CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
IL12B	3593	interleukin 12B	5	CLMF, IL-12B, NKSF, CLMF2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24909386	2014	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 91 Stage : -	ELISA	Down-regulation	-	Findings show clinical significance of the preoperative serum concentration for IL-12p40 and provide an additional prognostic biomarker for CRC survival. The levels of circulating interleukin IL-12p40 significantly decreased with the progression of CRC, whereas the levels of IL-23 remained with no significant differences between disease stages.

Gene Details

Chromosome 5 - NC_000005.10 (159314783..159330473, complement)
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Gene Type	protein coding
Gene Family	Interleukins and interleukin receptors, "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Chromosome	5
Location	5q31.1-q33
Start	159314783
End	159330473
Strand	-
Gene Sequence	>gi\|568815593:c159330473-159314783 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly CTGTTTCAGGGCCATTGGACTCTCCGTCCTGCCCAGAGCAAGGTAAGCACTTCCCAAGCCCCTACCTCCC TCCCCTCCCTGTGGGCCTGCAGCTGTCCAGGTGTAGAAACCGTTAGTGTGCTACCCCAGCAGCTGGCAGG AGGGAGTTGGTGGATTCCTGGAAGCATCCCTGGTGAGTCATCTGCTGGAACATTAGTGAAAACTTAGTAC TCTAGGGACCGATGTACAGTGTCCATTTTAAAAGCCACCTAATAATAACTGTATAGCAAGATCTGTGTGT ATGCATAGTTTGTGGAAATGTTTGTTTTATCTTATTTTGAAGTGGTGTGTATTGATGTATAAAAGTATAT TCCTAAATGTTAATGCCCATCAGTTAAAGGATTGTATAGAGCTAAAGTGAGTGGTGCCTGCCTTACTATT GAAATTTTTAAAAAGCCTTTCGTGCATTCCTTAAAGTAATTGGATTCATAATTATAATAATGTTACAAAT CAGACTTGCTCCCATATTTGTGATGGTCTTGGTCGTCAGTTGTGATATCAACCAAAATGACAGCTGGGAT CCCCATTCTTGTGGATTAACTAACTTTGGCCCCAGTTAAAAAATGAAAAGCTATTATTGCTTCCTAAAGA GTTTTTAAATCTGTGAGAAGGGGGAAAAAAAGGTTTTTTTACTTGCCCAGGTAAAATTGTGTGCAACAAC AATGTCATTTTAACAAAGGGATTACTAAACCCCAGGTGATGACCCACTTTTTCAAACAAGGAATTGCAAG ATACTAGATGGAATGTGGGTAACCTCTTAGAGTTTAGTTTACTGGAATCTGAAATTGTATGATTTCCGTA CATTCCTTCATGCTACTAATAAGTCATGGAATCCCTCTGTGCTGGACTCTGGGGGTAAAGTGCAAAACAA GATAGACATGATCCATGGCATAAGAGAGTTCACTCAGTGTGGCAGAGAAGACAAACAGTAAAGAAGAGAC TGTATTGTTGCCATTGTAGTAAATGCTGTGGAAGGAGGGGAGCAAATAGTGGGTCCTGACTTCATCTAGG CACCATGACACTTCACGTGAATTATGTCACTAACTCCTTACCACAGTAGCATGCCCATTTTATAGATCAG GAGTGTGGGGCTTAAAGGGGCCAAGTGACTCACCCAGAGTCACACAGTTCTAGAAGTCTGCCTGGCCCTC AAACTAGGGATCTTTGCATGTGCCACCCATGCCATCTGTGACTATATCTTTTTATTCTTTAATAATAACT CCCTTTTCTAATTAAAGGTAACAAACAAAACTTAAAAAAGAGATGCCCACCCAAGCGTCATTGGCATGCT GATGTTGGCACCAGTGTTGGGAAGCCCTTAGCATACTCCAGGAAGTAGGAGTGTGTAACGTGGGGTCCCT TTGTCCTTCATGCAAGGGTTTCAAGAGTTTAGAAAACCTATGAAATTGCACACACAAAAATGTGTTTTAA TCATCAAGACTCTCAGACTTACCATGCTGAGAAATGTGGGCTGAGGGATAGCGCTCCCTAGTATCAGCTG ATGGGCCAGAGAGCCAAAGGAGGAGACCCACCACCATCACCTCTCCTGGACAGTGCTCTGTGGTTTCAAA TGTAGGTGATACTAAAATGGGAGTTGCTTCTTAGAACCATGGCCGGGGTTCCCTTGACCCTGAAGTGCAG TTCACCTGAGATTGTCAAATGCATCTGAGGCATGCAGAGGAAGTGCTGGGCACACAGCTAGTGGGAATAC CTCAGCGTAAGTGGCCAGGAGATGCCAGGAATCTCCACTATTTCCCTTCCAGTGTGCCAGCCTCTGGGTT TTACAGGCGCATGTAATTGCAGTACCTCTGTGCACATTTCCCTACTGCCTAGAATGACTTTCTTGACTAT CCATGATATATAAAACACAGATACCGAATTGTTCCCTTACCTCTTCCTCTAGGTTCAAGTTAATATGTTA TTGGTTGCCTTCTATAATATGTTATCTCATTGCCTTTCCCAACAAGCCTTTGAGATAAGTATTAGGTCCA TTTTATAGACAAAGAGACTGAGGCTCAGCGAGTAACTTGGCCAACAAGTTGCTCCCACTGCTCAACAGCA AATGAGCGGTGGGACCAAAATTCAAGCCTGTGTCTGTTTAACTTCAAGCCTGTGAATGTACTAACCGGTG CCCTGTGCCAGCTAGTACTTTGCTACAGTCATAACCTAGACTGAAGTGATAGCCATGCCCCTAAAACTCC ATGCTGTGGTGACAGCACTGAGCAGTGTCCAAGAAGGCTTGACTTCTAGGCCTGTCTCTGCCACTCACAA ACTTTATAAGGGAATAAAGTACATAGCAAGGTCCGCCTAGAGTTAGTAGCAGTTCTGACAAAGCTGTAAT TTGTCAATATTCCGTCACCCAACCCAGGAATGCTCATTTTTAAGGTATTTGACTGAAACAGTTGAGCATT GCCCTTCATATAGTTTAAAACAGTGGTTTCAGAACCACTTTCCTCCAGACCATGGGTGCTCTGCAAGGTG AATGGAGTTGTTTCAGAATGTTTCAATAATCATCCCTACCTCATTCGTAAGTGGCATGTAATTTTTGCAA TCGGAAGATTTTCATAAACCCTGGATACTAACCTAGACTGGTTTCTATATCAGATGGTGGCTTATTTAAC ATAAAATTATGCATTTTACTATTTCATGGTGGATATATCAATATGTTGTGGTCTTTTCCCAATGAACACT TTGATTTTCAGGGGTTCTGGACCCTGAACATGGGTTAAACCAGTGGTTCTCAAGGTGTGGTCTTAGCGCC AGCAGCATCTGCTTCCCCTGGAAACTTTCTAGAAATGCATATTCTCAGGCCCTCATGCCTGCTGAATCAG ACACTCTGGGGGTGGGACTCAGCCGTCTGTTGTAGCAGTGCTTCCAGGTTATCCTGACAGTCACTCAAAT TTTAGAACCACTAGGTTCTCTATATGGGAGAGAGTAGTCTTTGAACTTGGAAAACAAGAGAAGCTAAACC CCTACAGCAAGGGCTGGTGACCAGGTCGTTGCCAGAACCTGAAAGTTCGCCTCTGTATTACCGTTCCTGT CCCTAACCCAAGTCCTTCAGTTCTGGGTGCTCCAGCACACACTGCTTTGTGCTGCAGTGATACAAATGTA TGGCTCATCTCCCCAGCTGGCGGGGAGGCATTTAACACACTGACTTAATAAATATTTATTGAGTAAAAGT ATTTGCTCCTAGGAAGCGGGATCCAGGTAAGCCCTTTTTTTCTCTCTCAACTGCTTCTAGCCCAGTGCTC TTTATGTAGTAAGCACTAAATAAACAACTGCTAGATGTTGATCCAGAAAGTCACATTCCTTCTCTAAGCT TTAAGTTTCTCATCTTAAAAATAAGAGGATTGTATCAGATGGCTTGCCTTAGGTCTCTTTCAGCTCCAGA GCCCCAAATACCCTATGGTTCTCTATTTAGAGATGTTCTTCCCCACAGACTGCCATAGAACTCCTGTAAT TTACTTAGTATTTGCTTGACAGTATGGAGAAGAAAGGGGAGAATCAAGATTTTATTTAAAAAAAAAGTAG CTAGAATGTGTATATGGTTCACAAAGGTAACAAGAATTATTGACATTCTTTCTTCTCTTTTTTCTTCCTC TTCCTTCTCTTTTCCTCCTTCTCTTCCCCCTGCTTCTCTCCCTTCTTATAGATGTGTCACCAGCAGTTGG TCATCTCTTGGTTTTCCCTGGTTTTTCTGGCATCTCCCCTCGTGGCCATATGGGAACTGAAGAAAGATGG TAACCAGCCTCTCATTATTCTCTGTGGAGGCCCCACTTCTAAGCCAGGACTCTTGGGCAGCCACTGGTGG GAAATCAAACTGAAATGGGCAACCATGCACTGGGTCCTCTAGAGAAAGCCATCACTCTGGGAAAATGCAA TGCCATATCTCTCTTTTCTACTTTGATGGTATCTATATTGTTTGGTTTTCACATTGGATGACATTGGTAC ACTATGGTGGGGAAAGACATATGATATATGATATGGTGGGGAAAGACATATGACATATGATATTTTCCAA TATTACTAAAAACTGTTTCACACAATTAAAATTCCAAAGTAGAGGATTTGCAAAGTATAACAACTGTGTT CGTTTCTCATTCCACCACATGATACTGCCCCCTCAGTTGGCACTGTGATGACTTACCTCTGACCAAGCAC TTTGGAGGAAGCATAGGATTCAGACTCACATTGACTTGGGTTCAAGTCCTAGGTCTGTCAATGACTGGTT ATGTGACTTTAAGCTGGGTCACCTCTAATCCTGAATTTCCTCAACTGTAAACTGGATGTTACAAAGTGGA TGCCTACCACGTGGGTTATTTAGTGGGTTAATGAATGCAGAATACAACTCGACAGATAGTAAAGTGAAAG TAAATGTCAGCTAGTATTACTATTTTGGTTGTTTAAAATATCTTTCATGATTCAAGAGATACTTTTTATT ATCCCAATGATCAGTAAAAATTATTAGTAGACTAATAGAATAGTTAATGGTAAAATAAGGAGTTCTGCCC ATCCTTCTAGTATCTCACACTCAGTAAATGTGCATTCTGACCGTTGGCTGTACCTGAAAGACCCTCAGAT TTTTATCACTGAAGCCAACATCATAATGTTGGCGATTACTATCTTTAATTGTATAATAATAATAGTTAAT GTTTATTGAGTGCACTGTCTCACTTAATTCTCACAAGAGCCATATGAAGTAGAGACTGTCTGTATCCCAT TTTACAGATGTTGGAAACTGAGGCCAGAGAGATTAAGTAACTTGCCCAATGTCACATACCTGGTAAGGGT GGAACAGGGACTTGATCCCAATTCTGTCTTGCTTCAAAGCTGGTGCACTTAAATTTGTGAAAACGTTTTT ACAAGGACATGAAGTAATTTTTTCCCAGGTCTTTGGAGAGCTGAATAAGAGGAAATGGACATAAATTAAG GATGAAAATATTTCAGCTGATGATCAGAAATAATCTTTTGATATTCTAGAAAGTACCATCTTGAAATGGG TACCTGAAAGAAATCTGGGACCACTCCTCTCTTCTCAAGAATTTTAGGAAGACAGAATCCAGCCACCCCT TCTCCATGAGAATTTGAGAGATTTAGACACTCTCTTAAGTAAAGGCAAAGGCCTGAGCCAGGGGTATATG GCAGATCCCTTCCAACCCTGGGATTGTTAGCGAGCTCAGGAACCTTGGTCCTGGCATATTTGACCCCTTA GTGACTTCTGATTTGGTAAACCACAGAAATTCCAGAAAATCAGTGTGAGAAACTCTCCGAGGTGTGACTT AGGAGGGCAGACGATGCAGTGAGGCTAAGTGCCAGGTTCTTGATGCTCCTCTTCAGCTTTCCTCCTGCAG CTGTTTTCCCTGCTGTTGAGCAAACATCTTCTAGGGCTTCCGAGCCTCAGTTGGGACAGGAAAGTAACCA TGCTCTTCAGGTGTCAGGGGGACAAAAAAAAAACCAAGAAAAAGCCAAAAGTGCCACATGGTTTTACATC AGCACAGCTAATCATTTCCCCAGAGTTGGACCCCAAATGCTTTTGACCTCTTATTTTTGTTATCCATTCA GTCCTTATAATCCAATTGATGTAAAGTGAAAACTTTATATTCTACAATGCTTTACATCCAGAGGCCAATA ACGAGAACCACCATTTATAAAGCATGTAAGGGCACTGTGTATGAGCTTATATAATCCACATATCCACCTT CTAAAGCAAGGGCTAATATTTTTCTCATTTTAAAGATGATGACACTGAGGCTTACAGTAGTTGAATGTCT TGCCAAAGGCCACAAGACTGGAGCAAGGGCTAGAGCTGCTTCTAAATCCAGGCCTCTGCCACTCCAAAAT GCAGGCTCTCAACCACTGTGACTCATAAACTTGAGCAGGCATCAGCACCATCTGGAGAGCTTAAGAACCA TATAACTAAATCCATCCCAAGGTTTCTGATTCAGCAGCTGAGAATTTGCATTTCTGATCTATTCCAAGGT GATGCTGCTGATGGTGTTTCATCGATCATGCTTTGGGAACTACTACATTAAACAATTCTATTCAATTAAT AATTTATGCATGGATTAAAAAAATGAATGAAGCTTTGCTATGACACACTCTGAAATACTATACTAAGCCA TTCCTCAAAGGCCAGTTTAGACACTAGCATTAGGCATCCCTTGCAAAGCCCAAGAGACAAAAGGTCTGAG CTGTAGCCCTTGTACTTCTGACTTGCTGTGACCATGCTTAGATCGTTGGCCTCAGTACGCTTCTTCATTA AATGGGAAGACTAAGCTCTACTGGACTGCTTCATAAGAGTGTAAGATAGCTAAAAATAATAATAATAATA ATAATAATGCAGAGAGAATGAAAATCTCCACTGGTGATTTAAAACAGAGGGAACGAAATCCTTAAATATC CATGGAAAATTGTTAAGAGAGTTTCTCTGTACAGTTGGCTGACTCCTCAGTCTATAAGTAACGATAACTA ACACCGAATTTACTGTGTGGCAGACACTGTGCTAAGTACTTTACGTGCTTTTTTTTTTTTTCATTTAATC CTCAGTCAAATGTAAGGCAGATACTGTTATTATTATCATTTTACAGATGAGGAAACTGAGGCTCATGATA ATGAAATACCTTGTTCCAAATCCCCCAGCTGGTTAGTGGAGACAGGATGACAGTCTTGGTTCGTTGTTCT CGACACCCTGAGCTTTTAACCACTATGTTACTCTGCTGAATATTGTGCCCTGCCGTATTCTCTATGAAAC TGAAATTGTGCTGGAAGTTTCTCTCCCCCAGACCTTTGGCAAAGAGTCTTGTGCTGTTTGCAGTTTTTGG TATATTAAGGTGTTTCCAATCTGCTAAATAATCAAAGGTTACTATTAAAGGCAGCCTTCCAGTCAATGAG TCGATGGCAGCTATAAAACTCTTTGTTTCTCTTTTCCATGACCTTGAGCCCAAGCAGGGTCTCATGCCTT GAGATCATCTCAGCAAGCATTTGCCAAATACTTGTTGTAAACAAGGTTGTGTTTAGGCAATGGGGATGCC CGAAGGGTTAATAAAACACAGTCCCAGAGTTCCTGGAGCTTACAGCCTGGTTCTCCACTTTATGTGCATT CCAGTTTATGTCGTAGAATTGGATTGGTATCCGGATGCCCCTGGAGAAATGGTGGTCCTCACCTGTGACA CCCCTGAAGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGGCAAAACCCT GACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACAAAGGAGGCGAGGTTCTAAGC CATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTGGTCCACTGATATTTTAAAGGACCAGAAAG GTAATTCTATACCCTTGGATAGTATCAATTTTCTCTTTCGCTCATAAGAGTTAAAAACAACAACAACAAC AAATTGAAAAGCCAAGTCATGGTGAGTGTAATGAATTAACATCAAGTCTCTTATTGATGTTAATTGATGT TAACCTCCATTTTCCTTTGCTTTCCTGGACCCTTTGGGTTATCAACCATCAAAATCTCATATTAAGGGAG TTTCATGATCAGTCTGAATGCTTAGCCTCATGTTTTCTTTAAATAATGGTGATATTATTTAATGGCTAAT GGAAATTAACCGATAGTGTATCACTCTGCACTGGGGTGATAGCCTTCAAAAAATGAATGCCTCTGCCAGG CATGTTAGGTGTGTAGTGTACTCTGCAGAATCAACACCCCACTGGGATACTCCCAATCCTTATGGAGCTA CCCAAGAGGCAACGCATGGAAGAACTTCACCCTGTACCATCTGGTGATCTGTGATTCATCACAATCAAAA CCTTTCTGCAAAAAACTCCTAAATATTGAATTTTTGTTTTTTTCAAATCCAGAACCCAAAAATAAGACCT TTCTAAGATGCGAGGCCAAGAATTATTCTGGACGTTTCACCTGCTGGTGGCTGACGACAATCAGTACTGA TTTGACATTCAGTGTCAAAAGCAGCAGAGGGTGAGTGAAACTGCTCTGGTTTCTCAGCATTTTTCTAGAA CTATTTCATTAAGAAATTAAGGGCAACCTCTCAGTGACCTATCAGTTAATGATAATGGGAAAAGCAAAGT CAAACCCGTGTTTTTTCAACCGCCCTTCCTTGTCTACATTGAAGAAAGAACATGGAGATTTTAGCCGATT GCTTGAATAAATGTATGTGTTGGGGCAGGATATTATTGGGAACTGAGAATAGTCTCTGCTGTGTTTGAAC CCACTCATCCAAATTGCCTGGCCATGCTTCCTGAAGCCTCATAGCACCAAAGAAAGGGATAAACGGAGAA TTCAAAGCTACAAATGACTTGCTGAAATTGCACCTTGAGTCAAAAATAAAAACAAGAGCTCCAGGGCGTA GATCTTAGGGGCCCTGAAGCAGACTCCAAAACTCGATGAGGCCTCCCGAAATTTTCCCAGGGCCACCTCA ACTCCTTTTACTTCTGCTGACACCACTAATCTGAAGTTCGCTGTTGGTCCAATGCACCTGGACTTTCCGT AAGAAAGCAACTTCCATAAATACAAGACCTATGTGTTAACCCCCATGTGGCTTACTTTAATCATCACCGA AGCAAACCCCAGGTGATCATCCTGACTTTACCATTATTTCACTGAGTAAATTAAGCATTGGGGTCTCACT TTTTCATCTTTAAAAGGAAAATGCTTACTAAAGAAATGTTTCTCCAAGTGCATAAAGACATAATCAGCAG AGGAATGGTTAAATAAAACATGGTACACTATACTCTTGCTTAATGTGCAGTCATTGAAGTGGATAACCCA ACCCATATGTTTTGTCATGGAGAGCTCCCCATAATATGTTCAGAGGGGAAAAGGATGGTTACATAATCAT ATGTATACAATTTGATCCTAGTTCATAAAAATAAAATCTATATGTATAAGTAAAATATATATAGTGGATA TATATAATGTAGAGATGTATATAACATGGATTATATATATAATGTGTGTATACATATGTGTGTGTGTGTG TGTGTGTATATATATATATATATATAAAATGTGTATACAATTATCTTGAATATTCATTGAAAAAGTTCTG GCCAGGCACAGTGGCTCACACCTGAAATCCTAACTCTTTGGGAGGCTGAGACAGAATGATTGCTTGAGGC CAGGAGTTCAAGACCAGCCTAGGCAACACAGTGAGACCCCATCTCAGAAAATATTAAAAATAAAAAAATT AGGTGGGTGTGGTGGCACACACCTGTAGTCCCAGCTACTTGGGAGGCAGAGGGAGGGGATCACTTGAGCC TAGGAGTTTGAGGCTACAGTGGGGTCTGATTCCACCACTTCACTCCAGCCTGGGTGGCAGAGCAAAACCC TGTCTCTTAAAAAAAAAAAGAGAGAGAGAGAGAGAAAGAAAAAGAAAAAGGAAGGTCTGGAAGGATACAA CAAGCTATTATTAGTACTTAAACCTGTGGAGAGCAGTTAAGGATGAAGGAGACATACACTTCTTTCCTTT ATATGGATCTTTATCATCTTTACTTTTATAATTAGTGTGTACTGATTTGTGTATTGATTTTATAATTAAA ATGGGAAAAAATGAATTTAAGTTTTTAACAAGGGGGTTTAATAATCAGAGATTCTAGATCTAAAACAAAC AAAAACTTCCATATTCATTTAGTCCAGAGACATGTAAGTGCTCTTGAATTTAAGCTTTTTCTCCTGGGGA GGGCAGTTTCTTACCCTCTGGGTAGAAATCAGCCCAGTTGGAGAAACTGTGTCCTCAGACAACAGTTGAG GCCTTACCTGCCTTACTGGCTACAATCACTAGGAACTCTCTCCCCAATGTGTAACACAGGCTAATTTCTG TCTTTGACTTCAGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGCTGCTACACTCTCTGCAGAGAGAGT CAGAGGGGACAACAAGGAGTATGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCCCAGCTGCTGAG GAGAGTCTGCCCATTGAGGTCATGGTGGATGCCGTTCACAAGCTCAAGTATGAAAACTACACCAGCAGCT TCTTCATCAGGGACATCAGTGAGTTTTGGATGATTATATGTGCTCCATAAGGAAAGATACTATTTGTCAC GTGTTCACAATGCCCCATGCACTGTGGGGTAGGTGGTTGACAAGCATCATCTCTTTTATTCTGCATCCAA AAACAAAATACGATGTAGATACTGTTATCTGCATTTTAAGGAAGAGGAAATTGAGTCTTAGAAAAGTTAA GCAACTTGCCCCAGATCTCAGATCTTACAGCTAGCCGTTCAAATCCAGATCCACTCCACTACAGCTGCTC TTTACTGCACTTTGATTCAGCTGCCAGATAGTTTCCATGATGAATCCCAGAGCCTAATCAAGCATAATAT TCATATTCAGAACCAGGGCTTCCTTACTAATGGCAATTATTCCCAACCAATCCTTCCTTAGCATTTGAAA AGGGACTTCTTTCTTAGAATATAAACCCTTCCAAAATGGACATCTTTTTTTTTAATTGGCAGATAGGGAT TTCACCATAAGTCATTTCCTTTACTATTTATTCATTGACCAGGCAGCATGATAAAGTGTAATAGAACCAG AGAACTTGCTTCAAAACTTATGGAGGGTTTGTACTTGGTGGGTGGGGTCTAGTTCACATAGGGTGGCCAA GGAAGGCCTCTCTGAGGAGGTGACATTTAGCTGACACCAAAAGGAAAGATGTCAGTTGTGTTAAGAGCAG AGGGAAGCATATGTGCGAAGCACCTGCTAGGAGCCGTGATCTTTGTGTGGAGCAGTGCCAGGCCTACAGA GCCCAACCACACACCCTAGCATGTCTCTGCCTCCTCTTATCTAGAAGACCTAATTGAGGAAGGAGTCTTT GTGAAACTCACTGCTGTATCCTTCATGCACAGTCCAGTGGCTGGAACATAATGGGCGCTCAGTATTCATG GAATAAACAAGCAAATTGAGCATAGAGACAATTGACTGTAACTGCTCCAAGACATGTCCGCACCAAAAGC TATGAAAAGACAAAAGAAAGGGCAGTAAATAGAAAATCTATCATCTCATCCCCAGGGAGAGGCTCAGCTT AGTTCCATGTTCAGTGCAAAGTGAGGGATTAGCACAGACAGGGTGGTCCTTCAATGCATGGCCCATAACC ATTAAAGCAGAGGTCTTCTCACTGTGCGGTCCCATCTGATTGTTCAGTGATGAGGATTCTGAGCATCTCT CAGATCCTGCAATACATGTGGATCTGAGATGTGGCCATTGATAATGACTGCCTTCCCGAGGCACCAGCGT GAGCACCTGCGGCAGAGGTGCCTCACATTTGCCAGCCAGGTGCTCACAGAAGTTAAGTAACTATCCAGTG GACTCACAGCTGATCAAAGGTGCAAGTGAGATCATAAGCCAAAACCACTGAACTCCAAAGCCTTATTAGG AAAATAAAGCATGTTTATCCTCTTCCACAGTCAAACCTGACCCACCCAAGAACTTGCAGCTGAAGCCATT AAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGAGTACCCTGACACCTGGAGTACTCCACATTCCTACTTC TCCCTGACATTCTGCGTTCAGGTCCAGGGCAAGAGCAAGAGAGAAAAGGTAAGAAGTGATTCAGGTGCAG TATATTCCTTGGTCAGTTTTACGGAGGCCCACCATAAAGTGAGAAGATGAATGATGATAATAACAATGAC ATCCATGTATCACTTAACAACAGGGATACATTCTGAGAAATTCATCTTTAGGCAGCTATATCATTGTGCA AACATATATGGTGTACCCACACAAACCTAGATGGTATAGCCTACTACGCTTCTAGGCTTTATGGTATAGC CTATTGCTCCTAGGCTGCAAACCTGTACAGCATGTTCCTGTACTGAATACTGTAGGCAATTACAACACAA TGGTTTGTATATCTAAACAGAAAAGATATAGCAAAAATACAATATTATAACAATATAGGACCACTGGTCA TATATGTGATCCTTCTTTGACTGAAATGTTATTATGTGATGCATAATTACTTTTCTTAGCACTTTTCTAT GTGTCTAGAGCTGTGCCAAGGGTTTTCCATGTTTATTTCACTTAATCTACAAAATTAACGCAACAAAGGT AGCTGATGTTATTCTTGTTTTTTTACCCCCTTTTTTGTGGAAAAGAGGCTTTCCTTTTTTCCAGAAACTG TGGCAAGGTAAAGTAAAGCTGTAGCTGATGCAGGAATTTTGTGTAGGTGTTAGCAGCACTGCCCTCACTA CGTGCTCATTGGACAGTAGCCCAACCCCAAGAAAAGGATGGTTGGTAGCCAGTAGTATTATCATCATTTC ACAAGTGATTGAAGACTCAGAGAGGTTAAGTGACTTTACCAAGGTCACCCAGCTAGGAAATGACATAACC AAGACATAAACTCAATCTGCCAGACAGAAAGGCCATGCACCTAACCACTCCACTACCTCTGATGTTGGTC ATTGATCTTGGCACTCAGAATTAGTCCTGATAGAGGAGACCTGGGCTCCAGAAGCCTAAAATTGTTGTTT CAACTGAGTGCATGTAATGAATGATAGAACAGGCAAGAGATATCGCCCCCAAAATGGATAGCTCCTGGCT GTTCCAGATATTATAAAATTATTTTACTAAACAGAATGTCTACACTTATAGAGGCTAAGATATTGGCTTC CCAGCTTCCTCACCTTACAGCAGAATTCCTTTGCCTGTTGCAAGGTTCCAGAGGCCCTTTTGTACCGCCC CAGACTCCTTTCACCCCACTTTTAAAATCACTGGACAAAGCCCTAATTCAGCATAGCATTTAGCATGTGG TAGAAATTCAGTGAGCTAGTTACTCTCTGGGAAAATAATTAGGTAGGGAGGCTATCCTGGAATAGATATT TACCTAAATATTATTTTACATCTTGGCAAGTACTTTCCCTATTTAAGATCTGTATGACTAATAGGTGATA TTGAGTGCTTCCTATGTGCTAAAGACTTGCTAAGAGTTTGACGTGATTTTTACCTTGAACTATAATTCTA TGAAGTAGGCATTATTGTTATCCCTATTTATAAGTGAGGAAACAGACACAGAGAACCTAAGACATTTTCC TGAAGTTACACAGCTATTAAGTAGCAGTGCCAGAATTTGAAGGCAAGTTTTCTGATGAAATGATCAGGAT ATGGTATTTCTCAATATCTCAGGGATGGCTAGAGCAAATCTGTCTCTCTCTCACCATCAGCTCAGGACTG GGTGAGTGGCCATGGGGTCTTGAGGCAAGGCAATTGTGCTAGAAAGATGAAAGCTGGGCCAAACGATTTC TCCCTCAAGGGCTTACAAAGTACAAAAGCTGCACCTACATGTGGAGTGTCTGCCAGTAGGTGGTGCAAGT TCTATGCACACCCCTGTGAATTGCAAGCACAGTGCCCTAAGACCAAGATGGGCTTGTTTTGGGAGAGTAT GCATTGCAGAAACAGGCTCAGCTTACCCTGTGACTATGTTGCCAAGGGGTCTTCACAGCTTTCCTTCTCT TTTGCAGAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCATCTGCCGCAAAAATGCCAGCATT AGCGTGCGGGCCCAGGACCGCTACTATAGCTCATCTTGGAGCGAATGGGCATCTGTGCCCTGCAGTTAGG TGAGCAGGCCCTCAAAGGCCAGCCCAGGCCTGCACTCTCAGTGCACCTGGATGCAGGGATATGATTGGGG GCTGTGTTGGAGAGGAAAGGGGGATGGAGTGGCCAGCACCCAGTTGCCAGAATCAGAAACATACATTTAT TCACTAACAGATATTTATTTGGTGCCTTTGTTATGTAGGACACTGTGCTGGCCACAGGGATATTGCAGGA AAGAAAACAGACCGGGGTTCTGGCCTCCTAAAGAGAAAGGCAAAGAAAAGAGAGAGGTAGCCAGGAGGCA GAGCATGGAGGACTTGCAAGCTTGCAGGACTCAGAATCTTGTTCTGGGGGCCCCGGGCCCTGAAACCCAC TGAAGGGTTTTCAGCAAGGAAGTAACACAATCAGATATTATTTTAAGAAAACCCTCAAGAAAGCCTCTGG CAAGCATGGTGCCAGCCAAATTCCAGGCCACATAAGGAAGGCCTGGGCCTTCTGGCATGAAATCCCTGAA ACCCAGTTGCCCAGGATCATATGTTGTGAGAAATAAGAAGAGACATTGCTGTTACAATGTCACCCCACAT CAACTTTTGGCATTCTCTTCCAGGTTCTGATCCAGGATGAAAATTTGGAGGAAAAGTGGAAGATATTAAG CAAAATGTTTAAAGACACAACGGAATAGACCCAAAAAGATAATTTCTATCTGATTTGCTTTAAAACGTTT TTTTAGGATCACAATGATATCTTTGCTGTATTTGTATAGTTAGATGCTAAATGCTCATTGAAACAATCAG CTAATTTATGTATAGATTTTCCAGCTCTCAAGTTGCCATGGGCCTTCATGCTATTTAAATATTTAAGTAA TTTATGTATTTATTAGTATATTACTGTTATTTAACGTTTGTCTGCCAGGATGTATGGAATGTTTCATACT CTTATGACCTGATCCATCAGGATCAGTCCCTATTATGCAAAATGTGAATTTAATTTTATTTGTACTGACA ACTTTTCAAGCAAGGCTGCAAGTACATCAGTTTTATGACAATCAGGAAGAATGCAGTGTTCTGATACCAG TGCCATCATACACTTGTGATGGATGGGAACGCAAGAGATACTTACATGGAAACCTGACAATGCAAACCTG TTGAGAAGATCCAGGAGAACAAGATGCTAGTTCCCATGTCTGTGAAGACTTCCTGGAGATGGTGTTGATA AAGCAATTTAGGGCCACTTACACTTCTAAGCAAGTTTAATCTTTGGATGCCTGAATTTTAAAAGGGCTAG AAAAAAATGATTGACCAGCCTGGGAAACATAACAAGACCCCGTCTCTACAAAAAAAATTTAAAATTAGCC AGGCGTGGTGGCTCATGCTTGTGGTCCCAGCTGTTCAGGAGGATGAGGCAGGAGGATCTCTTGAGCCCAG GAGGTCAAGGCTATGGTGAGCCGTGATTGTGCCACTGCATACCAGCCTAGGTGACAGAATGAGACCCTGT CTCAAAAAAAAAAATGATTGAAATTAAAATTCAGCTTTAGCTTCCATGGCAGTCCTCACCCCCACCTCTC TAAAAGACACAGGAGGATGACACAGAAACACCGTAAGTGTCTGGAAGGCAAAAAGATCTTAAGATTCAAG AGAGAGGACAAGTAGTTATGGCTAAGGACATGAAATTGTCAGAATGGCAGGTGGCTTCTTAACAGCCCTG TGAGAAGCAGACAGATGCAAAGAAAATCTGGAATCCCTTTCTCATTAGCATGAATGAACCTGATACACAA TTATGACCAGAAAATATGGCTCCATGAAGGTGCTACTTTTAAGTAATGTATGTGCGCTCTGTAAAGTGAT TACATTTGTTTCCTGTTTGTTTATTTATTTATTTATTTTTGCATTCTGAGGCTGAACTAATAAAAACTCT TCTTTGTAATC Download Select all
Length	15691
OMIM ID	161561
HGNC ID	HGNC:5970
Unigene ID	Hs.674
Ensembl ID	ENSG00000113302
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002187.2
Exon	join(1..42,3692..3779,7145..7420,7963..8080,9954..10168, 11581..11738,13658..13789,14374..15691)
mRNA Sequence	>3593 CTGTTTCAGGGCCATTGGACTCTCCGTCCTGCCCAGAGCAAGATGTGTCACCAGCAGTTGGTCA TCTCTTGGTTTTCCCTGGTTTTTCTGGCATCTCCCCTCGTGGCCATATGGGAACTGAAGAAAGA TGTTTATGTCGTAGAATTGGATTGGTATCCGGATGCCCCTGGAGAAATGGTGGTCCTCACCTGT GACACCCCTGAAGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTG GCAAAACCCTGACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACAAAGG AGGCGAGGTTCTAAGCCATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTGGTCCACT GATATTTTAAAGGACCAGAAAGAACCCAAAAATAAGACCTTTCTAAGATGCGAGGCCAAGAATT ATTCTGGACGTTTCACCTGCTGGTGGCTGACGACAATCAGTACTGATTTGACATTCAGTGTCAA AAGCAGCAGAGGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGCTGCTACACTCTCTGCAGAG AGAGTCAGAGGGGACAACAAGGAGTATGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCC CAGCTGCTGAGGAGAGTCTGCCCATTGAGGTCATGGTGGATGCCGTTCACAAGCTCAAGTATGA AAACTACACCAGCAGCTTCTTCATCAGGGACATCATCAAACCTGACCCACCCAAGAACTTGCAG CTGAAGCCATTAAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGAGTACCCTGACACCTGGAGTA CTCCACATTCCTACTTCTCCCTGACATTCTGCGTTCAGGTCCAGGGCAAGAGCAAGAGAGAAAA GAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCATCTGCCGCAAAAATGCCAGCATT AGCGTGCGGGCCCAGGACCGCTACTATAGCTCATCTTGGAGCGAATGGGCATCTGTGCCCTGCA GTTAGGTTCTGATCCAGGATGAAAATTTGGAGGAAAAGTGGAAGATATTAAGCAAAATGTTTAA AGACACAACGGAATAGACCCAAAAAGATAATTTCTATCTGATTTGCTTTAAAACGTTTTTTTAG GATCACAATGATATCTTTGCTGTATTTGTATAGTTAGATGCTAAATGCTCATTGAAACAATCAG CTAATTTATGTATAGATTTTCCAGCTCTCAAGTTGCCATGGGCCTTCATGCTATTTAAATATTT AAGTAATTTATGTATTTATTAGTATATTACTGTTATTTAACGTTTGTCTGCCAGGATGTATGGA ATGTTTCATACTCTTATGACCTGATCCATCAGGATCAGTCCCTATTATGCAAAATGTGAATTTA ATTTTATTTGTACTGACAACTTTTCAAGCAAGGCTGCAAGTACATCAGTTTTATGACAATCAGG AAGAATGCAGTGTTCTGATACCAGTGCCATCATACACTTGTGATGGATGGGAACGCAAGAGATA CTTACATGGAAACCTGACAATGCAAACCTGTTGAGAAGATCCAGGAGAACAAGATGCTAGTTCC CATGTCTGTGAAGACTTCCTGGAGATGGTGTTGATAAAGCAATTTAGGGCCACTTACACTTCTA AGCAAGTTTAATCTTTGGATGCCTGAATTTTAAAAGGGCTAGAAAAAAATGATTGACCAGCCTG GGAAACATAACAAGACCCCGTCTCTACAAAAAAAATTTAAAATTAGCCAGGCGTGGTGGCTCAT GCTTGTGGTCCCAGCTGTTCAGGAGGATGAGGCAGGAGGATCTCTTGAGCCCAGGAGGTCAAGG CTATGGTGAGCCGTGATTGTGCCACTGCATACCAGCCTAGGTGACAGAATGAGACCCTGTCTCA AAAAAAAAAATGATTGAAATTAAAATTCAGCTTTAGCTTCCATGGCAGTCCTCACCCCCACCTC TCTAAAAGACACAGGAGGATGACACAGAAACACCGTAAGTGTCTGGAAGGCAAAAAGATCTTAA GATTCAAGAGAGAGGACAAGTAGTTATGGCTAAGGACATGAAATTGTCAGAATGGCAGGTGGCT TCTTAACAGCCCTGTGAGAAGCAGACAGATGCAAAGAAAATCTGGAATCCCTTTCTCATTAGCA TGAATGAACCTGATACACAATTATGACCAGAAAATATGGCTCCATGAAGGTGCTACTTTTAAGT AATGTATGTGCGCTCTGTAAAGTGATTACATTTGTTTCCTGTTTGTTTATTTATTTATTTATTT TTGCATTCTGAGGCTGAACTAATAAAAACTCTTCTTTGTAATC Download Select all
Length	2347

CDS Information

Location	join(3692..3779,7145..7420,7963..8080,9954..10168, 11581..11738,13658..13789)
CDS Sequence	>lcl\|NM_002187.2_cds_NP_002178.2_1 [gene=IL12B] [protein=interleukin-12 subunit beta precursor] [protein_id=NP_002178.2] [location=43..1029] ATGTGTCACCAGCAGTTGGTCATCTCTTGGTTTTCCCTGGTTTTTCTGGCATCTCCCCTCGTGGCCATAT GGGAACTGAAGAAAGATGTTTATGTCGTAGAATTGGATTGGTATCCGGATGCCCCTGGAGAAATGGTGGT CCTCACCTGTGACACCCCTGAAGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGC TCTGGCAAAACCCTGACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACAAAGGAG GCGAGGTTCTAAGCCATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTGGTCCACTGATATTTT AAAGGACCAGAAAGAACCCAAAAATAAGACCTTTCTAAGATGCGAGGCCAAGAATTATTCTGGACGTTTC ACCTGCTGGTGGCTGACGACAATCAGTACTGATTTGACATTCAGTGTCAAAAGCAGCAGAGGCTCTTCTG ACCCCCAAGGGGTGACGTGCGGAGCTGCTACACTCTCTGCAGAGAGAGTCAGAGGGGACAACAAGGAGTA TGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCCCAGCTGCTGAGGAGAGTCTGCCCATTGAGGTC ATGGTGGATGCCGTTCACAAGCTCAAGTATGAAAACTACACCAGCAGCTTCTTCATCAGGGACATCATCA AACCTGACCCACCCAAGAACTTGCAGCTGAAGCCATTAAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGA GTACCCTGACACCTGGAGTACTCCACATTCCTACTTCTCCCTGACATTCTGCGTTCAGGTCCAGGGCAAG AGCAAGAGAGAAAAGAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCATCTGCCGCAAAAATG CCAGCATTAGCGTGCGGGCCCAGGACCGCTACTATAGCTCATCTTGGAGCGAATGGGCATCTGTGCCCTG CAGTTAG Download Select all
CCDS ID	CCDS4346.1

Protein Information

Protein ID	NP_002178.2
Protein Name	interleukin 12B
Molecular Wt. (Da)	34697
Protein Sequence	>3593 MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQ SSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTF LRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVE CQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSW EYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWS EWASVPCS Download Select all
Length	328
Uniprot ID	P14210
Ensembl Protein ID	ENSP00000222390

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	162
S	Phosphorylation	163

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
3592	IL12A	1193	NP_000873.2	in vitro	10899108

Pathway Information

Pathway Name	Pathway ID
African trypanosomiasis	hsa05143
Allograft rejection	hsa05330
Amoebiasis	hsa05146
Chagas disease (American trypanosomiasis)	hsa05142
Cytokine-cytokine receptor interaction	hsa04060
Herpes simplex infection	hsa05168
Inflammatory bowel disease (IBD)	hsa05321
Influenza A	hsa05164
Jak-STAT signaling pathway	hsa04630
Legionellosis	hsa05134
Leishmaniasis	hsa05140
Measles	hsa05162
Pertussis	hsa05133
Proteoglycans in cancer	hsa05205
RIG-I-like receptor signaling pathway	hsa04622
Toll-like receptor signaling pathway	hsa04620
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152
Type I diabetes mellitus	hsa04940

Structure Information

PDB ID	1F42
Resolution	2.5
Method	X-RAY DIFFRACTION
Chains	A
Molecule	INTERLEUKIN-12 BETA CHAIN
Model	View

Domain Information

ID	Location	Description
cd00063	235-325	FN3
cl21522	235-325	FN3 superfamily
pfam10420	125-217	IL12p40_C
cl11074	125-217	IL12p40_C superfamily
smart00408	42-90	IGc2
smart00410	42-91	IG_like
smart00409	42-91	IG

Ontology Information

HPRD ID	3080
Molecular Class	Cytokine
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P29460 DB05679 Ustekinumab BiotechDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO