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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23885148 | 2013 | Cell line : - Source : Gastrointestinal endoscopic units and surgical clinics located in geographically different parts of Poland. Sample Type : CRC Tumor and normal tissue No. of Sample : 4 Stage : DukeStage A-D | QPCR assay,Microsatellite instability status analysis,Bisulfite modification and methylation-specific PCR | Hypermethylation | - | Decreased expression of�LATS1�in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012] |
| Chromosome | 6 |
| Location | 6q25.1 |
| Start | 149979289 |
| End | 150039392 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 60104 |
| OMIM ID | 603473 |
| HGNC ID | HGNC:6514 |
| Unigene ID | Hs.549084 |
| Ensembl ID | ENSG00000131023 |
| PharmGKB ID | PA30301 |
Protein Information
| Protein ID | NP_001257448.1 |
|---|---|
| Protein Name | large tumor suppressor kinase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1130 |
| Uniprot ID | Q9Y2F9 |
| Ensembl Protein ID | ENSP00000254977 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 464 |
| T | Phosphorylation | 490 |
| S | Phosphorylation | 613 |
| S | Phosphorylation | 613;- |
| S | Phosphorylation | 334;- |
| S | Phosphorylation | 335;- |
| S | Phosphorylation | 464;- |
| S | Phosphorylation | 674;- |
| T | Phosphorylation | 246 |
| S | Phosphorylation | 278 |
| S | Phosphorylation | 244 |
| T | Phosphorylation | 261 |
| T | Phosphorylation | 611 |
| S | Phosphorylation | 1111 |
| S | Phosphorylation | 462 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3984 | LIMK1 | 3210 | NP_002305.1 | in vitro;in vivo | 15220930 |
| 6789 | STK4 | 5395 | NP_006273.1 | in vitro | 15688006 |
| 7791 | ZYX | 3592 | NP_003452.1 | in vitro;in vivo | 10831611 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05625 | 703-1084 | STKc_LATS1 |
| cl21453 | 703-1084 | PKc_like superfamily |
| cd14397 | 103-143 | UBA_LATS1 |
| cl21463 | 103-143 | UBA_like_SF superfamily |
| cd05598 | 703-1084 | STKc_LATS |
| cd05626 | 703-1084 | STKc_LATS2 |
| cd05573 | 703-1081 | STKc_ROCK_NDR_like |
| cd05599 | 705-1057 | STKc_NDR_like |
| cd05629 | 705-1083 | STKc_NDR_like_fungal |
| cd05627 | 705-1083 | STKc_NDR2 |
| cd05600 | 693-1081 | STKc_Sid2p_like |
| cd05123 | 711-1010 | STKc_AGC |
| cd05628 | 705-1083 | STKc_NDR1 |
| cd05579 | 714-1014 | STKc_MAST_like |
| cd05601 | 709-1046 | STKc_CRIK |
| cd05597 | 705-1080 | STKc_DMPK_like |
| cd05596 | 688-1056 | STKc_ROCK |
| cd05580 | 708-1040 | STKc_PKA_like |
| cd05611 | 708-1015 | STKc_Rim15_like |
| cd05574 | 705-1029 | STKc_phototropin_like |
| cd05570 | 709-1054 | STKc_PKC |
| cd05624 | 695-1047 | STKc_MRCK_beta |
| cd05622 | 691-1046 | STKc_ROCK1 |
| cd05623 | 694-1047 | STKc_MRCK_alpha |
| cd05621 | 694-1046 | STKc_ROCK2 |
| cd05581 | 705-1010 | STKc_PDK1 |
| cd05584 | 708-1063 | STKc_p70S6K |
| cd05609 | 705-1015 | STKc_MAST |
| cd05575 | 709-1080 | STKc_SGK |
| cd05582 | 709-1041 | STKc_RSK_N |
| cd05585 | 711-1064 | STKc_YPK1_like |
| cd14209 | 705-1040 | STKc_PKA |
| cd05612 | 705-1040 | STKc_PRKX_like |
| cd05592 | 709-1053 | STKc_nPKC_theta_like |
| cd05572 | 711-1010 | STKc_cGK |
| cd05571 | 709-1055 | STKc_PKB |
| cd05583 | 711-1013 | STKc_MSK_N |
| cd05610 | 705-1040 | STKc_MASTL |
| cd05578 | 705-1010 | STKc_Yank1 |
| cd05589 | 705-1041 | STKc_PKN |
| cd05587 | 708-1041 | STKc_cPKC |
| cd14003 | 708-1009 | STKc_AMPK-like |
| cd05117 | 705-1009 | STKc_CAMK |
| cd05614 | 705-1039 | STKc_MSK2_N |
| cd05619 | 699-1040 | STKc_nPKC_theta |
| cd14007 | 705-1011 | STKc_Aurora |
| cd05591 | 709-1054 | STKc_nPKC_epsilon |
| cd05620 | 709-1040 | STKc_nPKC_delta |
| cd05586 | 711-1041 | STKc_Sck1_like |
| cd05604 | 708-1042 | STKc_SGK3 |
| cd05603 | 709-1041 | STKc_SGK2 |
| cd05590 | 709-1041 | STKc_nPKC_eta |
| cd05595 | 709-1054 | STKc_PKB_beta |
| cd05588 | 709-1051 | STKc_aPKC |
| cd05577 | 711-1015 | STKc_GRK |
| cd05613 | 705-1033 | STKc_MSK1_N |
| cd05602 | 703-1041 | STKc_SGK1 |
| cd06606 | 705-1010 | STKc_MAPKKK |
| cd14014 | 708-995 | STKc_PknB_like |
| cd14099 | 705-1010 | STKc_PLK |
| cd05616 | 705-1040 | STKc_cPKC_beta |
| cd05605 | 705-1015 | STKc_GRK4_like |
| cd14009 | 711-1009 | STKc_ATG1_ULK_like |
| cd14008 | 711-1010 | STKc_LKB1_CaMKK |
| cd05630 | 705-1015 | STKc_GRK6 |
| cd05122 | 704-1010 | PKc_STE |
| cd05594 | 697-1040 | STKc_PKB_alpha |
| cd05593 | 696-1051 | STKc_PKB_gamma |
| cd05606 | 711-1033 | STKc_beta_ARK |
| cd05617 | 705-1053 | STKc_aPKC_zeta |
| cd05615 | 705-1040 | STKc_cPKC_alpha |
| cd05631 | 705-1015 | STKc_GRK4 |
| cd08215 | 705-1010 | STKc_Nek |
| cd00180 | 711-1008 | PKc |
| cd05618 | 705-1053 | STKc_aPKC_iota |
| cd05632 | 702-1015 | STKc_GRK5 |
| cd14663 | 709-1009 | STKc_SnRK3 |
| cd14098 | 708-1009 | STKc_Rad53_Cds1 |
| cd06627 | 711-1010 | STKc_Cdc7_like |
| cd06614 | 705-1011 | STKc_PAK |
| cd05607 | 705-1015 | STKc_GRK7 |
| cd06632 | 707-1009 | STKc_MEKK1_plant |
| cd14084 | 709-1008 | STKc_Chk2 |
| cd06623 | 705-1014 | PKc_MAPKK_plant_like |
| cd08217 | 708-1010 | STKc_Nek2 |
| cd14223 | 709-1055 | STKc_GRK2 |
| cd05633 | 709-1067 | STKc_GRK3 |
| cd14081 | 709-1010 | STKc_BRSK1_2 |
| cd14069 | 705-1010 | STKc_Chk1 |
| cd05608 | 705-1028 | STKc_GRK1 |
| cd14121 | 711-1009 | STKc_ULK3 |
| cd05118 | 707-1010 | STKc_CMGC |
| cd06648 | 697-1011 | STKc_PAK_II |
| cd14080 | 708-1010 | STKc_TSSK-like |
| cd14116 | 709-1009 | STKc_Aurora-A |
| cd14120 | 711-1009 | STKc_ULK1_2-like |
| cd06625 | 707-1010 | STKc_MEKK3_like |
| cd06612 | 711-1010 | STKc_MST1_2 |
| cd14006 | 711-1008 | STKc_MLCK-like |
| cd06609 | 705-1019 | STKc_MST3_like |
| cd14167 | 711-1009 | STKc_CaMKI_alpha |
| cd07830 | 708-1010 | STKc_MAK_like |
| cd14166 | 702-1009 | STKc_CaMKI_gamma |
| cd13996 | 705-995 | STKc_EIF2AK |
| cd06626 | 712-1009 | STKc_MEKK4 |
| cd06610 | 708-1010 | STKc_OSR1_SPAK |
| cd06629 | 705-1009 | STKc_Bck1_like |
| cd14079 | 709-1010 | STKc_AMPK_alpha |
| cd14083 | 702-995 | STKc_CaMKI |
| cd14095 | 709-1008 | STKc_DCKL |
| cd13994 | 711-950 | STKc_HAL4_like |
| cd08529 | 705-995 | STKc_FA2-like |
| cd14073 | 708-950 | STKc_NUAK |
| cd13999 | 711-987 | STKc_MAP3K-like |
| cd06628 | 704-1009 | STKc_Byr2_like |
| cd14096 | 708-1009 | STKc_RCK1-like |
| cd14086 | 711-1014 | STKc_CaMKII |
| cd08530 | 705-1008 | STKc_CNK2-like |
| cd06659 | 705-1010 | STKc_PAK6 |
| cd14118 | 711-1008 | STKc_CAMKK |
| cd14169 | 702-996 | STKc_CaMKI_beta |
| cd14097 | 711-954 | STKc_STK33 |
| cd14137 | 704-1011 | STKc_GSK3 |
| cd14165 | 710-1010 | STKc_TSSK1_2-like |
| cd14168 | 696-1009 | STKc_CaMKI_delta |
| cd14162 | 709-1010 | STKc_TSSK4-like |
| cd06644 | 692-1024 | STKc_STK10 |
| cd14106 | 709-1010 | STKc_DRAK |
| cd14078 | 709-950 | STKc_MELK |
| cd14186 | 711-1009 | STKc_PLK4 |
| cd14185 | 709-1009 | STKc_DCKL3 |
| cd14010 | 711-1009 | STKc_ULK4 |
| cd14117 | 709-1011 | STKc_Aurora-B_like |
| cd14202 | 702-1010 | STKc_ULK1 |
| cd14188 | 705-1010 | STKc_PLK2 |
| cd14002 | 712-1009 | STKc_STK36 |
| cd06613 | 704-1010 | STKc_MAP4K3_like |
| cd14091 | 710-1038 | STKc_RSK_C |
| cd06605 | 707-1011 | PKc_MAPKK |
| cd14187 | 705-1012 | STKc_PLK1 |
| cd14071 | 708-1010 | STKc_SIK |
| cd07840 | 705-1010 | STKc_CDK9_like |
| cd14092 | 706-1012 | STKc_MSK_C |
| cd14189 | 705-1010 | STKc_PLK3 |
| cd06647 | 702-1011 | STKc_PAK_I |
| cd14201 | 711-1011 | STKc_ULK2 |
| cd14074 | 709-1009 | STKc_SNRK |
| cd06631 | 711-1009 | STKc_YSK4 |
| cd14199 | 711-1009 | STKc_CaMKK2 |
| cd06917 | 703-1012 | STKc_NAK1_like |
| cd14093 | 750-1010 | STKc_PhKG |
| cd06611 | 708-1014 | STKc_SLK_like |
| cd14046 | 705-943 | STKc_EIF2AK4_GCN2_rpt2 |
| cd06658 | 705-1011 | STKc_PAK5 |
| cd14087 | 708-996 | STKc_PSKH1 |
| cd07829 | 705-1010 | STKc_CDK_like |
| cd07834 | 708-1046 | STKc_MAPK |
| cd06643 | 708-1021 | STKc_SLK |
| cd14082 | 709-988 | STKc_PKD |
| cd06630 | 705-1011 | STKc_MEKK1 |
| cd13978 | 711-951 | STKc_RIP |
| cd06657 | 705-1010 | STKc_PAK4 |
| cd08221 | 704-1010 | STKc_Nek9 |
| cd07832 | 711-1010 | STKc_CCRK |
| cd07841 | 705-1012 | STKc_CDK7 |
| cd14200 | 711-1009 | STKc_CaMKK1 |
| cd14103 | 711-1008 | STKc_MLCK |
| cd08224 | 704-950 | STKc_Nek6_7 |
| cd14072 | 708-963 | STKc_MARK |
| cd13993 | 707-951 | STKc_Pat1_like |
| cd05576 | 713-1010 | STKc_RPK118_like |
| cd08528 | 711-995 | STKc_Nek10 |
| cd14662 | 708-1009 | STKc_SnRK2 |
| cd14179 | 704-988 | STKc_MSK1_C |
| cd07833 | 707-1010 | STKc_CDKL |
| cd08218 | 705-995 | STKc_Nek1 |
| cd06655 | 702-1011 | STKc_PAK2 |
| cd06656 | 702-1011 | STKc_PAK3 |
| cd14665 | 708-1009 | STKc_SnRK2-3 |
| cd14175 | 705-1027 | STKc_RSK1_C |
| cd06608 | 708-1009 | STKc_myosinIII_N_like |
| cd14181 | 765-1010 | STKc_PhKG2 |
| cd06652 | 709-985 | STKc_MEKK2 |
| cd14004 | 705-1010 | STKc_PASK |
| cd13990 | 711-995 | STKc_TLK |
| cd14161 | 708-950 | STKc_NUAK2 |
| cd06653 | 709-1009 | STKc_MEKK3_like_u1 |
| cd14182 | 753-1011 | STKc_PhKG1 |
| cd14107 | 711-1010 | STKc_obscurin_rpt1 |
| cd14019 | 708-1010 | STKc_Cdc7 |
| cd14052 | 705-942 | PTKc_Wee1_fungi |
| cd14173 | 711-1009 | STKc_Mnk2 |
| cd14075 | 705-1009 | STKc_NIM1 |
| cd14070 | 709-950 | STKc_HUNK |
| cd14132 | 705-1011 | STKc_CK2_alpha |
| cd13997 | 705-1008 | PKc_Wee1_like |
| cd06654 | 702-1011 | STKc_PAK1 |
| cd14089 | 709-1008 | STKc_MAPKAPK |
| cd14131 | 705-1009 | PKc_Mps1 |
| cd08225 | 708-995 | STKc_Nek5 |
| cd06615 | 703-957 | PKc_MEK |
| cd07831 | 708-1010 | STKc_MOK |
| cd08222 | 705-963 | STKc_Nek11 |
| cd14192 | 709-988 | STKc_MLCK3 |
| cd08219 | 708-991 | STKc_Nek3 |
| cd14178 | 711-1017 | STKc_RSK3_C |
| cd14113 | 703-962 | STKc_Trio_C |
| cd08220 | 707-1008 | STKc_Nek8 |
| cd14184 | 709-1009 | STKc_DCKL2 |
| cd14076 | 709-1009 | STKc_Kin4 |
| cd06651 | 709-1009 | STKc_MEKK3 |
| cd07855 | 708-1012 | STKc_ERK5 |
| cd06640 | 702-949 | STKc_MST4 |
| cd14193 | 707-988 | STKc_MLCK4 |
| cd07838 | 711-1010 | STKc_CDK4_6_like |
| cd14183 | 709-1009 | STKc_DCKL1 |
| cd14090 | 711-1009 | STKc_Mnk |
| cd14180 | 711-1003 | STKc_MSK2_C |
| cd14005 | 711-1010 | STKc_PIM |
| cd14134 | 705-954 | PKc_CLK |
| cd14119 | 711-1010 | STKc_LKB1 |
| cd14190 | 711-1010 | STKc_MLCK2 |
| cd13989 | 711-971 | STKc_IKK |
| cd14197 | 709-1010 | STKc_DRAK1 |
| cd07852 | 708-1011 | STKc_MAPK15-like |
| cd14176 | 711-1029 | STKc_RSK2_C |
| cd14077 | 708-950 | STKc_Kin1_2 |
| cd06642 | 702-956 | STKc_STK25 |
| cd06645 | 705-1009 | STKc_MAP4K3 |
| cd06641 | 702-957 | STKc_MST3 |
| cd00192 | 709-950 | PTKc |
| cd14196 | 711-958 | STKc_DAPK2 |
| cd14016 | 704-854 | STKc_CK1 |
| cd13987 | 711-995 | STKc_SBK1 |
| cd14048 | 705-995 | STKc_EIF2AK3_PERK |
| cd14177 | 765-985 | STKc_RSK4_C |
| cd08228 | 709-950 | STKc_Nek6 |
| cd14194 | 711-996 | STKc_DAPK1 |
| cd14133 | 708-1010 | PKc_DYRK_like |
| cd07848 | 707-957 | STKc_CDKL5 |
| cd07857 | 708-1009 | STKc_MPK1 |
| cd13985 | 709-995 | STKc_GAK_like |
| cd14047 | 705-944 | STKc_EIF2AK2_PKR |
| cd14105 | 711-996 | STKc_DAPK |
| cd06646 | 708-1009 | STKc_MAP4K5 |
| cd14171 | 709-1009 | STKc_MAPKAPK5 |
| cd06624 | 711-1009 | STKc_ASK |
| cd07835 | 705-1010 | STKc_CDK1_CdkB_like |
| cd14174 | 711-1011 | STKc_Mnk1 |
| cd06620 | 699-950 | PKc_Byr1_like |
| cd14085 | 709-1011 | STKc_CaMKIV |
| cd07880 | 702-1041 | STKc_p38gamma |
| cd14027 | 711-1011 | STKc_RIP1 |
| cd06638 | 708-987 | STKc_myosinIIIA_N |
| cd08229 | 709-950 | STKc_Nek7 |
| cd14094 | 747-1011 | STKc_CASK |
| cd07860 | 704-1010 | STKc_CDK2_3 |
| cd07866 | 708-1010 | STKc_BUR1 |
| cd14198 | 709-995 | STKc_DRAK2 |
| cd06650 | 705-1015 | PKc_MEK1 |
| cd07879 | 705-1010 | STKc_p38delta |
| cd14191 | 711-1010 | STKc_MLCK1 |
| cd14172 | 709-996 | STKc_MAPKAPK3 |
| cd07836 | 705-1010 | STKc_Pho85 |
| cd14109 | 709-1010 | PK_Unc-89_rpt1 |
| cd08223 | 705-995 | STKc_Nek4 |
| cd06621 | 705-955 | PKc_Pek1_like |
| cd14114 | 711-1010 | STKc_Twitchin_like |
| cd14195 | 711-1011 | STKc_DAPK3 |
| cd07851 | 705-1011 | STKc_p38 |
| cd14104 | 711-1011 | STKc_Titin |
| cd14050 | 705-942 | PKc_Myt1 |
| cd14163 | 709-1010 | STKc_TSSK3-like |
| cd14164 | 709-950 | STKc_TSSK6-like |
| cd07854 | 703-1033 | STKc_MAPK4_6 |
| cd14017 | 708-854 | STKc_TTBK |
| cd07849 | 705-1009 | STKc_ERK1_2_like |
| cd07878 | 707-1064 | STKc_p38beta |
| cd07843 | 714-958 | STKc_CDC2L1 |
| cd07864 | 699-964 | STKc_CDK12 |
| cd06639 | 708-991 | STKc_myosinIIIB_N |
| cd07861 | 705-950 | STKc_CDK1_euk |
| cd14108 | 709-1010 | STKc_SPEG_rpt1 |
| cd06622 | 707-1011 | PKc_PBS2_like |
| cd07863 | 708-1010 | STKc_CDK4 |
| cd07839 | 707-1010 | STKc_CDK5 |
| cd14115 | 711-1009 | STKc_Kalirin_C |
| cd07845 | 705-957 | STKc_CDK10 |
| cd06618 | 696-1011 | PKc_MKK7 |
| cd14012 | 743-1009 | PK_eIF2AK_GCN2_rpt1 |
| cd14101 | 711-1011 | STKc_PIM2 |
| cd14322 | 103-141 | UBA_LATS |
| cd07837 | 707-1010 | STKc_CdkB_plant |
| cd14066 | 711-950 | STKc_IRAK |
| cd13974 | 802-988 | STKc_SHIK |
| cd14088 | 716-995 | STKc_CaMK_like |
| cd06636 | 704-956 | STKc_MAP4K4_6_N |
| cd14039 | 711-951 | STKc_IKK_alpha |
| cd05041 | 711-995 | PTKc_Fes_like |
| cd13983 | 825-1010 | STKc_WNK |
| cd07846 | 707-950 | STKc_CDKL2_3 |
| cd14058 | 711-995 | STKc_TAK1 |
| cd14100 | 711-1009 | STKc_PIM1 |
| cd07877 | 697-1010 | STKc_p38alpha |
| cd14145 | 699-993 | STKc_MLK1 |
| cd14226 | 708-991 | PKc_DYRK1 |
| cd14041 | 705-996 | STKc_TLK2 |
| cd13979 | 711-950 | STKc_Mos |
| cd06649 | 705-949 | PKc_MEK2 |
| cd07850 | 705-950 | STKc_JNK |
| cd14210 | 708-950 | PKc_DYRK |
| cd13982 | 752-1010 | STKc_IRE1 |
| cd07870 | 765-1010 | STKc_PFTAIRE2 |
| cd14212 | 708-950 | PKc_YAK1 |
| cd14222 | 711-947 | STKc_LIMK2 |
| cd07847 | 707-948 | STKc_CDKL1_4 |
| cd14061 | 711-972 | STKc_MLK |
| cd07876 | 689-963 | STKc_JNK2 |
| cd13988 | 711-950 | STKc_TBK1 |
| cd13986 | 708-985 | STKc_16 |
| cd05044 | 709-996 | PTKc_c-ros |
| cd07844 | 820-1010 | STKc_PCTAIRE_like |
| cd07871 | 705-957 | STKc_PCTAIRE3 |
| cd14158 | 711-950 | STKc_IRAK4 |
| cd06619 | 710-1009 | PKc_MKK5 |
| cd14038 | 711-966 | STKc_IKK_beta |
| cd07858 | 705-1010 | STKc_TEY_MAPK |
| cd14026 | 714-849 | STKc_RIP2 |
| cd08216 | 719-1018 | PK_STRAD |
| cd14111 | 753-963 | STKc_SPEG_rpt2 |
| cd14170 | 772-1054 | STKc_MAPKAPK2 |
| cd05080 | 702-868 | PTKc_Tyk2_rpt2 |
| cd14148 | 711-995 | STKc_MLK2 |
| cd07856 | 703-1009 | STKc_Sty1_Hog1 |
| cd06617 | 705-1011 | PKc_MKK3_6 |
| cd07873 | 705-963 | STKc_PCTAIRE1 |
| cd06616 | 825-1014 | PKc_MKK4 |
| cd06637 | 704-956 | STKc_TNIK |
| cd14154 | 772-954 | STKc_LIMK |
| cd14102 | 711-1009 | STKc_PIM3 |
| cd14065 | 711-944 | PKc_LIMK_like |
| cd14049 | 811-990 | STKc_EIF2AK1_HRI |
| cd14059 | 781-989 | STKc_MAP3K12_13 |
| cd13991 | 711-849 | STKc_NIK |
| cd07875 | 689-963 | STKc_JNK1 |
| cd05038 | 707-963 | PTKc_Jak_rpt2 |
| cd05079 | 701-995 | PTKc_Jak1_rpt2 |
| cd14060 | 712-972 | STKc_MLTK |
| cd05059 | 700-995 | PTKc_Tec_like |
| cd05072 | 708-995 | PTKc_Lyn |
| cd14147 | 709-983 | STKc_MLK3 |
| cd07865 | 701-853 | STKc_CDK9 |
| cd14040 | 705-996 | STKc_TLK1 |
| cd06633 | 702-951 | STKc_TAO3 |
| cd05060 | 709-950 | PTKc_Syk_like |
| cd13995 | 714-955 | STKc_MAP3K8 |
| cd14023 | 912-1010 | PK_TRB1 |
| cd07874 | 689-963 | STKc_JNK3 |
| cd13977 | 778-944 | STKc_PDIK1L |
| cd14221 | 711-954 | STKc_LIMK1 |
| cd14146 | 711-980 | STKc_MLK4 |
| cd07872 | 705-1013 | STKc_PCTAIRE2 |
| cd14225 | 708-973 | PKc_DYRK4 |
| cd07862 | 708-999 | STKc_CDK6 |
| cd14135 | 708-947 | STKc_PRP4 |
| cd14022 | 912-1010 | PK_TRB2 |
| cd13981 | 769-848 | STKc_Bub1_BubR1 |
| cd07853 | 820-963 | STKc_NLK |
| cd14398 | 104-143 | UBA_LATS2 |
| cd06607 | 704-950 | STKc_TAO |
| cd05085 | 711-962 | PTKc_Fer |
| cd05035 | 709-950 | PTKc_TAM |
| cd05116 | 709-997 | PTKc_Syk |
| cd14229 | 711-948 | STKc_HIPK3 |
| cd05113 | 708-963 | PTKc_Btk_Bmx |
| cd05046 | 708-950 | PTK_CCK4 |
| cd13976 | 912-1010 | PK_TRB |
| cd14011 | 823-1010 | PK_SCY1_like |
| cd05039 | 706-888 | PTKc_Csk_like |
| cd05084 | 709-962 | PTKc_Fes |
| cd13968 | 711-848 | PKc_like |
| cd05075 | 709-950 | PTKc_Axl |
| cd07859 | 806-1030 | STKc_TDY_MAPK |
| cd14064 | 711-950 | PKc_TNNI3K |
| cd14138 | 703-838 | PTKc_Wee1a |
| cd05056 | 709-864 | PTKc_FAK |
| cd05094 | 709-996 | PTKc_TrkC |
| cd14024 | 746-1009 | PK_TRB3 |
| cd05032 | 708-948 | PTKc_InsR_like |
| cd14664 | 711-950 | STK_BAK1_like |
| cd05049 | 708-950 | PTKc_Trk |
| cd05074 | 695-950 | PTKc_Tyro3 |
| cd06635 | 702-951 | STKc_TAO1 |
| cd14215 | 800-946 | PKc_CLK2 |
| cd07869 | 705-963 | STKc_PFTAIRE1 |
| cd05067 | 708-995 | PTKc_Lck_Blk |
| cd13980 | 709-954 | STKc_Vps15 |
| cd05092 | 711-950 | PTKc_TrkA |
| cd05081 | 708-849 | PTKc_Jak3_rpt2 |
| cd07842 | 712-1010 | STKc_CDK8_like |
| cd14224 | 708-950 | PKc_DYRK2_3 |
| cd14125 | 811-863 | STKc_CK1_delta_epsilon |
| cd14037 | 708-852 | STKc_NAK_like |
| cd05036 | 708-954 | PTKc_ALK_LTK |
| cd14228 | 708-950 | STKc_HIPK1 |
| cd14063 | 706-995 | PK_KSR |
| cd14036 | 813-996 | STKc_GAK |
| cd14205 | 708-944 | PTKc_Jak2_rpt2 |
| cd13998 | 778-996 | STKc_TGFbR-like |
| cd14214 | 841-946 | PKc_CLK3 |
| cd05093 | 709-950 | PTKc_TrkB |
| cd14112 | 750-961 | STKc_Unc-89_rpt2 |
| cd14227 | 708-950 | STKc_HIPK2 |
| cd06634 | 702-951 | STKc_TAO2 |
| cd14136 | 821-946 | STKc_SRPK |
| cd05082 | 708-859 | PTKc_Csk |
| cd05040 | 709-952 | PTKc_Ack_like |
| cd05053 | 700-950 | PTKc_FGFR |
| cd05090 | 725-950 | PTKc_Ror1 |
| cd14110 | 765-959 | STKc_obscurin_rpt2 |
| cd14149 | 711-1030 | STKc_C-Raf |
| pfam00627 | 101-138 | UBA |
| cd05033 | 706-950 | PTKc_EphR |
| cd05066 | 709-849 | PTKc_EphR_A |
| cd05073 | 709-995 | PTKc_Hck |
| cd05099 | 709-973 | PTKc_FGFR4 |
| cd05115 | 699-950 | PTKc_Zap-70 |
| cd14062 | 820-950 | STKc_Raf |
| cd14031 | 711-950 | STKc_WNK3 |
| cd14000 | 778-995 | STKc_LRRK |
| cd14139 | 705-836 | PTKc_Wee1b |
| cd14203 | 709-995 | PTKc_Src_Fyn_like |
| cd14013 | 815-852 | STKc_SNT7_plant |
| cd05114 | 700-957 | PTKc_Tec_Rlk |
| cd05055 | 709-950 | PTKc_PDGFR |
| cd14211 | 708-948 | STKc_HIPK |
| cd14213 | 800-950 | PKc_CLK1_4 |
| cd14051 | 705-838 | PTKc_Wee1 |
| cd14020 | 815-946 | STKc_KIS |
| cd05097 | 711-945 | PTKc_DDR_like |
| cd05098 | 697-963 | PTKc_FGFR1 |
| cd05120 | 755-851 | APH_ChoK_like |
| cd14054 | 711-959 | STKc_BMPR2_AMHR2 |
| cd14067 | 784-962 | STKc_LRRK1 |
| cd14150 | 708-950 | STKc_A-Raf |
| cd14159 | 711-949 | STKc_IRAK1 |
| cd13975 | 795-850 | PKc_Dusty |
| cd05065 | 705-950 | PTKc_EphR_B |
| cd14151 | 709-950 | STKc_B-Raf |
| cd05043 | 811-957 | PTK_Ryk |
| pfam00433 | 1029-1084 | Pkinase_C |
| cl11395 | 1029-1084 | Pkinase_C superfamily |
| cd14055 | 819-961 | STKc_TGFbR2_like |
| cd14025 | 775-1019 | STKc_RIP4_like |
| cd05095 | 711-869 | PTKc_DDR2 |
| cd14128 | 816-854 | STKc_CK1_alpha |
| cd05100 | 709-963 | PTKc_FGFR3 |
| cd05148 | 702-995 | PTKc_Srm_Brk |
| cd14144 | 709-943 | STKc_BMPR1 |
| cd14143 | 774-943 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05121 | 781-850 | ABC1_ADCK3-like |
| cd14127 | 816-863 | STKc_CK1_fungal |
| PRK14879 | 772-849 | PRK14879 |
| cd08226 | 800-972 | PK_STRAD_beta |
| cd05034 | 709-958 | PTKc_Src_like |
| PHA02882 | 767-853 | PHA02882 |
| smart00133 | 1011-1082 | S_TK_X |
| cd14018 | 788-850 | STKc_PINK1 |
| cd14057 | 914-989 | PK_ILK |
| cd05083 | 709-849 | PTKc_Chk |
| cd05071 | 702-861 | PTKc_Src |
| cd05064 | 706-848 | PTKc_EphR_A10 |
| cd05096 | 711-944 | PTKc_DDR1 |
| cd14204 | 700-870 | PTKc_Mer |
| COG3642 | 774-849 | Bud32 |
| TIGR03724 | 774-849 | arch_bud32 |
| smart00220 | 705-1010 | S_TKc |
| pfam00069 | 705-1010 | Pkinase |
| PTZ00263 | 710-1046 | PTZ00263 |
| PTZ00426 | 696-1056 | PTZ00426 |
| COG0515 | 705-1039 | SPS1 |
| PHA03390 | 699-1011 | pk1 |
| smart00221 | 706-995 | STYKc |
| smart00219 | 706-995 | TyrKc |
| pfam07714 | 705-1013 | Pkinase_Tyr |
| PTZ00267 | 721-963 | PTZ00267 |
| PTZ00024 | 698-989 | PTZ00024 |
| PRK13184 | 708-950 | pknD |
| PTZ00283 | 709-995 | PTZ00283 |
| PTZ00036 | 652-1062 | PTZ00036 |
| TIGR03903 | 726-948 | TOMM_kin_cyc |
| PTZ00266 | 708-950 | PTZ00266 |
| PLN00009 | 700-1015 | PLN00009 |
| PHA03210 | 806-944 | PHA03210 |
| PLN00034 | 703-1009 | PLN00034 |
| PHA03212 | 697-995 | PHA03212 |
| PHA03211 | 811-975 | PHA03211 |
| PHA03207 | 708-950 | PHA03207 |
| PHA03209 | 819-996 | PHA03209 |
| PLN03224 | 811-855 | PLN03224 |
| TIGR01982 | 721-849 | UbiB |
| PRK10263 | 448-596 | PRK10263 |
| PLN03225 | 694-854 | PLN03225 |
| PRK14950 | 473-558 | PRK14950 |
| PRK10263 | 467-655 | PRK10263 |
| PRK10263 | 369-588 | PRK10263 |
| COG0661 | 751-862 | AarF |
| PRK14950 | 483-593 | PRK14950 |
Ontology Information
| HPRD ID | 10377 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Deacetylase activity (GO:0019213) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.