Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20140740    | 2010 | Cell line : - Source : Department of surgery, Paik Hospital,Inje University Korea. Sample Type : CRC Blood sample No. of Sample : - Stage : TNM Stage I- III | real-timeRT- PCR | Down-regulation | - | B7/CD28 family PBTs may serve as valuable markers reflecting the pathological features of colon cancer. |
| 25497975    | 2015 | Cell line : - Source : First Affiliated Hospital of Soochow University . Sample Type : CRC tumor No. of Sample : 714 health controls, 382 CRC Stage : - | SNP genotyping,Luciferase reporter assays | Polymorhpism | - | rs7628626, rs13505, rs4404254, rs1559931, and rs4675379, through disrupting the regulatory role of miRNAs in the expression of B7/CD28 molecules, contribute to the occurrence and progress of colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing" |
| Description | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]   |
| Chromosome | 2 |
| Location | 2q33 |
| Start | 204571198   |
| End | 204603635   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 32438   |
| OMIM ID | 186760    |
| HGNC ID | HGNC:1653    |
| Unigene ID | Hs.443123    |
| Ensembl ID | ENSG00000178562    |
| PharmGKB ID | PA26207    |
mRNA Information
| mRNA ID | NM_006139.3 |
|---|---|
| Exon | join(1..274,20159..20515,23174..23298,28310..32438)   | mRNA Sequence |    Download   Select all |
| Length | 4900   |
CDS Information
| Location | 223..885 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS2361.1 |    
Protein Information
| Protein ID | NP_006130.1 |
|---|---|
| Protein Name | CD28 molecule |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 220   |
| Uniprot ID | P21359 |    
| Ensembl Protein ID | ENSP00000348498   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 191 |
| Y | Phosphorylation | 206 |
| Y | Phosphorylation | 209 |
| Y | Phosphorylation | 218 |
| N | Glycosylation | 129 |
| N | Glycosylation | 71 |
| N | Glycosylation | 92 |
| S | Phosphorylation | 189 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 941 |    CD80 |    202 |    NP_005182.1 |    in vitro |    7545666    |
| 2885 |    GRB2 |    150 |    NP_002077.1 |    in vitro;in vivo |    857   615   777   372   759   000   000    |
| 3592 |    IL12A |    1193 |    NP_000873.2 |    in vitro;in vivo |    7516408    |
| 3932 |    LCK |    1080 |    NP_005347.3 |    in vitro |    10430626    |
| 4905 |    NSF |    3380 |    NP_006169.2 |    in vivo |    11680900    |
| 5294 |    PIK3CG |    3135 |    NP_002640.2 |    in vivo |    9915850    |
| 5295 |    PIK3R1 |    1381 |    NP_852664.1 |    in vitro;in vivo |    86   216   077   737   275    |
| 5296 |    PIK3R2 |    4404 |    NP_005018.1 |    in vitro |    75   093   608   080   844    |
| 5335 |    PLCG1 |    1398 |    NP_002651.2 |    in vivo |    8386518    |
| 5788 |    PTPRC |    1050 |    NP_002829.2 |    in vivo |    1355979    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection |    hsa05330 |    
| Autoimmune thyroid disease |    hsa05320 |    
| Cell adhesion molecules (CAMs) |    hsa04514 |    
| Graft-versus-host disease |    hsa05332 |    
| Intestinal immune network for IgA production |    hsa04672 |    
| Measles |    hsa05162 |    
| Rheumatoid arthritis |    hsa05323 |    
| Systemic lupus erythematosus |    hsa05322 |    
| T cell receptor signaling pathway |    hsa04660 |    
| Type I diabetes mellitus |    hsa04940 |    
| Viral myocarditis |    hsa05416 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05721 | 21-136  | IgV_CTLA-4 |
| cl11960 | 21-136  | Ig superfamily |
| smart00406 | 36-114  | IGv |
| cd00099 | 28-135  | IgV |
Ontology Information
| HPRD ID | 2730 |    
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
