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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21344162    | 2011 | Cell line : COLO205, T84, HCT116, SW480 and SW403 Source : ATCC Sample Type : CRC tumor and normal tissue No. of Sample : 110 Stage : - | Oligonucleotide microarray analysis, real time RT-PCR | Up-regulation | - | CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class III Cys-based PTPs |
| Description | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   | Chromosome | 3 |
| Location | 3p21 |
| Start | 48198668   |
| End | 48230153   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 31486   |
| OMIM ID | 116947    |
| HGNC ID | HGNC:1725    |
| Unigene ID | Hs.437705    |
| Ensembl ID | ENSG00000164045    |
| PharmGKB ID | PA26259    |
mRNA Information
| mRNA ID | XM_011534316.1 |
|---|---|
| Exon | join(1..289,444..881,1880..1956,3964..4006,4823..4859, 5629..5730,7819..7938,10671..10805,11217..11288, 14202..14375,20715..20813,22766..22828,22925..23023, 24222..24352,29204..29315,29574..31481)   | mRNA Sequence |    Download   Select all |
| Length | 3899   |
CDS Information
| Location | 558..2132 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS2760.1 |    
Protein Information
| Protein ID | XP_011532618.1 |
|---|---|
| Protein Name | cell division cycle 25A |
| Molecular Wt. (Da) | 58956 |
| Protein Sequence |    Download   Select all |
| Length | 524   |
| Uniprot ID | P08138 |    
| Ensembl Protein ID | ENSP00000172229   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 76 |
| S | Phosphorylation | 76 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 18 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 18 |
| S | Phosphorylation | 116 |
| S | Phosphorylation | 124 |
| S | Phosphorylation | 178 |
| S | Phosphorylation | 279 |
| S | Phosphorylation | 293 |
| S | Phosphorylation | 124 |
| S | Phosphorylation | 239 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 178 |
| S | Phosphorylation | 279 |
| S | Phosphorylation | 293 |
| S | Phosphorylation | 239 |
| S | Phosphorylation | 253 |
| S | Phosphorylation | 124 |
| S | Phosphorylation | 124 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 |    AR |    2437 |    NP_000035.2 |    in vivo |    19013180    |
| 1017 |    CDK2 |    310 |    NP_001789.2 |    in vitro |    861   779   112   388   094    |
| 1523 |    CUX1 |    295 |    NP_853530.2 |    in vitro;in vivo |    11584018    |
| 4088 |    SMAD3 |    4380 |    NP_005893.1 |    in vivo |    15798217    |
| 5894 |    RAF1 |    1265 |    NP_002871.1 |    in vivo |    923   021   110   373   531    |
| 7529 |    YWHAB |    3184 |    NP_003395.1 |    in vitro;in vivo;yeast 2-hybrid |    7644510    |
| 7531 |    YWHAE |    5457 |    NP_006752.1 |    in vitro;in vivo;yeast 2-hybrid |    764   451   014   559   997    |
| 8260 |    NAA10 |    2056 |    NP_003482.1 |    yeast 2-hybrid |    16189514    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle |    hsa04110 |    
| MicroRNAs in cancer |    hsa05206 |    
| Progesterone-mediated oocyte maturation |    hsa04914 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01530 | 357-475  | Cdc25 |
| cl00125 | 357-475  | RHOD superfamily |
| pfam06617 | 86-329  | M-inducer_phosp |
| cl05906 | 86-329  | M-inducer_phosp superfamily |
| cd01443 | 357-474  | Cdc25_Acr2p |
| smart00450 | 378-477  | RHOD |
| pfam00581 | 378-476  | Rhodanese |
| cd00158 | 378-473  | RHOD |
| cd01531 | 357-470  | Acr2p |
| cd01518 | 358-469  | RHOD_YceA |
| COG0607 | 361-472  | PspE |
| cd01524 | 378-471  | RHOD_Pyr_redox |
| cd01519 | 378-431  | RHOD_HSP67B2 |
| cd01528 | 363-418  | RHOD_2 |
| COG5105 | 276-508  | MIH1 |
| COG2897 | 349-416  | SseA |
| PRK00142 | 358-438  | PRK00142 |
Ontology Information
| HPRD ID | 1131 |    
|---|---|
| Molecular Class | Dual specificity phosphatase |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
