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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDC25A 993 cell division cycle 25A  3- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21344162   2011Cell line : COLO205, T84, HCT116, SW480 and SW403

Source : ATCC

Sample Type : CRC tumor and normal tissue

No. of Sample : 110

Stage : -

Oligonucleotide microarray analysis, real time RT-PCRUp-regulation-CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients.


Gene Details



NC_000003.11 (48198668..48230153, complement)

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Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class III Cys-based PTPs
Description CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3p21
Start 48198668  
End 48230153  
Strand -  
Gene Sequence

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Length 31486  
OMIM ID 116947   
HGNC ID HGNC:1725   
Unigene ID Hs.437705   
Ensembl ID ENSG00000164045   
PharmGKB ID PA26259   

mRNA Information


mRNA ID XM_011534316.1
Exon join(1..289,444..881,1880..1956,3964..4006,4823..4859, 5629..5730,7819..7938,10671..10805,11217..11288, 14202..14375,20715..20813,22766..22828,22925..23023, 24222..24352,29204..29315,29574..31481)  
mRNA Sequence

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Length 3899  



CDS Information


   
Location558..2132
CDS Sequence

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CCDS ID CCDS2760.1



Protein Information


      
Protein IDXP_011532618.1
Protein Namecell division cycle 25A
Molecular Wt. (Da)58956
Protein Sequence

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Length 524  
Uniprot IDP08138
Ensembl Protein ID ENSP00000172229  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation76
SPhosphorylation76
SPhosphorylation116
SPhosphorylation18
SPhosphorylation116
SPhosphorylation18
SPhosphorylation116
SPhosphorylation124
SPhosphorylation178
SPhosphorylation279
SPhosphorylation293
SPhosphorylation124
SPhosphorylation239
SPhosphorylation253
SPhosphorylation178
SPhosphorylation279
SPhosphorylation293
SPhosphorylation239
SPhosphorylation253
SPhosphorylation124
SPhosphorylation124

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vivo19013180   
1017CDK2310NP_001789.2in vitro861   779   112   388   094   
1523CUX1295NP_853530.2in vitro;in vivo11584018   
4088SMAD34380NP_005893.1in vivo15798217   
5894RAF11265NP_002871.1in vivo923   021   110   373   531   
7529YWHAB3184NP_003395.1in vitro;in vivo;yeast 2-hybrid7644510   
7531YWHAE5457NP_006752.1in vitro;in vivo;yeast 2-hybrid764   451   014   559   997   
8260NAA102056NP_003482.1yeast 2-hybrid16189514   


Pathway Information


                  
Pathway Name Pathway ID
Cell cycle hsa04110
MicroRNAs in cancer hsa05206
Progesterone-mediated oocyte maturation hsa04914


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01530357-475  Cdc25
cl00125357-475  RHOD superfamily
pfam0661786-329  M-inducer_phosp
cl0590686-329  M-inducer_phosp superfamily
cd01443357-474  Cdc25_Acr2p
smart00450378-477  RHOD
pfam00581378-476  Rhodanese
cd00158378-473  RHOD
cd01531357-470  Acr2p
cd01518358-469  RHOD_YceA
COG0607361-472  PspE
cd01524378-471  RHOD_Pyr_redox
cd01519378-431  RHOD_HSP67B2
cd01528363-418  RHOD_2
COG5105276-508  MIH1
COG2897349-416  SseA
PRK00142358-438  PRK00142


Ontology Information


   
HPRD ID1131
Molecular ClassDual specificity phosphatase
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO