Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20380573    | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 273 CRC and 292 healthy controls Stage : - | PCR-RFLP | Polymorhpism | - | CD86 +1057G/A polymorphism may contribute to genetic susceptibility to CRC in a Chinese population. |
| 24834250    | 2013 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 150 CRC and 150 healthy control Stage : - | Single nucleotide polymorphism (SNP) | Polymorhpism | - | CD86 gene alteration could affect the individual's risk for developing CRC among Iranian population and could be used as an important prognostic factor associated with risk of CRC. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]   | Chromosome | 3 |
| Location | 3q21 |
| Start | 121774209   |
| End | 121839990   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 65782   |
| OMIM ID | 601020    |
| HGNC ID | HGNC:1705    |
| Unigene ID | Hs.171182    |
| Ensembl ID | ENSG00000114013    |
| PharmGKB ID | PA26243    |
mRNA Information
| mRNA ID | XM_011512739.1 |
|---|---|
| Exon | complement(5059..5155)   | mRNA Sequence |    Download   Select all |
| Length | 2592   |
CDS Information
| Location | 445..1548 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS3009.1 |    
Protein Information
| Protein ID | XP_011511041.1 |
|---|---|
| Protein Name | CD86 molecule |
| Molecular Wt. (Da) | 42179 |
| Protein Sequence |    Download   Select all |
| Length | 367   |
| Uniprot ID | Q13469 |    
| Ensembl Protein ID | ENSP00000360619   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 940 |    CD28 |    1727 |    NP_006130.1 |    in vivo |    110   215   287   513   726    |
| 941 |    CD80 |    202 |    NP_005182.1 |    in vitro |    12606712    |
| 1493 |    CTLA4 |    474 |    NP_005205.2 |    in vitro;in vivo |    11   279   501   110   215   200   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection |    hsa05330 |    
| Autoimmune thyroid disease |    hsa05320 |    
| Cell adhesion molecules (CAMs) |    hsa04514 |    
| Graft-versus-host disease |    hsa05332 |    
| Intestinal immune network for IgA production |    hsa04672 |    
| Rheumatoid arthritis |    hsa05323 |    
| Systemic lupus erythematosus |    hsa05322 |    
| Toll-like receptor signaling pathway |    hsa04620 |    
| Transcriptional misregulation in cancer |    hsa05202 |    
| Type I diabetes mellitus |    hsa04940 |    
| Viral myocarditis |    hsa05416 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00406 | 35-110  | IGv |
| cl11960 | 35-110  | Ig superfamily |
| cd05713 | 34-113  | Ig_MOG_like |
| cd00096 | 38-115  | Ig |
| cd07690 | 34-116  | Ig1_CD4 |
| cd00099 | 33-110  | IgV |
| cd05846 | 34-113  | Ig1_MRC-OX-2_like |
| cd05856 | 54-115  | Ig2_FGFRL1-like |
Ontology Information
| HPRD ID | 5619 |    
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P42081 | DB00098 | Anti-thymocyte Globulin (Rabbit) | BiotechDrug |
| P42081 | DB01281 | Abatacept | BiotechDrug |
| P42081 | DB06681 | Belatacept | BiotechDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
