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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KHSRP 8570 KH-type splicing regulatory protein (FUSE binding protein 2)  19FBP2; KSRP; FUBP2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Down-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 19; NC_000019.9 (6413115..6424822, complement)

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Gene Type protein coding
Gene Family -
Description The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]  
Chromosome 19
Location 19p13.3
Start 6413104  
End 6424811  
Strand -  
Gene Sequence

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Length 11708  
OMIM ID 603445   
HGNC ID HGNC:6316   
Unigene ID Hs.727344   
Ensembl ID ENSG00000088247   
PharmGKB ID -   

mRNA Information


mRNA ID NM_003685.2
Exon join(1..359,2376..2472,3124..3162,3495..3534,4341..4390, 4668..4739,5552..5609,5936..6110,6231..6329,6733..6831, 6971..7073,7725..7825,7930..8074,8162..8322,8405..8514, 8916..9004,9078..9278,9355..9432,9511..9671,10692..11708)  
mRNA Sequence

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Length 3262  



CDS Information


   
Locationjoin(111..359,2376..2472,3124..3162,3495..3534,4341..4390, 4668..4739,5552..5609,5936..6110,6231..6329,6733..6831, 6971..7073,7725..7825,7930..8074,8162..8322,8405..8514, 8916..9004,9078..9278,9355..9432,9511..9671,10692..10700)
CDS Sequence

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CCDS ID CCDS45936.1



Protein Information


      
Protein IDNP_003676.2
Protein NameKH-type splicing regulatory protein (FUSE binding protein 2)
Molecular Wt. (Da)72984
Protein Sequence

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Length 711  
Uniprot IDQ92633
Ensembl Protein ID ENSP00000351755  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation181;-
SPhosphorylation132;-
SPhosphorylation274;-
SPhosphorylation670;-
SPhosphorylation274;-
SPhosphorylation480;-
TPhosphorylation100
SPhosphorylation184
TPhosphorylation277
SPhosphorylation191
SAcetylation2
KAcetylation87
SPhosphorylation174

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5073PARN7250NP_002573.1in vitro;in vivo15175153   
23404EXOSC23758NP_055100.2in vitro;in vivo15175153   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00105146-208  KH-I
cl00098146-208  KH-I superfamily
cd00105325-386  KH-I
cl00098325-386  KH-I superfamily
cd00105426-492  KH-I
cl00098426-492  KH-I superfamily
cd00105235-300  KH-I
cl00098235-300  KH-I superfamily
smart00322143-212  KH
pfam00013146-208  KH_1
smart00322426-495  KH
cd02396151-204  PCBP_like_KH
smart00322234-303  KH
pfam00013426-491  KH_1
smart00322325-390  KH
pfam00013235-299  KH_1
pfam00013327-386  KH_1
pfam13014155-196  KH_3
cd02396238-299  PCBP_like_KH
cd02394146-208  vigilin_like_KH
cd02396431-469  PCBP_like_KH
pfam13014334-374  KH_3
cd02396329-386  PCBP_like_KH
pfam13014244-287  KH_3
cd02394426-492  vigilin_like_KH
pfam13014435-479  KH_3
cd02394325-382  vigilin_like_KH
cd02393141-209  PNPase_KH
cd02393238-286  PNPase_KH
cd02393428-492  PNPase_KH
cd02394237-300  vigilin_like_KH
pfam09005671-689  DUF1897
cl07567671-689  DUF1897 superfamily
pfam07650237-267  KH_2
cd02411232-262  archeal_30S_S3_KH
COG1094238-390  Krr1
PRK13763145-301  PRK13763
PRK11824238-305  PRK11824
PRK11824141-248  PRK11824
TIGR03665237-391  arCOG04150
PRK13763234-391  PRK13763
COG1185152-248  Pnp
COG1185428-493  Pnp
TIGR03591238-305  polynuc_phos
TIGR03591141-213  polynuc_phos
PRK11824428-493  PRK11824
COG1185238-305  Pnp
TIGR03591428-493  polynuc_phos
PRK08406240-274  PRK08406
TIGR02696316-364  pppGpp_PNP


Ontology Information


   
HPRD ID8834
Molecular ClassTranscription regulatory protein
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO