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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ADIPOQ 9370 Adiponectin, C1Q and collagen domain containing  3ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20331631   2010Cell line : -

Source : Memorial Sloan-Kettering Cancer, New York, Northwestern University in Chicago, Illinois.

Sample Type : Blood sample

No. of Sample : 441 CRC patients and 658 healthy volunteers and Case control study of 199 matched pairs of colorectal cancer cases and controls

Stage : TNM Stage I-IV

-Down-regulation-Adiponectin level may be a good biomarker of colorectal adenoma.

The adiponectin level in adenoma patients was significantly lower than that of controls on multivariate analysis (P = 0.04).

18827209   2008Cell line : -

Source : -

Sample Type : -

No. of Sample : 115 colorectal cancer patients

Stage : -

GenotypingPolymorhpism-The SNP rs266729, which tags the 5' flanking region of the ADIPOQ gene, is associated with decreased colorectal cancer risk.


Gene Details



Chromosome: 3; NC_000003.11 (186560463..186576252)

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Gene Type protein coding
Gene Family Endogenous ligands
Description This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]  
Chromosome 3
Location 3q27
Start 186842668  
End 186858463  
Strand +  
Gene Sequence

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Length 15796  
OMIM ID 605441   
HGNC ID HGNC:13633   
Unigene ID Hs.80485    
Ensembl ID ENSG00000181092   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011513324.1
Exon join(1..82,8439..8554,10384..10605,11517..15251)  
mRNA Sequence

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Length 4155  



CDS Information


   
Locationjoin(10392..10605,11517..12037)
CDS Sequence

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CCDS ID CCDS3284.1



Protein Information


      
Protein IDNP_001171271.1
Protein NameAdiponectin, C1Q and collagen domain containing
Molecular Wt. (Da)24982
Protein Sequence

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Length 244  
Uniprot IDP06733
Ensembl Protein ID ENSP00000234590  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KGlycosylation101
KHydroxylation101
KGlycosylation65
KHydroxylation65
KGlycosylation68
KHydroxylation68
KGlycosylation77
KHydroxylation77

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1012CDH133219NP_001248.1in vivo15210937   


Pathway Information


                                    
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
AMPK signaling pathway hsa04152
Longevity regulating pathway - mammal hsa04211
Non-alcoholic fatty liver disease (NAFLD) hsa04932
PPAR signaling pathway hsa03320
Type II diabetes mellitus hsa04930


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00110106-242  C1Q
cl00147106-242  TNF superfamily
pfam00386114-239  C1q
pfam0139142-106  Collagen
cl2294942-106  Collagen superfamily
pfam0139140-92  Collagen


Ontology Information


   
HPRD ID1555
Molecular ClassSecreted polypeptide
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO