Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PEA15 | 8682 | phosphoprotein enriched in astrocytes 15  | 1 | HMAT1, MAT1, PED, PEA-15, MAT1H, HUMMAT1H  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23481023    | 2013 | Cell line : - Source : DACHS study Sample Type : CRC tumor and normal tissue No. of Sample : 1262 human CRC specimens Stage : - | Tissue microarray | Up-regulation | - | PEA-15 protein regulates invasiveness, proliferation, and apoptosis resistance in CRC cells. PEA-15 might play an important role in chemoresistance, progression and metastasis in CRC. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants.   |
| Chromosome | 1 |
| Location | 1q21.1 |
| Start | 160205319   |
| End | 160215376   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 10058   |
| OMIM ID | 603434    |
| HGNC ID | HGNC:8822    |
| Unigene ID | Hs.517216    |
| Ensembl ID | ENSG00000162734    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001297576.1 |
|---|---|
| Exon | join(1..204,1815..1919,3146..3347,6225..6398,7792..7947, 8104..10058)   | mRNA Sequence |    Download   Select all |
| Length | 2816   |
CDS Information
| Location | join(3287..3347,6225..6398,7792..7947,8104..8168) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS72954.1 |    
Protein Information
| Protein ID | NP_001284506.1 |
|---|---|
| Protein Name | phosphoprotein enriched in astrocytes 15 |
| Molecular Wt. (Da) | 14909 |
| Protein Sequence |    Download   Select all |
| Length | 130   |
| Uniprot ID | Q12905 |    
| Ensembl Protein ID | ENSP00000355011   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 104 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 116;- |
| Y | Phosphorylation | 108 |
| T | Phosphorylation | 6 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 61 |
| Y | Phosphorylation | 4 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 841 |    CASP8 |    3459 |    NP_001073594.1 |    in vitro;in vivo |    1   049   372   510   442   630    |
| 5337 |    PLD1 |    3855 |    NP_002653.1 |    in vitro;in vitro;in vivo;in vivo;yeast 2-hybrid |    1   092   692   918   541   520    |
| 5338 |    PLD2 |    3857 |    NP_002654.3 |    in vivo |    10926929    |
| 5594 |    MAPK1 |    1496 |    NP_002736.3 |    in vitro;in vivo;yeast 2-hybrid |    11702783    |
| 5595 |    MAPK3 |    3479 |    NP_002737.2 |    in vitro;in vivo;yeast 2-hybrid |    11702783    |
| 6197 |    RPS6KA3 |    2092 |    NP_004577.1 |    in vitro;in vivo |    12796492    |
| 8772 |    FADD |    3909 |    NP_003815.1 |    in vitro;in vivo |    1   049   372   510   442   630    |
| 51631 |    LUC7L2 |    17456 |    NP_057103.2 |    yeast 2-hybrid |    16169070    |
| 55229 |    PANK4 |    7313 |    NP_060686.1 |    yeast 2-hybrid |    16169070    |
| 221264 |    AKD1 |    12871 |    NP_659462.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08338 | Feb-85  | DED_PEA15 |
| cl14633 | Feb-85  | DD superfamily |
| cd08304 | Aug-79  | DD |
| pfam01335 | Apr-87  | DED |
| cd00045 | Apr-80  | DED |
| smart00031 | Feb-81  | DED |
| cd08336 | Mar-82  | DED_FADD |
| cd08334 | Apr-83  | DED_Caspase_8_10_r2 |
| cd08792 | Apr-76  | DED_Caspase_8_10_r1 |
| cd08333 | Jul-77  | DED_Caspase_8_r1 |
| cd08814 | Apr-83  | DED_Caspase_10_r2 |
| cd08790 | 15-79  | DED_DEDD |
Ontology Information
| HPRD ID | 895 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
