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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15247132	2004	Cell line : - Source : - Sample Type : Population-based case control study No. of Sample : 1,346 colon cancer cases, 1,544 controls and 952 rectal cancer cases and 1,205 controls Stage : -	-	Polymorhpism	-	Both IRS1 and IRS2 variants were associated with colon cancer risk independently.

Gene Details

NC_000013.10 (110406184..110438914, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	Pleckstrin homology (PH) domain containing
Description	This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Chromosome	13
Location	13q34
Start	110406184
End	110438914
Strand	-
Gene Sequence	Download   Select all
Length	32731
OMIM ID	600797
HGNC ID	HGNC:6126
Unigene ID	Hs.442344
Ensembl ID	ENSG00000185950
PharmGKB ID	PA375

mRNA Information

mRNA ID	?NM_003749.2
Exon	join(1..4526,30260..32731)
mRNA Sequence	Download   Select all
Length	7014

CDS Information

   

Location	515..4531
CDS Sequence	Download   Select all
CCDS ID	CCDS9510.1

Protein Information

      

Protein ID	NP_003740.2
Protein Name	insulin receptor substrate 2
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	1338
Uniprot ID	P30048
Ensembl Protein ID	ENSP00000298510

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	1100
S	Phosphorylation	1203
T	Phosphorylation	520
S	Phosphorylation	915
Y	Phosphorylation	628
Y	Phosphorylation	632
S	Phosphorylation	736;-
S	Phosphorylation	1176;-
T	Phosphorylation	527;-
S	Phosphorylation	334;-
Y	Phosphorylation	75;-
Y	Phosphorylation	653;-
Y	Phosphorylation	675;-
Y	Phosphorylation	742;-
Y	Phosphorylation	823;-
S	Phosphorylation	730;-
S	Phosphorylation	731;-
S	Phosphorylation	1174;-
S	Phosphorylation	388;-
S	Phosphorylation	391;-
S	Phosphorylation	973;-
S	Phosphorylation	592;-
S	Phosphorylation	594;-
Y	Phosphorylation	978;-
S	Phosphorylation	560;-
S	Phosphorylation	309;-
Y	Phosphorylation	184
S	Phosphorylation	306
S	Phosphorylation	308
S	Phosphorylation	312
S	Phosphorylation	346
T	Phosphorylation	350
T	Phosphorylation	363
S	Phosphorylation	365
S	Phosphorylation	384
S	Phosphorylation	518
S	Phosphorylation	523
S	Phosphorylation	550
S	Phosphorylation	577
T	Phosphorylation	579
T	Phosphorylation	580
S	Phosphorylation	608
S	Phosphorylation	620
S	Phosphorylation	679
T	Phosphorylation	713
S	Phosphorylation	714
S	Phosphorylation	735
S	Phosphorylation	770
T	Phosphorylation	779
S	Phosphorylation	772
T	Phosphorylation	777
S	Phosphorylation	828
S	Phosphorylation	894
Y	Phosphorylation	919
S	Phosphorylation	1103
S	Phosphorylation	1109
S	Phosphorylation	1148
T	Phosphorylation	1151
S	Phosphorylation	1162
S	Phosphorylation	1149
T	Phosphorylation	1159
S	Phosphorylation	1164
S	Phosphorylation	1185
S	Phosphorylation	1186
T	Phosphorylation	1202
S	Phosphorylation	1283
S	Phosphorylation	985
S	Phosphorylation	976
Y	Phosphorylation	810
Y	Phosphorylation	814
T	Phosphorylation	604
S	Phosphorylation	606
S	Phosphorylation	619
S	Phosphorylation	672
S	Phosphorylation	1153
S	Phosphorylation	342
S	Phosphorylation	358

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                            

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
487	ATP2A1	157	NP_775293.1	in vitro;in vivo	9295312
598	BCL2L1	2497	NP_612815.1	in vivo	10679027
2057	EPOR	587	NP_000112.1	in vivo	9334184
3480	IGF1R	932	NP_000866.1	in vivo;yeast 2-hybrid	98   521   248   662   806
3566	IL4R	990	NP_000409.1	in vitro	8954948
3716	JAK1	992	NP_002218.2	in vivo	7499365
3718	JAK3	2547	NP_000206.2	in vivo	7499365
4914	NTRK1	1869	NP_002520.2	in vitro;yeast 2-hybrid	11147812
5293	PIK3CD	4161	AAB53966.1	in vitro;in vivo	9113989
5295	PIK3R1	1381	NP_852664.1	in vivo	121   077   469   852   124
5296	PIK3R2	4404	NP_005018.1	in vitro;in vivo	965   137   810   594   015
5335	PLCG1	1398	NP_002651.2	in vivo	9535722
5777	PTPN6	1475	NP_536859.1	in vivo	12198247
5781	PTPN11	1470	NP_002825.3	in vivo	8910607
6464	SHC1	2780	NP_001123512.1	in vitro	11505033
7297	TYK2	1490	NP_003322.3	in vitro;in vivo	8550573
7343	UBTF	2814	NP_055048.1	in vivo	12554758
8503	PIK3R3	5831	NP_003620.3	in vitro	10417350
8651	SOCS1	4669	NP_003736.1	in vivo	12228220
30837	SOCS7	12299	NP_055413.1	in vitro	12052866

Pathway Information

                                                                        

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
AMPK signaling pathway	hsa04152
cGMP-PKG signaling pathway	hsa04022
FoxO signaling pathway	hsa04068
Insulin resistance	hsa04931
Insulin signaling pathway	hsa04910
Longevity regulating pathway - mammal	hsa04211
Longevity regulating pathway - multiple species	hsa04213
MicroRNAs in cancer	hsa05206
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Regulation of lipolysis in adipocytes	hsa04923
Type II diabetes mellitus	hsa04930

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd01204	194-297	PTB_IRS
cl17171	194-297	PH-like superfamily
cd01257	31-147	PH_IRS
cl17171	31-147	PH-like superfamily
pfam02174	195-296	IRS
smart00310	196-296	PTBI
smart00233	31-144	PH
pfam00169	31-144	PH
cd00821	33-139	PH
cd00934	205-291	PTB
cd13298	31-139	PH1_PH_fungal
cd01266	45-142	PH_Gab1_Gab2
cd13324	35-141	PH_Gab-like
cd13267	45-139	PH_DOCK-D
cd13281	31-139	PH_PLEKHD1
pfam15413	33-139	PH_11
cd13255	30-141	PH_TAAP2-like
cd13253	33-145	PH1_ARAP
cd13282	33-145	PH1_PLEKHH1_PLEKHH2
PHA03247	805-1225	PHA03247

Ontology Information

   

HPRD ID	2658
Molecular Class	Adapter molecule
Molecular Function	Motor activity (GO:0003774)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO