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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ZNF148 | 7707 | zinc finger protein 148 | 3 | BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23576061 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 56 normal mucosa, 51 adenoma, 742 CRC (TNM stage I-IV), 16 familial adenomatous polyposis, and 21 metastatic CRC specimens. Stage : TNM Stage I-IV | Tissue microarray and immunohistochemistry | Up-regulation and Down-regulation | - | Expression of ZNF148 was found to increase consecutively from normal mucosa to stage I CRC, and then decreased consecutively from stage I to stage IV CRC. ZNF148 expression is related to colorectal carcinogenesis, high ZNF148 expression in patients with CRC appears to be inversely associated with malignant phenotypes and may serve as a significant prognostic factor after surgery for patients with CRC |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | - |
| Chromosome | 3 |
| Location | 3q21.2 |
| Start | 125225669 |
| End | 125375354 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 149686 |
| OMIM ID | 601897 |
| HGNC ID | HGNC:12933 |
| Unigene ID | Hs.592591 |
| Ensembl ID | ENSG00000163848 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_021964.2 |
|---|---|
| Exon | join(1..253,44117..44197,51911..52046,61699..62047, 87127..87252,96108..96231,97546..97629,141026..141144, 141416..149686) | mRNA Sequence | Download Select all |
| Length | 9573 |
CDS Information
| Location | join(61715..62047,87127..87252,96108..96231,97546..97629, 141026..141144,141416..143014) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3031.1 |
Protein Information
| Protein ID | NP_068799.2 |
|---|---|
| Protein Name | zinc finger protein 148 |
| Molecular Wt. (Da) | 88845 |
| Protein Sequence | Download Select all |
| Length | 794 |
| Uniprot ID | P10145 |
| Ensembl Protein ID | ENSP00000306512 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 306 |
| S | Phosphorylation | 412 |
| S | Phosphorylation | 784;- |
| S | Phosphorylation | 665;- |
| T | Phosphorylation | 788;- |
| T | Phosphorylation | 782;- |
| T | Phosphorylation | 25 |
| T | Phosphorylation | 37 |
| T | Phosphorylation | 194 |
| S | Phosphorylation | 250 |
| T | Phosphorylation | 305 |
| S | Phosphorylation | 311 |
| K | Acetylation | 607 |
| S | Phosphorylation | 304 |
| T | Phosphorylation | 670 |
| T | Phosphorylation | 669 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 10899165 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 14712222 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 11416144 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 214-238 | zf-H2C2_2 |
| cl22375 | 214-238 | zf-H2C2_2 superfamily |
| pfam13465 | 241-266 | zf-H2C2_2 |
| cl22375 | 241-266 | zf-H2C2_2 superfamily |
| pfam13465 | 185-210 | zf-H2C2_2 |
| cl22375 | 185-210 | zf-H2C2_2 superfamily |
| pfam00096 | 227-249 | zf-C2H2 |
| cl23491 | 227-249 | zf-C2H2 superfamily |
| smart00355 | 227-249 | ZnF_C2H2 |
| cl18194 | 227-249 | ZnF_C2H2 superfamily |
| PLN00104 | 253-281 | PLN00104 |
Ontology Information
| HPRD ID | 495 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.