CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CASP7	840	Caspase 7, apoptosis-related cysteine peptidase	10	MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
11381362	2001	Cell line : H T29 19A, HT 29 16E Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, Western blotting	Down-regulation	-	Immunohistochemistry showed downregulation of caspase 7 (22 of 26 cases) in colonic cancer samples compared with normal mucosa on the same tissue section. Caspase 7 deficiency thus appears as a new immunohistochemical marker of colonic neoplasia; its correction represents a potential basis for new therapies.
17848589	2007	Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncol?gicas (CNIO). Sample Type : - No. of Sample : - Stage : -	Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistoc	Down-regulation	-	-
12970753	2003	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 98 CRC and 50 GC Stage : -	Mutation analysis by PCR.	Mutation	-	We detected CASPASE-7 mutations in two of 98 colon carcinomas. Iinactivating mutations of the CASPASE-7 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human solid cancers.
20567846	2010	Cell line : - Source : - Sample Type : CRC tumo No. of Sample : 377 Stage : -	Genotyping	Polymorhpism	-	The RIPK1 and CASP7 polymorphisms can be considered as possible prognostic markers for survival after curative resection in patients with colorectal cancer. The RIPK1 rs2272990 in a dominant model and the CASP7 rs2227310 in a recessive model of the minor allele were associated with survival in a log-rank test.
22500158	2012	Cell line : - Source : Kyungpook NationalUniversityHospital(Daegu,Korea). Sample Type : - No. of Sample : 218 colon cancer, 179 rectal cancer Stage : TNM Stage I - IV	RT-PCR genotyping	Polymorhpism	-	None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer. In a previousstudy by Yoo et al. [17],significant associations between the CASP7 rs2227310 andCASP9 rs4645981 polymorphisms and prognosis were found in 411Korean patientswith early stageNSCLC. It remains to be elucidated whether or not the CASP7 rs2227310C?G polymorphism itself affects protein characteristics ,interactionsites, or protein solubility or stability,this polymorphism was associated with poor survival outcomes for patients suffering with NSCLC.

Gene Details

Chromosome: 10; NC_000010.10 (115438921..115490668)
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Gene Type	protein coding
Gene Family	Caspases
Description	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Chromosome	10
Location	10q25
Start	113679162
End	113730909
Strand	+
Gene Sequence	>gi\|568815588:113679162-113730909 Homo sapiens chromosome 10, GRCh38.p2 Primary Assembly AACAAATATTTCCCGAAAGATCCAGGAGCAGCATCTCCACCAGCAAGCTGGGCTGCTGGGTGGGTACTTC CTTCAAAGCTGAGGGAGCGTCCTACGCCCACGCGCGCAGGAGGGCGCCCCCCGCAAAGCAACGTCTAGGA GACCACAGTGGATGCCACAGCGGGCCCGAAGCGGATCAGCCTTGTGGGGTACGCATGCTAATGTAGGCGT GGAGTCCCCCAGGGGGACGCCAGCAGTTCCAGCTGGGATCCAGGTTTCGCTAGGGGAGAGCCTCTGGCTA TGGGAAAGGGGTCTCCGAGTTGATGTGAAGGCCCAGGTCGAGGTGTACACTGGGGGCGGGGAAGTGGAGG TGACCACACGAGCGCCCCATCACTGAGCGCCGCCGCGAAATCTGCGCTCTTTGGGTCACTTGGAGCGCGG CCAGTTTGGCAGATTTGTTTTTTTCCCGGAACAACCCGCGGCGGCTCGGCTGTCCCGGGAAACTGCAAAC TTTGCTGTGCGCGTTCTCCCGCGCGCGGGCTCAACTTTGTAGAGCGAGGGGCCAACTTGGCAGAGCGCGC GGCCAGCTTTGCAGAGAGCGCCCTCCAGGGACTATGCGTGCGGGGACACGGGTCGCTTTGGGCTCTTCCA CCCCTGCGGAGCGCACTACCCCGAGCCAGGGGCGGTGCAAGCCCCGCCCGGCCCTACCCAGGGCGGCTCC TCCCTCCGCAGCGCCGAGACTTTTAGTTTCGCTTTCGCTAAAGGGGCCCCAGACCCTTGCTGCGGAGCGA CGGAGAGAGACTGTGCCAGTCCCAGCCGCCCTACCGCCGTGGGAACGGTAACTGCAGCCCCCACCTCGGC CGGCGCCTCTCCAGCCCGCCGGCCGTGCGCGCCTTGCCTCCCTCCTTCCTGCCGGCTTCCTAGTTCCCCC CTGCGCCCCCAGCGTGGTCTAGGGGAGCCTGGTTGAGTGGGACTGAGTGGCCCCGACGGCCTGCGCTGAA ACTTTGGGAAGAGGGCCCGTTCCGCTCTCTCCATCGCTTGCCTTGCTCAGCTTGTCCTCCCTTCCCTCCT AGCCGGGGGGCTAGGGGACACCTCGTACTATTCGAGATTTAGGAGAGGAGGGCTCGTGATCTGGCACAGC GGCTAACAGCGAGGGCTCCTTTGCCTGCGTTCCGGTCCCCACCCCTTGCCTGCCGGCGGTGGGACCTCAA CCCTCTCTCTGTTAAATGGGAACCACGGTGATCCCCGCAGACTGTTGGCGGGGATGGACAGAGTTGATTA TGGTACGCGTTTCGCGGCAGTGGCTCTGTCAAGTCTGAGTACACTGGAGCTGAGCGTCCTTGCTGCAGGG CTCTTAGAGGGACCTTGAGGAGGTGGAAACCAGGCAGGAGACATTTAGACGTGTGGAGTGTTAGGCTCCA GGTGACAGCTTTGCGGTTTATGGAGCAGTAAAATTACTTGTGGGTGATTGTGGGTGTATCATTTCCAGAT CTTTATTCTTGAACTTCTGGGCTCCTGGGCTAGTTGACGTGGCCCTCCCTGTTGTCTCAACTTACAGGCT ATTTCCTCCTTTTGGGTCTCGCCGGCCTGACCTTCACCCTTGGTACCGCCATTGCCTAGATTCACAGTCC ACCTTCTGCCACCTGTAAACTGTGTGGCTTTGGACAGGTTACTTAACGTCTCTGAAGAAGCTAAAGTTTC TGCAATAGCAAAGTAAAGGCCCTGGTCTAGCAGTGCCATGAGCCTTGGGTGACGCAGCGGAGCGCTTGAG TGCCCAGCAGAGCCTCCCTTTCCCCCTCCCAGCTGCTAGAGGCAAGAGGGGGAGGTTTTCAGGTCTTCTC TGTGTGCCCTTTAGGAAGATTTTTATTTGGGCAAGAAGTGAGTCACAAATTGTATGATGTCACTTTTCAG GGGAAGCAGCTGCAGTCCATTTCCCCCTTCATGAAAGTAAAAAGTTCAGACAATAGCTGGGCAGTGACTT CTTACCCAGCTGTGTACCAGTTGCCCCAACATGTGGGCTCCTGTTCAACATGTTTAGAAATAATCACTAC AGGAACTTTTTTTCAGTCTCTACAAAATCTTTTTAAAATATGGATGTGGTTTTTAAATATCGGCAAAGGT TGACAGTTGCATATTATCTTAGTCTCGTGGGCAGTGGTGATAATGGGAATATTTCTTGACTATTTAGATT GTGCCACCTAGCATTTTACATGCATTGTTTCATTCATCCTCCCAACCACCTGTGACATAGGTACTGTTGT TTTCCCATTTTACAGATGAGGAAACTGAGGCTTAGAGAGGTCGAGCACTTTTTCTGAGGTCCCATGGCTA ATATGTGGAAGAACTGATTCAGCCCCAGATCTCAGGGTTCTCAACCACCCTCTTGGGTCTCCTTGGTTCT GCTGTTTGGACAGCAGTTTATTGAAGGGGCTGAAGGATTTGAAAATACATTTAAGTTAGATTTATAAAGA AAAATGGATTTGGTGCCTGCCATGTACCTGACATTTTTCTATGATTAAAAAAATGATTAAGATGAGGTCT CAGTCTGCAAACAGTGACAATCTTGGTGGCTAATAGTAAGAATAAGAGTTACAGTGACTAACCAAGACTT ACTATGTGCCTATCATTGTTAGTGCTTTGAGTGTCTCATGTATTAATTTATTTAAAGAGAAGTTAGACAT ATTTAACAGTGGGATAAGCAATCTCCCTCAAATGACTGCTCTTTGCAGCCTGGACCTTAAAAAGGGGACA GATATGAGAAAATAATGCCATGTGTACCCTCTACGGACAGCTTGGCAGAACTGAGATAGGTCTGGATTTT CTTGGTGCACTGTGATGATGAAAGGAGGAAATAAGAGGTCAAAACCAGGTCTTGGTTTGACTGAAATGAC GTGTCTGAGATCAGGCATTCCCCACTTGGTTACCACCCTGGGCTATGATCGCTCTTTGGAGGTTCCAAAA ATCAAGCCCAGTCTCATAGGAATAAGAAAGTAACTAATTGTTTAGCTTTACAGATTTGAAAGAGCCAAGT CCCACCACTGCTGACTTGGATTGTTAGAAGAGACACTTTCTGTCACTGCAGACAGTGTTCAGCATCAACC CAGAAGGATGCGGTAGGTTTCAGACAGAAGACCTAATGGCCTACTGTTTGGAGGGAAAGTTCTAGAAAGC GTCCCATCATTGAGCCACAGAAATCAGCCTGAATTTTACATCTCAGTAGCTAAGTCCAAAGCCCTCTCTT AGTGTCTGAGAAGGATGAGTTTAAGCTATACCCATCCTTTGGTGGAACATTTCAAATGTTTAATGAGTGC ACAGTTCTCTCTGCCTGCATCGCTCCCACCTACCCTCTCTGCTTCCCCCTTTTCAGTTCTCAGGTCAGAC ATTTCCTCCCCTGAGGAGTTTCCCTAATTTCTGTGAGGCTCTTGAGTTTCCCTGGTATGGCTACAGATTG TTCACCCTCAAGGCATACACCACAGTTGCATTTCAAACTAGACGCCATCCTTTTTTTCATGTCTGTTTCT CAACATGGCAGGACCAGGTCAATTTGCTCACAAGTATATCCCTAATTCCTAACTTCTAGTAAATATCCAT TGAATGAATGAAGAAGAGTCTCCAAAAGTCTCAGCAGTCCCAATAATATCAAAACAAAGGCTTGGCTTTC TTAGGAGCCATTTTGCTTAGGGTCTTCCCCTTTTTCAAAACCACTTTATTAAGGTATAGTTGAAATATAA AAAGCTAGGCATAGTTAATGCATGCATACCTACCAAGTTTGGAGATAAGCATAGATACACCCATGAAATC ATCACCACCTCAACAAAGCTACCACCTCCTAAAGTTTCCTCCCACACCGTTTAATGCTATTATTACTATT ATTTTTATTACTACTATTTTTTGAGGTGGAGTCTCAATGTGTCACCAGGCTGGAGTGCAGTGGCGCAATC TCGGCTAACTGCAACTTCTGCCTCCCGGGTTCAAGCGATTCCCCTGCCTCAGCCTCCCAAATAGCTGCGA CTACAGGCATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGG CCAGGATAGTCTCAATCTCTTGACCTTGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATCACAGG TGTGAGCCACCATGCCTGGCCAAAACTAGTATTTTTTGTGTGGTAAGAACATTCACCATAAGATCTACCC TTTTAGCAAATTGTAAGTATACCATATAGTATTGTTAGCTATGGGCACTATGCTATATAGGAGATCTCTA GAATTTATTCATCTTGCACAACTGAAACTGTGTACCCTTTGACTATCACTTCCCCATTTCTTCCTCGCTG CCCCCACCCCCAACCTCTGACAACCTCCATTCTATTCTCCACTTGTATGAGTTTGACTCTGTTAGATTCC ACATAGATGTGAGATCATACAGTAATTGTCTTTCTGTGTCTGGCTTATCTCACTTAGCGTAATGTTCCTT AGGTCCATCCATCTTGTCACAGATGGCAGGATTTCCTTCTTTTTTTATGGCAGAATAATATTCCATTGTG TGTGTATACCACATATTCTTTATCTATTCATTCATTGATGGACATTTAGATTGTTTCCATAATGTTACAG TGAATGTGGGAGTGCAGGTATCTTTTTGAGATCCTGATTTCAGTTTCTCTAGATATATAGCCAGAAGTGA GATTATTGGATCATATGCGATTTCTAGTTTCAATTTTTTGAGAAACCTCTAGACAGTTTTCCATAATGGC TGTACCAATTTATATTCCCACCAACAGTATAGAAGAGTTCCCTTGTTTTCACATCCTTGCTAACACTTAC CTTTATACACACACACATATATACATACACATACACATTATATATGCATATGTGTATGTGTATACACACA CACACACACACATATAAAATAGCTATCCTAACAGTTGCGAGATGATATCTTATTGTGGTTTTGCTTTGCA TTTCCCTGATGATTAGGAACATTGAGCACCTTTTCATATACCTGTTGCCCATTTGTATGTCTTTAGAGAA ATGTCTATTCGGGTTCTTTGCCCATTTTTTTAATTAGATTTTTTTTTTTTTTTTTTTTTTTTGCTATTCT GTTGTGTGAGTTCCTTGTGTATTTTGGATATTAACCCCTTTTCAGATATATGGTTTGTAAATATTTTCTC CCATTCCATAGGTTGCTTTTTCGTTTTTTGTATTGTTTCCTTGCTATGCAGAGCTTTTTAGTTTGGTGTA ATCCCACTTGTTTATTTTTGCCTTTGTTGCCTGTGCATTAGCATCATATGCAAAAACTCATTGTCAAGAC CAATGTCAAAGAGCTTTCTCCCTATGTTTTCTTCTAGCAGTTTTAAGGTCTCAGGTCTTATGTTGAAGTC TTTAATCCATTTTGAGTTGATTTTTTTGTATGGTGTGAAATAAGAGTCTAGTTTTATTCTTTTGCATGTG GATATCCAATTTTCCCAACACCATTTCTTGAAGAGACTATCCTTTCCATATTGAATATTTTTGGCACCCT TGTCAAAAATTAGTTGACTGTAATGTGTGGGTTTATTTCCAGACTCTCTATTCTGTTCCGTTGCTCCATG TGTCTGCTTTATGCCAGTATCATACGGTTTTGATTACTATAGCTTTGTAATATAATTTGAAGTGAGGAAA TGTGATGCCTCTAGCTTTGCTCTTGCTCAAGTTTGCTTTGGCTATTTAGGGTCTTTCGTAGCTACATATG AATTTTATAATTTTTTTATATGTCTGTGAAAATGCCATTGGAATTTAGATAGGGATTGCATTGAATCTGT TCAGTGATCAATTTGAGCAGCATGGACATTTTAACATATTAATTCTTCCAATCTATGAACATGGAATATC TTTCCATTTATTTATGTCTAATTTCTTTCATCAGTGTTTTGTAGTTTTGTTGTTCTGGCTCAAAGAAGAG CAGTGTGTTGCTTAATTTCCACATATTTGTGAATTCTCTAATTTCTCTCCTGTTACTGATTTCTACTTTC ATACCATTTGTGGTCAGAAAAGATACATGATATGACTTTAATCCTCCTAAATTAATTAAGACTTGTTTTG TAGCCTAGCATATGATCCATCTTGGAGAATGTTGTGTACACTTGAGAAGAATGTGTATTTTGCTGCTGTT GGATGAAATGTTGTATATATGTCTGTTAGGTCCATTTGGACTAGTGTTGTTCAAATCCACTGTTTCCTAA TTGATTTTCCATTTGGATGAAATATCCATAGTTGCAAGTGAGGTTTTGAAGTCCCTTACTCTTATCTATT GCTATTTCTTTCTGTAGTTCTATTAATACTTGTTTTATATATTTAGGTGTGCTAATGTTGATGCATATAT ATTTACAGTTGTTATGTCTTTGGTAAATTGATATCTATAGTTATAATATAATGACCTTCTTTATCTCGAA AGTTTTTTACTTTAGTCTATTTTGTCTGATATAAGTATAGCCCCCCCTGCTCTCTTTTGGTTACCATTCA TATGGATTATCTTTTTATATCCCTTCACTTTTAGCCTATGTGTGTCCTTAAATCTAAAGTGAGTCTCTTG TAAATATCATGTAGTTGGATCTTATGTTTTTACTCTATTTAGTCACTGTATGTATTTTGATTGGATAACT TAATCCATTTACATTTAAAGAAATTATTGATAGGTAAAGGGCTCACTGTTGCCATTTTGTGATTGTTTTC TGACTGTTTTATAGTTCATCTGTTTCTCTCTTCCTCTCTTGCTTCCCTCCCATGTGATTTGATCATTTTT TGTAGTGATATGCTTTGTTTCTTTTCTGTATATATTTTGCATATCTACTACAGATTTTTGCTTTGTTATT ACCATGAGGCTTACACAAAACATCTTATAACGTTCTATTCTAAGTTGATAACAACTTAGTCCATTTGGGA TGCTATTACAAAATACCCTAAACTGGGTAGCTTATAAACAACAGAAATATATTTCTTGTAGTTCTGGAGG CTGGCATGTTGAAGATCAAAGTGCTAACAGCATCAGTGTATAGCGAAGTTTCATTTCCTTGTTCATTTAT TATATCTTATCACATGGTAGATAGGGCAGGGCAGCTCTCTTTATATAAAAGTGCTAATCCCATTTATGGA GCTTTACCCTTTTGACCTAATCATACCCCAAATGCCCCACCTCCTAATACTATGACATTGGTGAATAGAT TTCAATGTGTAAATTTTGGGGGGTACGTAAACATTCAGACCATAGCAACAACTTAACTTCACGCACATTC AAAAATTCTGCAGTTTTATTCTCTCCTTCCATGTTTTATGTTATTGATGTCACAGTTTACATTTCTTTAT ATTGTATATCTATTAACAACTATATAGCTATGGTTATTGAAGCTAGAGTTGTTTTTAATACTTTAGTCTT TTAACTTTAGTAGAGTTCAAAGTGATTTATGCACAGCTAATACAGATGCTCCTCAACCTATGATGGGTTT ACATCCCTATAAACCCAATGTAAGTTGAAAATATCATAAGCTAAAAATGCCTTTAATGCAACTAATCTAT TGAATTTCAGAGCTTAGCCTAGCCTGTCTTAAACATGCTTATATCACATTAGCCTACAGCTGGGCATGAG AATCTAATACAAAGCTTATTTAATAATAAAGTGTTGAATATCTCATATAATTTATCAATACTGTACTAAA AGTAAAAACAGGATGGGTGTATGGTTACTTGAAGTATGGTTTCTACATGATGTGTTTTGCTTTTGCAGCA TTGGAAAGACAAAAGATCTTAAGTAAAACCATTGTAAGTCAAAGACCACCTGTAAATTATTCACATATTC TGGATTTGACTATACACTTACTTTTACCAGTGAGTTTAAAGAATGTCCTTTCATTTCAACCTGAAGTATT CCTTTTAGCATTTCTTGTAAGGCAGGTCTAGTAGTGATGAACACTGTCATTTTCATGTGTCTCAGAAAAG TATTTATCTTTTCTTCTGAAGGACAGCTTTGCTGGATATAATATTTGTGGTTGGCAGTTTCTTTCTTTTA GCACTTTGATTATATTATCCCACTCTTTCCAGGCCTGCAAGGTTTCTGGTGAGAAATCCACCAGATGGTC TTATGGACATTTCTTTGTATGTAATGAGGTGCTTTTCCGTGTGTGTGTGTGCATGTGTGTGTGTGTATGT ACATGTATACATGTACGTACATATATATGTATGTACATGTATACATGTACGTACATATATATGTACGTAC ATATATACATGTACATACACACACGTATATATCAATAGCTTTTGGAGTACAAGTAGATTTTGGTTACATG GATTAATTGTGTAGTGGTGAAGTCTGAGATTTTAGTGCACCTGTAACCCAAGTAGTGTACATTGCACCCA ATATGTAGTTTTTAAAAATCCCACATCCTCCTCCCACTCTCCCCTCTTCTGAGTCTCCAGTATCCATTAT ACCAATCTGAATGCCTTTGAATGCTCATAGCTTAGCTTCCACTTACAAGTGAAAACATAGATATTTGGTT TTCCATTCCTGACTTACTTCACTTAGAATAATGGCCTCCAGCTCCATCCAAGTTACTACAAAGACATTAT TGTAATGTCTCCATCTTCATTTCTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCCTTTC TTTCTTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCCTTTCTTTCTTTCTTTCCTTC CTTCTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTTCTTTCTTTTC TTTCTTTTTGAGACAGAGTCCCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGC AACCTCCACCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGCTGGGACTACAGCCGTGTGCC ACCATGCCTAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCAA TCTCTTGACCTATGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACGGGTGTGAGCCACTGTGCC TGGCCCTCCATCTTCATTTCTGATTTAGCTTATTTGAATGTTCTCTCTTCTTTTATTGGTAAATCTAGCT AATGGTCCCCTGAGTTTATCTTTTCAAGGAAGCAACTTTTTGTTTCATTGATCTTTTGCATTTTTTGTTT CAATTTCATTTATTCTGCCTTGATCTTTGTTATTTTCTTCTGCTAGCTTTGGGTTTGGTTTGTTCTTGCT TCTCTAGTTCCAGGAGGTGTGACTTTAGGTTGTCAATTTGTCATCTTTCAGACTTTTTGATGTAGATATT TAGCACCACAAACTTTCCTCTTAGCACTGCTTCTGTTGTATCCCAGAGGTTTTGATAATGTGTGTCACTG TTATCATTCGTTTTGAAGAATTTTCAAATTTCTATCTTGATTTCATTGTTAACCCAAAAATCAGTCAGGA GCAGACTGTTTAATTTCCTTGTTTTTATATAGTTTTGAGGGTTTCTTTTGGAGTCGATTTCTAGTTTGAT TCTGGTGTAGTCTGAGAAGATACTTGATATGATTTTCATTTTTAAAAATTAATTGAGACTTATTTTGTGG CCTATCACATGGTCTGTCTTAGAGAATGTTCCATATGCTGATGAGAAGAATGTATATTCTGCAGTTCTTG GGTAGAATGTTCTATAATTATCCGTTAGGTCCATTTGTTCTGGAGTGTAGTTTAAATTCAGTGTTTCTGT GTTGACTTTCTGCCTCAGTGATCTGTCTAGTGCTGTCAGTGGAGTATTGAAGTTCTCCAATATCATTATG TTGCTGTCTATCTCTTGTCTTAGGTCTAGTGGTAATTGTTTTATGAATCTAGGAGCTTCAGAGTTATGTG CATATATATTTAGGGTTATAATATCTTCCTGTTGGGTCAATCCTTTTATCATACTTTCTTTGTCTTTTTG TTTGTAAACTGTTTTTCTTTAAAGTTTGTTTTATCTGATATAAGAGTAGCAACTTCTGCTTGCTTTCGGT TTCTATTTGTGTGGAGTATCTTTTTCCACCCCTTTACCTTGATTCTATAAGAATCCTTTGTATTAATTAG CTCAGCTTCTTGAAGACAGCAGACATTTGGTTTGTGATTTTTTTTTTAATCCATTCTGCCAATCTGTATC TTTTAAGTGGAGCATTAGGCCATGTACATTCAACATTAATATTGAGGTGTGACCCAATCATCATGTTGAT TGTTACCTGGATACTTTGTTTTTTTTATTGTGTTATTGTTTTATAAGCCCTGTGAGTTTTGTGTTTTTGA GAGGTTCTATTCTGTTGCATATTGACCTTTTATTTCAGCGTTTAGAATTCCTTTTAGCATTTCTTGTCGG GCTGATCTGGTAGTGGCAAATTCCTTCAGCATGTGCTTGTCTGAGAAAGACTATATCCCCTTCATTTATG AAACTTAGTTTTGCTGTATACAACGTTTTTGGCTGAGAGTTATTCTGTTTAAGGAGGCTAAAAATAGGGC CCCAATCCTTTCTGGCTTATAAGGTTTCTGCTGAGAAGTCTACTGTTAGTCTGATAGCTTTTCCTTTGCA GGTTATCTGATACTTCTGTCTTACTGCTCTTAGAATTCTTTCCTTCATGTTGACATTAGTAATAGCCTGT TGACTGTATGCCTTGGAGATGTCCATTTTGCCATGAATCTCCCCGAAGGGCTTTGACCTTCTTGTATTTG GATGTCTAAATCTCTGGCAAGGCTAGGGAAGTCTTCCTCAATTATTCCCTCAAATAAATTTTCCAAAATT TTTACTTTTTCTTCTCCCTCAGGAACACCAGTGATTCTTAGCTTTGGCCATTTTACATAATCTCATATTT CTTAGAGACTTTGTTCATTTCTTTTAGTTATTTTTTCTTTATTTTTGTCTGACTGGGTTTATTCAAAAGC CTTGTCTTCGAGCTCTGAAATTCTTTATTCTACTTGGTCTAGTCTGTTGTTAAAACTTTCCACTTGTTTT GTAACTCCCTAAATGTGTCTTTCATTTCTAGAAGTTCTGATTGTTTTTTTTTCCTCTAAAGTATCTATCT CTTTAGAAAAATTTTCATTCATATCCTGAATTTTTAAAAAACTTTCTTTATATTGGTTTTCACCTTTTTC TTGTATCTCCTTGGGTAACTTAATAATCAACCATTTGGATTCTTTATTTGGTATTTCCAAGATTTCATCT TAGTTTGGATCCATTGCTGGAAAGCTAATGTGATCTTTTGGGGGTGTTATAGAACCCTGTTTTGTCATAT TGCCAGAATTATTTTTCTGGTTCCTTCTCATTTGGATAGACTGTTTCTTCTAATTATTTTTGAATTTATT TTTGATTCAACCGTTTCTTTCTAATTTCCTTTTTTCCACCTTATGGATGTGACTTCAATGATTATAGCTT ATTGTAACCTAATTTGGCTCTGGGTGCTTTTGGCGGTGAAGACTCTGTATAAGTTCCTTGGTTATAGAGA GTCTTTGTATGATGGTTTTCTCAGATGTAGTAGCAATGTGCTTCGTGTGTGAGCAGGTTGACTGTCTCTT GTGGGGTTGGAATGGCAAAAGTCTCTGAAGCTCATCCCCAGTGGTGTGCACTTATTTATTTATTCATTTG TTCATTCATTCATTCATTCATTCCTCCAGTATTACTGGGTTGAACAGTTCAGGCTTCAAGTCAGTATGGG AGTTGTCCCTGGGTAAAAACTGGGTGTGCCTAAAACAGGTAGATAAATACAATACCTAATGGAGGGCAGA GGTCCCAGCCTTGACGTAGGCGGCTGGAGAAGCTGTCATTGAAAAACACTGAGGTCTTTTCAGGGGGAAG GAAGGGGCTACCCCAGCTCCCATCCCAGGCCAGCAGGAGAAAAAACTGCCTCCCATTCACACTCCTGACC CAGTGTTCTGTCCATTCAAACCAGGCAGACACCACTTTCCAGCTGCAGAAATACTGATGTTCCATGTAGA GAGGGATTATAATTACCCCTCATGCAAGCCTGAACCTTGAGGGCACTTGTCCTATGAGGATGCAGTCACC CTGAAGTGTTCTAGAAAGGCTGTCTACAGATGCACCCATGCCACGCTCTTGTGGGAGAAGCCCAAGCTGT AGCTGCAGTGGTGGGTGAGGAGGAAAAGTCTCCTTCTCCAAGACCTGTCACAAGCACCAGGGATGCCTGA CTGTTGTAGTAGAGCCACAGACTTTCCCTTCTGAGTTCAGCATTGCACCTGTGCCTCTGCTGAAAAAAAC TTCCCACAAGCAGAAAGCTATGGGACTCAAGCTTTGCCATCTGGATTCTTTTGTCCCATGGGTTACTCCT TTGATGTGGTGCACTCCCCCTTCCCCTAGGAGTAGGAGCCCTGAGGGCCAGACTGTTGTGAATGCTGCTG CTTCTCTGGGTCTAGCCACCCAGTGGGGCTGCCACACTCCAGGAAAGTGCCGGGGAATGTCTGCAGGGGG TCCAGTGATGCGACCTGCCCTCAAATTTCCAGCAGTAGGTACCAGCATCTGTTCTGATGGGGGTGGCAGG GAAGTGACATAGACTCTGTGAGATTCCTTATAAATAGCCTTAGTGTGTTGGCTTTCTCACACACTAGCTA TAGTAGGAATGAACTGGTCATGTGGACAGACTCAGGACCTACTGATTAGCTGGGGGTAATGCAGGCAGTG GTGACAGATGGGGTCATGCGTAAGTTTTCTCCTTCCTGGGTGCTATGTTATTCTGCCAGCAGATGCTGTA ATGGACTGTGTTGGTTGGCCTCCAGGCAGGAAGTGGCACTTGGAAAAGAACACCAGCTGCGGTGGTAGCA GTGGGATTTGTGCTTCTTATGTTACCCAGGTGAGGTACTCTGGTGTCTCAGACAATGCGTGAGGCCATAG AGCTTCCCAAAGTTTCTGTCCTTTGTGTTAAGCTATGGAGTAGGGGGTAAAGGGGCAAAGCCAGGTGGGG GCTGGGTCACGTAAGTACATGCTATGGCTCTCCATGTGTGGGCTCAAGCAGAGGCCCCAGTGGGGATAAG AGGGCAGTCCTCTTGCCGCAGGGGTAATGTTCCAGGGAGGAGTGCAACTGCCTGTGCTGCACAGAAAGTC CACACAGGGAGTGGGGAGTAGCAGGTGACAGTAAGCTCTGCCCAGTTCCCATGCACTTGGCAAGGTAGGT CTCACACCGGTAGTGTTCCACTAGTAGCAGCTAGCTAGGTTCCAGGCATTCTGCTCTCAGAACTCAAAAC TGCCCCAGGCCATAAGCCTTCCCAGTTGAGACATACCATGGCTTTCAGGCCACGCCCCTTCTGGTCTGCC TGAGAAACAAAGGTACCCAGCTCTTGTGCTCGTGAGTATAACCCACTGCCCACTCACCCCTCGGTTCTGG CCAAGGGGGTTCATCGTCACTCGAGATTATATCACAAATGTCAATTGGGAACCTCTCTCAACCTATGACA GACTACTGAGTTTGCTGGAAGATGTCCACAAGGTCACCTGTGAGGTAGGACCTGGAATGACTTCCTTCTA TCCCTGCTGGAGACCGAGAGCACATGCAATGCACATCCCAATGCTATTCCTTCTCATGTATTCCCCAGTG CTCACTAAATCAGCTTCAGTGCTGGGTAGGGTTAAGACCTTTCCCTGTGGCCTGGATTGCCAAGTTCTCC AGTGGGAATGTATGTCCCAGAGACAGTTTATCCCCCTCACACTCCAGGGACTTAGAATTTTCTACCTGGT TCACAGTATAGGCTGCAGCCCACCACTTCTTTCAAAGGCTCTGTGGTTTCTTTCAGTTTTCCTATTAAGT TCCTGTGTTGCTTCTTGGAAAAAAGTACACAGCATGAATCTCTACACACTATTTTATCTTCCCAAGTGAG AGAGGCATGCTAACAATGCCTCCAATCTGCCATCTTGGAAAAAAATCAGTTGCTTTTCTTTTGCTGCTTT CAAGATTTTCTCCTTATCTGTTTTGACTCTTACCAGTGATTGTAATGTGTCTCAGTGAAGACCTATTTAT GCCCAATCTGTTTGGGGTTCTTTGGGCTTCATGAATCTAGATGTTCCTTTCCCTCTCCAGATTTGGGAAG TTTTCTGTCATAATTTCTTTAAATAAACTTTCTACCCTTTTCTCTTTGCTCCTTCTGAGACACCGATACT GCATATATTGGTTCACTTGATGGTGTCCAATAAATTGCATAGGTTTCTTCACTCTTTTTCATTCCTTTTT CTTTTTGTTCCTCTGACTGATTAATTTCAAATGATCTGTTTTCAAGTTCACTGACTCTTTCTTCTGATTG ATCAAGTCTACTGTTGAAACTCTCAATTGAATTTTTTATTTCAGACATTGTATTCTTCAGCTCCATAATT TCTGTTTCGTTCATTTATTGGTTTTTATTTCTTTGTTGAACTTCTCATTTTGTTTATTTGTTGTTTTTCT GATTTCATTTATTTGTCTGTCTGCTCTCTTGTTCCTCACTGGGCTTTTTTAAGATGATTATTTTGGATTC TTTGTCAGGTAATTCATAGATCTCCATTTCTTTGGGATCAGCCACTGGAGCTTTATTTTGTTCCTTTGGT GGTGTCATATTTCCTTGATTATTTGTGTTCTTTGAAGCCTCGCATTGTGTGTTCACACTTGAAGAAGCAG TCACCTCTTCCCGTCTTTATTGACTGGCTTTAGGAGAGAAAGACCTTTGCCAGTGAGCTTAGCTAGAGAT TCTGGGGATCTCTCACACTTTTTCTCTAGATATACCTGCTCCACACCTCTTGTTCCCTCTTTGGGATTAT ATGTGTTCTCTCAGTCCTGCAAAGGCAGACCTTGTGCTAAAAGCCTCCTGCTTATTCCTTAGGGTAGTAC CCTGAAATGTTCAAAGTTATATGTCTTCTCTCAATCCATCAAAGTTGAGCTGGCTGCTAATATCCCTACC TGCTGTTGAGATCCAAGCATTGTCTGTGGTTGTGTACAGACTGTTGTGCACTGAGGTACATATCAGCTGG TTGAAGGGGTACATAGGCAAGTTGTCCTGCAGGGTTTATGGGAGGGACTTAGGGTAGCATCCATGAGCTG GGTAGCAGAATCTATAGCCGGCTTTTGATAACCATACACTATTTGCACTCCTGCTGCTGCTTCTCCTTGC TCCTGGCTGCCCCAGACGATTCAGCCGTACTATTCCCCTCAGTGTTCTGGGTGGGATGAAACAGAAGTGG GTCTCCTAGACAACATCCTTTTGGGCTGGGAAAGCTGGGTGCTCACTTCACTCTCACTTCCCCCATGGGA GAATTGTGAGCTGGAGGGACCTCTCTTGGAACTGAGCTGTGCCACCTTAGGGGAGGGGTGATGTGGGTAA AGTGAGCTGCTCTTATTATACTCTTTGATGCATCCACTCTTCGATTTTTTGCTCCACCAGTGTGCTGAAA CCTCTCAGTGGACTCCTGTGGCCTCACAAAAGTATTCTTGTCCATAGGTGTAGTTGCCAAAATCAGTATT TCTATATAAGAATGAAAACTGGAACCTCCTATTCCGCTATCACACTGACATTTCTTCTTTCTTTTAAAAA TAGTGGTTATATTGTGTTGTCATCATATACCCTAGATTGAGCCTTTAAGATTAACTTTAGCAAAAGGGCC AACTTGATTAACACCACATATCAAAGTTAGTGTCTTTGTCTGGTGGATTTTTTTAAAACTTTGACTTACT AGTTTTGAAAATATGTGAGTGTGTATTGTGTTAATAACAGTCTATATTGGAAAGTAACTAAGTCTATGTA AAGGAGACAAGAGAGGCTATCAGGTATTTTCTGCATGTGTGGCCTTATGCTTATCTCCTCTGTGAGTTAT CTCCATTTTTGAGAAACTTTGGGTTCTAATCTGAAAAATCTGCCTCCCAACCAGAAACACATTGGTGATG ATGAAGGGAGGCTCATGATGTGTTGAGAAACAAGGTGACCATCTGACTTCCCATGGTCATTGTAGAGACC TGGCAGTAGGACTTTCCCTTCTTAGCTCCCTCCCCTCTTCCCAGTTCACCCTCAGATAAGCTGGAAGGTG ACACCATAATGCCATTCGGAGTGCAAGGCCACTAGGTTGTCACTTTGCCTCCTTGGACACCTCCTTCTGA ACTGCATTCCTTCTCCCCACCTCCAAAAGTTATTACTTGTGCTCAGCGGCACAAAATATTCTGTAAAGTA GATGCCTTCTTGTTTTCCAACTTAATGACAGCATCCCTGGGTGAGCCCTAACTGGAATACAGAACTGCAC CTGACAACCGCGGCCTGCTCAGTGAAGTTGCTCAGGGATTGTATCAGAGGCATTTGAACCGGAGCAACTC CATATTGAATAGGGGCTGGGTAAAATAAGACTGAGATCTACTGGGCTGCATTCCCAGGAGGTTAAGGCAT TCTTAGTCACAGGATGAGGTAGGAGGTTAGCAGAAGGTAGAGGTCATAAAGACCTTGTTGATAAAACAGG TTGCAGTAAAGAAGCCAGCCAAAACCCAGCAAAACCAAGATGGTGACAAGAGTGACCTCTGGTCACCCTC ACTGCTCATTATACACTAATTATAAGCCATTAGCATGCTAAAAGACACTCCCCCCAGCACCATGACAGTT TGCAAATGCTATAGCAATGTCTGGAAGCTACGCTATATGGTCTAAAAAGGGGAACTTCCTTAGTTCCTGG AATTTCCCACCCCTTCCTTGGAAAACTTGTGAATAGTCCACCCCTTGTTTTAGCATATAATCAAGAAATA ACTATGAGTATCCCTAGTCCAGCAGCCTAAGCTGCTGCTCTGCCTATGGAGTAGCCATTCTTTTATTCCT TTACCTTATTAATAAACTTGCTTTCACTTTACTCTATGGACTCACCCTTAATTCTTTCTTGCGCGAGGTC CAAACCCTCTCTTGGGGTCTGCATCAGGACCCTTTTCTAGTAACAGTTGGGACCAGGTAGAAATTGGAGT CTGAAGTTTCTCTTTATTCCTGAAAGTTGATCCCTGATCCCTTCATGGGGAAGAAAATGGGACTTGATTT AGGAGAAGTGATTCTAATACTGGCCAGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCA GAGTTTGAGACCAGCCTGGCCAACAGCCTGGCCCTGTCTCTACTAAAAATACAAAAAAAAATTAGCCAGA TGTGGTGGTGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAG GCGGAGGCTGCAGTGAGCGGAGATCACACCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCCATCT CAAAGACAAAAAAAAAAAATGATTCTAATACTGGCTCTGCCTTGGGCCAGCCACATCACCTTTAGCTAAT TCTTTCCCCTTAGGGTGTGTGTTTCATCCAGCCTTCCATTCAATTAAATATTTTAGTAAGCACCTTCTGT GTTCCAGCTACCTCTGCCATAATGAACTTATATTGTCTTATAGGAGCCAAACAGCAGAGCGCAAATAAAC AAGCCACATACGAAGGCTATGCGGGAAATGAAGGCAGAGGGTGGGGGTGGAAAGGGCCAGGTAGTAAATA TTTTTGGCTTTGTGGCCATCACTCAACTCTGCTCGTAGAGAGGAAACAGCCATAGGCAATACATAAATGA ATGGACATGGCTGTTTTCTAGTACAACTCTATTTACTGAAACAAGTGTTGGGCCATAGTATGCTGATTCC CAGACTAGATCAGAAAGGGCCTTAAAATCCAAGGAGATGGCTTTAGATTTGTACTTATAGTTAATGGGGA TCTCTTGAAAATTCTCAAGCTGGAATGTAATTTGATGGAAATCTATTTTGTGTAGAACCGTGTAAAAGCA TCTGACATAGAAAGAGAGCCTAATACCCCAGGTTGTCGCTGCTTTTGAATTGCGTATGAGCACTTTGTGA CCTGCTAGGAATTTAGGGGGAAATTTTCATTGTTGTAAACCTTGACAGACCTTCCACTGTTTCTTGTATG CAGTGAACATACAACAAAATTGTGGTTACTGGATTAGAAGCTCCCTGAGGGCAAGGACTTTGTTTTCTTT GTTGCCATATATGTAGTCTCTGGGATGTAAGCATATTCACATATTTGAATGCATTAATGGGGCGGTAACC CTGAAGCTTAAATATGCAAAACTTCTCACCCCTAGGCGTAATGGAAAACTGTATCACCTAATGAGTGTCA TTTAAAAATATCACAGTATCAGTGATGCCACTGACCTTGTGGCTTTTTTTCTCTCTTCCCAGATGGCAGA TGATCAGGGCTGTATTGAAGAGCAGGGGGTTGAGGATTCAGCAAATGAAGATTCAGTGGATGCTAAGCCA GACCGGTCCTCGTTTGTACCGTCCCTCTTCAGGTAAGTTTGCTTAATCAGGGACCCTGGACCACGTCAGC CTGCCATGCCTCTGCCATCTCCACCCACCCATGGGGAGGGGGACATTCAGGGAAGGAGGTTCATGCTGAG CATGAGGTTTGCACAGGTTCTTGCTAGCTGTACGTAGCAACACTAGTGTCCTCATGTGCACCCTGTTGTC TGTGGGCCAAGCCCAGGAATGGACAAAAGCAACCACTGGGAGTCTCCTGCTCAGCCGCTGAGTGTCTGGT AGCAGTTCCTAAGTATCAGGGGCTGTTCTCATTAGAGGTGATTTGCAGGCACCTTCAGAACAGAGCCTGG GCTGCTGCTGCCAGTGGGACCAAGTTTGACAACACAGAATCCAAGGGCTGAGGGACAGGAGGTTTTAGGG TGACTCACGCCCACCCTGTGTCTCCTGAGGCATTGCACTGATGGAAGGGAGATTGCATCCTGTTCATTAG TTCCTACCTTTCCATTTCTTGAGCTCACTTTTAAAATTCTAAATTTTGCATTTAATAATATAATAGCTTC ATTGATTAAACTCTTGTATGCCTGCTTGGTATTATTGCATTTAGTCTACATAATTGCACATTTAGTTTTA TTGTTATCACCATTTGTCAGGTAGGGAAACTGAGGTGCTGTGAGGTTGAATAGCTTGCCTTTTTGCTGAT AGTTAGTAAATGGTAAAGCTAAGATGAGAAACTAAACAATGCCAGCACCACTCACTTAAAGATTCTGCTG TGTGCTTCCCATTTAAAAGTCGGGCTAGCTTGGTGCAGTGGCTTACACCTGTAATCTCAGCACTGTGAGA GGCCAAGGAGGGAGGATCGCTTGAGCCCAGGAGTTTGGGACCAGACTGGACAACACAGTGAGAGCCCCGT CTCTACAAAAAAAGATAAGAAAATTAGCTGGGTGTGGTGGCGCGTGCTGGTAGTCTGGCTACTCGGGAAG CTGGGGCAGGAGGATCACTTGAGCCCAGGAGATCGAGGCTGCAGTGGGCCATGATTGCACCACTGCACTC CAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAACAAGTTGTTTTTTTTTTTAATAAAAAATATAA GTAGGGCTGTAAGGACATGGAGGAACCCCAACCCTCCCTTAACCTTGATCATGGATGGACAGTGAGTGGA ACTTCTTGAGAGACAGAAGGCAGCAGGAGTCAGACGCATCACACTTCTTTGGATTCCCTAAGCCAAGTCC TACTGGGAAAGATAGAGAGAGGGATAAAGGCCGAGGTTAGGGAGTGCTCCCAGGCAGTATTCAGGAGGGG AAGAGCTGGTGGGGATGGGCAGCCAGGCTCCCAACACCCCAGAGCAGACCTTGGGCCATATCATCCAACA TAGGACTTGGAAAAGTGGGAGAACCCCAACACTGTGGACCCAGATTCCGTTGTTTGCCAGATAGAGTCAA GAATATCCAATGAAATGACCAGAAAATACAGTTCTGACTCCTGGAACTTTCCAAAACCATGAGAAATCGG TGCAGGCCAACTTACTCCCCAAGGAAAGCCCCTTAGAGCAATGGTCTTCAAATGCCTTTGCTTATATGTG CTCAAAATAATATAAAGCTGTGTGTATATTTTAAGGTAACATACACATTTTTGTCAAGATAGTTGCAAAA AATGTAATAATATTTCACTCTTCCGAACCCTTTTTGAGTATCTGACTTCAGCAAGTTGTCTACAAGTGAA AGAAACGGGAATCATTTAATAATCATTTTGTAAGTCAGTTTAAGAACAGACTAATACACAGGACTCCAGC TCAGCAAAGCCTTTTGATGTACTTCCCAGAAATTATTAAAATAAATGGTGTGTTGTAAATACTGACATTT CAAAGTCGTTTCTTTAAATGTACCCAGTGGAATCTACATCCATAGTGATTTTATAACCACCTTTATCCAT TAAAAGAATACATGAACAGCTCTCCTGTAACAGCTAGAACTTTTATGTCTTTTTTCCCTTCAAACTTGGT TTTTTCATTCTCTTTTCCTCCACATTTTCTTCTGATGTAATAGATTTAGTTGCTTGAAAGTCTTATTGAT CACACCACATCATATACCTATGTAACATATACATGTATGCATATGTGTATCCATATAAATTTTAAGACAG TTTTCTAGATATCATGAGTATTAAAAGAAAGTTCTCCTAGACTAAGTTACTGTTTCAGCTTTAATGAATT CACAATTGATCTGAAAAATAAATGTTAATATATCATTAATATTATTAAATTGTCATTCATCAAAATAATT ATTAAATAGAAATTGCATTGAAGTTTCAACTTATAATGGAATGAAGGGGCTCTTAATAAGTTAGTTTCTA AAGAAATGGACAAATAATACTTATTGCTGGAATAAGAAAGAATTTGATATTACCTCTTTTTCCTATTTTT CATTTTTAGAGATAAGATGCACTGAGAAATCATGAATAAATACATGAGATGGTAGGAGTTTTGTTACAGT CATGTCACTTAATTCTTTGAATTCCTTCTGAGTTCTGGACCAAAAAATGACAACTTGATTAGGTCTTTCC TTAATTATGTTGGAAGAATTGGCAATTATCTAACTTACAAAAGGAATTATCATTCCGCCTTAAAGGTATT TAATTTTTTTAGTTTCTGGGAAGTACACCAAAAAACTTGTACCCAAACTTCTCAAACAGTTGTAAATTAA ATTTGCTCTTCTTTTATTTAGAGGCAGTCTGTTTAACTCAAAATGTTCCAGAAAAGATAATTAAGCATTA ATAAACATTTGTCAGTATCCTTTTTTTGATAAAATGCTTTTAAACCATATGCTTTTTAAAATGTATTTTT GTCAAGACGTTGGAGTTGCTAATGCAGCTCATTCATGTATGAAAATTGTCTGCTCTATAATCTAATGGAC AGAGCCAGTCCCTGTCAAACCAGTTAGCCATACCACACTTGTTTGCTGTCAGTAAAGGTCTGATACCATT TTTCAGTTCAGTGAATATGTTATTAGGCATCCTTGTGACAGTCATCTTGTTTCTGAATTCTAAATTTTTA TTCTTGGATAGATGAATGGATGGATGGGTAGAAGGGAAGAAGGATGAAAGGAAGAAAGAAAGGGTACCAA GCCCAGCCATGCCATGTTTACCTCCTGGAATCAGTGTTTGTTTTGTTCTCACAGGACTGATATGGTTTGG CTCTGTGTCCCCACCTAAATCTCGTCTTGAATTGTAATCACCATAATCCCTACGTGTTGAGGGAGAGACC CGGTGGGAGGTGACTGGATCATGGGGGTGGTTCCCCCATGCTGTTCTGGTGATAGTGAGTTCTCATGAGA TCTGATGGTTTTATGTGTTTGACGGTTCCTCCTACACACACTCTGTCTCTCCTGCTGCCATGTAAGACAT GTCTGCTCCCCCTTCCACCATGCTTCCCCAGCCATGTGGAACTGTGAGTCAATTAAACCTCTTTTCTTTA TAAATTACCCAATCTCAGGTAGCATCTTCATAGCAGTTTGAGAACAGACCAATACATAGGACTCCAGCTC AATAATAAAAAATCTTTGGAAATAAGGGAACGAAAAAGGCAAAGACATTAAATAAGAACCATCATCACTT CCATTTCATTCTATTATATATATATATTTTAACACATTTTTCAGTATATACAAGCATACTTTGTTTTACT GTGCTTTGCAGATACTGCTTTTCTTTCTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGT CCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAGCCTCCGCCTCCCAGGTACAAGCGATTCTCC TGCCTCAGCCTCCCAAGTAGCCAGACTACAGGCGTATGCCACCACGCCTAGCTAATTTTTATATGTATTT TAGTAAAGACAGGATTTTGCCATGTTTCCCAGGCTGGTCTTGAACTCCTGACCTTAAGTGATCCACCCCC CGCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCTGGCCCAGATATTGCATTTTTA ATAAATGGAAGGTTTGTGGCAACCCTGCAAACCTATTGGCTCCATTTTTCCAACAGCATATGCTCACTTT GTATCTCTATGTTACATTTTGGTAATTCTCACAACATTTTAAGTTTTTTAATTAGTGTTATATCTGTTAC TATGATCTGTGATCAGTAATCTTTTTTGTTGTCGTTGTTCAAATCCAGGATAATCTCTGTAAATGTGATG AGTGATCTTTGATGTTACTATTGTAATTGCTTTGGGGTGCCACAAAGCACACCTGTATAAGACAGCAGAC TTAAATGATAAATGTTAAGTGTGTTCTGACTGTTCCACCCACTGGCCATTCCTGTCTCTCTCCTTCTCCT TGGGCCTCCCTATTCCCTGAGGCAATATTGAAATTGGGCCAATTAATAGCCCTACAATGGCCTCTAGGTG TCTATTGAAAGGAAGAGTGATATGTCTGTCACTTTAAATCAAAAGCTAGAAGTGATTCAACTTAGTGAAG GCATGTTGAAGCCAAGACAGGCTGAAAGCTAGGCCTCCTGTGCCAAACAGCCAAGTTGTGAATGCAAAGG AAAAGTTCTTGAAGGAAATTAAAAGTGCTATTCCAGTGAACACACGGATAATAACATTATTGCTAATTAT TGCTGACTTGGAGAAAGTTTGAGTGGTCTGGATAGAAGATCAAACCAGCCCCAACTTTTTCTTAAGCTAA AGCCTAAGCCAGAGCAAGGCCCTAACTCTGCAGTTCTTTGAAGGCTGAGAGAGGTGAGAAAGCTGCAAAA GAAAAGTTTGAAGCTAGCAATGGTTGATCCATGAGGTTTAAGGAAAGAAGCCTTCTCCATAAAATAGAAG TTCAACATGAAGCAGCAAGTGCTGATGTAGAAGCTACAGCAAATTATCCAGAAGATCTAGCTAAGATCAT TGGTGAGAGTGGCTACACTAAACAACAGATTCTCAATGTAGACAAAGCAGCCTTCTATAGGAAGAAGATG CCATCTAAGATTGTCCTAGCTAGAGAAGAGAAGTCAATGCCTGACTTCAGTGCTTTATAAGGATGCTTGA CTCTCTTGTTAGGCAGACTGGTGACTTTAAGCCGAAGCCAATGCTCATTGACCAGTCTGAAAATCCTTAA GAATTATGCTAAATCTATACTCTTTCTGTGCCCTATAAATGGAAGAACAAAGCCTGGATGACACCTGTTT ATAGCATGGTTTACTGGATATTTTAAGCACACTGTTGAGACCTACTGCTCATTAAAATAAGATTCCTTTC ATTGACATTGCACCTGGTCACCCAGGAGCTCTGGTGAAGATGCAGAAGGAGATTAATGTTTTTATGCCTG CTAAAACATCCATTCTGCAGCTCATAGATCAAGGAGTAATTTCAACTTCCAAGTCTTATTACTTAAGAAA TAATGTCTTACTATTTGAGAAATATTATTTCAGAAATACATTTTATAAGGCTATAGTTGCCATAAATAAT GTTGGGAATAACATTATAGCTATAGTGTTACCGCTGATGGATCTGGGCAGTTAATTGAAAACCTTCTGGA AAGGATGCACCATTCTAGATGCCAGTAAGAACATTTGCGATTTATGGGAGGATGTCTGAACATTAATAGG AGTTTGGAAGAAGTTGATTCCAACCCTCATGGATGACTTTGATGGGTTCAAGACTTCCTTCAATGGAGGA AGTAACTGCAGGTGTGCCAATCATGGTGGAAATAGCAAGAGAACTAGAATTAGAAGTAGACCTGAAGATG TGGCTGAATTGCTGCAATCTTATGATAAAACTTGAACAGATAAGGAGTTTCTTCTTATGAATAAGCCAAG TAAGTGGTTTCTTGAGATGGAATCTACTGCTGGTGAATGTGCTGATACATTTTTGAAATATACATTTAGA ATATTACATAAACTTAGTTGGTAAAGCAGCCACAGAGTTTGAGAGGATTGACATGAATTTTGTATGTGTT TTAACTCTTTTTTTGTTTGTTTTCTTTTAAACTTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTAACGAAC ACTTTCGTTGAGGGCTGACTTTCAATAGATCGCAGTGAGGGAGCTGCTCTGCTACATACGAAACCCCAAC CCAGAAGCAGGTCATCTTTGAATGGTTTAGTGCCAGGTTCGCCAGGAACATGCATTGCGTGACAGGCGAG GGGACAATCACCTTTCTGTTGACTTGAATTTTGAATGAAGTTGTACTGTGAATAAAATGCTATCAAACAG AATGGTATGCTACAGAGAAATTGTTCATAAAAGGAAGAATCATTTGATGCAGCGAACTTCATTGCTGTCT TATTTTAAGAAATTGTCACAGCCACCCTAATTTTCGGCAGCCACCACCAGATTAATCAGCAGGCATCAGT GCTGAGGCCAGATCCTCCACCAGCCCAACAGTTACAACCCACTGAAGGCTCAAATGATTGTTAGCATTTT TTAGCAATAAAGTATGTTTTAATTAAGATATGTATTTTTTGGACATAATGCTGTTGCGTATACTCAGACT GGAGTACAGTGTGAACATAACTTTTCTACCCACTGGGAAACCAAAAAAGTCAGGCGACTCCATTTATTGC AATATTTGCTTTCCTGTGGTGGTCTGAAACTGAGCCGACGGTATATCTGAGTTGTGCCTATATTTGAATT TGGAACAGCCCAGTGTGGTCCCACGTACCCCCATTACTAGTGACATACTTCCCCTTTATCAGACTCATGT ATAAGTAAGAAGCCCACCACAGTGCCTGATTCAAGGAGACTCACAGATACATCTTGTTTGTCTCTTTGTG GATGACCTGGAGGTTTCATCACCCTGTAAGTGAGGTTCAGGGTGGGTGAGAAAGTCTGCCCTTCTTTTAC ACAGTGGGAGATGGGAGAATGGGCAAGGGAAAAGTGGTATCTCTGACAGACCAGTTTTAGAAAAAAATAC AAGTGGCAGTTGAGGACCTGGCCATTTATTCTTCCCTTAAGACTGTGCACCCCTGGGAAAGTTTTTGAGT ACCTTGCTGGAAGACTTCTGCCTAAAAGACCTTTTATTTTGCAAAAATAGATGTGGTCTGTGGTATGTCC CCCCCACCCCTCAGCTTTAAGTTCTTTGGAAAGATAAATAAGCCTGGAGGGTCTACATTCTGGTCCACTC TACCTTTTTCATAGCATGACTGATGTTGACGTCATTAAAATAAACAGTAAGTATCCCGAGGTCCTCTCTG CAGTTTCAGGAGCACCATGTGACCCAATGACAGATGTGGGGTGCGATGCATGGGAGTGCCACTGGCTCCT CTGGATGTTCGTTGTAGCTGAAGGTGCTCCGCCCCCCCCCCACACCCCTACAACCTTCCCTCCCATCCCA TCCCACCCTATTCCAGCTCCCTTCTCTAAGGAGCTCAGAATCACTGTTAGGCAGTGGAGGAGGCAGTAGC ATCTCTGACCTGACTCTAATCAAGGACCAGACTGCTCACCTGCCCTCCCCTGGAGACATGAAGGATCCTG GGTTGCAGAAAGAAATATCCCCTTCCCCAAAAAGCCAGGGTGGGACTCAGGTTTCAAATACTAACAGTTT CAAGCCCCTAGACTTGTCTTGGCCTTTTTTTTTGCCTCACAGCCACTAGATGGCAGGACAGCATCGTTTT ATTTCCAGTCCATAGGCACTAAAAATCCAGCCTGTTCTTTAAAAAAATATTTAGTGATTTTGTAATTTTC TGATTATTGAAGAACATTTGGAAAACACAGAAAAGCACAAAAAAAATCCAAATATCTTAAAATTTGTAAA GCATTCAGATTTTTAGTTATTTAGAGGAAATCATTGTGGGGCCAGTCCATATTCATTATGAACCACAGTT TATAGAACAGGGTCTAGGGTCCTCCTTGCACTTGAACAGGGTTCTGTCTTGATGTAAATATAACCCTATA GTCCTTGCCCTGGATATAAAGTCAAAGTTTTAACCAAATGCCTAGGCACAGCTACAGAAAATAATAACTA ATTGCTGAATTGTAGGACATAGCCTTGGAGCTGTGGGAGGTTGAGGAGGGAAGGATAAGGAAGGACTGGA GGAGGAGCTGAAACTTGAGTTGTCAGGAAAAGCAGGGGGGGTATCAGGGGACCGGTGGAACCTCAGGGCC AGGGTGGAGATGATGGTCAGGCAAGGCCACCGATGTGGCTTCTGCCTAGGAAAGTGGGCAAAATCTGCTG GACAGGGTGAGTTAGGTCTTAATAGCATAGGCCACAAGGAGCCATTGTAGGTCCAAGACCAAGCCCTGGC CAGCAGCCTAGAAGATATTCTCTCCTAGGAACCTGAGAAATCAGAGGCTCCCTTCTGAGCTCTGCTCAAG GTCAGAATTCAAGAAAAGGAAAAAAAGGGGAAAACAGGTTTCCCGCAGTCTCAGATTACCCCTGGGCCTC CGTGGAGTCTCGTGTGTCTCTGCTGAGGAGTTTGTTTACCCTTCTGGTTTCCCAGTGGAAGAGAGCAGGA GAAAAGATCTATTCTCAACATTTGCTAAACTCCCTATTTTCCAGGCACTGGCTCGGATCACATGGGTTTT ACCCTTGGCATCATCTCTGTTTTCCAGCCTTTGCCCCCTGGAGGGTGGTTAATAAATGCCACTTGGTTAT AATTCTCTCTCCTGGAGGCATCTTGGGCTTCTTCACCAGTGAGTGAAGATATGTAAACACATCCCTATAA AAAATGTGTTATTTGTATAATTATAAGGAAGATTCAAGTGGCATCCTTTTTCATTTGGAGAGGGGTTAAA AAACTGTTTTAGAAGACGCAATGCTTTGGAATTAGAGACAAGAACAAAGAAGGCAGACCTTAATTCATTC CAAAGAATACATTCCAAGTTAAGCAAAAATTGTGCCATGATGCCCATTGATTGAAAGGGGCCAGATCTGG GCCCACTAAAGAAAATATGAACATTGAAATTTATGCAGGGCGTTTACTTTTCAATAAAGGAAGGATTCAA ATTCAGCTTCCAGAAAATTGGATGCCTGTCTCCCAAATTTGTACATAGAGAATGATAAAGATTTAATGCT GTATTTGAAGCAGTGATGACACTATGTAAAATAATAGAAGTAGCAAAGTTGAGTCAGACAACCGGGGTTC AGATCCTGGCCCTTCCTCCCACTTACTATTTGAGGGACTATAGCAAGTCACGTGACCTTCCTGTGCCTCA GCTTCCTTATCTGCATAATAGAGATATTGATCTCTGCCCACGGGATTGTTATGAGAATCAGAGTAACCGT CAGCTTCCTGAATTACCTGAATGTGCCTGCTGAGGAAGAAATCATAGAATCATGATTTTAACACTGGGAG AACTTACCTAATTCCCTTCATTATGATCAAGGAAAGGAAGACCAGAGAGGTGATACGTAGCCACCCAAGA GGACCAGGACCGAGACACAGGCCTAACTTGTCCAGTGCTTCCCCCCAGCGTCAGGTGGCACCCACGACTT TGGTGGCACCAGGCTGTTCATCCACATTAATCCACCCACAGAGTGCTTTTTTCCTTCCACCCAAGTGGGT CAGCAAATTTTCTTCGTGTACACGGCTTCTTCTCTGCTTCACTTTGGCAGAGGGATGGTATAGGGACAGC TGTCCCAGCAGGGCGAGCAGTGGGCTTTCCAGTGGCGGAGGGATGGCATAGGGACAGCTGTCCCAGCAGG GCGAGCCATGGGCTTTCCAGCGGCGGACGGATGGCATAGGGACGCTGTCCCAGCAGGGCGAGCAGTGGGC TTTCCAGTGAAGAGGGCCAAGTGTACGTTTCAGGAGCAGCAAGCACAGGACACCAAAACGTGGGCAGAGG TCTAGAAACTGCAAAGCTGTAGCTTCTGCATGTGTGGGATACCTCCAGTTCTTTTCAGTTATTGCTCTTC TAGAGGGGATAAATTAAAGTGAAAAGGTAAGGTAAATCATCAGCTTTTCACAGTAATAGAAACCTAGAAC ACTATTAGCAGAGAAAAATTAAGCCTAGTAATAGAAAAGTACTATGAAAACATAACCAGTTGCTTCTCAC ATGAACATGTGATCACAGACAGGAAATGTGAGCGTGGCATTGCATGTTTAACCCCTGAGCTGCTGGTTTT CTTTCTCTCAAGGATCTGTGATGATGAGAATTTTGTTTGTTTTGTTTTGAGACAGAGTCTCACTCTGTTG CCCAGGCTGGAGTGCAGTGGTGTGATCTCACCTCCCTGCAACCTCCACCTCCCAGGTTCAAGCAATTCTC GTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGCGTGCCACCACTCCTGGCTAATTTTTTTGTATTT TTAGTAGAGACAGGGTTTCACCATGTTGGCTAGACTGGTCTCAAACTCCTGACATCAGGTAATCTGCCTG CCTCAGCCTCCCAAAGTGCTGGGATTATGGGCGTGAGCCACCCTGCCCGCCAATGGTCAGTTTTAAGGGG AAAAGATGGGTGGAGTGATTAAGGACTGAAGTATGTTAGCTGTTCTAATGCTGGACCCTGCAGCCGTAAT ACAGACGTATTGTATCCTCCATTCAGTCTATTAGGCTATTTAAAGACAATTCAGCCTTTTCTACCCCCTG GATGATTTGTTTTAAAGTCATTTGTCAATTTTTATTGTCAGGGACCCTACTGGTTTTGTTTTTTTGTTTT TTTTTTTTAGGGGAAAGAGGGAAATGTGGAGGTTGGTATGTTTTGGGGAGGGGGATCTATTCTTCTCCTT AGCCTCTTTTAAACTGAGTTTGCTTCCCCATGTTTATATTTTTGCAACTGACTTTCAGAGAAAAAAATGT ATAGAGCGAATTTTCTCTCCTGTTCACAGACCTGAGGATGGCAGGTGATCAAGAGGCTTGTGCAGGGTAG CAGGTGTCATAACCTCATTGTATCAGCTTCATACCCTTTCTAGACTGTGGTCCTGAACCAAGAAATGGAG AAAAGCGTTGCTGAGCCGTTCACTTTATAAGTGTTTGGTTTTTATGTGTTTGCATTTTCCTTGTTGCATT TGGAGGGTTGAGATGGGGAAATACAGCAACTCCTGGATCGTTCACTTTATGCAAGATCATTGAAAAATGT TTGTATGCCTCATTTAAAAATGAAGGGCTTTGGTATGCTTCCGTGGTCTCCTATTATTTTTATTCACTTG AGTACCTTTAAAGGAAAAACATAACCTAATGAACTTGAACTCTTTAATTCACCACACACTCACTTCCTGT TTTTGTTGATTAACTTACATATAGTTTGACATGTTTTGCCGTCATGTGAGTGCCGTTTTGCAGCCTGGTG TAGATTTGGGACTTCGGTGGGTTGACCATGTGTGATGCTCATCAACTTGAACTGTATGATGGTTTGTTCT GTTGATACTCTGTCTCTTGCTTAGCTATTCCCCTGTCGTTCCCAATTTTTCACTCTTAAAGATTGTGCTC CTGGCTGCATGTTTATGGAAATTTTGTTTTCTTTTTTCCTTTGGACCCCACGCTCACAGACAGTTGCTTT TTTCCACAGGAGCCATCCCAGGGTTGGGGGATGCTACAATGGGGAGCCGGGGCATTTCTGCCGGTCAGCA GAGAAGGGAGAGGCCAGTGTGACCTTCCCAGCCCGAGTTTGAATGGTCCTGTGGAAAACTCCAGCGTGCA GTTCACTGCTGATTCAGTCACAGGCCTTCAGGGCCAGGCAGCCTGTGCCAGTCTTCTATCCCCTGCTGAG CTCCGAGCATGTTGAGTTTTTATTATTACAGAGAAGAAGGAAACTCACTTCCTGTCGTCGCAGAGCACAG CCTAGTTCTGATGCAGAGGGGACTGTTTTCAGATGGAGACACTAGGTACTACTACCTGCACTCTTTCTTT TCTTCTCTGTCTTGCTCTGTGCCTTAATATGTTAGGACTGTGGGGATGCCCTCTGTTGAGATGTTGAGAC CATGAATGAATCATCCCAAAAATATTTAGACAAAGTGGCTACGAAAACCAGAGCTCTAGTTCCGAATGAA ACAGCTCTGGGGAAATGTGAGCCTGGTGGTGTGTTTACTTTCATGCTGATGAATGTCTGCAGGCAGATAG AGCTACTGGGAATCCTATTCATGGTGATGCTTTAGAAAATTAATCGCAGTGGGCTTCTTGCATGCTTATA TTCCTTTCCAAATATAGAAAGGCATAATTCACATTTTGAGTAGCCCAGGGGATCCATAAGAGGATAAAAC CTGTATTTATCCACTCCAGTGATGGGGAAAATTACACTTGCACCCGGAGTGGATTGTAAAAATCCATTGT ACTCTTTCTAAGGTTTTTCACTTCTTTGTAAAGTAGGCAGAATATTTTTATCCTATAACGTTTTCTGATA CAAGTTGCTGTAGGCTCTTCAAGGATGTCTTTTTATCTAAATAATCATGAGAGCTTGGTTATAATTTTTT GACTCTTGACTGTTGTAGTGAAAATGACTGAGTTGACCTCACACTGTGAAATTAGAAGTTGCAGGAAATG GCTCTCTACCTAAGAAGTTAGGACACTCTGGTTCCTTCCTGATAGTTGATGCTGGCATTATTTGTGTTCC TAGCAGAGATTTATGCTTATCTGAACACATCTGGAAATGAAGATAGTGGTACTTGCCCATACTGGCGAAG AAGCTCAACATGAAGAAAGAGATGGGATGGTTAGGAAGCACTGGGTTCAACCTGCTGTGTTAACTTTCCT TTGCATTTTAGTGTACACTTAAGTGCACTTAATAAGTCATTCTACCAAGATATTGTAGTGTGTTGTGATC TTGCTTGTCTGGCTCTAAGCATAGTGATTTAGTAGCCAGGTTTCTTTTTTTAAATCTGCAGTGAATTGTG GAACACAGAAGCTTTTAAGCGGATTTAGAACTTTCAATTCACTGCTCTGGTTTATCTTGGACTTTGCACT TAATGGCAGGTTCCAAAACAAGAATCCTATGTTTCTTCGCAAAGTAATCTTAGTAAAAGTCTTCCGAATA TAAACGGGGCCAAAGTAAAGGTAGTTGCATCAGCAGTTAGCAAAGAGAGGAAAAAGAGGAGGATGGATAG AATGGGAAGCGACAAACTCTGGAGGAAAAACTACCCTGGCCAGTTTTATTTGCCTTGTCTTTCTTTGCCT CTCATCTGTACTTTGCAGAATCAGTGGGATAATGATTGTTAATTCAATTTGTAAAGCATAAGCCTATAAA AATATTCATACTTCTTCATGGTGACTTAAAAAATATCTGAAGTGGTTCCTCCACCGTTTGTGTCGTTCAT CAGCTTCGGAAGAAAGACTCATACCCGTTGATCTGGACTTGAAAGAATCTCAGTGGCCTTTTCCTCCTGC CCCTCCGTTTGGCGGGGTACAGCAGTTCTCACATGCTTCAGCATCTTCTGCAGTGAGGTCCTAGGAACCT GGAGAAACAACAACAGCCACTTTTAGAAAATCATGTCTTTGGGGATGATTGCCAGCTGAAGAAGTTTCTA ATCTGGACCTTTGAAAGCATTTTATTTTCCTTCTTTTTCCCTCCCCAGCTCCCACCCCTGGGAGAACCTG CTGGACTGAGCTATGGACTGTTGCCTTCTTTGTGCCATTGGCTAATTAATTAGCACAATCTCCTGGGAGC CCTTGAGGCCCTTTCTTCTGTCCAATAGCAGTTGTTTAGCTGATGATCTGCTCGACTCCAGCAGCTGATT TCCAAGCAGACAGTAACTCTTTTATTCGCTGCTGGGACTGAGATCACAAAGCATGTCTCCTCTGACTGTG CTGAGAGTGAATTACTGCTCACACCTAGGCTGCCCTGGGGACTCTACACAGTTTGTTACAAAGGAAGGAG ACTCTAAGGATGACACTGCCTGCTGGGGCATTTCCTGGAAGGATTTTGGTGGTGGCATTAAAGGAATTTC AGTTTAATGTTCAGCTCAGCTGTCATTGCTGGGAGACCTTGCAGGTTCCAAGGAGAGTTGTAAATTGCCC CCGTGGCCCTAAACATACCCTCACTGCTGCAGAGGGGCACCTTCCAGAGGCCGTGCTTCCTGAGGTATGT CAGGTTCCATCTCCTGGCCAAGAGCCAAGGAGCCAAAAGGCTGTGCACAGCTGGAGAGGTGTTTGATACC GTAGAGCGAGCTGGTGTTCTCCGCCCCACACAGGAGTGTGAATCGGCACCACGCAGGAATGTGGGGCCAA CATCTTCCATCAACTTCTCCACTTCCACGGGCTCTGGAAGTAGGCGAGGGGCTTGAAACAAGATCAGAGA CAGCAATGAAAGGTCAGAGCCAAGAGGGCCTATGCAGTGGGCGGACAGGCTTGTCATCGTGACCCTCAAG CTTCAGAGGGTCCGAGATGCTCAGACCCTCTGCTGCTGCCATTGATCAGCATGTTGCTTTTGTTCTGTGC TTAACACTACTTATTGGAGATCATCCCAGGAGAACGCCCACACCTGACCTGAGACTCATTCTGTAGGTCT AGAGCAAAGCATAGGATTCCGAATTTTAACAAAGTTGAGAAACTCTGGAATAGGAGACTTGGGGTTACAC CTTGGAATGAATCCAGGCTCTATTCCTCTCTAGCTTTGTAATTTTGGACAAGCTGATTTCATCCCTCTCT GTGAAATGGAACTAATACCTCACAGAACTCTTGAAGATTAAATGAGATAATATATGTAAAGTGGTAAATG ATCAAAAAATGATGTTTATTATAACTGTATTTATTATTGTTGTTATTGCTGACACAGTGGAGTAAGAAGT TTAAAAGGCTAGGCAGAGGGATAAAGTCACAGTGAAAAATAGAAAAACGGGGTGTCTAGGGAGCCCCCTC AATTAGCACAAAAAAGTATGAATCCAGTGATCTTCAAAATAAGCCAGATCTTGAAATCCGTTTGTAGCAA GCAAGAGACTTTTAACTGTTAAATGGCAATTATTAGTTTAGTGTTTTAAATAACTTATTTGCATATAATA AAAAGTTACACAGAGTTCTTCCACTCTTGCCTACTGTCTGCTCCCAGCTCCCTGTAACACAGATAACCAC GCTGAAAGATAGACATAATAATGAACCGGCGTCAGTGTCGGGAGTAAATACCCAAGATTCATTGTCTCAC GGCCACGGAAAACTAAGACACAGACACACAAATACTGAGGTTCAGAGTGGAAGTTTAATAAGCAAAAGAA AGAGAAGAGCTCTCTCTACTGCAGAGAGAGGGGTCCAAGAGAAATGGATTGCTGGTTCCGCAGTGGAATG CAAGGCGTTTCATAGATGAGCTTGAGGAGGCAGTGGCTGATTTACATAGGATGCAAAAGATTGGTTGAAC CAGGTGTGTCATTTGCATAGGGCACCAAAAACTGTTTAGGGCTAGGTGTGTCATTTGCGTAGGGCATGAA AAAGCTGGCCACCCCACACTCATCTTTTATTATGCAGCTGGTTCTCCACCTGGCCAGCGCCATGTTACCT GTTTCCTTACTGTACATGTGGTGGCAAAGAAAAGGGAAGAGTGGAGCCTCCATGTTAAACATACCTGGCC CTTACGTAGCCCTTTTCTACTGGCATAGCTGCCGGTGTTCACCCGTGCAAGCTTCCAGCTTGCTTATCTA TGTCTGCAGCTTGATTTTTCAGACTGCTCTTTGTTAAAAAAAAAGAAATTATTTGGGGCCTGCTTTTTGT TAAAAGGGAAATTCTGTGGAGGACTCTTATACCCTTACTATCTGCCTAAATAATTTCTATCTCCTGTATC AATAACAGTAATAATCATGATGTTTATTTACCACTTACAACAGGACACACACTGTTCTAAATGCTTTGTG AAGATTAACTTGTTTACAGGCTCTGAGCAAATGCTGTTATTTTGTCCTTTTAACAAATGAGGAAGCACAA GCACAGAGAGGTTAAGTAATTTGCCCACAGTCACACAGCTATGCAGTAGAATAGGGAGTCAAATCCACAC AGCCCAGCCCCTGAATCCATGGATTTATCTACTGCACCATCCTTCAAGTGTCTCTTTATGCAGATACGAG CAAATCTAAACATATTTTCTTTTCTTCTTTTTTTTTTCCAAAAGGTAGCACACTGCTGCCATTGTTCTGC AATTTGGTTTTGTTCTGCACTTAACACGACTTATTGGAGATTGTCCCACATCAGAACATAAAGAGGTTCC TCATTCTTGTTTACTGTACTGTGTGATTTTGATTAAAGAACCCTCCCTTTATGATCCAACCTGGTTATTA TGGGAGCGAGTGACTAATTGAATAAGCTTATGTCTGCCAGATAGCTCTTGTAATTGAAGTGTGCTATGAA GGTTCAACACTGGAAATGGGAGAGTCAGGGGAAATGAGGGAAGAAAACTTATTACTCCAAAAATGTTTCC AGGTAGTATTAGGTCTCCCACCTGAAAGAAATACTCAAGCAAGAGTTGTCCTGCGTTCGGGCTGCCCTAA ATTAACTCCCTCTCAGAAATCTGTTCTCTTCCTATATGTGAGCTTTGAGCCTAATGAGGCTGTACCTAAT GAGTGTCTCTGCAGCAGCCTTGCAACAAGAATTGGCAAAATGGAAGTGCGGGTACCAGTGTGCCTGCCCC TCCCTCACCTGCCCCTGACATGTCCTGCTGGTCACCAGGCAGGACGGCAGCTCCATTTAGCTGATCACCT AAACAGAGGTGGCCCAGGGCCTCTGACTGTGGTGTTTCTTCAGCACGAAACGCTCTTCACTCATTCACAA AACACTGTTGAGCACCTGCTATGTGTCTGGCACTGTTGTAGAAGCTGGGGGAACTGCAGTGAAGTAGTCC AGGTCCTGCCCTCATAGAGTTTACACTCTAGCAGGAGACAACATAGCTCTGTAATTTGAGGTCAGGTGAT GAATTTAAAAATTAAAGCAGGGGCCGGCGTGGTGGCTTACACCTGTAATCCCAGCACCTCGGGAGGCCGA GGTGGGCAGATTACCTGAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGATGAAACCCCATCTCTACT AACAAAATACAAAAAAAATTGCCCGGTTATGGTGGCGTGCACGTGTAATCCCAGCTACTCCTGAGGCTGA GGCAGGAGTGGGAAGGAAAAAGTGGATATAATAGGGGTAGTAACTCATGTAGGCCCTGTGGGCTGTGGTC AGGACCCTGGAGTTCCTTCCCAGCATATGGGAAAACCACTGGATGGCTCTGGGCAAGGAACTAATCTGAC TGGATTTATATATTTTTTTTTTTTTAAATACAGGGTCTCCGTTGCCGAGGCTGGAATGCAGTGGCGCGAT CTCGGCTCACTGCAGCCTCTGCCTCCCAGGCTCAAGTGATCCTCCCACCTCAGCCTCCCAAGCAGCTGGG ACTATAGGCGTGCACCACCACGCCTGGCTAAAATTATTTATTTATTTGTTTGTTTGTTTGTATTTTTTGT GGAGACCAAGTTTCTCCCTGTCGAACTCCTGGACTCAAGTGATCTGCCCACACTGGCCTTGGAAAGTGTT GGGATTACAGGCACGAGCTACCGCACCTGGCCTTACCATTTTATTTAAAAGCTCACTTTGGAGAGAAGCC AGTTAGGAGGCAATGGTGGACAACAGGTCAGAAGATGATGTACCTTGAGCGTTCCAGGGTCCTGGCCTGA GGGAGCAAGCAGCATGATGCCCAATGAACTAGGGTTGTTGTGTGCAGAGACAAGAGACCCAGGGATAGTG GCCAGCTCCACCGGGTGGGAGCCATCGTGGGTGCCCTGGGTCCTGCCATGCCCTGTGATCCTCCGCAAGC AGGTCTGAGCCGTGCAGGGGAGAGCTGCACCAGGACTGGGGCCGACAGGCCAGCAGGGACACCCTGAAGG CTTCAGAAACCCTGGAACGGAGTTTCACAGGGAGCCCTGGGAGGGCTTTAAGTGGTGATGGTGGAATCTG ATTTTTGTTGTTGTTGTTGTTGAGACAGTCTTGTTCTGTCACCCAGGCTGGAGTGCAATGGCATGATCTC GGCTTACTCAAACCTCCGCCTCCCGGATTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTTGGGAT TACAGGCACAAGCCACCACGCCCAGCTAATTTTTGTAGAGATGGGGTTTCGCCACGTTGGCCAGGCTGGT CTTGAATTCCCTACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGAATACAGACGTGAGCC ACTGTGCCCAGCTTGATTTCTCTTTTTAAAGGAACGCTCAGGCTCACAGGAATCTTGGGTGAACGTTACC CACTCTCCTCTTCCATTCCCACATTTCTCTTATCCATTGGCTTTGTTCTGCCCAATCTTTGCCAGTCTGT CCTCTTGGCTCCTCAAGCCACATGGTAAAACATGGCGGCCACCAACTCTCATTTTAACCACCTTGACAGA ATGACTCTTTTTCTCAATTTCAATTCTCAAATTCCCAGGGAAGAGGGCTGATTGACCCAGCCTAGGGATC AGGTGCCCCCTGGACCAATCAGTGGTGGCTGCAAGGTCAAGGGGACAGGATGGCAAATCACTTTCTACCA ATATGGTGGCTCTCACTGTAGCCTCAAAGGGAGAATAGGGATGAAAGGGATTTAATCCCCAGGGGAAAGA AGGTGCCTTAAAACATCACAGCTTAGGTGGAAGCCTAATCTCTTGGACTCTCATTCTTGCAGAATATATC TATAAGCAGTGGACTTTTAGTCCCTCTCCCCTTTTTTCTGGTGCTTTCCTCCTGATGCCTTCTAGACAAT CATTTGCACCTTTTCTTTGTCTGTCTCCAGTTACATGTTTTAATCATCGGGGTTTGCTTCCTCAAAGTTA AGCTATGGATGGAGTTTTCCCAAGGCCAGCTCTTCTTAGGAGGATGAATTGAATTCATCCTCCTAAGAAG AGATTGAATTGATAGTCACTCACAAACACACATCTGTGGTCTGGGAAGATGTGGGTTTAACAAAAAGCTA TTTTGGTTAGAAGGAAAAATTAATATTGACTGACTCAAATCCAGAAAGAGGAAGCAGATACCAAGTTCAT TTTGAAAAATAAGAGTTCATTTTAGGGGCAGACTAGCTAAGCTCTTTTGCTTAGAAGGAGAAATTAATAT TGGCGGACTCAAATCCAGAAGGAGGAAGCAGATATTAAGTTCATTTTGAAAAATAGGAGTTCAATTTAGG GGCAGGCTAGGTATCACCCTTTTGAGATATTTACCAGGAGTGAGGACCACATTTCATATTCAGTTGTAAG GTACTTTTCATAACCATGGACAGTGTTTTCTTAAAGTGTTTCTCTTTCTTCCCCTATTGTGTTCTTTTTA TGTAACCAGTTAATTTTCCAAATTTTATTCTGATAGAACCAGAGTCCTTTTATTTTTTACATAACATATC TAATTCTGTTTTTCTCTTAAAGGATGCTTGCTGGTTTTGTTTTGTTCATCACTGAGGATGAGCTAATGAC AGCTTTTAAAACATCCCAGCTTGTTTTTTACTTGGATATCATCATAGAGATCCATACCACAGAAGAAAGA AGTAGGACTTTTATCTCTGAAAGGATTTTAGTGCATAAACTGTGACTTCCAGCCTGCTAGACTTCATGCT AGTCTTAGGATCTTTGAATAGCCTTAAATTAGCTGCAGGATCCAGGAAGCTTGCTCTGAAATTCAGTTGA CATGGTAAGAACCCTACTTTAGGCCAGATGTGGTAGCTCACACCTGTAATCCCAATACTTTGGGAGGGCG AGGCGGGTGGATCACCTGAGGTCATGAGTTCAAGACCAGCCTTGGCAACATGGTGAAAACCTGTCTACTA AAAATACAAAAATTAGCTGGGCGTGGTGGTGCACACCTGTAATCACAGCTACTCAGGAGGCCGAGGCATG AGAATCACTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGAGC GACAGAGAGAGACTCCATCTCAAAAATAAATAAATAAATAAAAACTCTACTTTACCTATTCAGTGTTCTT TTCTTTTATCCCATTCTGGCATTTTCTGAAGGGTTGCAGAGAGCACTGGTTGAAGCCTATCCTGAAGCTA CCTTGGTAGAGGAGTTAATTGCACCAGGAGACCTAATTTCAGAAAGGTCACAGATTATATTCCACCCTCC ACAAAAGTAACCTGGAAGATGAGTAAGTCCTGTCCTAAATTTTAGTACCAAAAACAGTGTTTGCTCAAAG AAAAAATAGTCTAGTAGAGAAAAGCACACCCTTTGGGGTCAGACCACCAGGAATCACATACAAACTCTGA ACCTGAATTTTCTTATCTACACGAAGGCAGCATGGCTGTGAGAACATGCAGTGATTTTATAAAACTCCTG GCCCATAGGTGGCAGGTATTAATAGGAAATAGCTACGTAAATATACTTCTTCTGGACTTAGGTACTGTTT TTGCATTGGTCACCTCTGCTTTTGAGTCTCACTCAAGAAATCTTTGCCCAGACCAATGTCCTGGAGAGTT TCCCCAACATTTTCTTCTAGTATTTTCATAGTTTCAGGTCTTAGCTTTAAATCTTCCATCCATTTTGATT TAATTTTTGTATATGGCAAGAGTTAGGGGTCCAGTTTCATTCTTTTGCATATGGCTATCTAGTTTTCCCA GCACCATTTATTGAAGACATTGTCCTTACCCCAATGTATGCTCTTAGCCCCTTTGTTGAAAATGAGTTTA CTGTAAATGCATAGATTTCTTTCTGGATTTTCTCTTTTTTTTTCCATTGGTCCGTGTGTCTTGTTTTTAT GCAAGTCCTATGCTGTTTTGGTTATTATAGCTTTGTAGTATAATCTGAACTCAGGTAATGTGATTTCTCC AGTTTTGTTCCTTTTGCTCAGGATGGCTTTGGTTATTCTGGGTCTTTTGTGGTTTCATATAAATTTTAGA ATTTTTTCTTCTATCTCTGAAGAATGTCATTGGTATTTTGATAGGGATTGCATGGAATCTGTAGATTGCT TTGAGCAGTATGGAGATTTTTAACAATTTTAATTCTTTGAATCCATGGCCAACTTGCTTGGATTTGGACT TGCTGTGCCCCCTCACAACCCTGAGCTAGTTACTTGCCCACCCCAAGCCTCCGCAGCTCATCCTTAAAGG GGGTTACGATGATATCTGCCTCCCTCTTTGAGTTGCTATCAGAATTCAGTGAGGACATGCAGATGAGAGT TTTAACAATATCTGGGCCCCTAGTAAGCACTGACAAATGTTAATTATTATTGTTACTTGTAAAATGGGCA TGATTATCCCCCACTACCTACCTCTGAGGCACCTATCGAACACCAGAGATTTTGTGTGTTCGAAAGACTG TGCACACATTATTTTAAAAAGTACAGAGGACACTGTCAATAGCAGTCATTAACAGGGTGGCAATAAGGAA ATCCTATTGCTGCCTGAATGGTGTGTCCTTGAACAGTGCAGAAACTCCCTTTGCTGATACATCTCCAAGG GGCAGGGGGTGGGGATACATCACAGGAAGTACCTGCTGCCACTGCAACTCCCATCTAATTTTGCGACAGT CACGAAATGCGTCACCTACTGCATGCAACTGACTGCGTCACATGAGAGGAAGTTGGTTTTCTGCAAAGGG TAACAACTCACCGGATCAGGTCACACGGGCGGGTGGACGCAGAGCTCCGACTAGCCGCAAGTCCAGCGCT CTTTTGTGCTGCTTCTTTGTGGAAGGAAATGTGAAGAAAACCCAGCGTCACCCTGTAAACCAGACAAAAT ACAAAACAGTGGAGAAGCCCAGAGAAGGCAAAACAGATTCCGGATATTTCTCTTTTAAAAGTAAAATGGC ATCATGGAAGAAATTTGGCCTTCCGAAAGTGGAGGATAAAGTCATGTTCAAGGGGAAGAACAGCAATACA GCATCTGCGGCTTAGACATACAGAGCTCGTCTGTAATTTGGAGTAAGATAGGAGTGGGGGCGGAGAGGGG GAAGGCCATGCCCTTTCAGAGATTCTGAGAAACTCCAACCATAAAAGTCCATGACAACTCAAGTGCAGTA CCCGTGACCCCATGTTTGTCAGGTAACAAGCTGGGTTTTGACTTTTATTTTGCTGCTTCTAACTCTGGCT GGGCGCCATGGGAGAAGGGCGGGCAGATCACTCTATTGAATACTCCAGGGGACAGTGTTGCAGACTGGGA CCCACCCTTCACTAGCTGGGTGACCTGGGACAATCCCCGTCTCCCCATGGACCTCAGTTTCCGTATCTGT AAAATGAAGTGGATACAATTCTATTCATTCATTTATATAACAAATATTTATTCAGCAACTTATATGTTGG GCATTGTTCTCCCTATTGGGGATTCAGTGATTTTCAGAACGGAGAAATGTCTCCCTCCTGGAGCTCACGT TGGCATAGATGGCTGGCAAGACAGCTTCCCACCCTCATTGGAAATGTGTCCCTCTGCCCGCTCCATGGTG CCTCATGCCCCACCACACTGCCTACCTGCTAGACTTTTGGCAAACTGGACCACCAGTTGTCTGGAGATTG GAAAGAGCCTACTTTTTTGTTGTAATCCTTCTGTTCCTTTTTCCCCCTTTTAATGTAAATGTTATTAAAA CATAACATCCACATAGAAAGTGCACATACTGATAAATTTTCACCAACAGAAACACACATGTAACCAGCAC CCACACCAAGAAACAAAATATGACTCACACTGAAGAAAGACCCCATGTCCCTCTGGTCTCTGATCTCCAC CGTAGGGAAAACCATCTCCAGATTTCTGATCCTAGGTATTAGTTTTGTTCTTTTTAACTTTGTCTTTGTA TATACCCTTTTGTATGTCAGTTCTTTCACTCATTGTTATATTTGTGAGGTTTATTCATGTTGCTTCACAT TGTGGTGGTTTGTTTATTCTCGTATAGTATTTCATTAGACGAACGTTCAACAATGTGTGCATTTGACTGT GAATGGACGTACAGATTATTTTCTGCTGGAGGCCATCGCTGAATGGTATTGCTGTGACGTGTGGACCTAT CTTAGTGAACGTGTTTGCTTTTCCCAGGGGAGTTGCTGTGGCATAGGTTATGTATACATTCCATTTCAGT ACATTCTGCTGGTTTTCCACAATGGGTGTACAAAGTAGGTTCCCACCAGCAATGTTTGATAATCCAGGGA GCTGAACATTTTGCATCTTTTACGCTGTAGCCATTCTGGTAAGTGTGTACTGGTATCACATGGTGATTTT AATTTGCATTTTTCTGGCATCTAATAAAATTTGCCAGGGGACCCTGTTCCACTTAAACATGACAATTAAA CAGAGCCGTCTGTCCACGCCAGGTCTTTTCTTCAAGGATACTGCAGTTTTCTTAGGCATCCCCCGCTTTC ACACTAGTAGTAAAATGAAGAGACGTTACTATACACACTTCTTCCACAGCCCCTGACTCTGGAACTTTAT ATTTCACCAGTAAGAAGAAGAAAAATGTCACCATGCGATCCATCAAGACCACCCGGGACCGAGTGCCTAC ATATCAGTACAACATGAATTTTGAAAAGCTGGGCAAATGCATCATAATAAACAACAAGAACTTTGATAAA GTGACAGGTGGGTGTGTGGGCATGGGCTCATCTTTCCGGTTCCCTTTCATCTTCTCCTATTTGTATCAGA CATTTATGGGAGAAATGCTGCACCTACCTACTGTGGCAGACAGCCCCTCTGAAGGCAAGGTTCCTGTATT CAGGGGAAAGGGTTATGCGGAAATCAAGAATGTTCAGTCTAAGGCCCCACCACGTGTATTAGCTGATGCG GGGCTTTGACCAAAGGGCTAAGAATCCAGGGGAACCTTGGCTTTGATGGGAGCTGAATGTTACCAGGAGG CTCACCTGTTGCGGGCAGGTGGCACTGTTAGCCTCCCCTTTGAGTTTGCTTCAGTTCATTTAAATTGTGG CCTTGGAAGGCATTGTATATACTTGGAGTGTTTCTGCTGCAGCTGGCACCAGTACATTTAGCACCCGGCC CACTGGCGCCCGCATGTAGTATTCAGCCAGGGGATGCTCACCTGTGGATTCATTGCTTGATTCCCACAGG TATGGGCGTTCGAAACGGAACAGACAAAGATGCCGAGGCGCTCTTCAAGTGCTTCCGAAGCCTGGGTTTT GACGTGATTGTCTATAATGACTGCTCTTGTGCCAAGATGCAAGATCTGCTTAAAAAAGGTGAGTGCTGCC AGGAGTGGTGGCTCATGCCTGCAATCCCAGAACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAACCCAG GAGTGCAAGACTAGCCTGGGCAAAATGGCAACACCCTATCTTGAAATTTTTTTTTTTTTTTAAGTAGCCA GGCATGATGGCATGTGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGTGGAAGGATTGCTTGAGCCTAGG AGGTTAAGGGTGCAGTGAGCCATGATAACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTC ACAAAAAAAGAAAAGTTGAGCCCTTACCGCCCCTCCATCTATCTTCTTCCTGTACCCAAGGGAGGCGATC CGCCCACCATGGCCAGGCCCATCTCAGAAGGATGCCTGTGCAGGGCAGAGGAATTTCAGTGTGAGAAACC TCCCTCCCTCTTGACCAGTCCATACCTGTCCTGGAGTAGGCAGGTTTCCTTGAGGAGCCTTCAATCTCTT TGTAAAATGATGAAATCAGCTTAAAGTCCAGCAAAAGAAATAGATTATTTGTATACAGAATGGTCACAAT TTCAAAAGACTCATTCCTGGGAAGTAACAAATCTGTGTCATCCTTTCTAGAATGAAGTGTAAGCGTAAAC TTTTCCCTTGTGGCAGATAGAGAATAATAATTCCATATACTTTAGAACTATGTTATTTTTTATATAGCAT GTTCACAAAATTATTTCATTAGATCTTTAACAGAAGCCCTGCAATGTTGGGCAACAGAATATTATGCTCA TTTTATAAATATAGGGGTGGGCCACGTGTGGTGTCTCACACCTGTAATCCCAGCAGTTTGGGAGGCCAAG GCAGGAGGATTGCTTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATGATGAAACCCCGTCTCTACTT AAAAATACAAAAATTAGCTAAGTGTGGCGACACACACCTGTAATCACAGCTACTCGGGAGGCTGAGGCAT GAGAATCACTTGAACCCGGGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATGGCACCACTGCACTGC AGCCTGGGTGACAGAGCAGGACTCTGTCTCAAAAAAAAATAATAATAATAAAATAAAAAATAAAATAAAA GAAGGGGTGGAGCTTCAGAGAGGAAGAAAGATACACTGAAGGGTGCAGTTAGTAGGGGCAGAACCGAAAC CCACGCTCTGGTCTTCTAACTCCAGGACAAATGCGTTTCCTATTACACGACCCTCTCTAATGGATGCCAC CTAAGGTATTCTGGCATTTAGGGCAAGTGTTTGAAAGTAACATCCTATCAATTCACTAGACACAGACCCA CAGGAAGTAGATAGGAACACAATCTAAATCACTGCTATTTTTCTTAACCTCACAGCTAAAACAAAAAAAG TCCCCACCATCTTTTTTTTTTTTTAAAACTAGGCATTTTTCCTAATTTCCTCCAACTTGACTCTTACAAG CTGACCTTTTGTACCCTAGTAGGTTATGTCCTAGACCAGACTAGAAATCAGGAGTCTGAGATCTGGGTCT GGCCCAAGTTCTAACAGGCAACCCAGGCAAGGCAACCACATCATCCTGATTTTTTTGCTTTCCTGAAAGG CAGATTATGATACCAGCTCCTGCTGTTTCTTGGGGATGGAGTGAGGAAGCCTGTGAGCCAAGAGGAATTT TGTGAGCGTGCTTCGAGAAGTATAATGGCCCAGATAGGCATATGAACTTGTCCCAATTGTAGTTTCTGTT TGGTTTTTGTTTGTTTGTTTTGTTTTGTTTTGTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTTGAGT GCAGTGGTGCAATCTCGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTC CCAGGTAGCTGGCATTACAGATGCGTGCCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTAGTAGAGA TGGGGTATTACCATGCTGGCCAGGCTGGTCTCAAACTCATGACCTCATGATCCGCCTGCCTTGGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCGTTTCTGTTCTTTTGAAAGGTGATTCATTC TGCCCAAGTCCAGAGCATGTCACAATCAGAGAATTCTTGCTTATTGTCCTATCAAACTAGTAAAGCACTT ATTTTTTCTGACTTTACATGCAGTCAGTTCCAGTGAAGACAAAACTCCCATTTTCTAACTGTCCTAATTT GTGTACTCTTAAAATAAGCTAAGAACTCCAGCTTTCATCACCATCACCTTGTACCTCTACTGTCAAAACT AATACAAGAATCACTGGGGAGATAATGCAAAGTGTCTTGGTAATTCGAATGGGAGAGGCCACTCTTACTC TGCCTGGAACTGGTGAGGTAGCTGGACTTTGCAGTGTCCTGGGCTTGAAAAACGGCCCCAAGGCTCCAAC GTGTTCTACCACCTTTGGGGAAGGTTATGAGACCTCTCCGAGATTCCATTTTTTTAAATCAGTGAAATAA AGATAAATGAGGCCTACTTCCAGTCTTGTAGGAATTAAAAATAACTCATGTAAAGTACCTAGATCAGTGT CTGCACATAGTATTTGCTCAAGAAATTCTAAATATTATTCCTTCCCCCCTCATTAATCATAGAGAAGAAG AAAGGATATGTGTATTAGCTAGTTATAGGTTGGTGCAAAAGTAATTGCGGTTTTTGGCATTAAAAGTAAT GGTTAGTTCACCTATAGCTGGTTAGTTAGTATCATAGAACCTTTGGTGAGTTCTAGCTGGGCCAACTAGC TACATGGTTTATGATTCCTCTCCTCAGTATCCTAAATGGACAGCCAAGCTAGTATTTTTATTTATTTTTC TTTAATTTTGTTTAATTGTGGTAAAATACACATAACGTAAAATTACCATCATAACCATTTTTAAATGTAT AGATCAGAATGACTTCACATGGTTGTGTCACCATCACCACCATCCATCTCAGGCTTTCTTTCATCTTCCG TAACTGAAACTTTATCTCCATTAAACACTAACTGGCTATTTCCCCTTCCCTCCAGCCCCTGGCAACCACC GTTCTATATTCTGTGATCTTGACTACTCAGGGTACCTCCTGAAAGTGGAATCATGCGATGCTTGCCCTTT AGTGACTGGCTTATTGCACTTAGCGTAATATTTTATTCTCTTTAACAAACACTTGCATGATGCTTATTAT GTGGCGTGTTTTACAAATATTAACTCATTTAATGAGTTAATATTGATCTTCAATGTACAGATAAGGAAAT CAAGGCACAAAATGGTTCAGTAACATTCCTGATGTCACAGAACTAGCCAACAGCAGGGCCACACACATCA GCCCCCATACACTGTACCTATCCCTCTCTCTTAACGTCTTAGATAAGTCTGATCCTTTGAAAGGAGCCCA GTCCCCAGCTCCTCCCCTCCCCTCCCTTGTAACCCTCTAATAGTCAGAGGCAGCTGCCAGGCTGCCTCTG AAAATGCTGCATCTGAGGCTCCCCAGAACTTAGACCTTAATTCTTCAATGTTCGTATTATTTGCTTGCAG CTTCTGAAGAGGACCATACAAATGCCGCCTGCTTCGCCTGCATCCTCTTAAGCCATGGAGAAGAAAATGT AATTTATGGGAAAGATGGTGTCACACCAATAAAGGATTTGACAGCCCACTTTAGGGGGGATAGATGCAAA ACCCTTTTAGAGAAACCCAAACTCTTCTTCATTCAGGTAATCTCTTTTCAATGCCAATACACTTGAAAAT GGGAAAGATTGCAGAGTGACGGGGATGGCATCATTTTTACAAATCCAAATGCTGCTTCCATATTCAAATT AGGGTTTTATTTTTCTGGGAAAGATTACAGAGTGACGGGGATGGCATCATTTTTACAAATCCAAATGCTG CTTCCATATTCAAATTAGGGTTTTATTTTTCTATCTCTGAATGGTTAGCATATGTGTTTCCACTGGATCA CAAATTATGAAGGTTTCTTTTTTTTTTTCTTTGAGATGGAATCTTGCTCTGTCACCCAGGCTGGAGTGCA GCGGCGTGATCTCGGAAGACTGCAACCTCCACCTCCCAGGTTCAAGCAATACTCCTGCCTCAGCCTCCTG AGTAGCTGGGATTACAGGCACGCACCACCACGCCTGGCTAATTTTTGTATTTTTAGAAGAGAGGGGTTTC GCCATGTTGGCCAGGCTGGTCTCAAACTCCTGGCGTCAAGTGATCCACCCACCTCAGGCTCCCAAAGTGC TGGGATTACAGGTGTGAGCCTCCACACCCAGCCACAAATTATGAAGGTTTCTTTAAGACATTGCAATACT TTTATTTGCTTTGCTTAGTCATTTGAAACACATTCATTCATTTATCTTTTCATCAAATTATCATTGAGCT CCTAAGTATGCCAGGCACAGTTCTAGGTATCAGGACACAGCAGTGAACAGCACGTACATTTCTGTTCCCA ACTGCATAGAATGATGTCTGCTTTGATATTTAGGCTTGCCGAGGGACCGAGCTTGATGATGGCATCCAGG CCGACTCGGGGCCCATCAATGACACAGATGCTAATCCTCGATACAAGATCCCAGTGGAAGCTGACTTCCT CTTCGCCTATTCCACGGTTCCAGGTATCATGTCCATTGTCTGCCAAGCATACTTCAGTCCATTCCATCAT CAAAACACAGATTTGGGGACTGTATTCGTTTCCTCTTGCTGCAGTAATACATTACTACAAACACAGTGGC TTAAAATACACAAATGTATTATCTTGCAGTTCTGGAGGTCAGAATTCCAAAATAGGTTGGCAGGGCTACG TTCCTTTTGGAGGCTCAAGGGAAAATCCATTTCCCAGCCTTTACGTGGCATGTTAGAACCACCTGCATTC CTTGGCTGTGGCCCCTTCCTTCATCTTCAAAGCCAGCAACTTTGCATCTCTCTGACCCTTCTGTCGTTTA CCGTGCTCTCTTTCTGACCACAGCTGAGAAAGGACACCTGTGATTAGATGGAACCCACCTGGATGCTCCA GGATCATCTCCCCATGTCAGTCCGATACCCTTAACCACATCTGCAAAGTCCTTTCTTCCACATAAGGTTT CATGTTCATAGGTTCCAGGGTTAGGGCGTGGACATCTTTGGGCACCATTATTCTGCCTACCACAGAAATG CATTCACTTTTCTCTCCAGGAAAGCTGAATTCTCTCATTTGTTATTATTATTATTGTTTTAGTAGTTATA AGGACAAACATTTCTGTAGTACTTTGCAATATAGAGTATCTTTCATGTGTTTTTTCTCATATACAATAAT ACCGTAAGTATTTAGGAAAGGTGTTATTCCTGTCCTGATTTTACAGGTAAAATAAAAGAATTTTTAGTTT GGATGAATCTAAGTGATATGCCTAAGGTCAGGTAGAGATTTCAGTGCACAGTAGAGCTGTGAGTCAGCCA AGGTTCCTTTACACGGCAGCCTGTACACAGATACCAGAAAACGCCAGCAATGGGCAAGCCTACTCACTAT TTACCAAGCACTACATTTGACTGAATCTGTTCAATGAAAGTCCTTCCTTTGTTTTGGGTACAAACCAGCA CTAAGTTAGAATTTTCCCAGCTGTAATAGTAGTTGTGTCAAGTATTTGGCACAAGGGTACTGGTTACAGT AAATAGGTTGATGTGTTTGGAAAACCAGCTCTGGCAGGATCTACAGATGAGATTTTGTGAGAGCGATAAC TTCACAAGTTTTAAGGATGGCATAAGATCGAAAATAATTTGGTCTTTCTGCTCTTGAGAGGGAGGTGGTG TAATGGGGGCATATGTCTGTGTAAACAAACCCAGTGGTAGAGTTGTAGTTGCTCTGAGCAAGGAGGCAGT TGAGAAAAGCTATGTTAAAAAGGAGCTGCTGGGCCGGGCACGGTGGCTCACATCTGTAATCCCAGCACTT TGGGAGGCCAGGGCAGGTGGATCTCAAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCC ATCTCTACTAAAAATACAAAAAAAAAAAAAAATAGCTGGGCATGGTGGTGGGCGCCTGTAATCCCAGCTA CTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACTTGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCACC ACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAGGAGCTGCT ATAACTGAGCCTAAAATTTCAAACAACATAGGTAAAAGAAGGATGGCTTGTCAGACGGAGTGCTGAGGGG CTGGATAGCCCAGTGCATTTGGTAAAACTCGGGGCTGGATCTCAGGGTATATCAGTCTTCTTGGGCTGCT ATAGCAAAATACCTTAGACAAGGTGGCTTAAACAACAGACATTTATTTCTCTAAGTTATGGATGCTGGGA AGTCCAAGATCAAGGTGCCGGCTAAGTTGCTTTCTGGTGAGGGCTCCCTTTCTAGCTCATAAATGGTCAC GTTCTTGCTATAGCCTCATATGGCAGAGATTGAGAGCAAGACTGAGTGAGGTCTGTTGTGTCTCTTCTTA TAAGGACACCAATCCTCTTGGATCAGAGCCCTACCCTAGTGACCTCATTGGACCTTAATTACCTCCATAA AGACCCTGCCTCTAAACACAGTCACATTATGGGGTGCGGCTTCAATAAATGAATTTTGGGAAGACATAGT TCAGTCCATAGCAAGGGATATGACAGGGCATGGCCAGGGTCAAACCAGGACAGGTAGGCAGGTGGCCCTG TCATGGTGGAACCTGTGTGCTATGTCAAGCAGCCTGAACTTTACTCAGATAAAGTGGCGCAAGGGAACGG TTTTAGGTTAGGGAGTTATAGGATGAGATTTGCCCTCCCGGGTCATCAGGCTCTCCTGGCCCTGCCCCTC AGACAATTGGGCATTCAGCTTCCTTGTGCCTCTAGATTTCTTCAGCAAGGTCCAACTCTACTCCTATGTA TCCCAGCAGCAGGAACACATCTCAGAATTCCTTGAGGTTCTCTGCAAATTCCTTCTCTAGTAGGCTTGGA TTAGGAAGTAGCACTGACCCCTAAAGGATAGTGAGGAGTTCCAGAGTTATGGAATAGACCTCCAGCATTT CCTTTGGAAGTCTGCACATGCAGATCTGTCTCACACCCACGTATCTGATATTTATCAGGTGGGTACGTCC ATCAAAACTGACACAAGAGAGTACCCTGGCAACATCCACCAATGCTGGCCCTTAGTGATGCTGTCTGTCA TGGGATTTCCATGCTGAAATACTCAAAGCATTTTCTAGCATCTTCATGCCAGCCGTTAAATCTCAGATGT TTGCTCTCTGAGCACACCAGCATAATTCTCATTAATGACTTGTGTGCAGAGTAGAGTGAAATAGTTTCTG AAAAGCAGGTGTGAAAGTGCCATATACTCATTCTCATTGGTGAGTGGAGCAGCTGTCAGAATTAGCTGAT TTGGTCGTCTCCTTTCTTTCCTGTTGAAGGCTATTACTCGTGGAGGAGCCCAGGAAGAGGCTCCTGGTTT GTGCAAGCCCTCTGCTCCATCCTGGAGGAGCACGGAAAAGACCTGGAAATCATGCAGATCCTCACCAGGG TGAATGACAGAGTTGCCAGGCACTTTGAGTCTCAGTCTGATGACCCACACTTCCATGAGAAGAAGCAGAT CCCCTGTGTGGTCTCCATGCTCACCAAGGAACTCTACTTCAGTCAATAGCCATATCAGGGGTACATTCTA GCTGAGAAGCAATGGGTCACTCATTAATGAATCACATTTTTTTATGCTCTTGAAATATTCAGAAATTCTC CAGGATTTTAATTTCAGGAAAATGTATTGATTCAACAGGGAAGAAACTTTCTGGTGCTGTCTTTTGTTCT CTGAATTTTCAGAGACTTTTTTTATAATGTTATTCATTTGGTGACTGTGTAACTTTCTCTTAAGATTAAT TTTCTCTTTGTATGTCTGTTACCTTGTTAATAGACTTAATACATGCAACAGAAGTGACTTCTGGAGAAAG CTCATGGCTGTGTCCACTGCAATTGGTGGTAACAGTGGTAGAGTCATGTTTGCACTTGGCAAAAAGAATC CCAATGTTTGACAAAACACAGCCAAGGGGATATTTACTGCTCTTTATTGCAGAATGTGGGTATTGAGTGT GATTTGAATGATTTTTCATTGGCTTAGGGCAGATTTTCATGCAAAAGTTCTCATATGAGTTAGAGGAGAA AAAGCTTAATGATTCTGATATGTATCCATCAGGATCCAGTCTGGAAAACAGAAACCATTCTAGGTGTTTC AACAGAGGGAGTTTAATACAGGAAATTGACTTACATAGATGATAAAAGAGAAGCCAAACAGCAAGAAGCT GTTACCACACCCAGGGCTATGAGGATAATGGGAAGAGGTTTGGTTTCCTGTGTCCAGTAGTGGGATCATC CAGAGGAGCTGGAACCATGGTGGGGGCTGCCTAGTGGGAGTTAGGACCACCAATGGATTGTGGAAAATGG AGCCATGACAAGAACAAAGCCACTGACTGAGATGGAGTGAGCTGAGACAGATAAGAGAATACCTTGGTCT CACCTATCCTGCCCTCACATCTTCCACCAGCACCTTACTGCCCAGGCCTATCTGGAAGCCACCTCACCAA GGACCTTGGAAGAGCAAGGGACAGTGAGGCAGGAGAAGAACAAGAAATGGATGTAAGCCTGGCCCATAAT GTGAACATAAGTAATCACTAATGCTCAACAATTTATCCATTCAATCATTTATTCATTGGGTTGTCAGATA GTCTATGTATGTGTAAAACAATCTGTTTTGGCTTTATGTGCAAAATCTGTTATAGCTTTAAAATATATCT GGAACTTTTTAGATTATTCCAAGCCTTATTTTGAGTAAATATTTGTTACTTTTAGTTCTATAAGTGAGGA AGAGTTTATGGCAAAGATTTTTGGCACTTTGTTTTCAAGATGGTGTTATCTTTTGAATTCTTGATAAATG ACTGTTTTTTTCTGCCTAATAGTAACTGGTTAAAAAACAAATGTTCATATTTATTGATTAAAAATGTGGT TGCTTAATTCCTAACCAG Download Select all
Length	51748
OMIM ID	601761
HGNC ID	HGNC:1508
Unigene ID	Hs.9216
Ensembl ID	ENSG00000165806
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001267056.1
Exon	join(1..188,18333..18442,41871..42007,42490..42618, 46201..46376,47144..47273,50150..51748)
mRNA Sequence	>840 AACAAATATTTCCCGAAAGATCCAGGAGCAGCATCTCCACCAGCAAGCTGGGCTGCTGGGTGGG TACTTCCTTCAAAGCTGAGGGAGCGTCCTACGCCCACGCGCGCAGGAGGGCGCCCCCCGCAAAG CAACGTCTAGGAGACCACAGTGGATGCCACAGCGGGCCCGAAGCGGATCAGCCTTGTGGGATGG CAGATGATCAGGGCTGTATTGAAGAGCAGGGGGTTGAGGATTCAGCAAATGAAGATTCAGTGGA TGCTAAGCCAGACCGGTCCTCGTTTGTACCGTCCCTCTTCAGTAAGAAGAAGAAAAATGTCACC ATGCGATCCATCAAGACCACCCGGGACCGAGTGCCTACATATCAGTACAACATGAATTTTGAAA AGCTGGGCAAATGCATCATAATAAACAACAAGAACTTTGATAAAGTGACAGGTATGGGCGTTCG AAACGGAACAGACAAAGATGCCGAGGCGCTCTTCAAGTGCTTCCGAAGCCTGGGTTTTGACGTG ATTGTCTATAATGACTGCTCTTGTGCCAAGATGCAAGATCTGCTTAAAAAAGCTTCTGAAGAGG ACCATACAAATGCCGCCTGCTTCGCCTGCATCCTCTTAAGCCATGGAGAAGAAAATGTAATTTA TGGGAAAGATGGTGTCACACCAATAAAGGATTTGACAGCCCACTTTAGGGGGGATAGATGCAAA ACCCTTTTAGAGAAACCCAAACTCTTCTTCATTCAGGCTTGCCGAGGGACCGAGCTTGATGATG GCATCCAGGCCGACTCGGGGCCCATCAATGACACAGATGCTAATCCTCGATACAAGATCCCAGT GGAAGCTGACTTCCTCTTCGCCTATTCCACGGTTCCAGGCTATTACTCGTGGAGGAGCCCAGGA AGAGGCTCCTGGTTTGTGCAAGCCCTCTGCTCCATCCTGGAGGAGCACGGAAAAGACCTGGAAA TCATGCAGATCCTCACCAGGGTGAATGACAGAGTTGCCAGGCACTTTGAGTCTCAGTCTGATGA CCCACACTTCCATGAGAAGAAGCAGATCCCCTGTGTGGTCTCCATGCTCACCAAGGAACTCTAC TTCAGTCAATAGCCATATCAGGGGTACATTCTAGCTGAGAAGCAATGGGTCACTCATTAATGAA TCACATTTTTTTATGCTCTTGAAATATTCAGAAATTCTCCAGGATTTTAATTTCAGGAAAATGT ATTGATTCAACAGGGAAGAAACTTTCTGGTGCTGTCTTTTGTTCTCTGAATTTTCAGAGACTTT TTTTATAATGTTATTCATTTGGTGACTGTGTAACTTTCTCTTAAGATTAATTTTCTCTTTGTAT GTCTGTTACCTTGTTAATAGACTTAATACATGCAACAGAAGTGACTTCTGGAGAAAGCTCATGG CTGTGTCCACTGCAATTGGTGGTAACAGTGGTAGAGTCATGTTTGCACTTGGCAAAAAGAATCC CAATGTTTGACAAAACACAGCCAAGGGGATATTTACTGCTCTTTATTGCAGAATGTGGGTATTG AGTGTGATTTGAATGATTTTTCATTGGCTTAGGGCAGATTTTCATGCAAAAGTTCTCATATGAG TTAGAGGAGAAAAAGCTTAATGATTCTGATATGTATCCATCAGGATCCAGTCTGGAAAACAGAA ACCATTCTAGGTGTTTCAACAGAGGGAGTTTAATACAGGAAATTGACTTACATAGATGATAAAA GAGAAGCCAAACAGCAAGAAGCTGTTACCACACCCAGGGCTATGAGGATAATGGGAAGAGGTTT GGTTTCCTGTGTCCAGTAGTGGGATCATCCAGAGGAGCTGGAACCATGGTGGGGGCTGCCTAGT GGGAGTTAGGACCACCAATGGATTGTGGAAAATGGAGCCATGACAAGAACAAAGCCACTGACTG AGATGGAGTGAGCTGAGACAGATAAGAGAATACCTTGGTCTCACCTATCCTGCCCTCACATCTT CCACCAGCACCTTACTGCCCAGGCCTATCTGGAAGCCACCTCACCAAGGACCTTGGAAGAGCAA GGGACAGTGAGGCAGGAGAAGAACAAGAAATGGATGTAAGCCTGGCCCATAATGTGAACATAAG TAATCACTAATGCTCAACAATTTATCCATTCAATCATTTATTCATTGGGTTGTCAGATAGTCTA TGTATGTGTAAAACAATCTGTTTTGGCTTTATGTGCAAAATCTGTTATAGCTTTAAAATATATC TGGAACTTTTTAGATTATTCCAAGCCTTATTTTGAGTAAATATTTGTTACTTTTAGTTCTATAA GTGAGGAAGAGTTTATGGCAAAGATTTTTGGCACTTTGTTTTCAAGATGGTGTTATCTTTTGAA TTCTTGATAAATGACTGTTTTTTTCTGCCTAATAGTAACTGGTTAAAAAACAAATGTTCATATT TATTGATTAAAAATGTGGTTGCTTAATTCCTAACCAGAAAAAAAAAAAAAAAA Download Select all
Length	2485

CDS Information

Location	join(594..817,18333..18442,41840..42007,42490..42618, 46201..46376,47144..47273,50150..50379)
CDS Sequence	>gi\|388596697:189-1100 Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant e, mRNA ATGGCAGATGATCAGGGCTGTATTGAAGAGCAGGGGGTTGAGGATTCAGCAAATGAAGATTCAGTGGATG CTAAGCCAGACCGGTCCTCGTTTGTACCGTCCCTCTTCAGTAAGAAGAAGAAAAATGTCACCATGCGATC CATCAAGACCACCCGGGACCGAGTGCCTACATATCAGTACAACATGAATTTTGAAAAGCTGGGCAAATGC ATCATAATAAACAACAAGAACTTTGATAAAGTGACAGGTATGGGCGTTCGAAACGGAACAGACAAAGATG CCGAGGCGCTCTTCAAGTGCTTCCGAAGCCTGGGTTTTGACGTGATTGTCTATAATGACTGCTCTTGTGC CAAGATGCAAGATCTGCTTAAAAAAGCTTCTGAAGAGGACCATACAAATGCCGCCTGCTTCGCCTGCATC CTCTTAAGCCATGGAGAAGAAAATGTAATTTATGGGAAAGATGGTGTCACACCAATAAAGGATTTGACAG CCCACTTTAGGGGGGATAGATGCAAAACCCTTTTAGAGAAACCCAAACTCTTCTTCATTCAGGCTTGCCG AGGGACCGAGCTTGATGATGGCATCCAGGCCGACTCGGGGCCCATCAATGACACAGATGCTAATCCTCGA TACAAGATCCCAGTGGAAGCTGACTTCCTCTTCGCCTATTCCACGGTTCCAGGCTATTACTCGTGGAGGA GCCCAGGAAGAGGCTCCTGGTTTGTGCAAGCCCTCTGCTCCATCCTGGAGGAGCACGGAAAAGACCTGGA AATCATGCAGATCCTCACCAGGGTGAATGACAGAGTTGCCAGGCACTTTGAGTCTCAGTCTGATGACCCA CACTTCCATGAGAAGAAGCAGATCCCCTGTGTGGTCTCCATGCTCACCAAGGAACTCTACTTCAGTCAAT AG Download Select all
CCDS ID	CCDS73200.1

Protein Information

Protein ID	NP_001253986.1
Protein Name	Caspase 7, apoptosis-related cysteine peptidase
Molecular Wt. (Da)	43597
Protein Sequence	>840 MRAGTRVALGSSTPAERTTPSQGRCKPRPALPRAAPPSAAPRLLVSLSLKGPQTLAAERRRETV PVPAALPPWERWQMIRAVLKSRGLRIQQMKIQWMLSQTGPRLYRPSSAPDSGTLYFTSKKKKNV TMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFD VIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRC KTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSP GRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL YFSQ Download Select all
Length	388
Uniprot ID	P04083
Ensembl Protein ID	ENSP00000257497

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
D	Proteolytic Cleavage	56
D	Proteolytic Cleavage	231
D	Proteolytic Cleavage	198
D	Proteolytic Cleavage	23
D	Proteolytic Cleavage	23
D	Proteolytic Cleavage	198
D	Proteolytic Cleavage	23
S	Phosphorylation	49
S	Phosphorylation	16
S	Phosphorylation	16
S	Phosphorylation	16

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
329	BIRC2	3419	NP_001157.1	in vitro	938 457 111 084 335
330	BIRC3	3426	NP_001156.1	in vitro	9384571
331	XIAP	2094	NP_001158.2	in vitro;in vivo	923 044 211 359 776 000 000 000 000 000
831	CAST	233	NP_001741.4	in vitro	10731697
835	CASP2	2800	NP_116764.2	in vitro	11399776
998	CDC42	309	NP_001782.1	in vitro;in vivo	11278572
1511	CTSG	289	NP_001902.1	in vitro	15650747
1832	DSP	513	NP_004406.2	in vitro	15500642
2802	GOLGA3	3990	NP_005886.2	in vitro;in vivo	10791974
3309	HSPA5	682	NP_005338.1	in vivo	11943137
4137	MAPT	1142	NP_001116538.1	in vitro;in vivo	12888622
4149	MAX	1113	NP_002373.3	in vitro;in vivo	11535131
4205	MEF2A	2807	NP_005578.2	in vitro	11904443
4209	MEF2D	2810	NP_005911.1	in vitro;in vivo	11904443
4734	NEDD4	3786	NP_940682.2	in vitro;in vivo	9593687
5590	PRKCZ	1504	NP_002735.3	in vitro	11016947
5610	EIF2AK2	1468	NP_002750.1	in vitro;in vivo	11555640
5663	PSEN1	87	NP_000012.1	in vitro;in vivo	10069390
5664	PSEN2	2860	NP_000438.2	in vivo	9 990 034 921 969 510 000 000
5757	PTMA	1778	NP_001092755.1	in vitro	10675528
5879	RAC1	3627	NP_061485.1	in vitro	11278572
5885	RAD21	5924	NP_006256.1	in vitro	11875078
5888	RAD51	1557	NP_597994.3	in vitro	109 980 589 607 320
5921	RASA1	745	NP_002881.1	in vitro	10200531
5925	RB1	1574	NP_000312.2	in vitro	1 573 570 111 420 700
6722	SRF	2788	NP_003122.1	in vitro	11387340
7132	TNFRSF1A	1861	NP_001056.1	in vitro	11755217
7431	VIM	1899	NP_003371.2	in vitro	104 691 731 142 390 000 000 000
8428	STK24	10385	NP_003567.2	in vitro;in vivo	12107159
8837	CFLAR	4671	NP_003870.4	in vitro;in vivo	9228018
10197	PSME3	5500	NP_789839.1	in vitro	11859414
10277	UBE4B	11659	AAD02233.1	in vitro	11802788
11168	PSIP1	4688	NP_150091.2	in vitro	12181742
63967	CLSPN	9257	NP_071394.2	in vitro	16123041

Pathway Information

Pathway Name	Pathway ID
Alzheimer's disease	hsa05010
Apoptosis	hsa04210
Legionellosis	hsa05134
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
Pertussis	hsa05133
TNF signaling pathway	hsa04668

Structure Information

PDB ID	1F1J
Resolution	2.35
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	CASPASE-7 PROTEASE
Model	View

Domain Information

ID	Location	Description
cd00032	60-301	CASc
cl00042	60-301	CASc superfamily
smart00115	60-302	CASc
pfam00656	68-301	Peptidase_C14

Ontology Information

HPRD ID	1060
Molecular Class	Cysteine protease
Molecular Function	Calcium ion binding (GO:0005509)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO