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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CASR 846 calcium-sensing receptor  3FHH, NSHPT, GPRC2A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26178670   2015Cell line : Caco-2, HT29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-Expression of the CaSR in colorectal tumors is often reduced.


Gene Details



NC_000003.11 (121902530..122005350)

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Gene Type protein coding
Gene Family GPCR / Class C : Calcium-sensing receptors
Description The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q21.1
Start 121902530  
End 122005350  
Strand +  
Gene Sequence

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Length 102821  
OMIM ID 601199   
HGNC ID HGNC:1514   
Unigene ID Hs.435615   
Ensembl ID ENSG00000036828   
PharmGKB ID PA26097   

mRNA Information


mRNA ID XM_011513238.1
Exon join(1..146,61556..61779,62780..64575,70282..70708, 73415..73721,77862..78746,92146..92376,98447..98570, 100021..102837)  
mRNA Sequence

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Length 6957  



CDS Information


   
Location2409..5645
CDS Sequence

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CCDS ID CCDS3010.1



Protein Information


      
Protein IDXP_011511540.1
Protein Namecalcium-sensing receptor
Molecular Wt. (Da)120544
Protein Sequence

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Length 1078  
Uniprot IDP35749
Ensembl Protein ID ENSP00000300036  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation130
NGlycosylation261
NGlycosylation287
NGlycosylation446
NGlycosylation468
NGlycosylation488
NGlycosylation90
TPhosphorylation888
TPhosphorylation888
TPhosphorylation888

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2316FLNA2060NP_001104026.1in vitro;in vivo;yeast 2-hybrid1   139   038   011   390   370   
25897RNF19A6176NP_056250.3in vitro;yeast 2-hybrid16513638   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0636420-530  PBP1_CaSR
cl1001120-530  Periplasmic_Binding_Protein_Type_1 superfamily
cd0636329-531  PBP1_Taste_receptor
cd0636230-511  PBP1_mGluR
cd0635033-525  PBP1_GPCR_family_C_like
cd0637530-510  PBP1_mGluR_groupII
pfam00003622-860  7tm_3
cl02802622-860  7tm_3 superfamily
cd0636133-494  PBP1_GPC6A_like
cd0636530-530  PBP1_Pheromone_receptor
cd0637426-509  PBP1_mGluR_groupI
cd0637630-530  PBP1_mGluR_groupIII
cd0626933-324  PBP1_glutamate_receptors_like
cd0450934-314  PBP1_ABC_transporter_GCPR_C_like
cd0636673-351  PBP1_GABAb_receptor
cd0139163-307  Periplasmic_Binding_Protein_Type_1
pfam07562538-591  NCD3G
cl08456538-591  NCD3G superfamily
cd0626870-306  PBP1_ABC_transporter_LIVBP_like
cd06379131-532  PBP1_iGluR_NMDA_NR1
cd0637062-262  PBP1_Speract_GC_like
COG068376-338  LivK
cd0635277-512  PBP1_NPR_GC_like
cd0635176-313  PBP1_iGluR_N_LIVBP_like
cd06367160-297  PBP1_iGluR_NMDA
cd06346139-225  PBP1_ABC_ligand_binding_like_11
cd0634277-291  PBP1_ABC_LIVBP_like
cd0636872-291  PBP1_iGluR_non_NMDA_like
cd0633077-282  PBP1_Arsenic_SBP_like
cd0639372-219  PBP1_iGluR_Kainate_GluR5_7
cd0633395-373  PBP1_ABC-type_HAAT_like
cd0637373-221  PBP1_NPR_like
cd0638276-289  PBP1_iGluR_Kainate
cd06344136-305  PBP1_ABC_ligand_binding_like_9
cd0634572-292  PBP1_ABC_ligand_binding_like_10
cd06340139-310  PBP1_ABC_ligand_binding_like_6
cd0637261-212  PBP1_GC_G_like
cd03254134-164  ABCC_Glucan_exporter_like
cl21455134-164  P-loop_NTPase superfamily
pfam0109469-495  ANF_receptor
pfam1345870-308  Peripla_BP_6
pfam12698682-854  ABC2_membrane_3
PRK11176129-161  PRK11176


Ontology Information


   
HPRD ID1166
Molecular ClassG protein coupled receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P41180DB01012CinacalcetSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO