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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CCND2 894 cyclin D2  12- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16012517   2005Cell line : HT29, LoVo39

Source : Soroka Medical Center.

Sample Type : CRC tumor and normal tissue

No. of Sample : 57

Stage : TNM Stage I-IV

Western blotting,mRNA analysis,Cell cycle analysis,Alkaline phosphatase assay. Up-regulation-Overexpression of cyclins D1 and/or D2, but not cyclin D3, is linked to colon carcinogenesis and that overexpression of cyclin D2 may be related to a higher TNM stage of the tumour.


Gene Details



NC_000012.11 (4382901..4414522)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]  
Chromosome 12
Location 12p13
Start 4382901  
End 4414522  
Strand +  
Gene Sequence

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Length 31622  
OMIM ID 123833   
HGNC ID HGNC:1583   
Unigene ID Hs.376071   
Ensembl ID ENSG00000118971   
PharmGKB ID PA26150   

mRNA Information


mRNA ID XM_005253813.3
Exon join(1..503,2273..2488,5028..5187,11543..11743)  
mRNA Sequence

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Length 1080  



CDS Information


   
Location309..962
CDS Sequence

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CCDS ID CCDS8524.1



Protein Information


      
Protein IDXP_005253870.1
Protein Namecyclin D2
Molecular Wt. (Da)24893
Protein Sequence

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Length 217  
Uniprot IDP19338
Ensembl Protein ID ENSP00000318195  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1019CDK4447NP_000066.1in vitro11896535   
1020CDK5449NP_004926.1in vivo;yeast 2-hybrid9422379   
1027CDKN1B2867NP_004055.1yeast 2-hybrid16189514   
5925RB11574NP_000312.2in vitro;in vivo900   378   111   254   678   
7703PCGF210621NP_009075.1yeast 2-hybrid16182291   


Pathway Information


                                                                                    
Pathway Name Pathway ID
Cell cycle hsa04110
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Hippo signaling pathway hsa04390
HTLV-I infection hsa05166
Jak-STAT signaling pathway hsa04630
Measles hsa05162
MicroRNAs in cancer hsa05206
p53 signaling pathway hsa04115
PI3K-Akt signaling pathway hsa04151
Prolactin signaling pathway hsa04917
Transcriptional misregulation in cancer hsa05202
Viral carcinogenesis hsa05203
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0004355-144  CYCLIN
cl0005055-144  CYCLIN superfamily
pfam0013425-151  Cyclin_N
pfam02984154-257  Cyclin_C
cl00050154-257  CYCLIN superfamily
smart0038561-144  CYCLIN
COG502430-207  COG5024
COG533379-217  CCL1
TIGR0056975-207  ccl1


Ontology Information


   
HPRD ID16034
Molecular ClassCell cycle control protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO