Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BUB1B | 701 | BUB1 mitotic checkpoint serine/threonine kinase B  | 15 | BUBR1, MAD3L, Bub1A, SSK1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18699967    | 2008 | Cell line : - Source : Departments of Surgery at three Norwegian regional hospitals (Ullev�l University Hospital, Asker and B�rum County Hospital and Vestfold County Hospital, T�nsberg, Norway). Sample Type : CRC tumor and normal tissue No. of Sample : 67 Stage : - | Immunohistochemistry , flow cytometry, comparative genomic hybridization | Down-regulation | - | A significant reduction of�BUB1B�level was detected in aneuploid compared to diploid�colorectal�cancers. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]   | Chromosome | 15 |
| Location | 15q15 |
| Start | 40453210   |
| End | 40513337   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 60128   |
| OMIM ID | 602860    |
| HGNC ID | HGNC:1149    |
| Unigene ID | Hs.513645    |
| Ensembl ID | ENSG00000156970    |
| PharmGKB ID | PA82    |
mRNA Information
| mRNA ID | NM_001211.5 |
|---|---|
| Exon | join(1..247,4045..4188,9054..9113,9529..9673,15469..15665, 22706..22875,24157..24371,24543..24634,35537..35766, 38607..38719,39236..39351,39923..39972,41397..41457, 41581..41686,45176..45450,47629..47762,48627..48767, 49102..49202,51491..51640,52324..52466,56488..56659, 57448..57554,59556..60128)   | mRNA Sequence |    Download   Select all |
| Length | 3749   |
CDS Information
| Location | 213..3365 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10053.1 |    
Protein Information
| Protein ID | NP_001202.4 |
|---|---|
| Protein Name | BUB1 mitotic checkpoint serine/threonine kinase B |
| Molecular Wt. (Da) | 119387 |
| Protein Sequence |    Download   Select all |
| Length | 1050   |
| Uniprot ID | P00156 |    
| Ensembl Protein ID | ENSP00000354554   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 1042;- |
| S | Phosphorylation | 435 |
| S | Phosphorylation | 670 |
| S | Phosphorylation | 1043 |
| S | Phosphorylation | 543 |
| T | Phosphorylation | 434 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 162 |    AP1B1 |    2541 |    NP_001118.3 |    yeast 2-hybrid |    12419313    |
| 163 |    AP2B1 |    3015 |    AAH06201.1 |    in vitro;yeast 2-hybrid |    12419313    |
| 675 |    BRCA2 |    2554 |    NP_000050.2 |    in vitro;yeast 2-hybrid |    10749118    |
| 996 |    CDC27 |    304 |    NP_001107563.1 |    in vivo |    10477750    |
| 1062 |    CENPE |    316 |    NP_001804.2 |    in vitro;in vivo;yeast 2-hybrid |    104   777   509   763   420    |
| 4216 |    MAP3K4 |    3886 |    NP_005913.2 |    in vitro |    9482735    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle |    hsa04110 |    
| HTLV-I infection |    hsa05166 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14029 | 750-1045  | STKc_BubR1_vert |
| cl21453 | 750-1045  | PKc_like superfamily |
| pfam08311 | 57-179  | Mad3_BUB1_I |
| cl07066 | 57-179  | Mad3_BUB1_I superfamily |
| smart00777 | 56-178  | Mad3_BUB1_I |
| cd13981 | 752-1043  | STKc_Bub1_BubR1 |
| cd14028 | 785-1031  | STKc_Bub1_vert |
| cd00180 | 793-963  | PKc |
| PRK14879 | 837-920  | PRK14879 |
| TIGR03724 | 837-920  | arch_bud32 |
| cd14182 | 842-948  | STKc_PhKG1 |
| cd14202 | 811-929  | STKc_ULK1 |
| cd14097 | 844-916  | STKc_STK33 |
| cd13974 | 832-895  | STKc_SHIK |
| COG3642 | 830-920  | Bud32 |
| cd14091 | 862-919  | STKc_RSK_C |
| TIGR02169 | 357-485  | SMC_prok_A |
| PTZ00121 | 369-488  | PTZ00121 |
| TIGR03319 | 383-493  | RNase_Y |
| COG0515 | 837-1015  | SPS1 |
| PTZ00121 | 373-488  | PTZ00121 |
| PRK12704 | 383-463  | PRK12704 |
| PHA03390 | 838-882  | pk1 |
| PTZ00121 | 373-488  | PTZ00121 |
| PRK09510 | 416-488  | tolA |
| pfam11600 | 378-481  | CAF-1_p150 |
| smart00220 | 838-912  | S_TKc |
| COG1196 | 373-489  | Smc |
| pfam12072 | 383-463  | DUF3552 |
Ontology Information
| HPRD ID | 6158 |    
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
