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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PEA15 8682 phosphoprotein enriched in astrocytes 15  1HMAT1, MAT1, PED, PEA-15, MAT1H, HUMMAT1H 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23481023   2013Cell line : -

Source : DACHS study

Sample Type : CRC tumor and normal tissue

No. of Sample : 1262 human CRC specimens

Stage : -

Tissue microarrayUp-regulation-PEA-15 protein regulates invasiveness, proliferation, and apoptosis resistance in CRC cells. PEA-15 might play an important role in chemoresistance, progression and metastasis in CRC.


Gene Details



Chromosome 1 - NC_000001.11 (160205319..160215376)

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Gene Type protein coding
Gene Family
Description This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants.  
Chromosome 1
Location 1q21.1
Start 160205319  
End 160215376  
Strand +  
Gene Sequence

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Length 10058  
OMIM ID 603434   
HGNC ID HGNC:8822   
Unigene ID Hs.517216   
Ensembl ID ENSG00000162734   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001297576.1
Exon join(1..204,1815..1919,3146..3347,6225..6398,7792..7947, 8104..10058)  
mRNA Sequence

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Length 2816  



CDS Information


   
Location join(3287..3347,6225..6398,7792..7947,8104..8168)
CDS Sequence

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CCDS ID CCDS72954.1



Protein Information


      
Protein IDNP_001284506.1
Protein Namephosphoprotein enriched in astrocytes 15
Molecular Wt. (Da)14909
Protein Sequence

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Length 130  
Uniprot IDQ12905
Ensembl Protein ID ENSP00000355011  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation104
SPhosphorylation116
SPhosphorylation116
SPhosphorylation116;-
YPhosphorylation108
TPhosphorylation6
SPhosphorylation25
SPhosphorylation61
YPhosphorylation4

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
841CASP83459NP_001073594.1in vitro;in vivo1   049   372   510   442   630   
5337PLD13855NP_002653.1in vitro;in vitro;in vivo;in vivo;yeast 2-hybrid1   092   692   918   541   520   
5338PLD23857NP_002654.3in vivo10926929   
5594MAPK11496NP_002736.3in vitro;in vivo;yeast 2-hybrid11702783   
5595MAPK33479NP_002737.2in vitro;in vivo;yeast 2-hybrid11702783   
6197RPS6KA32092NP_004577.1in vitro;in vivo12796492   
8772FADD3909NP_003815.1in vitro;in vivo1   049   372   510   442   630   
51631LUC7L217456NP_057103.2yeast 2-hybrid16169070   
55229PANK47313NP_060686.1yeast 2-hybrid16169070   
221264AKD112871NP_659462.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd08338Feb-85  DED_PEA15
cl14633Feb-85  DD superfamily
cd08304Aug-79  DD
pfam01335Apr-87  DED
cd00045Apr-80  DED
smart00031Feb-81  DED
cd08336Mar-82  DED_FADD
cd08334Apr-83  DED_Caspase_8_10_r2
cd08792Apr-76  DED_Caspase_8_10_r1
cd08333Jul-77  DED_Caspase_8_r1
cd08814Apr-83  DED_Caspase_10_r2
cd0879015-79  DED_DEDD


Ontology Information


   
HPRD ID895
Molecular ClassTransport/cargo protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO