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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ZEB2 | 9839 | zinc finger E-box binding homeobox 2 | 2 | KIAA0569, SIP-1, SIP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22042972 | 2011 | Cell line : - Source : Department of General, Visceral, and Transplantation Surgery, University of Heidelberg Sample Type : CRC tumor and normal tissue No. of Sample : 175 Stage : - | real time RT-PCR, immunohistochemistry | Up-regulation | - | ZEB2 may be interesting as biomarker and potential target for treatment of colorectal cancer. Overexpression of ZEB2 at the invasion front correlates with tumor progression and predicts cancer-specific survival in primary colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type, "Homeoboxes / ZF class" |
| Description | The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene. |
| Chromosome | 2 |
| Location | 2q22.3 |
| Start | 144384375 |
| End | 144520393 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 136019 |
| OMIM ID | 605802 |
| HGNC ID | HGNC:14881 |
| Unigene ID | Hs.34871 |
| Ensembl ID | ENSG00000169554 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001171653.1 |
|---|---|
| Exon | join(3..455,2975..3116,90368..90625,115370..115558, 116264..116478,119087..119195,120124..122093, 123802..123982,130366..136019) | mRNA Sequence | Download Select all |
| Length | 9171 |
CDS Information
| Location | join(404..455,90368..90625,95527..95598,115370..115558, 116264..116478,119087..119195,120124..122093, 123802..123982,130366..130943) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001165124.1 |
|---|---|
| Protein Name | zinc finger E-box binding homeobox 2 |
| Molecular Wt. (Da) | 133676 |
| Protein Sequence | Download Select all |
| Length | 1190 |
| Uniprot ID | P23229 |
| Ensembl Protein ID | ENSP00000264107 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 782 |
| S | Phosphorylation | 784 |
| K | Acetylation | 377 |
| K | Acetylation | 372 |
| S | Phosphorylation | 1203 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1487 | CTBP1 | 4015 | NP_001319.1 | in vivo;yeast 2-hybrid | 12714599 |
| 1488 | CTBP2 | 4016 | NP_073713.2 | in vivo;yeast 2-hybrid | 12714599 |
| 4086 | SMAD1 | 3356 | NP_005891.1 | yeast 2-hybrid | 104 006 771 523 174 000 000 000 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vitro;in vivo;yeast 2-hybrid | 104 006 771 523 174 000 000 000 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | yeast 2-hybrid | 104 006 771 523 174 000 000 000 |
| 4090 | SMAD5 | 4381 | NP_005894.3 | yeast 2-hybrid | 1 040 067 712 714 590 |
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
| 10980 | COPS6 | 16735 | NP_006824.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
Structure Information
| PDB ID | 2DA7 |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | Zinc finger homeobox protein 1b |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 653-695 | homeodomain |
| cl00084 | 653-695 | homeodomain superfamily |
| pfam13465 | 296-319 | zf-H2C2_2 |
| cl22375 | 296-319 | zf-H2C2_2 superfamily |
| pfam13465 | 1041-1066 | zf-H2C2_2 |
| cl22375 | 1041-1066 | zf-H2C2_2 superfamily |
| pfam13465 | 1013-1038 | zf-H2C2_2 |
| cl22375 | 1013-1038 | zf-H2C2_2 superfamily |
| smart00389 | 650-696 | HOX |
| pfam00096 | 282-304 | zf-C2H2 |
| cl23491 | 282-304 | zf-C2H2 superfamily |
| smart00355 | 282-304 | ZnF_C2H2 |
| cl18194 | 282-304 | ZnF_C2H2 superfamily |
| COG5048 | 1024-1125 | COG5048 |
| COG5576 | 594-726 | COG5576 |
Ontology Information
| HPRD ID | 961 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.