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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SPAG9 9043 sperm associated antigen 9  17HSS, SYD1, KIAA0516, MGC14967, MGC74461, MGC117291, JLP, PHET, HLC4, PIG6, FLJ13450, FLJ14006, FLJ26141, FLJ34602, CT89 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21356354   2011Cell line : -

Source : -

Sample Type : CRC tissue and blood sample

No. of Sample : 78 CRC tissues and 54 blood samples

Stage : -

Immunofluorescence Microscopy and Flow Cytometry, RT-PCR,Immunohistochemistry,ELISA and Western BlottingUp-regulation-There was a close relationship between SPAG9 protein expression and humoral immune response in the majority of early-stage CRC patients, indicating that anti-SPAG9 antibodies could be a novel serum biomarker for early diagnosis.

SPAG9 may have a role in tumor development and early spread and thus could serve as a novel target for early detection and for cancer immunotherapy.


Gene Details



Chromosome 17 - NC_000017.11 (50962174..51120865, complement)

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Gene Type protein coding
Gene Family
Description This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.  
Chromosome 17
Location 17q21.33
Start 50962174  
End 51120865  
Strand -  
Gene Sequence

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Length 158692  
OMIM ID 605430   
HGNC ID HGNC:14524   
Unigene ID Hs.463439   
Ensembl ID ENSG00000008294   
PharmGKB ID -   

mRNA Information


mRNA ID NM_003971.5
Exon join(1..512,41162..41282,64384..64454,73397..73491, 79215..79365,99501..99708,100608..100707,106513..106634, 113540..113597,114629..114781,115603..115654, 119021..119151,121149..121205,122249..122422, 124172..124301,125333..125422,125642..125809, 126931..127102,130198..130416,130994..131189, 133629..133754,135088..135168,135876..135943, 138194..138342,140949..141120,143645..143758, 145919..146095,150010..150159,154479..158692)  
mRNA Sequence

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Length 8243  



CDS Information


   
Location join(210..512,41162..41282,64384..64454,73397..73491, 79215..79365,99501..99708,100608..100707,106513..106634, 113540..113597,114629..114781,115603..115654, 119021..119151,121149..121205,122249..122422, 124172..124301,125333..125422,125642..125809, 126931..127102,130198..130416,130994..131189, 133629..133754,135088..135168,135876..135943, 138194..138
CDS Sequence

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CCDS ID CCDS11577.1



Protein Information


      
Protein IDNP_001123999.1
Protein Namesperm associated antigen 9
Molecular Wt. (Da)145005
Protein Sequence

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Length 1311  
Uniprot IDQ9UK53
Ensembl Protein ID ENSP00000328436  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation203
SPhosphorylation718
SPhosphorylation719
SPhosphorylation368
SPhosphorylation369
SPhosphorylation60
SPhosphorylation203;-
SPhosphorylation60;-
TPhosphorylation334;-
TPhosphorylation191;-
SPhosphorylation109;-
TPhosphorylation404;-
SPhosphorylation716;-
SPhosphorylation366;-
SPhosphorylation251;-
SPhosphorylation245;-
SPhosphorylation254;-
SPhosphorylation108;-
SPhosphorylation102;-
SPhosphorylation111;-
SPhosphorylation183;-
SPhosphorylation185;-
SPhosphorylation377;-
SPhosphorylation373;-
SPhosphorylation374;-
TPhosphorylation217;-
TPhosphorylation74;-
TPhosphorylation226
TPhosphorylation83
SPhosphorylation238
SPhosphorylation95
TPhosphorylation261
TPhosphorylation276
TPhosphorylation118
TPhosphorylation133
TPhosphorylation262
TPhosphorylation278
TPhosphorylation119
TPhosphorylation135
SPhosphorylation297
SPhosphorylation154
SPhosphorylation315
SPhosphorylation318
SPhosphorylation172
SPhosphorylation175
TPhosphorylation316
TPhosphorylation173
SPhosphorylation325
SPhosphorylation350
SPhosphorylation182
SPhosphorylation207
TPhosphorylation572
SPhosphorylation714
SPhosphorylation364
SPhosphorylation1130
TPhosphorylation1250
SAcetylation297
SAcetylation154
SPhosphorylation580
TPhosphorylation581
SPhosphorylation242
SPhosphorylation99
TPhosphorylation244
SPhosphorylation258
TPhosphorylation101
SPhosphorylation115
SPhosphorylation190
SPhosphorylation194
SPhosphorylation229
SPhosphorylation86
SPhosphorylation333
SPhosphorylation190
SPhosphorylation349
TPhosphorylation351
SPhosphorylation206
TPhosphorylation208
SPhosphorylation367
SPhosphorylation691
YPhosphorylation699
SPhosphorylation341
YPhosphorylation349

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1432MAPK142619NP_001306.1in vitro12391307   
3831KLC12489NP_001123579.1in vivo;yeast 2-hybrid15987681   
4149MAX1113NP_002373.3in vitro;in vivo12391307   
4215MAP3K33965NP_976226.1in vitro12391307   
4609MYC1818NP_002458.2in vitro12391307   
4790NFKB11238NP_003989.2in vivo14743216   
5599MAPK83100NP_620637.1in vitro;in vivo12391307   
6416MAP2K43213NP_003001.1in vitro12391307   


Pathway Information


No matching records could be found.

Structure Information


PDB ID2W83
Resolution1.93
MethodX-RAY DIFFRACTION
Chains C, D  
Molecule C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4  
Model View



Domain Information




ID Location Description
pfam0974424-181  Jnk-SapK_ap_N
cl1804224-181  RILP-like superfamily
cd1444527-96  RILP-like
pfam0393881-162  OmpH
cl2148581-162  OmpH superfamily
pfam05565100-180  Sipho_Gp157
cl05239100-180  Sipho_Gp157 superfamily
COG138260-161  GimC
cl0911160-161  Prefoldin superfamily
pfam0792656-162  TPR_MLP1_2
COG119633-178  Smc
COG041922-527  SbcC
COG11965-203  Smc
TIGR0216958-166  SMC_prok_A
TIGR0452367-176  Mplasa_alph_rch
COG437259-343  COG4372
PRK0391833-178  PRK03918
PRK0222459-166  PRK02224
COG041958-226  SbcC
pfam1021178-161  Ax_dynein_light
pfam1212822-161  DUF3584
TIGR0216844-200  SMC_prok_B
PRK0577150-159  PRK05771
pfam0411156-191  APG6
COG119630-178  Smc
PTZ0012168-640  PTZ00121
PRK1270466-176  PRK12704
TIGR0216974-200  SMC_prok_A
TIGR0216833-200  SMC_prok_B
TIGR0452374-155  Mplasa_alph_rch
pfam0530066-165  DUF737
TIGR0452360-166  Mplasa_alph_rch
COG243390-177  COG2433
pfam0003872-193  Filament
TIGR0331966-184  RNase_Y
COG184272-199  PspA
COG119644-207  Smc
TIGR0060674-193  rad50
COG320651-167  GumC
pfam1155943-168  ADIP
TIGR0216939-198  SMC_prok_A
TIGR0216927-165  SMC_prok_A
COG119622-198  Smc
PRK1144866-151  hsdR
TIGR0216833-162  SMC_prok_B
TIGR0216934-152  SMC_prok_A
COG119630-159  Smc
pfam0567266-178  MAP7


Ontology Information


   
HPRD ID929
Molecular ClassIntegral membrane protein
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO