Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TPR | 7175 | Translocated promoter region (to activated MET oncogene)  | 1 | -  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]   | Chromosome | 1 |
| Location | 1q25 |
| Start | 186311652   |
| End | 186375848   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 64197   |
| OMIM ID | 189940    |
| HGNC ID | HGNC:12017    |
| Unigene ID | Hs.279640     |
| Ensembl ID | ENSG00000047410    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_005807.4 |
|---|---|
| Exon | complement(join(<61287..62168,62955..63080,63477..63674))   | mRNA Sequence |    Download   Select all |
| Length | 5050   |
CDS Information
| Location | complement(join(<62071..62168,62955..63080,63477..63674)) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS1369.1 |    
Protein Information
| Protein ID | NP_003283.2 |
|---|---|
| Protein Name | Translocated promoter region (to activated MET oncogene) |
| Molecular Wt. (Da) | 267163 |
| Protein Sequence |    Download   Select all |
| Length | 2363   |
| Uniprot ID | P40879 |    
| Ensembl Protein ID | ENSP00000345873   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2037 |
| S | Phosphorylation | 2037 |
| S | Phosphorylation | 1185;- |
| S | Phosphorylation | 1185;- |
| S | Phosphorylation | 920;- |
| S | Phosphorylation | 2034;- |
| S | Phosphorylation | 2050;- |
| S | Phosphorylation | 2034;- |
| S | Phosphorylation | 2050;- |
| S | Phosphorylation | 528;- |
| S | Phosphorylation | 530;- |
| S | Phosphorylation | 523;- |
| S | Phosphorylation | 528;- |
| S | Phosphorylation | 530;- |
| S | Phosphorylation | 523;- |
| S | Phosphorylation | 529;- |
| S | Phosphorylation | 527;- |
| S | Phosphorylation | 529;- |
| S | Phosphorylation | 527;- |
| T | Phosphorylation | 381;- |
| T | Phosphorylation | 381;- |
| S | Phosphorylation | 2073;- |
| S | Phosphorylation | 2073;- |
| T | Phosphorylation | 650;- |
| T | Phosphorylation | 650;- |
| S | Phosphorylation | 2155;- |
| S | Phosphorylation | 2155;- |
| S | Phosphorylation | 379 |
| S | Phosphorylation | 379 |
| S | Phosphorylation | 648 |
| S | Phosphorylation | 648 |
| S | Phosphorylation | 652 |
| S | Phosphorylation | 652 |
| T | Phosphorylation | 653 |
| T | Phosphorylation | 653 |
| S | Phosphorylation | 1459 |
| S | Phosphorylation | 1462 |
| S | Phosphorylation | 1459 |
| S | Phosphorylation | 1462 |
| T | Phosphorylation | 1666 |
| T | Phosphorylation | 1666 |
| S | Phosphorylation | 1676 |
| S | Phosphorylation | 1691 |
| S | Phosphorylation | 1676 |
| S | Phosphorylation | 1691 |
| T | Phosphorylation | 1677 |
| T | Phosphorylation | 1677 |
| S | Phosphorylation | 1838 |
| S | Phosphorylation | 1838 |
| T | Phosphorylation | 1839 |
| T | Phosphorylation | 1839 |
| S | Phosphorylation | 2048 |
| S | Phosphorylation | 2048 |
| S | Phosphorylation | 522 |
| S | Phosphorylation | 522 |
| S | Phosphorylation | 646 |
| S | Phosphorylation | 646 |
| S | Phosphorylation | 2047 |
| S | Phosphorylation | 2047 |
| S | Phosphorylation | 1804 |
| S | Phosphorylation | 1804 |
| S | Phosphorylation | 1725 |
| S | Phosphorylation | 1725 |
| K | Acetylation | 755 |
| K | Acetylation | 755 |
| K | Acetylation | 723 |
| K | Acetylation | 723 |
| K | Acetylation | 713 |
| K | Acetylation | 713 |
| K | Acetylation | 428 |
| K | Acetylation | 428 |
| K | Acetylation | 748 |
| K | Acetylation | 748 |
| K | Acetylation | 457 |
| K | Acetylation | 457 |
| K | Acetylation | 252 |
| K | Acetylation | 252 |
| K | Acetylation | 345 |
| K | Acetylation | 345 |
| K | Acetylation | 312 |
| K | Acetylation | 312 |
| S | Phosphorylation | 2054 |
| S | Phosphorylation | 2054 |
| S | Phosphorylation | 1847 |
| S | Phosphorylation | 1847 |
| T | Phosphorylation | 2175 |
| T | Phosphorylation | 2175 |
| S | Phosphorylation | 2180 |
| S | Phosphorylation | 2180 |
| S | Phosphorylation | 2178 |
| S | Phosphorylation | 2178 |
| S | Glycosylation | 1676 |
| S | Glycosylation | 1676 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 135 |
| S | Phosphorylation | 270 |
| S | Phosphorylation | 270 |
| T | Phosphorylation | 641 |
| T | Phosphorylation | 641 |
| T | Phosphorylation | 1252 |
| T | Phosphorylation | 1252 |
| T | Phosphorylation | 1255 |
| T | Phosphorylation | 1255 |
| S | Phosphorylation | 1385 |
| T | Phosphorylation | 1390 |
| S | Phosphorylation | 1398 |
| S | Phosphorylation | 1385 |
| T | Phosphorylation | 1390 |
| S | Phosphorylation | 1398 |
| T | Phosphorylation | 1458 |
| T | Phosphorylation | 1458 |
| T | Phosphorylation | 1692 |
| T | Phosphorylation | 1692 |
| T | Phosphorylation | 647 |
| T | Phosphorylation | 663 |
| T | Phosphorylation | 647 |
| T | Phosphorylation | 663 |
| T | Phosphorylation | 740 |
| T | Phosphorylation | 740 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3428 |    IFI16 |    969 |    NP_005522.2 |    in vivo;yeast 2-hybrid |    12513910    |
| 4928 |    NUP98 |    3012 |    NP_057404.2 |    in vivo |    11248057    |
| 5594 |    MAPK1 |    1496 |    NP_002736.3 |    in vitro;in vivo |    12594221    |
| 6464 |    SHC1 |    2780 |    NP_001123512.1 |    in vitro |    11896612    |
| 9972 |    NUP153 |    4899 |    NP_005115.2 |    in vitro;in vivo;yeast 2-hybrid |    12802065    |
| 10971 |    YWHAQ |    886 |    NP_006817.1 |    yeast 2-hybrid |    12513910    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pathways in cancer |    hsa05200 |    
| RNA transport |    hsa03013 |    
| Thyroid cancer |    hsa05216 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03961 | 75-155  | DUF342 |
| cl19219 | 75-155  | DUF342 superfamily |
| pfam07926 | 1036-1167  | TPR_MLP1_2 |
| COG1196 | 817-1619  | Smc |
| TIGR02168 | 773-1619  | SMC_prok_B |
| TIGR02169 | 785-1649  | SMC_prok_A |
| COG1196 | 663-1619  | Smc |
| COG1196 | 146-1049  | Smc |
| COG1196 | 677-1565  | Smc |
| TIGR02168 | 121-1053  | SMC_prok_B |
| COG1196 | 53-796  | Smc |
| TIGR02168 | 974-1640  | SMC_prok_B |
| TIGR02168 | 832-1622  | SMC_prok_B |
| COG1196 | 1277-1621  | Smc |
| TIGR02168 | 227-1066  | SMC_prok_B |
| COG1196 | 1-346  | Smc |
| pfam01576 | 829-1645  | Myosin_tail_1 |
| TIGR00606 | 667-1628  | rad50 |
| COG1196 | 939-1633  | Smc |
| COG1196 | 35-956  | Smc |
| TIGR02168 | 671-1334  | SMC_prok_B |
| COG0419 | 22-620  | SbcC |
| TIGR02168 | 56-964  | SMC_prok_B |
| TIGR02169 | 683-1623  | SMC_prok_A |
| TIGR02168 | 413-1174  | SMC_prok_B |
| COG1196 | 1368-1645  | Smc |
| COG1196 | 69-491  | Smc |
| TIGR02168 | 23-884  | SMC_prok_B |
| COG1196 | 23-367  | Smc |
| TIGR02168 | 973-1646  | SMC_prok_B |
| PTZ00121 | 930-1644  | PTZ00121 |
| TIGR02168 | 1284-1621  | SMC_prok_B |
| TIGR02169 | 932-1673  | SMC_prok_A |
| COG0419 | 925-1528  | SbcC |
| PRK03918 | 26-612  | PRK03918 |
| COG1196 | 451-1382  | Smc |
| COG1196 | 1010-1645  | Smc |
| pfam12128 | 815-1623  | DUF3584 |
| COG0419 | 887-1455  | SbcC |
| TIGR02168 | 664-1453  | SMC_prok_B |
| COG1196 | 413-1179  | Smc |
| PTZ00121 | 979-1632  | PTZ00121 |
| COG0419 | 661-1115  | SbcC |
| TIGR02169 | 660-1513  | SMC_prok_A |
| TIGR02169 | 74-478  | SMC_prok_A |
| TIGR04523 | 19-507  | Mplasa_alph_rch |
| pfam02463 | 678-1584  | SMC_N |
| TIGR02168 | 1-742  | SMC_prok_B |
| pfam02463 | 217-1085  | SMC_N |
| COG0419 | 2-490  | SbcC |
| PRK03918 | 23-493  | PRK03918 |
| TIGR04523 | 1283-1623  | Mplasa_alph_rch |
| TIGR00606 | 889-1629  | rad50 |
| COG0419 | 1026-1626  | SbcC |
| TIGR04523 | 942-1596  | Mplasa_alph_rch |
| TIGR02169 | 94-1053  | SMC_prok_A |
| COG0419 | 783-1382  | SbcC |
| PRK03918 | 879-1447  | PRK03918 |
| pfam12128 | 772-1506  | DUF3584 |
| COG1196 | 6-615  | Smc |
| PRK03918 | 1187-1638  | PRK03918 |
| TIGR01612 | 54-1122  | 235kDa-fam |
| TIGR00618 | 872-1556  | sbcc |
| COG0419 | 1194-1620  | SbcC |
| pfam02463 | 5-805  | SMC_N |
| TIGR02169 | 20-352  | SMC_prok_A |
| TIGR02169 | 11-306  | SMC_prok_A |
| TIGR02169 | 1368-1646  | SMC_prok_A |
| TIGR04523 | 680-1436  | Mplasa_alph_rch |
| TIGR02169 | 967-1645  | SMC_prok_A |
| COG0419 | 661-1218  | SbcC |
| TIGR00618 | 992-1628  | sbcc |
| PRK04863 | 994-1633  | mukB |
| PTZ00121 | 117-612  | PTZ00121 |
| PRK02224 | 1052-1619  | PRK02224 |
| TIGR02168 | 1382-1648  | SMC_prok_B |
| TIGR04523 | 667-1046  | Mplasa_alph_rch |
| PRK03918 | 671-1220  | PRK03918 |
| pfam12128 | 669-1154  | DUF3584 |
| PRK02224 | 672-1169  | PRK02224 |
| pfam05483 | 677-1142  | SCP-1 |
| pfam02463 | 410-1275  | SMC_N |
| pfam13166 | 664-1064  | AAA_13 |
| TIGR04523 | 1368-1644  | Mplasa_alph_rch |
| pfam13514 | 1240-1631  | AAA_27 |
| pfam12128 | 663-1106  | DUF3584 |
| PTZ00121 | 278-1119  | PTZ00121 |
| COG0419 | 1355-1620  | SbcC |
| pfam05483 | 680-1427  | SCP-1 |
| pfam13514 | 759-1529  | AAA_27 |
| PRK11281 | 744-1063  | PRK11281 |
| PRK03918 | 662-1139  | PRK03918 |
| pfam09726 | 1368-1570  | Macoilin |
| TIGR01612 | 33-1049  | 235kDa-fam |
| pfam13166 | 1274-1622  | AAA_13 |
| TIGR04211 | 1483-1596  | SH3_and_anchor |
| pfam05557 | 1009-1593  | MAD |
| pfam10174 | 1004-1633  | Cast |
| TIGR02169 | 5-615  | SMC_prok_A |
| PRK02224 | 110-511  | PRK02224 |
| pfam05483 | 1240-1633  | SCP-1 |
| COG4942 | 1365-1588  | EnvC |
| PHA02562 | 1313-1535  | 46 |
| PRK03918 | 143-596  | PRK03918 |
| PRK03918 | 724-1337  | PRK03918 |
| COG4372 | 1367-1583  | COG4372 |
| COG4913 | 1423-1636  | COG4913 |
| PLN02939 | 787-1046  | PLN02939 |
| TIGR02169 | 10-273  | SMC_prok_A |
| TIGR04523 | 12-274  | Mplasa_alph_rch |
| pfam04111 | 1476-1615  | APG6 |
| pfam05483 | 32-335  | SCP-1 |
| TIGR02168 | 19-257  | SMC_prok_B |
| pfam13514 | 938-1646  | AAA_27 |
| PRK02224 | 1276-1640  | PRK02224 |
| PRK02224 | 1156-1640  | PRK02224 |
| PRK01156 | 65-499  | PRK01156 |
| TIGR02680 | 1401-1630  | TIGR02680 |
| pfam09730 | 1286-1623  | BicD |
| TIGR04523 | 84-509  | Mplasa_alph_rch |
| TIGR01612 | 673-1564  | 235kDa-fam |
| PRK03918 | 1-274  | PRK03918 |
| PRK05771 | 1444-1619  | PRK05771 |
| PRK02224 | 23-511  | PRK02224 |
| PRK11281 | 1280-1527  | PRK11281 |
| COG4372 | 1268-1555  | COG4372 |
| COG5022 | 51-521  | COG5022 |
| pfam05483 | 119-514  | SCP-1 |
| PTZ00121 | 118-996  | PTZ00121 |
| TIGR03007 | 1432-1622  | pepcterm_ChnLen |
| pfam10174 | 894-1657  | Cast |
| COG4372 | 1244-1452  | COG4372 |
| pfam01496 | 53-399  | V_ATPase_I |
| TIGR01612 | 13-1579  | 235kDa-fam |
| PHA02562 | 837-1049  | 46 |
| pfam00038 | 1316-1541  | Filament |
| PRK01156 | 980-1623  | PRK01156 |
| COG4372 | 938-1135  | COG4372 |
| COG4942 | 853-1087  | EnvC |
| PRK09039 | 1475-1595  | PRK09039 |
| pfam01576 | 1278-1612  | Myosin_tail_1 |
| PRK12704 | 1484-1615  | PRK12704 |
| PRK01156 | 232-781  | PRK01156 |
| COG4717 | 674-1335  | YhaN |
| COG4372 | 695-944  | COG4372 |
| COG4477 | 1288-1596  | EzrA |
| PRK01156 | 926-1508  | PRK01156 |
| pfam05911 | 1284-1565  | DUF869 |
| pfam07888 | 727-1058  | CALCOCO1 |
| COG3096 | 953-1645  | MukB |
| PRK02224 | 24-269  | PRK02224 |
| pfam05557 | 44-594  | MAD |
| PRK02224 | 970-1551  | PRK02224 |
| COG4372 | 76-257  | COG4372 |
| COG2433 | 56-169  | COG2433 |
| pfam02463 | 1305-1644  | SMC_N |
| pfam04156 | 917-1038  | IncA |
| TIGR00606 | 413-1206  | rad50 |
| PRK05771 | 51-325  | PRK05771 |
| PTZ00121 | 780-1421  | PTZ00121 |
| TIGR03007 | 1350-1542  | pepcterm_ChnLen |
| TIGR04211 | 1467-1585  | SH3_and_anchor |
| pfam09726 | 784-1228  | Macoilin |
| pfam05557 | 937-1384  | MAD |
| TIGR04211 | 1442-1541  | SH3_and_anchor |
| pfam01496 | 1279-1493  | V_ATPase_I |
| PRK04863 | 1246-1645  | mukB |
| pfam04111 | 65-194  | APG6 |
| pfam09731 | 1346-1621  | Mitofilin |
| pfam05557 | 115-508  | MAD |
| COG5022 | 413-1069  | COG5022 |
| TIGR03185 | 1272-1585  | DNA_S_dndD |
| PRK12705 | 1498-1619  | PRK12705 |
| pfam13166 | 104-484  | AAA_13 |
| TIGR00998 | 1480-1613  | 8a0101 |
| pfam07888 | 1279-1599  | CALCOCO1 |
| pfam05483 | 44-602  | SCP-1 |
| PTZ00108 | 1284-1640  | PTZ00108 |
| pfam09726 | 1284-1529  | Macoilin |
| COG4372 | 1428-1649  | COG4372 |
| pfam04111 | 1520-1627  | APG6 |
| pfam07888 | 1002-1338  | CALCOCO1 |
| TIGR00618 | 51-548  | sbcc |
| PRK04863 | 667-1036  | mukB |
| pfam05483 | 963-1627  | SCP-1 |
| pfam04111 | 24-149  | APG6 |
| pfam04111 | 894-1039  | APG6 |
| pfam13514 | 442-1122  | AAA_27 |
| COG4942 | 1459-1643  | EnvC |
| TIGR03319 | 940-1107  | RNase_Y |
| PTZ00440 | 670-1216  | PTZ00440 |
| TIGR04527 | 964-1050  | mycoplas_twoTM |
| COG1340 | 1288-1555  | COG1340 |
| PRK05431 | 1402-1504  | PRK05431 |
| TIGR01843 | 1377-1583  | type_I_hlyD |
| pfam13166 | 83-483  | AAA_13 |
| pfam15070 | 781-1046  | GOLGA2L5 |
| PRK12704 | 1435-1607  | PRK12704 |
| pfam01576 | 23-469  | Myosin_tail_1 |
| PRK11637 | 898-1108  | PRK11637 |
| COG5283 | 946-1179  | COG5283 |
| TIGR01000 | 1443-1575  | bacteriocin_acc |
| PRK00409 | 962-1110  | PRK00409 |
| PHA02562 | 7-170  | 46 |
| COG5022 | 1199-1513  | COG5022 |
| pfam05557 | 1370-1624  | MAD |
| TIGR02169 | 22-560  | SMC_prok_A |
| pfam10186 | 1521-1633  | Atg14 |
| pfam02463 | 116-491  | SMC_N |
| TIGR04523 | 147-801  | Mplasa_alph_rch |
| COG0172 | 1402-1504  | SerS |
| COG3264 | 1384-1594  | MscK |
| pfam00038 | 831-1071  | Filament |
| PRK01156 | 672-1044  | PRK01156 |
| pfam12128 | 52-619  | DUF3584 |
| TIGR04211 | 161-255  | SH3_and_anchor |
| pfam04912 | 775-1007  | Dynamitin |
| pfam13166 | 15-271  | AAA_13 |
| pfam10174 | 963-1567  | Cast |
| pfam05483 | 678-1079  | SCP-1 |
| TIGR04211 | 77-172  | SH3_and_anchor |
| pfam02463 | 12-354  | SMC_N |
| PRK00409 | 1494-1633  | PRK00409 |
| PRK12704 | 974-1107  | PRK12704 |
| pfam06818 | 1474-1647  | Fez1 |
| pfam05109 | 1634-1880  | Herpes_BLLF1 |
| PRK11281 | 1345-1545  | PRK11281 |
| pfam10174 | 696-1137  | Cast |
| PRK10929 | 1395-1605  | PRK10929 |
| COG1579 | 1369-1552  | COG1579 |
| pfam07888 | 29-275  | CALCOCO1 |
| pfam06637 | 891-1123  | PV-1 |
| pfam07888 | 1393-1632  | CALCOCO1 |
| pfam14362 | 1515-1623  | DUF4407 |
| PRK10929 | 1467-1627  | PRK10929 |
| COG1579 | 1279-1435  | COG1579 |
| pfam13166 | 1263-1528  | AAA_13 |
| pfam12128 | 29-690  | DUF3584 |
| COG5185 | 1241-1595  | HEC1 |
| pfam15070 | 1313-1640  | GOLGA2L5 |
| PRK04863 | 1368-1623  | mukB |
| pfam13514 | 6-861  | AAA_27 |
| TIGR03794 | 1466-1617  | NHLM_micro_HlyD |
| pfam04111 | 944-1066  | APG6 |
| TIGR03319 | 891-1035  | RNase_Y |
| TIGR04211 | 1244-1341  | SH3_and_anchor |
| pfam05483 | 832-1548  | SCP-1 |
| TIGR04211 | 927-1024  | SH3_and_anchor |
| PRK00409 | 57-179  | PRK00409 |
| COG4372 | 898-1130  | COG4372 |
| PRK05771 | 202-484  | PRK05771 |
| pfam10186 | 1509-1622  | Atg14 |
Ontology Information
| HPRD ID | 2604 |    
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
