Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HMGA2 | 8091 | high mobility group AT-hook 2 | 12 | BABL, LIPO |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21252160 | 2011 | Cell line : - Source : City of Hope National Medical Center, 2nd affiliated hospital, Zhejiang University School of Medicine Sample Type : - No. of Sample : 89 CRCs from a training set and 191 CRCs Stage : - | multiple tissue array (MTA), immunohistochemistry, Western blotting | Up-regulation | - | HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy. Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | High-mobility group / Canonical |
| Description | This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Chromosome | 12 |
| Location | 12q15 |
| Start | 65824460 |
| End | 65966291 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 141832 |
| OMIM ID | 600698 |
| HGNC ID | HGNC:5009 |
| Unigene ID | Hs.505924 |
| Ensembl ID | ENSG00000149948 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003483.4 |
|---|---|
| Exon | join(1..922,3542..3628,14060..14110,126924..126956, 138786..141832) | mRNA Sequence | Download Select all |
| Length | 1274 |
CDS Information
| Location | join(812..922,3542..3628,14060..14110,126924..126956, 138786..138833) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS44936.1 |
Protein Information
| Protein ID | NP_001287848.1 |
|---|---|
| Protein Name | high mobility group AT-hook 2 |
| Molecular Wt. (Da) | 16293 |
| Protein Sequence | Download Select all |
| Length | 147 |
| Uniprot ID | P29459 |
| Ensembl Protein ID | ENSP00000303231 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 44 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 44 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 44 |
| T | Phosphorylation | 40 |
| T | Phosphorylation | 40 |
| T | Phosphorylation | 40 |
| S | Phosphorylation | 14 |
| S | Phosphorylation | 14 |
| S | Phosphorylation | 14 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Phosphorylation | 102 |
| S | Phosphorylation | 101 |
| T | Phosphorylation | 100 |
| S | Phosphorylation | 105 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro | 11034995 |
| 1459 | CSNK2A2 | 279 | NP_001887.1 | in vitro | 11034995 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro | 18832382 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro | 12693954 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro | 12693954 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 981 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.