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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CD86 942 CD86 molecule  3B7.2, B7-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20380573   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 273 CRC and 292 healthy controls

Stage : -

PCR-RFLPPolymorhpism-CD86 +1057G/A polymorphism may contribute to genetic susceptibility to CRC in a Chinese population.

24834250   2013Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 150 CRC and 150 healthy control

Stage : -

Single nucleotide polymorphism (SNP) Polymorhpism-CD86 gene alteration could affect the individual's risk for developing CRC among Iranian population and could be used as an important prognostic factor associated with risk of CRC.


Gene Details



NC_000003.11 (121774209..121839990)

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Gene Type protein coding
Gene Family CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]  
Chromosome 3
Location 3q21
Start 121774209  
End 121839990  
Strand +  
Gene Sequence

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Length 65782  
OMIM ID 601020   
HGNC ID HGNC:1705   
Unigene ID Hs.171182   
Ensembl ID ENSG00000114013   
PharmGKB ID PA26243   

mRNA Information


mRNA ID XM_011512739.1
Exon complement(5059..5155)  
mRNA Sequence

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Length 2592  



CDS Information


   
Location445..1548
CDS Sequence

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CCDS ID CCDS3009.1



Protein Information


      
Protein IDXP_011511041.1
Protein NameCD86 molecule
Molecular Wt. (Da)42179
Protein Sequence

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Length 367  
Uniprot IDQ13469
Ensembl Protein ID ENSP00000360619  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
940CD281727NP_006130.1in vivo110   215   287   513   726   
941CD80202NP_005182.1in vitro12606712   
1493CTLA4474NP_005205.2in vitro;in vivo11   279   501   110   215   200   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   


Pathway Information


                                                                  
Pathway Name Pathway ID
Allograft rejection hsa05330
Autoimmune thyroid disease hsa05320
Cell adhesion molecules (CAMs) hsa04514
Graft-versus-host disease hsa05332
Intestinal immune network for IgA production hsa04672
Rheumatoid arthritis hsa05323
Systemic lupus erythematosus hsa05322
Toll-like receptor signaling pathway hsa04620
Transcriptional misregulation in cancer hsa05202
Type I diabetes mellitus hsa04940
Viral myocarditis hsa05416


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart0040635-110  IGv
cl1196035-110  Ig superfamily
cd0571334-113  Ig_MOG_like
cd0009638-115  Ig
cd0769034-116  Ig1_CD4
cd0009933-110  IgV
cd0584634-113  Ig1_MRC-OX-2_like
cd0585654-115  Ig2_FGFRL1-like


Ontology Information


   
HPRD ID5619
Molecular ClassCell surface receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P42081DB00098Anti-thymocyte Globulin (Rabbit)BiotechDrug
P42081DB01281AbataceptBiotechDrug
P42081DB06681BelataceptBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO