in vitro;yeast 2-hybrid12419313   
675BRCA22554NP_000050.2in vitro;yeast 2-hybrid10749118   
996CDC27304NP_001107563.1in vivo10477750   
1062CENPE316NP_001804.2in vitro;in vivo;yeast 2-hybrid104   777   509   763   420   
4216MAP3K43886NP_005913.2in vitro9482735   


Pathway Information


            
Pathway Name Pathway ID
Cell cycle hsa04110
HTLV-I infection hsa05166


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14029750-1045  STKc_BubR1_vert
cl21453750-1045  PKc_like superfamily
pfam0831157-179  Mad3_BUB1_I
cl0706657-179  Mad3_BUB1_I superfamily
smart0077756-178  Mad3_BUB1_I
cd13981752-1043  STKc_Bub1_BubR1
cd14028785-1031  STKc_Bub1_vert
cd00180793-963  PKc
PRK14879837-920  PRK14879
TIGR03724837-920  arch_bud32
cd14182842-948  STKc_PhKG1
cd14202811-929  STKc_ULK1
cd14097844-916  STKc_STK33
cd13974832-895  STKc_SHIK
COG3642830-920  Bud32
cd14091862-919  STKc_RSK_C
TIGR02169357-485  SMC_prok_A
PTZ00121369-488  PTZ00121
TIGR03319383-493  RNase_Y
COG0515837-1015  SPS1
PTZ00121373-488  PTZ00121
PRK12704383-463  PRK12704
PHA03390838-882  pk1
PTZ00121373-488  PTZ00121
PRK09510416-488  tolA
pfam11600378-481  CAF-1_p150
smart00220838-912  S_TKc
COG1196373-489  Smc
pfam12072383-463  DUF3552


Ontology Information


   
HPRD ID6158
Molecular ClassSerine/threonine kinase
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO