Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SPAG9 | 9043 | sperm associated antigen 9  | 17 | HSS, SYD1, KIAA0516, MGC14967, MGC74461, MGC117291, JLP, PHET, HLC4, PIG6, FLJ13450, FLJ14006, FLJ26141, FLJ34602, CT89  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21356354    | 2011 | Cell line : - Source : - Sample Type : CRC tissue and blood sample No. of Sample : 78 CRC tissues and 54 blood samples Stage : - | Immunofluorescence Microscopy and Flow Cytometry, RT-PCR,Immunohistochemistry,ELISA and Western Blotting | Up-regulation | - | There was a close relationship between SPAG9 protein expression and humoral immune response in the majority of early-stage CRC patients, indicating that anti-SPAG9 antibodies could be a novel serum biomarker for early diagnosis. SPAG9 may have a role in tumor development and early spread and thus could serve as a novel target for early detection and for cancer immunotherapy. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.   | Chromosome | 17 |
| Location | 17q21.33 |
| Start | 50962174   |
| End | 51120865   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 158692   |
| OMIM ID | 605430    |
| HGNC ID | HGNC:14524    |
| Unigene ID | Hs.463439    |
| Ensembl ID | ENSG00000008294    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_003971.5 |
|---|---|
| Exon | join(1..512,41162..41282,64384..64454,73397..73491, 79215..79365,99501..99708,100608..100707,106513..106634, 113540..113597,114629..114781,115603..115654, 119021..119151,121149..121205,122249..122422, 124172..124301,125333..125422,125642..125809, 126931..127102,130198..130416,130994..131189, 133629..133754,135088..135168,135876..135943, 138194..138342,140949..141120,143645..143758, 145919..146095,150010..150159,154479..158692)   | mRNA Sequence |    Download   Select all |
| Length | 8243   |
CDS Information
| Location | join(210..512,41162..41282,64384..64454,73397..73491, 79215..79365,99501..99708,100608..100707,106513..106634, 113540..113597,114629..114781,115603..115654, 119021..119151,121149..121205,122249..122422, 124172..124301,125333..125422,125642..125809, 126931..127102,130198..130416,130994..131189, 133629..133754,135088..135168,135876..135943, 138194..138 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS11577.1 |    
Protein Information
| Protein ID | NP_001123999.1 |
|---|---|
| Protein Name | sperm associated antigen 9 |
| Molecular Wt. (Da) | 145005 |
| Protein Sequence |    Download   Select all |
| Length | 1311   |
| Uniprot ID | Q9UK53 |    
| Ensembl Protein ID | ENSP00000328436   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 203 |
| S | Phosphorylation | 718 |
| S | Phosphorylation | 719 |
| S | Phosphorylation | 368 |
| S | Phosphorylation | 369 |
| S | Phosphorylation | 60 |
| S | Phosphorylation | 203;- |
| S | Phosphorylation | 60;- |
| T | Phosphorylation | 334;- |
| T | Phosphorylation | 191;- |
| S | Phosphorylation | 109;- |
| T | Phosphorylation | 404;- |
| S | Phosphorylation | 716;- |
| S | Phosphorylation | 366;- |
| S | Phosphorylation | 251;- |
| S | Phosphorylation | 245;- |
| S | Phosphorylation | 254;- |
| S | Phosphorylation | 108;- |
| S | Phosphorylation | 102;- |
| S | Phosphorylation | 111;- |
| S | Phosphorylation | 183;- |
| S | Phosphorylation | 185;- |
| S | Phosphorylation | 377;- |
| S | Phosphorylation | 373;- |
| S | Phosphorylation | 374;- |
| T | Phosphorylation | 217;- |
| T | Phosphorylation | 74;- |
| T | Phosphorylation | 226 |
| T | Phosphorylation | 83 |
| S | Phosphorylation | 238 |
| S | Phosphorylation | 95 |
| T | Phosphorylation | 261 |
| T | Phosphorylation | 276 |
| T | Phosphorylation | 118 |
| T | Phosphorylation | 133 |
| T | Phosphorylation | 262 |
| T | Phosphorylation | 278 |
| T | Phosphorylation | 119 |
| T | Phosphorylation | 135 |
| S | Phosphorylation | 297 |
| S | Phosphorylation | 154 |
| S | Phosphorylation | 315 |
| S | Phosphorylation | 318 |
| S | Phosphorylation | 172 |
| S | Phosphorylation | 175 |
| T | Phosphorylation | 316 |
| T | Phosphorylation | 173 |
| S | Phosphorylation | 325 |
| S | Phosphorylation | 350 |
| S | Phosphorylation | 182 |
| S | Phosphorylation | 207 |
| T | Phosphorylation | 572 |
| S | Phosphorylation | 714 |
| S | Phosphorylation | 364 |
| S | Phosphorylation | 1130 |
| T | Phosphorylation | 1250 |
| S | Acetylation | 297 |
| S | Acetylation | 154 |
| S | Phosphorylation | 580 |
| T | Phosphorylation | 581 |
| S | Phosphorylation | 242 |
| S | Phosphorylation | 99 |
| T | Phosphorylation | 244 |
| S | Phosphorylation | 258 |
| T | Phosphorylation | 101 |
| S | Phosphorylation | 115 |
| S | Phosphorylation | 190 |
| S | Phosphorylation | 194 |
| S | Phosphorylation | 229 |
| S | Phosphorylation | 86 |
| S | Phosphorylation | 333 |
| S | Phosphorylation | 190 |
| S | Phosphorylation | 349 |
| T | Phosphorylation | 351 |
| S | Phosphorylation | 206 |
| T | Phosphorylation | 208 |
| S | Phosphorylation | 367 |
| S | Phosphorylation | 691 |
| Y | Phosphorylation | 699 |
| S | Phosphorylation | 341 |
| Y | Phosphorylation | 349 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1432 |    MAPK14 |    2619 |    NP_001306.1 |    in vitro |    12391307    |
| 3831 |    KLC1 |    2489 |    NP_001123579.1 |    in vivo;yeast 2-hybrid |    15987681    |
| 4149 |    MAX |    1113 |    NP_002373.3 |    in vitro;in vivo |    12391307    |
| 4215 |    MAP3K3 |    3965 |    NP_976226.1 |    in vitro |    12391307    |
| 4609 |    MYC |    1818 |    NP_002458.2 |    in vitro |    12391307    |
| 4790 |    NFKB1 |    1238 |    NP_003989.2 |    in vivo |    14743216    |
| 5599 |    MAPK8 |    3100 |    NP_620637.1 |    in vitro;in vivo |    12391307    |
| 6416 |    MAP2K4 |    3213 |    NP_003001.1 |    in vitro |    12391307    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2W83 |
|---|---|
| Resolution | 1.93 |
| Method | X-RAY DIFFRACTION |
| Chains | C, D   |
| Molecule | C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam09744 | 24-181  | Jnk-SapK_ap_N |
| cl18042 | 24-181  | RILP-like superfamily |
| cd14445 | 27-96  | RILP-like |
| pfam03938 | 81-162  | OmpH |
| cl21485 | 81-162  | OmpH superfamily |
| pfam05565 | 100-180  | Sipho_Gp157 |
| cl05239 | 100-180  | Sipho_Gp157 superfamily |
| COG1382 | 60-161  | GimC |
| cl09111 | 60-161  | Prefoldin superfamily |
| pfam07926 | 56-162  | TPR_MLP1_2 |
| COG1196 | 33-178  | Smc |
| COG0419 | 22-527  | SbcC |
| COG1196 | 5-203  | Smc |
| TIGR02169 | 58-166  | SMC_prok_A |
| TIGR04523 | 67-176  | Mplasa_alph_rch |
| COG4372 | 59-343  | COG4372 |
| PRK03918 | 33-178  | PRK03918 |
| PRK02224 | 59-166  | PRK02224 |
| COG0419 | 58-226  | SbcC |
| pfam10211 | 78-161  | Ax_dynein_light |
| pfam12128 | 22-161  | DUF3584 |
| TIGR02168 | 44-200  | SMC_prok_B |
| PRK05771 | 50-159  | PRK05771 |
| pfam04111 | 56-191  | APG6 |
| COG1196 | 30-178  | Smc |
| PTZ00121 | 68-640  | PTZ00121 |
| PRK12704 | 66-176  | PRK12704 |
| TIGR02169 | 74-200  | SMC_prok_A |
| TIGR02168 | 33-200  | SMC_prok_B |
| TIGR04523 | 74-155  | Mplasa_alph_rch |
| pfam05300 | 66-165  | DUF737 |
| TIGR04523 | 60-166  | Mplasa_alph_rch |
| COG2433 | 90-177  | COG2433 |
| pfam00038 | 72-193  | Filament |
| TIGR03319 | 66-184  | RNase_Y |
| COG1842 | 72-199  | PspA |
| COG1196 | 44-207  | Smc |
| TIGR00606 | 74-193  | rad50 |
| COG3206 | 51-167  | GumC |
| pfam11559 | 43-168  | ADIP |
| TIGR02169 | 39-198  | SMC_prok_A |
| TIGR02169 | 27-165  | SMC_prok_A |
| COG1196 | 22-198  | Smc |
| PRK11448 | 66-151  | hsdR |
| TIGR02168 | 33-162  | SMC_prok_B |
| TIGR02169 | 34-152  | SMC_prok_A |
| COG1196 | 30-159  | Smc |
| pfam05672 | 66-178  | MAP7 |
Ontology Information
| HPRD ID | 929 |    
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
