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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ZNF148 7707 zinc finger protein 148  3BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23576061   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : 56 normal mucosa, 51 adenoma, 742 CRC (TNM stage I-IV), 16 familial adenomatous polyposis, and 21 metastatic CRC specimens.

Stage : TNM Stage I-IV

Tissue microarray and immunohistochemistryUp-regulation and Down-regulation-Expression of ZNF148 was found to increase consecutively from normal mucosa to stage I CRC, and then decreased consecutively from stage I to stage IV CRC.

ZNF148 expression is related to colorectal carcinogenesis, high ZNF148 expression in patients with CRC appears to be inversely associated with malignant phenotypes and may serve as a significant prognostic factor after surgery for patients with CRC


Gene Details



Chromosome 3 - NC_000003.12 (125225669..125375354, complement)

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Gene Type protein coding
Gene Family Zinc fingers, C2H2-type
Description -  
Chromosome 3
Location 3q21.2
Start 125225669  
End 125375354  
Strand -  
Gene Sequence

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Length 149686  
OMIM ID 601897   
HGNC ID HGNC:12933   
Unigene ID Hs.592591   
Ensembl ID ENSG00000163848   
PharmGKB ID -   

mRNA Information


mRNA ID NM_021964.2
Exon join(1..253,44117..44197,51911..52046,61699..62047, 87127..87252,96108..96231,97546..97629,141026..141144, 141416..149686)  
mRNA Sequence

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Length 9573  



CDS Information


   
Location join(61715..62047,87127..87252,96108..96231,97546..97629, 141026..141144,141416..143014)
CDS Sequence

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CCDS ID CCDS3031.1



Protein Information


      
Protein IDNP_068799.2
Protein Namezinc finger protein 148
Molecular Wt. (Da)88845
Protein Sequence

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Length 794  
Uniprot IDP10145
Ensembl Protein ID ENSP00000306512  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation306
SPhosphorylation412
SPhosphorylation784;-
SPhosphorylation665;-
TPhosphorylation788;-
TPhosphorylation782;-
TPhosphorylation25
TPhosphorylation37
TPhosphorylation194
SPhosphorylation250
TPhosphorylation305
SPhosphorylation311
KAcetylation607
SPhosphorylation304
TPhosphorylation670
TPhosphorylation669

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vitro;in vivo10899165   
6774STAT326NP_644805.1in vivo14712222   
7157TP531859NP_000537.3in vitro;in vivo11416144   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam13465214-238  zf-H2C2_2
cl22375214-238  zf-H2C2_2 superfamily
pfam13465241-266  zf-H2C2_2
cl22375241-266  zf-H2C2_2 superfamily
pfam13465185-210  zf-H2C2_2
cl22375185-210  zf-H2C2_2 superfamily
pfam00096227-249  zf-C2H2
cl23491227-249  zf-C2H2 superfamily
smart00355227-249  ZnF_C2H2
cl18194227-249  ZnF_C2H2 superfamily
PLN00104253-281  PLN00104


Ontology Information


   
HPRD ID495
Molecular ClassTranscription factor
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessImmune response (GO:0006955)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO