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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16012517    | 2005 | Cell line : HT29, LoVo39 Source : Soroka Medical Center. Sample Type : CRC tumor and normal tissue No. of Sample : 57 Stage : TNM Stage I-IV | Western blotting,mRNA analysis,Cell cycle analysis,Alkaline phosphatase assay. | Up-regulation | - | Overexpression of cyclins D1 and/or D2, but not cyclin D3, is linked to colon carcinogenesis and that overexpression of cyclin D2 may be related to a higher TNM stage of the tumour. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]   |
| Chromosome | 12 |
| Location | 12p13 |
| Start | 4382901   |
| End | 4414522   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 31622   |
| OMIM ID | 123833    |
| HGNC ID | HGNC:1583    |
| Unigene ID | Hs.376071    |
| Ensembl ID | ENSG00000118971    |
| PharmGKB ID | PA26150    |
mRNA Information
| mRNA ID | XM_005253813.3 |
|---|---|
| Exon | join(1..503,2273..2488,5028..5187,11543..11743)   | mRNA Sequence |    Download   Select all |
| Length | 1080   |
CDS Information
| Location | 309..962 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8524.1 |    
Protein Information
| Protein ID | XP_005253870.1 |
|---|---|
| Protein Name | cyclin D2 |
| Molecular Wt. (Da) | 24893 |
| Protein Sequence |    Download   Select all |
| Length | 217   |
| Uniprot ID | P19338 |    
| Ensembl Protein ID | ENSP00000318195   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1019 |    CDK4 |    447 |    NP_000066.1 |    in vitro |    11896535    |
| 1020 |    CDK5 |    449 |    NP_004926.1 |    in vivo;yeast 2-hybrid |    9422379    |
| 1027 |    CDKN1B |    2867 |    NP_004055.1 |    yeast 2-hybrid |    16189514    |
| 5925 |    RB1 |    1574 |    NP_000312.2 |    in vitro;in vivo |    900   378   111   254   678    |
| 7703 |    PCGF2 |    10621 |    NP_009075.1 |    yeast 2-hybrid |    16182291    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle |    hsa04110 |    
| Focal adhesion |    hsa04510 |    
| FoxO signaling pathway |    hsa04068 |    
| Hippo signaling pathway |    hsa04390 |    
| HTLV-I infection |    hsa05166 |    
| Jak-STAT signaling pathway |    hsa04630 |    
| Measles |    hsa05162 |    
| MicroRNAs in cancer |    hsa05206 |    
| p53 signaling pathway |    hsa04115 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Prolactin signaling pathway |    hsa04917 |    
| Transcriptional misregulation in cancer |    hsa05202 |    
| Viral carcinogenesis |    hsa05203 |    
| Wnt signaling pathway |    hsa04310 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 55-144  | CYCLIN |
| cl00050 | 55-144  | CYCLIN superfamily |
| pfam00134 | 25-151  | Cyclin_N |
| pfam02984 | 154-257  | Cyclin_C |
| cl00050 | 154-257  | CYCLIN superfamily |
| smart00385 | 61-144  | CYCLIN |
| COG5024 | 30-207  | COG5024 |
| COG5333 | 79-217  | CCL1 |
| TIGR00569 | 75-207  | ccl1 |
Ontology Information
| HPRD ID | 16034 |    
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
