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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CD28 940 CD28 molecule  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20140740   2010Cell line : -

Source : Department of surgery, Paik Hospital,Inje University Korea.

Sample Type : CRC Blood sample

No. of Sample : -

Stage : TNM Stage I- III

real-timeRT- PCRDown-regulation-B7/CD28 family PBTs may serve as valuable markers reflecting the pathological features of colon cancer.

25497975   2015Cell line : -

Source : First Affiliated Hospital of Soochow University .

Sample Type : CRC tumor

No. of Sample : 714 health controls, 382 CRC

Stage : -

SNP genotyping,Luciferase reporter assaysPolymorhpism-rs7628626, rs13505, rs4404254, rs1559931, and rs4675379, through disrupting the regulatory role of miRNAs in the expression of B7/CD28 molecules, contribute to the occurrence and progress of colorectal cancer.


Gene Details



NC_000002.11 (204571198..204603635)

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Gene Type protein coding
Gene Family CD molecules, "Immunoglobulin superfamily / V-set domain containing"
Description The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]  
Chromosome 2
Location 2q33
Start 204571198  
End 204603635  
Strand +  
Gene Sequence

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Length 32438  
OMIM ID 186760   
HGNC ID HGNC:1653   
Unigene ID Hs.443123   
Ensembl ID ENSG00000178562   
PharmGKB ID PA26207   

mRNA Information


mRNA ID NM_006139.3
Exon join(1..274,20159..20515,23174..23298,28310..32438)  
mRNA Sequence

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Length 4900  



CDS Information


   
Location223..885
CDS Sequence

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CCDS ID CCDS2361.1



Protein Information


      
Protein IDNP_006130.1
Protein NameCD28 molecule
Molecular Wt. (Da)0
Protein Sequence

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Length 220  
Uniprot IDP21359
Ensembl Protein ID ENSP00000348498  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation191
YPhosphorylation206
YPhosphorylation209
YPhosphorylation218
NGlycosylation129
NGlycosylation71
NGlycosylation92
SPhosphorylation189

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
941CD80202NP_005182.1in vitro7545666   
2885GRB2150NP_002077.1in vitro;in vivo857   615   777   372   759   000   000   
3592IL12A1193NP_000873.2in vitro;in vivo7516408   
3932LCK1080NP_005347.3in vitro10430626   
4905NSF3380NP_006169.2in vivo11680900   
5294PIK3CG3135NP_002640.2in vivo9915850   
5295PIK3R11381NP_852664.1in vitro;in vivo86   216   077   737   275   
5296PIK3R24404NP_005018.1in vitro75   093   608   080   844   
5335PLCG11398NP_002651.2in vivo8386518   
5788PTPRC1050NP_002829.2in vivo1355979   


Pathway Information


                                                                  
Pathway Name Pathway ID
Allograft rejection hsa05330
Autoimmune thyroid disease hsa05320
Cell adhesion molecules (CAMs) hsa04514
Graft-versus-host disease hsa05332
Intestinal immune network for IgA production hsa04672
Measles hsa05162
Rheumatoid arthritis hsa05323
Systemic lupus erythematosus hsa05322
T cell receptor signaling pathway hsa04660
Type I diabetes mellitus hsa04940
Viral myocarditis hsa05416


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0572121-136  IgV_CTLA-4
cl1196021-136  Ig superfamily
smart0040636-114  IGv
cd0009928-135  IgV


Ontology Information


   
HPRD ID2730
Molecular ClassCell surface receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO