Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10850455    | 2000 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 10 Stage : - | real time RT-PCR,immunohistochemistry | Up-regulation | - | CDC25B is a novel independent prognostic marker of colorectal carcinoma and that it may be clinically useful for selecting patients |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class III Cys-based PTPs |
| Description | CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]   |
| Chromosome | 20 |
| Location | 20p13 |
| Start | 3767419   |
| End | 3786765   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 19347   |
| OMIM ID | 116949    |
| HGNC ID | HGNC:1726    |
| Unigene ID | Hs.153752    |
| Ensembl ID | ENSG00000101224    |
| PharmGKB ID | PA26260    |
mRNA Information
| mRNA ID | NM_001287516.1 |
|---|---|
| Exon | join(1..368,10851..10978,11641..11692,13517..13558, 13691..13727,13972..14094,14200..14322,14483..14617, 14951..15031,15153..15329,15510..15605,16139..16201, 16337..16435,16633..16766,17798..17909,18050..19350)   | mRNA Sequence |    Download   Select all |
| Length | 3071   |
CDS Information
| Location | 361..1911 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS13065.1 |    
Protein Information
| Protein ID | NP_001274445.1 |
|---|---|
| Protein Name | cell division cycle 25B |
| Molecular Wt. (Da) | 58753 |
| Protein Sequence |    Download   Select all |
| Length | 516   |
| Uniprot ID | P14543 |    
| Ensembl Protein ID | ENSP00000264187   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 172 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 186 |
| S | Phosphorylation | 187 |
| S | Phosphorylation | 146 |
| S | Phosphorylation | 160 |
| S | Phosphorylation | 339 |
| S | Phosphorylation | 312 |
| S | Phosphorylation | 353 |
| S | Phosphorylation | 307 |
| S | Phosphorylation | 280 |
| S | Phosphorylation | 321 |
| T | Phosphorylation | 376 |
| T | Phosphorylation | 341 |
| T | Phosphorylation | 314 |
| T | Phosphorylation | 355 |
| T | Phosphorylation | 243 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 361 |
| S | Phosphorylation | 334 |
| S | Phosphorylation | 375 |
| S | Phosphorylation | 263 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 |    CDK1 |    302 |    NP_001777.1 |    in vitro |    9   585   407   973   365   090   000   000   000   000   000   000   000   000   000    |
| 1432 |    MAPK14 |    2619 |    NP_001306.1 |    in vitro |    15629715    |
| 1460 |    CSNK2B |    278 |    NP_001311.3 |    in vivo |    12527891    |
| 2810 |    SFN |    3185 |    NP_006133.1 |    in vivo |    15173315    |
| 7533 |    YWHAH |    215 |    NP_003396.1 |    in vitro;in vivo |    10713667    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle |    hsa04110 |    
| MAPK signaling pathway |    hsa04010 |    
| MicroRNAs in cancer |    hsa05206 |    
| Progesterone-mediated oocyte maturation |    hsa04914 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01530 | 412-531  | Cdc25 |
| cl00125 | 412-531  | RHOD superfamily |
| pfam06617 | 113-384  | M-inducer_phosp |
| cl05906 | 113-384  | M-inducer_phosp superfamily |
| cd01443 | 412-531  | Cdc25_Acr2p |
| smart00450 | 433-534  | RHOD |
| pfam00581 | 433-529  | Rhodanese |
| cd00158 | 433-529  | RHOD |
| cd01531 | 412-526  | Acr2p |
| cd01446 | 415-537  | DSP_MapKP |
| COG0607 | 416-528  | PspE |
| cd01519 | 436-487  | RHOD_HSP67B2 |
| cd01524 | 433-460  | RHOD_Pyr_redox |
| cd01521 | 418-487  | RHOD_PspE2 |
| COG5105 | 395-564  | MIH1 |
| PRK11784 | 425-464  | PRK11784 |
| COG2897 | 415-463  | SseA |
Ontology Information
| HPRD ID | 2098 |    
|---|---|
| Molecular Class | Dual specificity phosphatase |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
