Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TPR 7175 Translocated promoter region (to activated MET oncogene)  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Up-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 1; NC_000001.10 (186280784..186344457, complement)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1q25
Start 186311652  
End 186375848  
Strand +  
Gene Sequence

   Download   Select all

Length 64197  
OMIM ID 189940   
HGNC ID HGNC:12017   
Unigene ID Hs.279640    
Ensembl ID ENSG00000047410   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005807.4
Exon complement(join(<61287..62168,62955..63080,63477..63674))  
mRNA Sequence

   Download   Select all

Length 5050  



CDS Information


   
Locationcomplement(join(<62071..62168,62955..63080,63477..63674))
CDS Sequence

   Download   Select all

CCDS ID CCDS1369.1



Protein Information


      
Protein IDNP_003283.2
Protein NameTranslocated promoter region (to activated MET oncogene)
Molecular Wt. (Da)267163
Protein Sequence

   Download   Select all

Length 2363  
Uniprot IDP40879
Ensembl Protein ID ENSP00000345873  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2037
SPhosphorylation2037
SPhosphorylation1185;-
SPhosphorylation1185;-
SPhosphorylation920;-
SPhosphorylation2034;-
SPhosphorylation2050;-
SPhosphorylation2034;-
SPhosphorylation2050;-
SPhosphorylation528;-
SPhosphorylation530;-
SPhosphorylation523;-
SPhosphorylation528;-
SPhosphorylation530;-
SPhosphorylation523;-
SPhosphorylation529;-
SPhosphorylation527;-
SPhosphorylation529;-
SPhosphorylation527;-
TPhosphorylation381;-
TPhosphorylation381;-
SPhosphorylation2073;-
SPhosphorylation2073;-
TPhosphorylation650;-
TPhosphorylation650;-
SPhosphorylation2155;-
SPhosphorylation2155;-
SPhosphorylation379
SPhosphorylation379
SPhosphorylation648
SPhosphorylation648
SPhosphorylation652
SPhosphorylation652
TPhosphorylation653
TPhosphorylation653
SPhosphorylation1459
SPhosphorylation1462
SPhosphorylation1459
SPhosphorylation1462
TPhosphorylation1666
TPhosphorylation1666
SPhosphorylation1676
SPhosphorylation1691
SPhosphorylation1676
SPhosphorylation1691
TPhosphorylation1677
TPhosphorylation1677
SPhosphorylation1838
SPhosphorylation1838
TPhosphorylation1839
TPhosphorylation1839
SPhosphorylation2048
SPhosphorylation2048
SPhosphorylation522
SPhosphorylation522
SPhosphorylation646
SPhosphorylation646
SPhosphorylation2047
SPhosphorylation2047
SPhosphorylation1804
SPhosphorylation1804
SPhosphorylation1725
SPhosphorylation1725
KAcetylation755
KAcetylation755
KAcetylation723
KAcetylation723
KAcetylation713
KAcetylation713
KAcetylation428
KAcetylation428
KAcetylation748
KAcetylation748
KAcetylation457
KAcetylation457
KAcetylation252
KAcetylation252
KAcetylation345
KAcetylation345
KAcetylation312
KAcetylation312
SPhosphorylation2054
SPhosphorylation2054
SPhosphorylation1847
SPhosphorylation1847
TPhosphorylation2175
TPhosphorylation2175
SPhosphorylation2180
SPhosphorylation2180
SPhosphorylation2178
SPhosphorylation2178
SGlycosylation1676
SGlycosylation1676
SPhosphorylation62
SPhosphorylation62
SPhosphorylation135
SPhosphorylation135
SPhosphorylation270
SPhosphorylation270
TPhosphorylation641
TPhosphorylation641
TPhosphorylation1252
TPhosphorylation1252
TPhosphorylation1255
TPhosphorylation1255
SPhosphorylation1385
TPhosphorylation1390
SPhosphorylation1398
SPhosphorylation1385
TPhosphorylation1390
SPhosphorylation1398
TPhosphorylation1458
TPhosphorylation1458
TPhosphorylation1692
TPhosphorylation1692
TPhosphorylation647
TPhosphorylation663
TPhosphorylation647
TPhosphorylation663
TPhosphorylation740
TPhosphorylation740

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3428IFI16969NP_005522.2in vivo;yeast 2-hybrid12513910   
4928NUP983012NP_057404.2in vivo11248057   
5594MAPK11496NP_002736.3in vitro;in vivo12594221   
6464SHC12780NP_001123512.1in vitro11896612   
9972NUP1534899NP_005115.2in vitro;in vivo;yeast 2-hybrid12802065   
10971YWHAQ886NP_006817.1yeast 2-hybrid12513910   


Pathway Information


                  
Pathway Name Pathway ID
Pathways in cancer hsa05200
RNA transport hsa03013
Thyroid cancer hsa05216


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0396175-155  DUF342
cl1921975-155  DUF342 superfamily
pfam079261036-1167  TPR_MLP1_2
COG1196817-1619  Smc
TIGR02168773-1619  SMC_prok_B
TIGR02169785-1649  SMC_prok_A
COG1196663-1619  Smc
COG1196146-1049  Smc
COG1196677-1565  Smc
TIGR02168121-1053  SMC_prok_B
COG119653-796  Smc
TIGR02168974-1640  SMC_prok_B
TIGR02168832-1622  SMC_prok_B
COG11961277-1621  Smc
TIGR02168227-1066  SMC_prok_B
COG11961-346  Smc
pfam01576829-1645  Myosin_tail_1
TIGR00606667-1628  rad50
COG1196939-1633  Smc
COG119635-956  Smc
TIGR02168671-1334  SMC_prok_B
COG041922-620  SbcC
TIGR0216856-964  SMC_prok_B
TIGR02169683-1623  SMC_prok_A
TIGR02168413-1174  SMC_prok_B
COG11961368-1645  Smc
COG119669-491  Smc
TIGR0216823-884  SMC_prok_B
COG119623-367  Smc
TIGR02168973-1646  SMC_prok_B
PTZ00121930-1644  PTZ00121
TIGR021681284-1621  SMC_prok_B
TIGR02169932-1673  SMC_prok_A
COG0419925-1528  SbcC
PRK0391826-612  PRK03918
COG1196451-1382  Smc
COG11961010-1645  Smc
pfam12128815-1623  DUF3584
COG0419887-1455  SbcC
TIGR02168664-1453  SMC_prok_B
COG1196413-1179  Smc
PTZ00121979-1632  PTZ00121
COG0419661-1115  SbcC
TIGR02169660-1513  SMC_prok_A
TIGR0216974-478  SMC_prok_A
TIGR0452319-507  Mplasa_alph_rch
pfam02463678-1584  SMC_N
TIGR021681-742  SMC_prok_B
pfam02463217-1085  SMC_N
COG04192-490  SbcC
PRK0391823-493  PRK03918
TIGR045231283-1623  Mplasa_alph_rch
TIGR00606889-1629  rad50
COG04191026-1626  SbcC
TIGR04523942-1596  Mplasa_alph_rch
TIGR0216994-1053  SMC_prok_A
COG0419783-1382  SbcC
PRK03918879-1447  PRK03918
pfam12128772-1506  DUF3584
COG11966-615  Smc
PRK039181187-1638  PRK03918
TIGR0161254-1122  235kDa-fam
TIGR00618872-1556  sbcc
COG04191194-1620  SbcC
pfam024635-805  SMC_N
TIGR0216920-352  SMC_prok_A
TIGR0216911-306  SMC_prok_A
TIGR021691368-1646  SMC_prok_A
TIGR04523680-1436  Mplasa_alph_rch
TIGR02169967-1645  SMC_prok_A
COG0419661-1218  SbcC
TIGR00618992-1628  sbcc
PRK04863994-1633  mukB
PTZ00121117-612  PTZ00121
PRK022241052-1619  PRK02224
TIGR021681382-1648  SMC_prok_B
TIGR04523667-1046  Mplasa_alph_rch
PRK03918671-1220  PRK03918
pfam12128669-1154  DUF3584
PRK02224672-1169  PRK02224
pfam05483677-1142  SCP-1
pfam02463410-1275  SMC_N
pfam13166664-1064  AAA_13
TIGR045231368-1644  Mplasa_alph_rch
pfam135141240-1631  AAA_27
pfam12128663-1106  DUF3584
PTZ00121278-1119  PTZ00121
COG04191355-1620  SbcC
pfam05483680-1427  SCP-1
pfam13514759-1529  AAA_27
PRK11281744-1063  PRK11281
PRK03918662-1139  PRK03918
pfam097261368-1570  Macoilin
TIGR0161233-1049  235kDa-fam
pfam131661274-1622  AAA_13
TIGR042111483-1596  SH3_and_anchor
pfam055571009-1593  MAD
pfam101741004-1633  Cast
TIGR021695-615  SMC_prok_A
PRK02224110-511  PRK02224
pfam054831240-1633  SCP-1
COG49421365-1588  EnvC
PHA025621313-1535  46
PRK03918143-596  PRK03918
PRK03918724-1337  PRK03918
COG43721367-1583  COG4372
COG49131423-1636  COG4913
PLN02939787-1046  PLN02939
TIGR0216910-273  SMC_prok_A
TIGR0452312-274  Mplasa_alph_rch
pfam041111476-1615  APG6
pfam0548332-335  SCP-1
TIGR0216819-257  SMC_prok_B
pfam13514938-1646  AAA_27
PRK022241276-1640  PRK02224
PRK022241156-1640  PRK02224
PRK0115665-499  PRK01156
TIGR026801401-1630  TIGR02680
pfam097301286-1623  BicD
TIGR0452384-509  Mplasa_alph_rch
TIGR01612673-1564  235kDa-fam
PRK039181-274  PRK03918
PRK057711444-1619  PRK05771
PRK0222423-511  PRK02224
PRK112811280-1527  PRK11281
COG43721268-1555  COG4372
COG502251-521  COG5022
pfam05483119-514  SCP-1
PTZ00121118-996  PTZ00121
TIGR030071432-1622  pepcterm_ChnLen
pfam10174894-1657  Cast
COG43721244-1452  COG4372
pfam0149653-399  V_ATPase_I
TIGR0161213-1579  235kDa-fam
PHA02562837-1049  46
pfam000381316-1541  Filament
PRK01156980-1623  PRK01156
COG4372938-1135  COG4372
COG4942853-1087  EnvC
PRK090391475-1595  PRK09039
pfam015761278-1612  Myosin_tail_1
PRK127041484-1615  PRK12704
PRK01156232-781  PRK01156
COG4717674-1335  YhaN
COG4372695-944  COG4372
COG44771288-1596  EzrA
PRK01156926-1508  PRK01156
pfam059111284-1565  DUF869
pfam07888727-1058  CALCOCO1
COG3096953-1645  MukB
PRK0222424-269  PRK02224
pfam0555744-594  MAD
PRK02224970-1551  PRK02224
COG437276-257  COG4372
COG243356-169  COG2433
pfam024631305-1644  SMC_N
pfam04156917-1038  IncA
TIGR00606413-1206  rad50
PRK0577151-325  PRK05771
PTZ00121780-1421  PTZ00121
TIGR030071350-1542  pepcterm_ChnLen
TIGR042111467-1585  SH3_and_anchor
pfam09726784-1228  Macoilin
pfam05557937-1384  MAD
TIGR042111442-1541  SH3_and_anchor
pfam014961279-1493  V_ATPase_I
PRK048631246-1645  mukB
pfam0411165-194  APG6
pfam097311346-1621  Mitofilin
pfam05557115-508  MAD
COG5022413-1069  COG5022
TIGR031851272-1585  DNA_S_dndD
PRK127051498-1619  PRK12705
pfam13166104-484  AAA_13
TIGR009981480-1613  8a0101
pfam078881279-1599  CALCOCO1
pfam0548344-602  SCP-1
PTZ001081284-1640  PTZ00108
pfam097261284-1529  Macoilin
COG43721428-1649  COG4372
pfam041111520-1627  APG6
pfam078881002-1338  CALCOCO1
TIGR0061851-548  sbcc
PRK04863667-1036  mukB
pfam05483963-1627  SCP-1
pfam0411124-149  APG6
pfam04111894-1039  APG6
pfam13514442-1122  AAA_27
COG49421459-1643  EnvC
TIGR03319940-1107  RNase_Y
PTZ00440670-1216  PTZ00440
TIGR04527964-1050  mycoplas_twoTM
COG13401288-1555  COG1340
PRK054311402-1504  PRK05431
TIGR018431377-1583  type_I_hlyD
pfam1316683-483  AAA_13
pfam15070781-1046  GOLGA2L5
PRK127041435-1607  PRK12704
pfam0157623-469  Myosin_tail_1
PRK11637898-1108  PRK11637
COG5283946-1179  COG5283
TIGR010001443-1575  bacteriocin_acc
PRK00409962-1110  PRK00409
PHA025627-170  46
COG50221199-1513  COG5022
pfam055571370-1624  MAD
TIGR0216922-560  SMC_prok_A
pfam101861521-1633  Atg14
pfam02463116-491  SMC_N
TIGR04523147-801  Mplasa_alph_rch
COG01721402-1504  SerS
COG32641384-1594  MscK
pfam00038831-1071  Filament
PRK01156672-1044  PRK01156
pfam1212852-619  DUF3584
TIGR04211161-255  SH3_and_anchor
pfam04912775-1007  Dynamitin
pfam1316615-271  AAA_13
pfam10174963-1567  Cast
pfam05483678-1079  SCP-1
TIGR0421177-172  SH3_and_anchor
pfam0246312-354  SMC_N
PRK004091494-1633  PRK00409
PRK12704974-1107  PRK12704
pfam068181474-1647  Fez1
pfam051091634-1880  Herpes_BLLF1
PRK112811345-1545  PRK11281
pfam10174696-1137  Cast
PRK109291395-1605  PRK10929
COG15791369-1552  COG1579
pfam0788829-275  CALCOCO1
pfam06637891-1123  PV-1
pfam078881393-1632  CALCOCO1
pfam143621515-1623  DUF4407
PRK109291467-1627  PRK10929
COG15791279-1435  COG1579
pfam131661263-1528  AAA_13
pfam1212829-690  DUF3584
COG51851241-1595  HEC1
pfam150701313-1640  GOLGA2L5
PRK048631368-1623  mukB
pfam135146-861  AAA_27
TIGR037941466-1617  NHLM_micro_HlyD
pfam04111944-1066  APG6
TIGR03319891-1035  RNase_Y
TIGR042111244-1341  SH3_and_anchor
pfam05483832-1548  SCP-1
TIGR04211927-1024  SH3_and_anchor
PRK0040957-179  PRK00409
COG4372898-1130  COG4372
PRK05771202-484  PRK05771
pfam101861509-1622  Atg14


Ontology Information


   
HPRD ID2604
Molecular ClassUnclassified
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO