Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PIWIL1 | 9271 | piwi-like RNA-mediated gene silencing 1  | 12 | PIWI, HIWI, CT80.1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21933617    | 2011 | Cell line : - Source : Beijing Cancer Hospital & Institute Sample Type : - No. of Sample : 270 CRC patients Stage : - | Western blotting, immunohistochemistry, ELISA | Up-regulation | - | HIWI could be a potential prognostic biomarker for the patients with colorectal cancer, especially for those at early stages or without lymph node metastasis. HIWI protein expression in several cancer cell lines and demonstrated positive expression of HIWI in 69 out of 270 (25.6%) colorectal cancer tissues; 15 of 236 (6.4%) matched adjacent non-cancerous tissues were also positive for HIWI. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Argonaute/PIWI family |
| Description | This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.   | Chromosome | 12 |
| Location | 12q24.33 |
| Start | 130337887   |
| End | 130426260   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 88374   |
| OMIM ID | 605571    |
| HGNC ID | HGNC:9007    |
| Unigene ID | Hs.405659    |
| Ensembl ID | ENSG00000125207    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011539002.1 |
|---|---|
| Exon | join(1..133,4694..4783,5104..5215,7867..7992,8484..8698, 9055..9176,10217..10297,11353..11550,11970..12081, 16651..16777,17002..17119,17667..17781,19032..19219, 19595..19667,23294..23494,23612..23715,24880..24950, 25105..25258,29247..29372,33290..33437,33596..34442)   | mRNA Sequence |    Download   Select all |
| Length | 2797   |
CDS Information
| Location | join(4706..4783,5104..5215,7867..7992,8484..8698, 9055..9176,10217..10297,11353..11550,11970..12081, 16651..16777,17002..17119,17667..17781,19032..19219, 19595..19667,23294..23494,23612..23715,24880..24950, 25105..25258,29247..29372,33290..33437,33596..33712) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_004755.2 |
|---|---|
| Protein Name | piwi-like RNA-mediated gene silencing 1 |
| Molecular Wt. (Da) | 98473 |
| Protein Sequence |    Download   Select all |
| Length | 861   |
| Uniprot ID | P08476 |    
| Ensembl Protein ID | ENSP00000242208   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 23405 |    DICER1 |    5875 |    NP_803187.1 |    in vitro |    14749716    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Dorso-ventral axis formation |    hsa04320 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04658 | 401-844  | Piwi_piwi-like_Euk |
| cl00628 | 401-844  | Piwi-like superfamily |
| cd02845 | 276-393  | PAZ_piwi_like |
| cl00301 | 276-393  | PAZ superfamily |
| pfam02171 | 555-847  | Piwi |
| smart00950 | 555-847  | Piwi |
| cd04657 | 438-840  | Piwi_ago-like |
| cd02826 | 450-841  | Piwi-like |
| smart00949 | 277-415  | PAZ |
| pfam02170 | 277-397  | PAZ |
| cd02825 | 278-390  | PAZ |
| cd04659 | 538-843  | Piwi_piwi-like_ProArk |
| cd02844 | 299-387  | PAZ_CAF_like |
| pfam05831 | 17-101  | GAGE |
| cl05418 | 17-101  | GAGE superfamily |
| cd02846 | 299-387  | PAZ_argonaute_like |
| cd02843 | 307-362  | PAZ_dicer_like |
| PLN03202 | 251-849  | PLN03202 |
| COG1431 | 562-861  | COG1431 |
Ontology Information
| HPRD ID | 923 |    
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
