CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CD74	972	CD74 molecule, major histocompatibility complex, class II invariant chain	5	-

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20614481	2010	Cell line : CT26 Source : - Sample Type : - No. of Sample : - Stage : -	real time RT-PCR, Western blotting, Flow cytometry	Up-regulation	-	CD74 is expressed on CEC and colon carcinoma cells and serves as a survival receptor in these cells.

Gene Details

NC_000005.9 (149781200..149792543, complement)
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Gene Type	protein coding
Gene Family	CD molecules
Description	The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Chromosome	5
Location	5q32
Start	149781200
End	149792543
Strand	-
Gene Sequence	>gi\|568815593:c150412936-150401637 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly CTGCCTGGGGAGCCCCCCCGCCCCACATCCTGCCCCGCAAAAGGCAGCTTCACCAAAGTGGGGTATTTCC AGCCTTTGTAGCTTTCACTTCCACATCTACCAAGTGGGCGGAGTGGCCTTCTGTGGACGAATCAGATTCC TCTCCAGCACCGACTTTAAGAGGCGAGCCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAG CTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTATCTCCAACAATGAGCAACTGCCC ATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGGTATGTGTGAGCACCAGGAAAGGGCACACCGATCCTGG ACTGCAGAGCCGTGCGCATGTGCTGGGAAGAAGCACCGGCCAGGAGTCACAGGAAAGAGGGATTCAGGCT CTGACTCTAACATTGACTTTTTGGGTGATTTTGAGCAAGTCTTTGGCCTGCTCTGGGCTCCGGCTCCCTC TCTTGTCAAATGAGGGGGTTCCTTTAAGAGCAGGAGTTTGTAACTTTCCTTGCATCACACCGCCTCCTTC TGAAAAGCAGAAGAGAGCATGGGTTCTCTCCCTAGAGTTTCACATGCTATGCAGGGGCTTTGAGATCCCA CTAAAGCTGGGCTGTGAATGCTAGGTTAAAGGCCTTGGAACAGGCTGTGCCTGGTGGCTCCCGCCTGTAA TCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCAGCTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAAC ATGTTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGTACACCTGTAATCCCA CCTACTTGGGAGGTTGAGACATGAGAATCACTTCAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTG TGCAACTGTACCCCACCCTGGGTGACACAGTGACACTCTGTCTCAAAAAAAATAAATAAATAAATAAAGA CCTTGCACCAGATTTTGAAAATGTTCAAGATCCCAGTGGAGAAAGAGTTTCTAAAAGAGGATGGTAGAAG CAGTTCTTCACAGAGGAGTTCCCTCCTAATTACCACGGATCAAGGGAATGATAGTTGCAGGTGTCTGTAG AGTAGATGGAGACATCTGCCATCACAGGAGGGATTGTGAGATGTTGGGGGCAGGCAAGAAAGGAGGGACA GGCTCTGGTTAAATTTCTGGAGGGGGCTCAGGGTTGACGGGGGTCATGTCCTTGCCTGTGCCCCTCTCCC TTGCAGCCAGAGGCCAGCACAGCCATCCAGGGGACACCAGGCCCCCACTTCCCAGCCCCAAAATAGCCTC ACCCATGTGTTTCCCTCAAAAAGGGCTAGAAGGCTATTACCCCAATGCCCCTGCTACCCCCAGTCTCCAA AAAGTAATTTGCGATCTACAGGGACTTACAGCTAGGTGTGATGTCAGCTGTTGCCAGGCAGAAAGGGGTT TGGGAGAACCCTGCAGAGATGTTATGACAAGCTATGTTCTGGGGAACAAGGTAACCTGCTGCAGACCATT AGAGCTGTGGCCTGTGAAAACCCCAGGGAATCCCATGGCAAGGAGGGAGACTGTTTTGTGAGGAATGGAT TCAGGTCTAGGCCACGCGTGACCTTGGATAAATCACTGCCTCTCCCTGAGTCTCAGTAATAATATAATAG CCATAATAGTTCTCATCCACTGTGTACCTGTCACCAGGCCTCAGCCACTGTTAGTTAGTACTGTGATTAT TTACATACGTAAAGGCTAAACTCAATTTTAATTCTTACAGTCACCCTATGAATCAGGTACTTTTGTTGTC CCTTTTTACAGAAGAGGAAATTGAGGTCATATTGGTAAGTGACTTACCCAAGTAATCATAGCTAGTGAGT GGTTGGAGGCAGAATTTGAACCAGGACTAGTCTGACATCAAAGTGTTAGCTCACTCCACCATTTGGCCCC CTTTCAGAGGTGCATTTTGTGGGAAGGGGAGGTGAGACCCCTCTGAGCTCAGACCACTCAGTGATTTACA GACCCAGGTGGGCTCAGTGTTCAGAGTGCATGTCCCCTTGTCTAATCCTTGTCTAGTTTTCCCTTTATTC AGTTACTGCTTCTAAAGCTGGCTATGTGTGCTTAGGCCATTCCAGACTGGAGCCTGTTTTGGAGGCTTTT GTGAATGCTTCTGCCTGGCAACATCTGTGTCACGATTCCTGCTAGCTCTGGTTGGCTCCTGACTTTGGCT TTTTTTTTTTTTTTTTTAATTGCAGAAGAAGGTAGTGTAAATGAGGAAATAAAGAGGGGGGTGACAAGAG TTGGCACTCTACCAGAACCAGGGGACAGGCGTTCAAGATGCATAAAGAGGAAGAAAAGCAGATGCTAAAC TTAACTACGAACTCCCCTGAGAATTGCACTGAGTGTAATTTATTTATAGAGTGCTAACAATGTGCTAGGT GTGGAGCCAAGAGCTTTACCCTCATCATCTTATTTAATGTAACAGCCCTTGGAGCAGATGTTTTACCCGA TTTTACTCACACAGAGGGTTAATCAACTTAGATGGTCCCAGAACTAACCGACTCCAGAGCCAGGATTCCA ATCCAGGTTATGTGGTCTCGTCTTCAGGGTGAATCTCTAGGTTCTTAGGCCTCCTGAGGAACTGTGGTGC AGAGAGGGGAAGGTACTGTCCCATGTCGTGTGTGGGAGGTAGAGCTGGGGCTAGAATTGGGTGTGGGGTT GCAGAAGCACTGAACAGGTGGAGGATGAGGCTGGAGAGCCTGAACACAGGCTAGGCCACCCGTGTTCCTT GAGAAGGCCAAGAAGTAGAATTTGTTTTCCCTTCCTGTCTGGTCTCCCCACTTCCCCCCCGCCCCCCGCC CACCGTCGGGTTTTTGCTGTTTCCTTCCCGAATAACTCTCCCTTGGGCTGGGCCTTATCCCAGAAAGCAC AGACTGGCACGCAGCAAGCCAATGAGAATGAGCCAGTCTGTGATGTCATGAGTTACCAGGCACAAGGGAC TCCTGGAGCGTCCTAAACCATCCTTGCTGGTTGCTGGAGTAGGCAGGGTGCAGCCTCATCCTTGCAGTTC CCAATGGGTCTGTTTTAGTCCGTTTTGTGCCGCTTTAACAGAATACCACAGACTGCGTAATATACAAACA AACAAACAAACAAACAAAAAACACCCAGAAATTTATTTCTCACAGTTCTGGAGGGGCTTTCTTGTTTTTT TTTTTTTTTTTTGTTATGTTTTTTGAGACAGAGTCTCACTCTATCCCCCAGGATGGAATGCAGTGGTGTG ATCTTGGCTCACAGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTG GGACTACAGGTGCCCACCACTACGCCCGGCTAATTTTTTCTTTTTTTTTTGAGATGGAGCCTCACTCTGT TGCCCAGGCTGGAGTGCAATGGCATGATCTCAGCTCACTGCAACCTCCACCTTCCAGGTTCAAGGGATTC TCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCTCGCCACCACGTCCGGCTAATTTTTGCATTT TTAGTAGAGACAGGGTTTCACCACGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTACCTG TCTTGGCTTCCTAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCGGCCTAGCTTGCTTTCTTTTTT TTTTCTGAGACAGTCTCCTTCTGTCACCCAGGCTGGAGTGCAGTGACGTGATCTCGGCTCACTGCAACCT CCGCCTCCCGGGTTCAAGTGATTCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTAGAGGTGCACGCCAC CATGCCTGGCTAAGTTTTTTGTATTTTTTTGTAGAGACGGGGTTTCGCCATGTTGGCCAGACTGGTCTCG AACTCCTGGCCTCAAGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACCA CACCCAGCCTGGTGAGGGGCTTCCTTGATGTGTCCTCATATGGTGGAAGGCAGAAGGGCAAGAGAGAACC AACTCCTTCCATCAAGCCGTCTTACAGGGCACCTAATCCCATTCGTGAGGGAGAAGGCCTTGTGGCCCGA TCACCTCCCAACACCTTCACATTGGCAACACCTGGACTAGGGTCTTAGTAGTCCCACCCCTGGGGTCGTC AAAGAACAGATCAGAAACTCCTGGGGTGTAGGGGCAGGATCCTTACATCCCCTGTACTGTAACATATGCA TGCACCCCCCAGTCGCATCCAAGTCCCACAGATACAAGGGCTTGCTGAGGTCCGAGGGTCTGGATGGTGA GTCCAGGGAGCATGAGAAATTCATCCAGGCCACACAGGCTCAGGCACCTATACTCCTGCCCACCCCCTGC AGGATGGATATTACCATTTGAAATACTTTGGCGCTTGCAGTGAGATCTTGCTTAAAAGAAGAAACCCACC AAATTCTAGAATCGCAGAGGTGGGGGCACCTATGTGACAAATGAGGGAACAGAGGCACAGAGATTGGCAG GGACATGCTCAAAGACATGGAGAGCCTGGGCAGAGGATGGCCCCAGAGTGGGTGGTGCCTGGCCCTGCTT CAGCCTGACATTGTCCAAGCCTCCCCCAGCCCACTCCTAAAATGGCCAGGCCCCACTTCTTCCCAGGTGG GCTACATTTTCTGCTGTCCCGGTCCCACTTCCTTACCTTTTCTCCTTAAATCTGATTTCACTGTGAGGGT GGGAGGTTGGGCAGAGGGGTGAAAACCCTCTTCCCCTTACTTGGTAAGCACATACAATTTTTTTTGGTTT TGTCAATTAAAAAAAATAACATACCTGGTTGATCCTGCCAGCAGAAAAAAAAAACAAAACAAAAGGCTGG GCGCGGTGACTCACGCTTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACGAGATCAGGAGA TCGAGACCACGGTGAAACCCCGTCTCTATCAAAAATACAAAATAATTAGCCAGGCGTGGTGGCGGGTGCC TGTAGTCCCAGCTACTCGGAGAGGCTGAGGAAGGAGAATGGCATAAACCCAGGAGGTGGAGGTTGCAGTG AGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCAAAAAACAAAACAAA ACAAAACAAAACAAAAACCAAACCTGTTCCCCTTGAGGGCAGCCCTGATCATCAGGAGATCCGCACGGCA AAGGGAGCCTGGGAAGACCCCCCCACCTCAACCCCTCATCGCACAGGCAGGACCCTAAGGTCCAGAGAGG ACAAAGAGCATGCCTCTTTGCTCTTCTCTGTTCAACTCAGGCCCGTGGCAGCTGCAGGGTCTCTGCCAGG GAAGACTTCAGGCACATCGATGGTTGGAAGGAGGGGTGGGGTGAGGTCTTCAAGCTGTGTTTCCATAGCC AGCTTACTGTTTGTGCTTCAAATGCATTGTTTATTAGGGGTGGCTTAGGGGTCTAATGGAGATGGGGGTA TACATTTCCCCATTCCTAGCCAGCCCTTGGGGCAGCCACCACTGTGGATCCTCCTCTGACCTATCCTCCC CACCTCCCACAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTTCCATCCTGGTGACTCTGCTCCTC GCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCTGGACAAACTGACAGTCACCT CCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCGTGCGTGCACCCCTACATCCTGATA CCCCCCACCTCCCACCATCCCTCAACTCAGAGACCCGCATCCCTGCACCCAGCTGGGCCCACTGTCCTCT CCCTCCGGTTTGGAATTCCAGCCCTTCCTCATCTGGGTCTGATACCCTCCTCCCTGGGCACCGGGGCCAC ACTTACCCTCGTTCCTGTCCCCACAGCTCCCAAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGCTG ATGCAGGCGCTGCCCATGGGAGCCCTGCCCCAGGGGGTAAGGACAGCCCCAGGGTGGTGGGAGGGGCAAG GTTATCCCGCCTGGATGGAGGACAGTGCCAAGGGGAGGGGCAGGGAAGAGAGCCCACCTGGGGAGGGGTC CTGACTGCTGCGGGAGGGACAGTGCCTGCCTCAGGAAGAATCGGGCTCCCCAGGTGTGGAGGGCACAGGT GAAGAGTCTCTTGGTGCCATCCCTGGGAGGAAGGCTCAGCCCTCTACAGTTTACAAAGTGCTTCTCATTT CCTATAGCATCTCACTGTCCTCTCCCATTCTCAAAGACCTTGCTATCATGCATTGACAATATTTATATTC ACAATACTGTGCTGTGGACAAAACCCTGGGCAGGAAAGCTTATGCCAGTTTGACCAATGAGGACATTGAG GCAGGAAGCTAAAGTGACTTGCTCGAGCTCTCATGTTTGGAGGTGGCAGAGATGGAACCATTGACCAAGT GCCTGCGATTCCAGTCTCTTACCTAGATCCCAGCAACCGGCTCCTGCTCCATACCCCCTGCTCCAGGGAC CAGCTCTGGTAACCTTCTGTTACTTCCTCCCACAGCCCATGCAGAATGCCACCAAGTATGGCAACATGAC AGAGGACCATGTGATGCACCTGCTCCAGGTGAGTGCAGGGAGCTAGCTGGGTGGTCCTGCCTGCCCACCC AGGACCCTGGCCGGGCCAAGCTCCAAGGCCTGTATACCTGGCTCATGGCAGACTTTCAACATGTGCTCTC TGGATTACTGAATACAAGGGTGACCCTTAAATGTTATATGTAGTCTGGCCTCTGCATTTTTGAGATAAAC AGGCTCGGCTGGGTGCAGTGGCTCATGCCTGTAATCTCAGCACTTTGGGAGGCCTAGGCAGGCAGATCAC CTGAGGCCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAAGTCTCTACTAAAAATACAAAAATTAGC CGGATGTGGTGGCAGTCACCTGTAATCCCAGCTACTCATGAGGTTGAGGCAGGAGAATCGCTTTAACCCG GGAAGTGGAGGTTGCAGTGAGCCGAGATCATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACT CCATTTCAAAAAATAAAATAAAATAAAAATAAAAAAAGAAACTGAGGCTCAAAGTTTGGAAGTGACTTGC TCAAGACACCCTTTTTTTCTCCCCAAATTTGTACTGCGTGTCTGTCCTATGCCAGCACTGTGCAAGGCTC TGGGCCCACAATGGGGAGCAATTGGACCCAGCTCCTGAAGCCATGGGGATCCCAGGCTAGTGTGGGAGAC AGACAAGTGACCAGGTGATGACAGAAGTGCAGGGGGCTTTGTGAAGAAAGAGGCAGAGGACTCAACCTAG CTGGGGGCAGTCAAGGTTGGGTCCTCACCTGCTGGAGCAGGTAAGACCTGAAAGCTGAGCAGCCATCCAC AGGGAGGACACTGGGGCTTGTTGGTAGAGCTGGCCTGGAATCTGGAACTCGACTCGCAACGCTGCAGTCT CGTAGCTGAACAGCTGGACTACCCTTACCCGTACCCTCCCCTCCCCTCCCATCATGGCTGAAGTCCAGGG TTTAGGCTTGGTGTAGCTCTGGTCCATTCCTCAGAATGGAAGACCAAGGGAACGTGGGCTACACATTTCA CACTGCCTGCCAGGGAGCTCTTCTTGAACCATCCTTCCTGCCCTGCTACCCTGTAGAATGCTGACCCCCT GAAGGTGTACCCGCCACTGAAGGGGAGCTTCCCGGAGAACCTGAGACACCTTAAGAACACCATGGAGACC ATAGACTGGAAGGTCAGCAGGTTTCCCTGCATGGGAACTCTCTCTTTCCTCTGGTGTCTAGGGCAGGGCT AGGAGAGGTGGGGTGAGGGTGGGCTGGGGAAGCCATTCTCAGGAAGCTGAAGGGGTTTACCAGCACTTCC AAAACCTGGATGCTGCAGAGTATGTGGGGTTCAGCCCCAGGGGTCTTTAAGAGGGAACCAGGCTGCAGCT GGACCCGGGTGTTGGGGCCCTATTTGGCCCTGCATGTTTCTGTCCCCAGGGGCAAAGCCAGGCAGTGTAG GGGCTTGGTGGTGGCCATCGAACCTGACCTCCACCTCTATCCGTATTAGGTCTTTGAGAGCTGGATGCAC CATTGGCTCCTGTTTGAAATGAGCAGGCACTCCTTGGAGCAAAAGCCCACTGACGCTCCACCGAAAGGTA CAGGGAGTGGGAGCTTTAGCGTGCCAGGGCTTCTGGACCCTCGGGGCTCTCCTGAAGCTGCTGAGGCCGG GGCCTCCAGCACTCCCTGGTCCCAGCACCGCGGAATCTCCCATCCTCTCAGCTCTCACTTCTTTCTCACT TCTCTCTCTCTCCTGTCTGTTCCTTCTTGGTTTGGCTGTCCCCCTCCCCTGACCCACCCCCATCTTGTCT AAGGGTTCCTAAGGGCCCACAGAGGCCTGTCACCACAGGGTACAGGTGACCTCTCTCATAGAGGATGGTA CAGCACAGGGTGCCTGGGGTAGAACCTGCCCGAAACACTGCAGAAAGGAATCCTTGTAATGACCTTGCCC CAGTGCTGCCCGCAATCCAGTGAGGGCGCCAAGGTCACAGCTGCTGCCAAGAGAGCCTTGGGCGTTTCCC ACCTCATGGACAATGCAGACTAGGATGTTTTTAGACCCAAAGACAGAGTGCTGTTTCTATCCCGGTGCTG TCTCTAATTTGCTATGTAACTTTGGACAAGTCCCCTTCCCTCTAGGATTCAGGGTCCTGAAGTAGAAGGT CAAAGGGCCACCCTGCCTGGGGCCTCAGTTTCTGCATCAGATTCATAGAAGGCACCTTACATGCTATCTC CAACTCCTAGCTGATGCTTAAACCCCTCTAAGACATCTCCAACAAACGGTAAACCCCATTTCTACTTGAG AACTCCCAGTAACAGGAAGCTTAGACTTACCAAGGTGCCCATTGCTTTTCTCTAGAATCAGAATCGCAAG TGCAATTCCAAACTGTAATGGTGTTTTTTTGTTTGATTGTTTGTTTTTGAGATAGAGTCTGGCTCTGTCG CCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAACCTCAGCCTCCCGGGTTCAAGCAATTCTC CTGCCTCGGCCTCCCGAGTAGCTGGGATTATAGGCATGTGCCACCACGCCCAGCTAATTTTTGTATTTTT AGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCCACC TCGGCCTCCCAAAGTGCTAAGATTACAGGCATGAGCCACTGTGCCTGGCCCAAAACTGTAATGGGCTTTG AGTGTCAGAAGAAACCATCAACTTCTGAGGTGAATTGGACACATGGCCATTCACTTCCTTTTTGATCTCA GACCTTGTTGGTCTAGGCCTCAGTTTTCCCATCCGTGTGATGGCTGGAGTGAGTAAAGCCACTTGGGAAG AAGGCATTAAGCCCACAGCAGTGGTGTGTGGGTCTTTAGCTCTGCTCAGACCCTGGTTCAGAGCTCACTC ACTCACTGTGTCCTCATCATGCCTGTCGCTTCAGTACTGACCAAGTGCCAGGAAGAGGTCAGCCACATCC CTGCTGTCCACCCGGGTTCATTCAGGCCCAAGTGCGACGAGAACGGCAACTATCTGCCACTCCAGTGCTA TGGGAGCATCGGCTACTGCTGGTGTGTCTTCCCCAACGGCACGGAGGTCCCCAACACCAGAAGCCGCGGG CACCATAACTGCAGTGGTAAGCAGTGGCACTGTGCCAGTGTCAGAGGACCAGGAAGGACTAGGAAGGTTG AGGGGCAAGAGGTCCCCTCTGAAGCACATGGGACCAGGACACCCAGGATGGCAGCTCCTGGGGGCAGTGA CGTAGTCATGCGTCCAGCCCTTTATCCATCCACCCACCTGTGCATTCCTATTTGTCCATTTATCATCTCT CCTCTTACATGCACTCATATTTGTTCACTTATCCGTCAGTCCTTTCATCTGTGAATTTCATCCATCCACG CGCCATCCTCTAGCATCCAGGAGTCCTACAGACCCACCCATCTCATTTCATCACCCCCTTCTCACTCGAG CCCCCATTACACCTCTTTGTTGCTGCTTGCAGCTGTCCTTCCCTGGGTACCTGCTTTCCCAGGCACTAAG CCTGTGGCTAGGTGGGAAGCACTGCCCTCAGGCATCTTGGGTCAGGTAGGCTGCACTTCAAGTGACAAAC GGACTTGCTGCTCCTTTGCAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCA GGATCTGGGCCCAGGTAAGGGCCTTGCAGAGGGGCATCTGGTCACCAGCAGCTCATCCCCAGCAGGGCCA GCTCCTTTGTGGGCAGGTGAAGGAGTGTGACGCTGGGCCACTCTCCAACATTCCTGGGATGTCCATTTCA CAGACGAAGGAACAGGGTTGGGGGGCTGTGGGGAGTTACACAAATCCATGATGGTCATTATTGGACCTGA GCAGGGGGCAGGGGAGGGTGGACAGTCCTTAACTGCTCTGCAGGTCCAGGATGTTAGAAAGGGGCAGGGA CAACAAATGGGTGACCCCAACCTCAACCTGCTGCTTCTCTCTCCAGTCCCCATGTGAGAGCAGCAGAGGC GGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCC CATCTCCCACCCTGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACA AACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGCCCTGCTGCCCAATCTCCATCTGTCAACAGGGGC GTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGCAGCCTCCAACACA AGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGAC CCCAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCT GCAGGCTGAGCCACTCTCTTCCCTTTCCCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCAT AATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTTATCAGCTTTCAGGGCCATGGTTC ACATTAGAATAAAAGGTAGTAATTAGAACA Download Select all
Length	11344
OMIM ID	142790
HGNC ID	HGNC:1697
Unigene ID	Hs.436568
Ensembl ID	ENSG00000019582
PharmGKB ID	PA26236

mRNA Information

mRNA ID	NM_001025158.2
Exon	join(1..312,5613..5785,5977..6056,6616..6678,10312..10374, 10687..11300)
mRNA Sequence	>gi\|343403786\|ref\|NM_001025158.2\| Homo sapiens CD74 molecule (CD74), transcript variant 3, mRNA CTGCCTGGGGAGCCCCCCCGCCCCACATCCTGCCCCGCAAAAGGCAGCTTCACCAAAGTGGGGTATTTCC AGCCTTTGTAGCTTTCACTTCCACATCTACCAAGTGGGCGGAGTGGCCTTCTGTGGACGAATCAGATTCC TCTCCAGCACCGACTTTAAGAGGCGAGCCGGGGGGTCAGGGTCCCAGATGCACAGGAGGAGAAGCAGGAG CTGTCGGGAAGATCAGAAGCCAGTCATGGATGACCAGCGCGACCTTATCTCCAACAATGAGCAACTGCCC ATGCTGGGCCGGCGCCCTGGGGCCCCGGAGAGCAAGTGCAGCCGCGGAGCCCTGTACACAGGCTTTTCCA TCCTGGTGACTCTGCTCCTCGCTGGCCAGGCCACCACCGCCTACTTCCTGTACCAGCAGCAGGGCCGGCT GGACAAACTGACAGTCACCTCCCAGAACCTGCAGCTGGAGAACCTGCGCATGAAGCTTCCCAAGCCTCCC AAGCCTGTGAGCAAGATGCGCATGGCCACCCCGCTGCTGATGCAGGCGCTGCCCATGGGAGCCCTGCCCC AGGGGCCCATGCAGAATGCCACCAAGTATGGCAACATGACAGAGGACCATGTGATGCACCTGCTCCAGAG TCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGT GAGAGCAGCAGAGGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGC CCCCAGCCCCTCCCCCATCTCCCACCCTGTACCTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCA CCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGCCCTGCTGCCCAATCTCCA TCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACA GCAGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATA ACCCTACACCCAGACCCCAGGCTGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTT CTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTCCCCAGCATCACTCCCCAAGGAAGAGCCA ATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTTATCAGCTT TCAGGGCCATGGTTCACATTAGAATAAAAGGTAGTAATTAGAACAAAAAAAAAAAAAAAAAA Download Select all
Length	1322

CDS Information

Location	188..670
CDS Sequence	Download Select all
CCDS ID	CCDS34276.1

Protein Information

Protein ID	NP_001020329.1
Protein Name	CD74 molecule, major histocompatibility complex, class II invariant chain
Molecular Wt. (Da)	18197
Protein Sequence	>lcl\|NM_001025158.2_prot_NP_001020329.1_1 [gene=CD74] [protein=HLA class II histocompatibility antigen gamma chain isoform c] [protein_id=NP_001020329.1] [location=188..670] MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYF LYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTED HVMHLLQSHWNWRTRLLGWV Download Select all
Length	160
Uniprot ID	P25963
Ensembl Protein ID	ENSP00000216797

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	130
N	Glycosylation	136
S	Phosphorylation	25
S	Phosphorylation	42
C	Palmitoylation	44
S	Phosphorylation	45

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
960	CD44	115	NP_000601.3	in vivo	8343954
1514	CTSL1	293	NP_001903.1	in vitro	10022822
3113	HLA-DPA1	835	NP_291032.2	in vivo	16242130
3115	HLA-DPB1	832	NP_002112.3	in vivo	16242130
3117	HLA-DQA1	6765	NP_002113.2	in vivo	16242130
3119	HLA-DQB1	5054	NP_002114.3	in vivo	16242130
3122	HLA-DRA	833	NP_061984.2	in vivo	16242130

Pathway Information

Pathway Name	Pathway ID
Antigen processing and presentation	hsa04612
Herpes simplex infection	hsa05168
Tuberculosis	hsa05152

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00191	212-271	TY
cl00150	212-271	TY superfamily
pfam09307	17-129	MHC2-interact
cl07809	17-129	MHC2-interact superfamily
pfam08831	136-207	MHCassoc_trimer
cl07439	136-207	MHCassoc_trimer superfamily
pfam00086	213-271	Thyroglobulin_1
smart00211	230-273	TY

Ontology Information

HPRD ID	8874
Molecular Class	MHC complex protein
Molecular Function	Growth factor activity (GO:0008083)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Important Information

Mechanism Up-regulation
Biomarker -
Drug Target -
Biological Process Immune response