Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDC25B 994 cell division cycle 25B  20- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10850455   2000Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 10

Stage : -

real time RT-PCR,immunohistochemistryUp-regulation-CDC25B is a novel independent prognostic marker of colorectal carcinoma and that it may be clinically useful for selecting patients


Gene Details



NC_000020.10 (3767419..3786765)

View Larger Image
   
Gene Type protein coding
Gene Family Protein tyrosine phosphatases / Class III Cys-based PTPs
Description CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]  
Chromosome 20
Location 20p13
Start 3767419  
End 3786765  
Strand +  
Gene Sequence

   Download   Select all

Length 19347  
OMIM ID 116949   
HGNC ID HGNC:1726   
Unigene ID Hs.153752   
Ensembl ID ENSG00000101224   
PharmGKB ID PA26260   

mRNA Information


mRNA ID NM_001287516.1
Exon join(1..368,10851..10978,11641..11692,13517..13558, 13691..13727,13972..14094,14200..14322,14483..14617, 14951..15031,15153..15329,15510..15605,16139..16201, 16337..16435,16633..16766,17798..17909,18050..19350)  
mRNA Sequence

   Download   Select all

Length 3071  



CDS Information


   
Location361..1911
CDS Sequence

   Download   Select all

CCDS ID CCDS13065.1



Protein Information


      
Protein IDNP_001274445.1
Protein Namecell division cycle 25B
Molecular Wt. (Da)58753
Protein Sequence

   Download   Select all

Length 516  
Uniprot IDP14543
Ensembl Protein ID ENSP00000264187  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation172
SPhosphorylation173
SPhosphorylation186
SPhosphorylation187
SPhosphorylation146
SPhosphorylation160
SPhosphorylation339
SPhosphorylation312
SPhosphorylation353
SPhosphorylation307
SPhosphorylation280
SPhosphorylation321
TPhosphorylation376
TPhosphorylation341
TPhosphorylation314
TPhosphorylation355
TPhosphorylation243
SPhosphorylation396
SPhosphorylation361
SPhosphorylation334
SPhosphorylation375
SPhosphorylation263

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
983CDK1302NP_001777.1in vitro9   585   407   973   365   090   000   000   000   000   000   000   000   000   000   
1432MAPK142619NP_001306.1in vitro15629715   
1460CSNK2B278NP_001311.3in vivo12527891   
2810SFN3185NP_006133.1in vivo15173315   
7533YWHAH215NP_003396.1in vitro;in vivo10713667   


Pathway Information


                        
Pathway Name Pathway ID
Cell cycle hsa04110
MAPK signaling pathway hsa04010
MicroRNAs in cancer hsa05206
Progesterone-mediated oocyte maturation hsa04914


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01530412-531  Cdc25
cl00125412-531  RHOD superfamily
pfam06617113-384  M-inducer_phosp
cl05906113-384  M-inducer_phosp superfamily
cd01443412-531  Cdc25_Acr2p
smart00450433-534  RHOD
pfam00581433-529  Rhodanese
cd00158433-529  RHOD
cd01531412-526  Acr2p
cd01446415-537  DSP_MapKP
COG0607416-528  PspE
cd01519436-487  RHOD_HSP67B2
cd01524433-460  RHOD_Pyr_redox
cd01521418-487  RHOD_PspE2
COG5105395-564  MIH1
PRK11784425-464  PRK11784
COG2897415-463  SseA


Ontology Information


   
HPRD ID2098
Molecular ClassDual specificity phosphatase
Molecular FunctionRNA binding (GO:0003723)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO