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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23649548 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 203 CRC case Stage : - | Tissue microarray and immunohistochemistry | Up-regulation | - | CUL4B might promote the progression of colon cancer and can be served as a novel independent prognostic marker for the prediction of recurrence in colon cancer. Immunohistochemistry on a tissue microarray containing 203 cases of colon cancer was performed to analyze the association between CUL4B expression and clinicopathological features. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | X |
| Location | Xq23 |
| Start | 120524589 |
| End | 120575829 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 51241 |
| OMIM ID | 300304 |
| HGNC ID | HGNC:2555 |
| Unigene ID | Hs.102914 |
| Ensembl ID | ENSG00000158290 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003588.3 |
|---|---|
| Exon | join(1..424,1200..1279,15205..15747,17791..17906, 28591..28694,29214..29283,30313..30386,31187..31349, 31627..31716,32021..32103,32797..32864,34110..34228, 35268..35460,36458..36562,37060..37170,37621..37706, 38796..38903,39887..40000,41244..41349,43236..43408, 45576..45728,48974..51241) | mRNA Sequence | Download Select all |
| Length | 5198 |
CDS Information
| Location | join(1213..1279,15205..15747,17791..17906,28591..28694, 29214..29283,30313..30386,31187..31349,31627..31716, 32021..32103,32797..32864,34110..34228,35268..35460, 36458..36562,37060..37170,37621..37706,38796..38903, 39887..40000,41244..41349,43236..43408,45576..45728, 48974..49069) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS35379.1 |
Protein Information
| Protein ID | NP_001073341.1 |
|---|---|
| Protein Name | cullin 4B |
| Molecular Wt. (Da) | 102168 |
| Protein Sequence | Download Select all |
| Length | 895 |
| Uniprot ID | Q14005 |
| Ensembl Protein ID | ENSP00000302935 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 49 |
| T | Phosphorylation | 42 |
| T | Phosphorylation | 46 |
| S | Phosphorylation | 53 |
| T | Phosphorylation | 24 |
| T | Phosphorylation | 28 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 47 |
| S | Phosphorylation | 29 |
| T | Phosphorylation | 48 |
| T | Phosphorylation | 52 |
| T | Phosphorylation | 30 |
| T | Phosphorylation | 34 |
| T | Phosphorylation | 31 |
| S | Phosphorylation | 146 |
| S | Phosphorylation | 128 |
| S | Phosphorylation | 193 |
| S | Phosphorylation | 175 |
| S | Phosphorylation | 138 |
| S | Phosphorylation | 152 |
| S | Phosphorylation | 120 |
| S | Phosphorylation | 134 |
| S | Phosphorylation | 141 |
| S | Phosphorylation | 142 |
| S | Phosphorylation | 123 |
| S | Phosphorylation | 124 |
| S | Phosphorylation | 143 |
| S | Phosphorylation | 144 |
| S | Phosphorylation | 125 |
| S | Phosphorylation | 126 |
| S | Phosphorylation | 145 |
| S | Phosphorylation | 127 |
| T | Phosphorylation | 148 |
| T | Phosphorylation | 130 |
| T | Phosphorylation | 85 |
| T | Phosphorylation | 67 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 8 |
| S | Phosphorylation | 10 |
| S | Phosphorylation | 12 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vivo | 17392787 |
| 1642 | DDB1 | 10952 | NP_001914.3 | in vivo | 18593899 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vivo | 17392787 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Nucleotide excision repair | hsa03420 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
| PDB ID | 2DO7 |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | Cullin-4B |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00182 | 596-736 | CULLIN |
| cl10551 | 596-736 | CULLIN superfamily |
| pfam10557 | 842-907 | Cullin_Nedd8 |
| cl11186 | 842-907 | Cullin_Nedd8 superfamily |
| smart00884 | 842-907 | Cullin_Nedd8 |
| pfam00888 | 217-815 | Cullin |
| COG5647 | 191-913 | COG5647 |
Ontology Information
| HPRD ID | 2976 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.