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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIWIL1 9271 piwi-like RNA-mediated gene silencing 1  12PIWI, HIWI, CT80.1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21933617   2011Cell line : -

Source : Beijing Cancer Hospital & Institute

Sample Type : -

No. of Sample : 270 CRC patients

Stage : -

Western blotting, immunohistochemistry, ELISAUp-regulation-HIWI could be a potential prognostic biomarker for the patients with colorectal cancer, especially for those at early stages or without lymph node metastasis.

HIWI protein expression in several cancer cell lines and demonstrated positive expression of HIWI in 69 out of 270 (25.6%) colorectal cancer tissues; 15 of 236 (6.4%) matched adjacent non-cancerous tissues were also positive for HIWI.


Gene Details



Chromosome 12 - NC_000012.12 (130337887..130426260)

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Gene Type protein coding
Gene Family Argonaute/PIWI family
Description This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.  
Chromosome 12
Location 12q24.33
Start 130337887  
End 130426260  
Strand +  
Gene Sequence

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Length 88374  
OMIM ID 605571   
HGNC ID HGNC:9007   
Unigene ID Hs.405659   
Ensembl ID ENSG00000125207   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011539002.1
Exon join(1..133,4694..4783,5104..5215,7867..7992,8484..8698, 9055..9176,10217..10297,11353..11550,11970..12081, 16651..16777,17002..17119,17667..17781,19032..19219, 19595..19667,23294..23494,23612..23715,24880..24950, 25105..25258,29247..29372,33290..33437,33596..34442)  
mRNA Sequence

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Length 2797  



CDS Information


   
Locationjoin(4706..4783,5104..5215,7867..7992,8484..8698, 9055..9176,10217..10297,11353..11550,11970..12081, 16651..16777,17002..17119,17667..17781,19032..19219, 19595..19667,23294..23494,23612..23715,24880..24950, 25105..25258,29247..29372,33290..33437,33596..33712)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_004755.2
Protein Namepiwi-like RNA-mediated gene silencing 1
Molecular Wt. (Da)98473
Protein Sequence

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Length 861  
Uniprot IDP08476
Ensembl Protein ID ENSP00000242208  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
23405DICER15875NP_803187.1in vitro14749716   


Pathway Information


      
Pathway Name Pathway ID
Dorso-ventral axis formation hsa04320


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04658401-844  Piwi_piwi-like_Euk
cl00628401-844  Piwi-like superfamily
cd02845276-393  PAZ_piwi_like
cl00301276-393  PAZ superfamily
pfam02171555-847  Piwi
smart00950555-847  Piwi
cd04657438-840  Piwi_ago-like
cd02826450-841  Piwi-like
smart00949277-415  PAZ
pfam02170277-397  PAZ
cd02825278-390  PAZ
cd04659538-843  Piwi_piwi-like_ProArk
cd02844299-387  PAZ_CAF_like
pfam0583117-101  GAGE
cl0541817-101  GAGE superfamily
cd02846299-387  PAZ_argonaute_like
cd02843307-362  PAZ_dicer_like
PLN03202251-849  PLN03202
COG1431562-861  COG1431


Ontology Information


   
HPRD ID923
Molecular ClassUnclassified
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO