Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CASR | 846 | calcium-sensing receptor | 3 | FHH, NSHPT, GPRC2A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26178670 | 2015 | Cell line : Caco-2, HT29 Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Expression of the CaSR in colorectal tumors is often reduced. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class C : Calcium-sensing receptors |
| Description | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3q21.1 |
| Start | 121902530 |
| End | 122005350 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 102821 |
| OMIM ID | 601199 |
| HGNC ID | HGNC:1514 |
| Unigene ID | Hs.435615 |
| Ensembl ID | ENSG00000036828 |
| PharmGKB ID | PA26097 |
mRNA Information
| mRNA ID | XM_011513238.1 |
|---|---|
| Exon | join(1..146,61556..61779,62780..64575,70282..70708, 73415..73721,77862..78746,92146..92376,98447..98570, 100021..102837) | mRNA Sequence | Download Select all |
| Length | 6957 |
Protein Information
| Protein ID | XP_011511540.1 |
|---|---|
| Protein Name | calcium-sensing receptor |
| Molecular Wt. (Da) | 120544 |
| Protein Sequence | Download Select all |
| Length | 1078 |
| Uniprot ID | P35749 |
| Ensembl Protein ID | ENSP00000300036 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 130 |
| N | Glycosylation | 261 |
| N | Glycosylation | 287 |
| N | Glycosylation | 446 |
| N | Glycosylation | 468 |
| N | Glycosylation | 488 |
| N | Glycosylation | 90 |
| T | Phosphorylation | 888 |
| T | Phosphorylation | 888 |
| T | Phosphorylation | 888 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2316 | FLNA | 2060 | NP_001104026.1 | in vitro;in vivo;yeast 2-hybrid | 1 139 038 011 390 370 |
| 25897 | RNF19A | 6176 | NP_056250.3 | in vitro;yeast 2-hybrid | 16513638 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06364 | 20-530 | PBP1_CaSR |
| cl10011 | 20-530 | Periplasmic_Binding_Protein_Type_1 superfamily |
| cd06363 | 29-531 | PBP1_Taste_receptor |
| cd06362 | 30-511 | PBP1_mGluR |
| cd06350 | 33-525 | PBP1_GPCR_family_C_like |
| cd06375 | 30-510 | PBP1_mGluR_groupII |
| pfam00003 | 622-860 | 7tm_3 |
| cl02802 | 622-860 | 7tm_3 superfamily |
| cd06361 | 33-494 | PBP1_GPC6A_like |
| cd06365 | 30-530 | PBP1_Pheromone_receptor |
| cd06374 | 26-509 | PBP1_mGluR_groupI |
| cd06376 | 30-530 | PBP1_mGluR_groupIII |
| cd06269 | 33-324 | PBP1_glutamate_receptors_like |
| cd04509 | 34-314 | PBP1_ABC_transporter_GCPR_C_like |
| cd06366 | 73-351 | PBP1_GABAb_receptor |
| cd01391 | 63-307 | Periplasmic_Binding_Protein_Type_1 |
| pfam07562 | 538-591 | NCD3G |
| cl08456 | 538-591 | NCD3G superfamily |
| cd06268 | 70-306 | PBP1_ABC_transporter_LIVBP_like |
| cd06379 | 131-532 | PBP1_iGluR_NMDA_NR1 |
| cd06370 | 62-262 | PBP1_Speract_GC_like |
| COG0683 | 76-338 | LivK |
| cd06352 | 77-512 | PBP1_NPR_GC_like |
| cd06351 | 76-313 | PBP1_iGluR_N_LIVBP_like |
| cd06367 | 160-297 | PBP1_iGluR_NMDA |
| cd06346 | 139-225 | PBP1_ABC_ligand_binding_like_11 |
| cd06342 | 77-291 | PBP1_ABC_LIVBP_like |
| cd06368 | 72-291 | PBP1_iGluR_non_NMDA_like |
| cd06330 | 77-282 | PBP1_Arsenic_SBP_like |
| cd06393 | 72-219 | PBP1_iGluR_Kainate_GluR5_7 |
| cd06333 | 95-373 | PBP1_ABC-type_HAAT_like |
| cd06373 | 73-221 | PBP1_NPR_like |
| cd06382 | 76-289 | PBP1_iGluR_Kainate |
| cd06344 | 136-305 | PBP1_ABC_ligand_binding_like_9 |
| cd06345 | 72-292 | PBP1_ABC_ligand_binding_like_10 |
| cd06340 | 139-310 | PBP1_ABC_ligand_binding_like_6 |
| cd06372 | 61-212 | PBP1_GC_G_like |
| cd03254 | 134-164 | ABCC_Glucan_exporter_like |
| cl21455 | 134-164 | P-loop_NTPase superfamily |
| pfam01094 | 69-495 | ANF_receptor |
| pfam13458 | 70-308 | Peripla_BP_6 |
| pfam12698 | 682-854 | ABC2_membrane_3 |
| PRK11176 | 129-161 | PRK11176 |
Ontology Information
| HPRD ID | 1166 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P41180 | DB01012 | Cinacalcet | SmallMoleculeDrug |