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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15247132 | 2004 | Cell line : - Source : - Sample Type : Population-based case control study No. of Sample : 1,346 colon cancer cases, 1,544 controls and 952 rectal cancer cases and 1,205 controls Stage : - | - | Polymorhpism | - | Both IRS1 and IRS2 variants were associated with colon cancer risk independently. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Pleckstrin homology (PH) domain containing |
| Description | This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008] |
| Chromosome | 13 |
| Location | 13q34 |
| Start | 110406184 |
| End | 110438914 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 32731 |
| OMIM ID | 600797 |
| HGNC ID | HGNC:6126 |
| Unigene ID | Hs.442344 |
| Ensembl ID | ENSG00000185950 |
| PharmGKB ID | PA375 |
mRNA Information
| mRNA ID | ?NM_003749.2 |
|---|---|
| Exon | join(1..4526,30260..32731) | mRNA Sequence | Download Select all |
| Length | 7014 |
Protein Information
| Protein ID | NP_003740.2 |
|---|---|
| Protein Name | insulin receptor substrate 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1338 |
| Uniprot ID | P30048 |
| Ensembl Protein ID | ENSP00000298510 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1100 |
| S | Phosphorylation | 1203 |
| T | Phosphorylation | 520 |
| S | Phosphorylation | 915 |
| Y | Phosphorylation | 628 |
| Y | Phosphorylation | 632 |
| S | Phosphorylation | 736;- |
| S | Phosphorylation | 1176;- |
| T | Phosphorylation | 527;- |
| S | Phosphorylation | 334;- |
| Y | Phosphorylation | 75;- |
| Y | Phosphorylation | 653;- |
| Y | Phosphorylation | 675;- |
| Y | Phosphorylation | 742;- |
| Y | Phosphorylation | 823;- |
| S | Phosphorylation | 730;- |
| S | Phosphorylation | 731;- |
| S | Phosphorylation | 1174;- |
| S | Phosphorylation | 388;- |
| S | Phosphorylation | 391;- |
| S | Phosphorylation | 973;- |
| S | Phosphorylation | 592;- |
| S | Phosphorylation | 594;- |
| Y | Phosphorylation | 978;- |
| S | Phosphorylation | 560;- |
| S | Phosphorylation | 309;- |
| Y | Phosphorylation | 184 |
| S | Phosphorylation | 306 |
| S | Phosphorylation | 308 |
| S | Phosphorylation | 312 |
| S | Phosphorylation | 346 |
| T | Phosphorylation | 350 |
| T | Phosphorylation | 363 |
| S | Phosphorylation | 365 |
| S | Phosphorylation | 384 |
| S | Phosphorylation | 518 |
| S | Phosphorylation | 523 |
| S | Phosphorylation | 550 |
| S | Phosphorylation | 577 |
| T | Phosphorylation | 579 |
| T | Phosphorylation | 580 |
| S | Phosphorylation | 608 |
| S | Phosphorylation | 620 |
| S | Phosphorylation | 679 |
| T | Phosphorylation | 713 |
| S | Phosphorylation | 714 |
| S | Phosphorylation | 735 |
| S | Phosphorylation | 770 |
| T | Phosphorylation | 779 |
| S | Phosphorylation | 772 |
| T | Phosphorylation | 777 |
| S | Phosphorylation | 828 |
| S | Phosphorylation | 894 |
| Y | Phosphorylation | 919 |
| S | Phosphorylation | 1103 |
| S | Phosphorylation | 1109 |
| S | Phosphorylation | 1148 |
| T | Phosphorylation | 1151 |
| S | Phosphorylation | 1162 |
| S | Phosphorylation | 1149 |
| T | Phosphorylation | 1159 |
| S | Phosphorylation | 1164 |
| S | Phosphorylation | 1185 |
| S | Phosphorylation | 1186 |
| T | Phosphorylation | 1202 |
| S | Phosphorylation | 1283 |
| S | Phosphorylation | 985 |
| S | Phosphorylation | 976 |
| Y | Phosphorylation | 810 |
| Y | Phosphorylation | 814 |
| T | Phosphorylation | 604 |
| S | Phosphorylation | 606 |
| S | Phosphorylation | 619 |
| S | Phosphorylation | 672 |
| S | Phosphorylation | 1153 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 358 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 487 | ATP2A1 | 157 | NP_775293.1 | in vitro;in vivo | 9295312 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vivo | 10679027 |
| 2057 | EPOR | 587 | NP_000112.1 | in vivo | 9334184 |
| 3480 | IGF1R | 932 | NP_000866.1 | in vivo;yeast 2-hybrid | 98 521 248 662 806 |
| 3566 | IL4R | 990 | NP_000409.1 | in vitro | 8954948 |
| 3716 | JAK1 | 992 | NP_002218.2 | in vivo | 7499365 |
| 3718 | JAK3 | 2547 | NP_000206.2 | in vivo | 7499365 |
| 4914 | NTRK1 | 1869 | NP_002520.2 | in vitro;yeast 2-hybrid | 11147812 |
| 5293 | PIK3CD | 4161 | AAB53966.1 | in vitro;in vivo | 9113989 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vivo | 121 077 469 852 124 |
| 5296 | PIK3R2 | 4404 | NP_005018.1 | in vitro;in vivo | 965 137 810 594 015 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vivo | 9535722 |
| 5777 | PTPN6 | 1475 | NP_536859.1 | in vivo | 12198247 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vivo | 8910607 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vitro | 11505033 |
| 7297 | TYK2 | 1490 | NP_003322.3 | in vitro;in vivo | 8550573 |
| 7343 | UBTF | 2814 | NP_055048.1 | in vivo | 12554758 |
| 8503 | PIK3R3 | 5831 | NP_003620.3 | in vitro | 10417350 |
| 8651 | SOCS1 | 4669 | NP_003736.1 | in vivo | 12228220 |
| 30837 | SOCS7 | 12299 | NP_055413.1 | in vitro | 12052866 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| cGMP-PKG signaling pathway | hsa04022 |
| FoxO signaling pathway | hsa04068 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| MicroRNAs in cancer | hsa05206 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Regulation of lipolysis in adipocytes | hsa04923 |
| Type II diabetes mellitus | hsa04930 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01204 | 194-297 | PTB_IRS |
| cl17171 | 194-297 | PH-like superfamily |
| cd01257 | 31-147 | PH_IRS |
| cl17171 | 31-147 | PH-like superfamily |
| pfam02174 | 195-296 | IRS |
| smart00310 | 196-296 | PTBI |
| smart00233 | 31-144 | PH |
| pfam00169 | 31-144 | PH |
| cd00821 | 33-139 | PH |
| cd00934 | 205-291 | PTB |
| cd13298 | 31-139 | PH1_PH_fungal |
| cd01266 | 45-142 | PH_Gab1_Gab2 |
| cd13324 | 35-141 | PH_Gab-like |
| cd13267 | 45-139 | PH_DOCK-D |
| cd13281 | 31-139 | PH_PLEKHD1 |
| pfam15413 | 33-139 | PH_11 |
| cd13255 | 30-141 | PH_TAAP2-like |
| cd13253 | 33-145 | PH1_ARAP |
| cd13282 | 33-145 | PH1_PLEKHH1_PLEKHH2 |
| PHA03247 | 805-1225 | PHA03247 |
Ontology Information
| HPRD ID | 2658 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Motor activity (GO:0003774) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.