CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
KPNB1	3837	Karyopherin (importin) beta 1	17	IMB1; IPO1; IPOB; Impnb; NTF97

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : -	Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.	Up-regulation	-	-

Gene Details

Chromosome: 17; NC_000017.10 (45727275..45761004)
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Gene Type	protein coding
Gene Family	Importins, Armadillo repeat containing
Description	Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Chromosome	17
Location	17q21.32
Start	47649838
End	47683638
Strand	+
Gene Sequence	>gi\|568815581:47649838-47683638 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly AACGGCCAATCGTCGTGGAGCGCGGCGCCTCCGCGGAGAGGTCCGGTCCGAATATCCCTCCGCCTTCCTC CCTCCCTCGCTCCCTCCCTGCGCGCCGCCTCTCACTCACAGCCTCCCTTCCTTCTTTCTCCCTCCGCCTC CCGAGCACCAGCGCGCTCTGAGCTGCCCCCAGGGTCCCTCCCCCGCCGCCAGCAGCCCATTTGGAGGGAG GAAGTAAGGGAAGAGGAGAGGAAGGGGAGCCGGACCGACTACCCAGACAGAGCCGGTGAATGGGTTTGTG GTGACCCCCGCCCCCCACCCCACCCTCCCTTCCCACCCGACCCCCAACCCCCATCCCCAGTTCGAGCCGC CGCCCGAAAGGCCGGGCCGTCGTCTTAGGAGGAGTCGCCGCCGCCGCCACCTCCGCCATGGAGCTGATCA CCATTCTCGAGAAGACCGTGTCTCCCGGTAGGACGCAGGAGCCGGGGGTAGGGCTGAGGTGATTGGGGTG GGGGAGGGGAGGCCCGGCCCCTCTGACCCCGCTCCGTCTCCCACTTTCCTCCCCCTAGATCGGCTGGAGC TGGAAGCGGCGCAGAAGTTCCTGGAGCGTGCGGCCGTGGAGAACCTGGTGCGTGCTACCCCGCCGCGCCC ATCCCGCCGCGTCCCCATCCCCTGCGTGCGGGGCCTTCCCGCCCTCCCGGAGGCCCAGGCCTCGGGAACC TACCCCGCCCCATCCCGTCCCCCTCCCCCCTCCCCCTCCCCCCCCAACCCGGTCCAACCTAACCCCGCCA TCGGGAAGCCGGTGGGTGTGTCCCGCCCCGGGCCTCGCGACTGGCCAATGGCTTGGCGCGCCGAGCTGCC TGCCGCCCAATCGTTGCGCGGCCTGAGGGCGGCGGTGCAGCGGGAGGGAGAAAGAGGGAGGGAAGGGAAG TTAGGTTGCGCGGCGCTGCGTGTTCAGCAGGGGTGGGGGCGGGGGAGTCGGGCCTAGGGGCCATGTGGAA GCTCCGGGCCCGGCCGCCCGCCCTGTCTGACCCCGGCCGGCTTCTCCTTCCTATCCCGTGGCCCCTGTGG CTCTCCCCACCTATTTCCTAGAGCTCTGCCCTTTCCTAGCTACCTTGGTCTGTACTCATGGCCAGGCCTG GCACCCGACTGCCTCTTAACCCATTTCCACTGATATTTTTCCCTCTTTGCTCGGTTATTCCTCTCTTGGG GTTTTTTCTTTTTCTTTCTTTCTTTTTTTTTTTTCTTCTGACCTGGATGAATAGAGACCTAATCACTAGG GATCTGCACCCAGAAAACAGACTGAGGCTCATCTTTGAGATGGGGCCTGTTTGCTGATGAAATCACAGGG GAAAGTTCCTCGTTTTTCATATTTTAAAATTTAAGGGGTCCGGAGAAAATGAAGCTAAGTCCGCTAGAGA CTGGTCCTTTGTATAAAAATGTGGGATGGATTGGTTGAAACAGCCTAGATGCCAGTTAAGTTTCTCTTTG GTGTCCATCTCCTGTTGGGGGATGGGGTCAGAGGGAAGGATTGGATGATGCTTGACATCTTTGAGAAAGG TAATAGGAATTAAGTCTGAGTAACACTAACCATATGTGTTCCTTTGTGTTATATAGGCAAAATGTCAACA TCAACAAAGTGACAAGGCTTATTTTATACAGACTGCCTTTGAATGATTTTTTTGTTGTTTTTCATATGTG CCAATTTTTACAACTAACCTGTTTATCCTTTCCTAGAAGAGATTTTTCCACTAGTATAGGCTGATAATTC CATTTAGGGTATTATTCCTGTTTCTGCTTTTGCAAATTTTGCAAAAAGCTTTTTATCTTATTCCTAACAT TCTTAACATTCTTTAGTGGTACATAATTAATAAAACTTTTAAGAATTATCTTCTGCTGTGATTGCAGAGC TTGTTAGCAGTAAGAAAAATGTGTCTGCTTTTGACTTTTCCTGCTAACTTTGCTGTTTGGGCACGGTTTT TGGTGGAGAGGTGTGTGTGTGCTAAATTTTTAAACAAAGGGAGTAGTTTTTGAGGCCTGTGGATTACAAA AGGTTACAAAAGAACATGCTTTTCAGGGATCCACTGTATTCCTCAACTAAAGTCCAAATGTAAAGGAGCA AGTAATTGTTGATCATTAGATACAAAGTTATTTTGCTTGAACAGCTTGCCTGAAGATTTTTTCTTTCACT TTTTCCCTATTTCTAAATATCTTATCACTTTTCCTTATAAATCTGCTTTTTTCATTGTTCCCTTTTTGCT GAGTGCCCACAAATAAAACGGAGGATGAGGCTCCTAAGTTTGTTTTAGGCTTATCTGTATTTCCCCCTCT CATAAAAGATCACCTCCTTCCATGGATTGAAAAGCTACCCTGCTGCTGCCATGAGATGGAAAGTTGGATC ATTCTTTTGGGACCAAGGTTTTTGAAATTTAGATAAACAGTTTTATTTTCTACCCCCCATCATAACAGCC ATTCATTTAACAAACATTGAGTACCAGACATTATTAAAAGTTCTTGGGACACCTCAGTATACATAGAAGA CTGACTACTACTACCATACTCTGAAACCTTGCAATTCGGGGGTCTAACATGACAATTTGGGCACTAAGAA TGATCTTGATAGGGAAATCTGTAATTCCTCATTAAGTGCTAGGCTCCACGAGAAAAGTGGAAGACTTCCT GTTACACTAAGTAACATTTTTATAGAAGTCAGTGAAGTAAATATTTTGTGGTTTCCTGAAATGCTTATAT CAAAAAAAAATTAGACATTAGTTCCCCCCCTCGCCGCCCCTCTGGTGGTTCAGTGCTCTATAAATTATCC TCAGTTGTGGAAATTCCTAAGATATTTTTATTTACAAATTTATCTTCCCTTAACAGCCCACTTTCCTTGT GGAACTGTCCAGAGTGCTGGCAAATCCAGGAAACAGTCAGGTTGCCAGAGTTGCAGCTGGTCTACAAATC AAGAACTCTTTGACATCTAAAGATCCAGATATCAAGGCACAATATCAGCAGAGGTGGCTTGCTATTGATG CTAATGCTCGACGAGAAGTCAAGAACTATGTGAGTAACGCTTATCTGTTTGGTTATATTGCCCAGAGAAC AAGAAATCGCTTTCTCAGATCTTTTGCTATTTGCATGGGATAGAGCTAACAGTGTGATAGGTTTCTGGGA CCTCAACTTTACCTAAAGATAAAAATTGTCTTTGTCTTAAATCTTTCTCAACACAGCTTGTCCATTCCCA TTGATGGATTGGAATTCTTTTTAGATGACTGAGGTAGGCTGCAGCAGTTTGGGAAACTTTAATTACGTGC CATAATTGGTAAAATCTGTTTGGCAAATGGGAGTAGTGTACAAATTGGTGCTACATTTGTATAAAAATTA GGGAATTTGTTAATAGGTATTTCCAAGCTCTCCAGAAATTCCGATTCGGTACTTCTGGAGTACAGCTCAG GGAATTTTTTTTTTTTTTTTTTTTTGGAGACAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGGCATG ATCTCGGCTCACTGCAGCCTCCGCCTCCCAAGTAGCTGGGATTACAGGCACCCACCACCATGCCCAGCTA ATTTTTGTACTTGAAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAG GTGATCTGCCTGCCTTGGCTTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACCTCGCCTGGCTGTTGTT GTTTTTAAATTAAGTTCTTTAGTGATCTGTCTTACATGGGTAAGGCACAAAGAGGAGTGAGTTAAATATC TGTGCAGTCATCATTTTGTCCTTGGTATTTGAGTGGAAACTAGTGGGGAATTCCTACATATGTACTTGTG CAGGACATGGTTATGCACATCATACTTGCTATTTCCTGGTTCTAGATATCAGCATTAGGTAAAGTAGTGC CCTGTAAGGCAGTAACTTCTGTATCTGGTTGTGTACCTCCTTCTGTCACCAATCTTGCATACCCATGATA AGGAGCCGGGTTATTAAATCCAACTTGGTTTCAAATCGTTTTGGAGCATGTAGAGCTGTTTCTATTCATG TTGGTTCTGCTTGTGTAATAACAACATTTTAATTCCTTCTCCCTCAGCTAAGTGACATAAATGGAAGTAT ATTCTATCACTGGAAATCTCGATACTGATAGTGCCCATTCAGTTTCTCATCTTCCTTAATTTACACACTA GTAAATGGGATAAGATGTAATTGGAATTGTAATTGGCTTATTTTTTGGCACATCACTCTTAACACCAACC CTTTAAAAAAAAATTAGACAATAATGGCTGGGCGCAGTGGCTCATGCCTGTCATCCCAGCACTTTGAGAG GCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCGAAACCCTGTCT CTACTAAAAATACAAAAATTAGCTGGCTGTGGCGGTGGATACCTGTAGTCTCAGCTACTCTGGAGGCTTA GGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGATTGTGGTGAGCCAAGATTGCGCATTGCACTCCAGCC TGGGTGACAGAGTGACACTCCATTTCTTAAAAAAAAAAAAAAAAAAAAAATTAGATAATTTGTATAGGCA TGGTTAAGCCCTCGGGCATGAGAAAAAAGCTAACAGTACCTTGGCCTTTTTCCCTTTCATAGCACAACGA TAACTAATACTAAGTTTCACTGTTGGTGATCTTTTTTGAAATCTGGATATTGGGGCACAATTGGGAGCTA GTTTCTCTTTTCTGATAATTGAATATTACTATTAAGGTTACCTCTAGTTTAAACAGAAAACTTTTAGTAC TCAGGAGGTGGACATCCGTAGTTTCTAAATCACCTCAAGTAATATGGAGTCTTCAGAAAGCAATCTAAAG GAAAAAGGTAAAGGTAGAATGGGATTCAGTGCACTCCACATATGTACTAGGAGACTATGTAGTGTGGTGT GAAGGCACCCTGGACTTGGGTTAATAATACCCATTCAGCCCCTGATATTTTGGACAATTCACCTTGTTTT TCCCCCTCATTCCCTCGTGTCTTTGACATACCGTTTTTGTCCATTCTAGCTCTGCTAGTCCTCGAGAGCA AAGCCTTTCATTTAACATCAATCAGAACTGTTTGTAGTTGGGTAGAGCTGATGGGGGTGGGGGCCAGGGA TGATGATATACCGTATAAGAAGGAAAGGGGGAGTTCATTATTGGTGCTAGCTGCAAAGCAGGATACTAAG TGATCCGACCCAGTCAGCAGAGCTGGCCTGAATATCTGGCAGCTATTCTTTGTCCCGTGTTCATGCCAGA ACAGTTAACTGTTTGCCTTTGAGTGGACTACTGATTCTTAGTGAGTTCATTGACTGAATTAGCTGATCAC GGTAATAATTAGCTCTAGGTCAATTGTGGCTTCATCTTTTATCATACCTGTGCCTTTACTCTTTACATAA ATGGTGGCGTGGTTACCATGTCAAGCGAGACATGTTTAATGACAAGTGGATCTTGTTTTGACATCTGGCT AGATTTTGGTATCTGTCAGTGATAGAACAGTTCTTTGATTCTTGGGCAAACAGAACAAATCCTTTCAGAT TGGAAGTTATATAAAGATTAGTTCATAGGTGTTATTAACATCAGCAACGTTGTTTTTGTATTTAGTGATG TTGTTACTTGACCAAGGCCTTTCTATGTAAGTCACCCCGAATGCTGAGTTGTTAGTGATTAGAAGGAAAA AGTTTTGTTTCAGCCCACGTCTCATGAGTAAGATCTCCTTGGATCAGATTAGACAGTGATCTACTGTGAA TAAGACCCACCTGAATGCCCCAGAACTAGCTTCATTCTAGTGTCCATGTCTGTCTACAAAACGAGGGTGT GAACATCCTTTCCTTATAACAGCAACAATGAGCCTGGAAGATGAGTTTTGTCCCCATCTCTCTCCTTTGC CATTTACTGCTACCTCCTCTTGTAACTTCTGGTTTCCCACCTCGTGTTGAAGGTTGAAGTGAGGTGGGAT GACTGGTTTTGTTTCTAGGTTCTAGGGCAGTGTTGATTATGCTGATGTTGCTACTGAGGCTGGTTTTTTC TGACAGCCTTTCCTACTTCTCCGTATTATAGATAAGAATTCTGAGGCCAGGCACAGTGGCTCACGCCTGT CATCCCAGTACTTTGGTAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACTGTCCTGGCCA ACATGGTGAAACCCCATCTCTACTAAAAATACAAAAACTAGCCGGGCATGGTGGCAGGCACCTGTAATCC CAGCTACTTGCTGGGGGGAGCTAAGGCAGGAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCC GAGATCGCGCCATCATGCTCCAGCCTGGGGGACACGAGCGAGACTTTGTCTCAAAAAAAAAAAGAATTCT GAGACAGCTGCCTGGGCACAGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCAGGAATTTGAGAC CAGCCTGGGCAACATAGGGAGACCCCCATCTCTACTAAAAACCCAAAAAAGTTAGCTGGGTGTGATGGCA TGTGCCTGTAGTCTAAGCTACTCAGGGAGGCCTGGGAGGTCAAGGCTGCAGTATCGTTGTGCCATTGCAC TATCGTTTTGCTACTACACTCCACCCTGGACAACTGACTGAGGCCTTGTATTTTCCTTTTTTTTTTTTTG AGCCTGGGCAATATGGTGATGCCCTGTCTCAACAAAAGATAGCTGGGCATGTCAGCATATCCACCCCTGT AGTTCAGTTACTCAGGAGCCTGAGGCGGGAGGATAGATTGCACCGTAGAGATTGAGGCTACAGTGAGCTG TGATCGTGCCACTGCACTCCAGTCCGGGCAACATAGTGAGACCCTGTCTTAAGAAAGAAAGAAAAAAAAG AATTCAGAGACACTAATATAAGTATGGTGGTGGGCAAAATGTGGTCAAATAGTGTTAGAAATTTGTATCT TTTGTCTTTTTTTTTGGTGCAGGTTTTGCAGACATTGGGTACAGAAACTTACCGGCCTAGTTCTGCCTCA CAGTGTGTGGCTGGTATTGCTTGTGCAGAGATCCCAGTAAACCAGTGGCCAGAACTCATTCCTCAGCTGG TGGCCAATGTCACAAACCCCAACAGCACAGAGCACATGAAGGAGTCGACATTGGAAGCCATCGGTTATAT TTGCCAAGATATAGTAAGTGCTTGCCTAATGTATCTGGTTTATATACCTCTGATTGCCTCTAGCTGTGAC ATCAATGATATTAGTACTACCTTATTGAATCACGAAGAAAGCCAAGCTAAATTGCACAGTTTTGAAAGTG AGACTGATTTATTTCCCTTAGGCCTGTGTCTTCACATTGCTAATCATGCCCTAAAGTAAAGAAACTTGAG GATCGCAAACTGAAAACAGAAGTCTATGTTTGAAGAGTCTTAGATTCTAGACTTACAAAATGAGGATATT CTCATTTGGATTATCCCTGACCCAGTCTTTTTTCTTAAGATCCCGAATGTACCATGAATGTTGTGGCGCA TTTTCATTTACAACATTACGGAAAGTTTTGCCAACATTTGATGTAGTTGGTTTAGCCACTGGAGACACAG TATTTTAGATGTAGCCCCCCCAGCACTGTTGTTCCTGATGAGGTTACCACTCTTGGTGTGTATTTTAATA TATAGACTTTATGAAGCAAAGGAGCCCACAGCACTTGACCCAGACTTAGACTCCCTAGATGTGCCTAGGT GTCGATCCTTGGCCTTGGCCCTTAAATGCCCTGAAGCTTTACTTTAGAGTACAGATGGCCTGGAAAATAC GAACAGACTGCCATCTCCATTTGCACAGAAGTGGGGAGGAAAGCGAATATTACCTCATACCCAGAGTCAT TATGCTAAGAAGTCAAAGATGAAGTTGATGAGTTTGACTTGGTTTTGTTCAGTTCTGGATTGCCAGTACC ATGAGACATTTTGCAGGTGGTTTGCAGTGTTATTCCCAAATGGAAACGGGTGGGGAAAGATCACCAATTC ATGATACTTTCTTGAGTGAACTTTACAGTTAAAAGGACTGCCAATTAAGCCAGGCACAGTGGCTTACACC TGTAGTCCCAGCTGCTTGGGAAGCTGAGGTGGGAGGATCACTTGAACCCAGGAATTTGAGGGTTCAGTGC ATTGTGGTAGTGCCTGTGAATAGCCACTGCACTTTAGTCTGGGCAATACAGACCCTGTCTCTTAAGAACA GAAGAAGGACTGCTTCTGTCGTGAAGCTCCTTATGGCAGTCTTTTGGAGGGGATTGATTCCAGCACCCTC CTCAGGTACCAAAATCCTCAGATGTTCAAGTCTGTTACATAAAATGGTGTAGTATTTGCATATAACCTAT GCACATCCTCCCATATACTTTAAATCATCTCTAGAATACTTACAATACCTAATTCAATGTAAATGCTATA TTAATAGTTGGTATACTGTATTAAGGGAATGATGACAAGAAAAAAAGGTGTACATGCACCTTTTGGTGCA GTACAGATGCAACCATCCATTTTTTTTCCTCTAAATATTTTCAATCCATAGTTGTTTGAATCCACAGATG TGGAACCCATGGCTGCAGAGGGCTGACTGTATATTCATTGCACTTCTCTGCTTGTTACAGGACCCAGAGC AGCTACAAGATAAATCCAATGAGATTCTGACTGCCATAATCCAGGGGATGAGGAAAGAAGAGCCTAGTAA TAATGTGAAGCTAGCTGCTACGAATGCACTCCTGAACTCATTGGAGTTCACCAAAGCAAACTTTGATAAA GAGGTAAGTTTTTTGACAATAAGGTATAGATTCAGACAGTAAGGGATGAAAGAGTTGAATGAAAGTTTTT TGTTTTGTTTTCTTAAGTTTATGGTTTAGAAAGTACCACCTACTTAAAAGTATTTGTTTCCAGTTTAGTC GAGTTCGTATTGTGTGAGATATCCCCATGGAGTGTTTGCCGTTTCTCATCATGCTTTTGGAAATAAAGTG TTTCTAAGCTTAGGTTTTTCCTTTTGCAGTCCAAAGTGTGGAATGTTGTTGGGTTTTTTTAAATTATAGG GCATGGTGGTGCATACTGGTACTCCAGCTACTTCAGAGGCTAAGGCGGGAGGATTGCTTGAGTCCAGTTA TTCAAGGCCAGCCTGGGCAACAAAGTCAGATATCGTCCCTTAAAAAAAAGAAAGGAATAGGCTGGGCGAT GTGGCTTAAGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCATCAGGTCAGGAGTTTGAG ACCAGCCTGACGAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTAGCCGGGTGTGGTGGC GTGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTT GCAGTGAGCCGAGATTGCAGCACTGTATTCCAGCCTGGGCGACAGAGCAAGACTGTCTCAAAAAAAATAA AAAATAAAAAAAATAAAAGAAAGAAATTATGGTATGTACTATATATGTTGGTTTACTTTGGTTTCTTTTA AGATTGTGTGAATCTTTTGCCTTGTACTAAAGATTTTGTGGAGGCCGGGTGCTGGGGCTCACATCCAGTA ATCCCAACACTTTGGGCCACCAAGGCAAGAGGATCACTTGAAGCCAGGAGTTTGAGACTAGCCTGTGCAA CGTAACAAAACCCTGTCTCTAAAAAAATTTCTGTGGAGAAGAACAACTGAGTTGTTAACCAGTTTTGTGA GCTCTTGTGTTTACAGGGCTTATAATGGAAAAAAAATAATGAAAAATGAAATAAATAAAAATTATAGCAA TTGGTCTGTTTCATACCACCTTAGGAAGGTGTTTTTAAGAAACAGGATATATAGCCAGGTGCTTTGGCAC ATGCCTGTAATCCCAGCTACTTGGGAAGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGTTCAAGGCTCA AGATTTCACCACTGTACTTCAGCCTGGGCAACAGTGCAAGACTCTGTCTCCAAAAAAAAAAAATATATAT ATATGTATATGTATGTGTATGTATAATATATATGTAAACATTTTGGCTGAAAATGCAATGAATAACATAA AATTTACCATCTTAAATCATTTTTAAATGTATAGTTAGTTAAGTAGATTCACATTGCTGTGGAAACAATC TCCAGAACTTTTTCATCTTGCAAAACTGAAACTGTACATACTGAACAACAACTCCTCATTTCCCCCTTTC TCAGCCACTGGTAACGACCATTTTACTTTCAGTTTCTATGTATTTTACTACTCTAACGAAATACCTTACG TAAGTGGAATCATATTTGTCTTTTTGCGACTGGTTTGTTTTACTTAGTATGATGTCCTCGAGATTCATCT AAGGGGTAGCATTTGTCAAAATTGGCTTTTTAAGGGTGATTAATATTCCATTATATGTATATGCCACATT TTGTTTATCTAGTCTTCCATCCATGGCCATTTGGTTTGCATCCACCTTTTGGCTATTGTGGGTAATGCTG CTATGAACATGGGCATGCATGTGTATCTTTGAGACTCTGCTTTCAGTTCTTTAGGGTAAATACCGACAAG TAAAATTGCCAGGGTCATGGTCTGAAAGTATTTCTGTATATATGTTTGTTGACACTTCAGCTGGGTTTTT ACCATTTCTTGACTTTGGAAAGGTCTGAAACCCCAGAGCAAATGGCAATTCTAATTGATTAGAAAACTGG ATTTTTCCTTAATAGATTTTGGAAGATTTAGGAGGGTAGCACATAAAGTTCATTCTCCCTTTTCTCACCA CATTTGATGTGAATTTGCTACCTCTCAGAAAACAAATTTGGTCTCTGAAATAAAGCAGATGTTTTGAATT CTCTTATATAAGGAAACTGATTTTCCTACATGTAAATTTTTATCTTTTAACCATTTTTATTTAAAACTTG TGACCTACATTTTTCTGTTTCCTCCCTGAAGTCTTTGTTAGTGGTCATTTTGGAGATTAAAAGATTAGGG ACCTCATTGGAGGGCAAGTCACATAGCAGACACCGAAGGTAAACTCTTTATAGCCTTTATAGTGCTGTAC CATCTCAAGGGAGAGTGGCTTGATTGTACCAGGCAGGGCTGTGTGGGGCCCTGAGGGGGAGTGAGAGGTT TTCCTTGTAGAGGGAGTCTGGAAATCTTCCTACGTACAGGTTATGCTCTCCTAATTCTCTTTATTTTTAT TCCTCCTACAGTCTGAAAGGCACTTTATTATGCAGGTGGTCTGTGAAGCCACACAGTGTCCAGATACGAG GGTAAGTGTGAGGTTATATGAAAAATCTGTCTTACATCTTTCTTAGGAAATGTCAAATCTAATATAAGTT TGAAATACTGGGAATCAGTTGACTTCAGCAATAAGGTTTGATTAATATTGTTACTAATAATTAATATTCT GGCTGGGCATGGTGGCTCACACCTGTAATCCCAGCACTTAGGGAGGCCATGGCAGGCAGTTCACCTGAGG TTAGGAGTTTCATACCAGTCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATAAAAAAAAATTAGC TGGGTGTGGTGGCACGTGCCTGTAGTCCCAGCTGCTGGGGAGGCTGAGGTACAAGAATCGCTTGAACCTG GGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCAAACAGACTCCATCTCAAAAAATAATAATGA TAATTAATAAAAACATTAGAGAAGAGGGAAGAATTGTCATGGAAGTTGCCATCCTCTTAAAAAAGGTTTA AGGTGCCAGTGTGGTGGCTCACACTATAATCCCAGCAATTTGGGAGGCCAAAGCAGGAGGATCACTGAGG TCAGGAGTTGGAGACCAAACTGGGCAACATAGTGACACCATCTCTACTAAAAAATATGTATACACAAATA AACAGTTAAGGGAGAAAAGGTTTTCGATCAGCTTCGCTACTTCATTGCCGTAGGTTATTCAAGCCATTTC TACTAAAAAATATATATACACAAACAGTTAAGGGAGAAAAGGTTTTTGATCAGCTTTGCTACTTTATTGC CATAGGTTATTCAAGTGATTGTTTTCCCCTGTAGCCATTAAAGCAGCTTTGCTATTGCTATACCCAAAAC CTGACCCTTCAAGAAGATAGAAGTAATATCTTCAGTCTGAATAGTATTAGTGAATTTAGCCGTACCATGG GTTCCACACGCACCTTTAATGCAAAAAAAAAGACTGAGGCCAGGCGCGGTGGCTTACGCCTGTAATCCCA ACACTTTACAGGCGCATGTCTGTAATCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGG GAGGCGGAGGTTGTAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGAGACTCCATCTCAAAAAAA AAAAGGACTGGCTGTGGTGGCTCACACCTATAATACCAGCACTTTGGGAGACCGAGGCCAGAGGATCACT TGAGCCCAGGAGTTGGAGACCAGTCTGGGCAACATGGCGAAACTCCATGTCCACAAAGATTAGCTGTGCG TGATGGGGCGAGCCTGTAGTCCTAGCTACGTGGGAGGCTGAAGTGGGAGGATTGCTTGAGCCTGGTGGTT GAGGCTGCAGTGAGCCGTGATCATGGCCACTATACTTGCACCAGGGCGACAGAGCAAGAAGACTGTCTCA AAAAAAAAAAAAAGAGAAAAATGGCCGGGCGCAGTGGCTCACACCTTTAATCCTAGCACTTTAGGTGGCC GAGGTGAGTGGATTGTCTGAGCTCAGGAGTTCGAGATGAGCCTGGTCAACATAGCAAAACCCCGTCTCTA CTAAAAATACAAAAAATTAGCCGGGCATGGTGGCGGGCACCTGTAGTCCCAGCTACTTGGAAGGCTGAGG CACGAGAATTGCTTGAATCGGGGAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCT GGGCAACAGGAGCGGAACTCTGTCCCTTCCCCGAAAAAGAGAGACAAAATGGGAAAATAAAGGAACAGAT AATGAGGGAATTAAAGGGAGAGAATGAATTTTAGGGAAATGATAACGTATCCCATATTTACCTCAATTAA TCCTTAGGATTATTGGCCCATTTGAGTGAATCTAACTTTGTCAGATTGCGTTGTTATTTTAGTAAACTAT CTGATCTGCTGTTCATAAAAGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATT ATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAGTAAGTATTTCTATTTATGTGATTTGAGC TTGTGGCTAATTACAGAGCCCATCATCCTTAGTCGCTATTTTGCCAATTCTGTAATATTTTACTTAATAC TATGGAATCAAGGAAATTCCTCGAGACTGTTCGGTTTAAGCTCATCAGTGGTGTGCCAAGAAAACTGGTG CTAACTTTGTGTGGGTAAAAGACCTTCATTTTGAGGTCAGGCCCGGTGGCTAACGCCTGTAATCCCAGCA CTTTGGAAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATATGGTGAA ACCCCGTCTATACTGAAAACACAAAAATTAGCTGAACGTGGTGGCACGTGCCTGTAATCCCAGCTACTCT GGAGGCTGAGGCTGGAGAATCGCTTGAACCCAGGAGACGGAGGGTGCAGTGAGCCAAGATCACGCCATTG CACTCCAACCTGGGCCAGAAAGCGAGACTCTGTCTCAAAAAGAAAAAAGAAACAACCTGCATTTTGAAAA TCTGAGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCAGTTTGGGAGGCTGAGACTGACAGATCGCT TGAGTCCAGGAGTTTGAGACCAGCCTAGGCAATATGGTGAAACCCCGCCTCTACAAAAAATACAAAAATA AGCTGGGTGAGGTGGCATGCACTTGTGGTCCCACCTATGGAGGAGGCTGGGGTGGGAGGTTTGTTTGAGC CTGGGAGGTGGAGGTTGCAGTAAGCTGAGATTGTGCTGCTGTACTCCAGCCTGTGTGACAGAGTGAGACC CCATCACCAAAAAAAAAAAAAAGAAAAGAAAATCTTTCTTTTCCTATCTTTTCTTTCAAGCCTAGCTTCC TTTTTATAGTTACATTTCTGAAATTTGCATGTCTGTGGTTAAAGCCGGGTTGGGGCAGGGACTCACTTGA ATCAGTACTTATTTGGGGCCTGGGGTGTTTTTCTTCTTAAGATCACAATCGAAGCAATGAAAAGTGACAT TGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATT GAAGCTTCAGAGGTGAGCTGGGGAGAACTATTACTCTGAATACGCTTTGGGACATATCTCATTTGTGGAT GATGTTCCCCTTCTAGGAGAACTTTATTCTGTCTGGGTTTAGAGGGTATCTCCATTGGCAGAGATTTTGA TTTTTCTGCTAGCCAGAGCCCTTCATGAAGGAGGCACATCAGTAATGAGGGCTCACGTTCTTGCCAAGCA GTCAGGCATGATTGATCGTAAATAGTGGTATTATCACTGTGAACACAAGGGGGCAGCAGGCTGTCGCAGT TTACCAAGGTGATGCCTGATGCTGAATTATTTCCTTTTGGAAGTCCTAATGCAAGCCTAGGATGTATAAT TGATACTTTACTAACTCTGGTGAAAGAGTCAGATATGGAAGAGAATGGGGAGTTCTGTACTTGGGATCTT TGAATTCAAGTTTTGTTTCCAGCTTGGTCTTTACACACTTTTATTTCAGGACAAAAATAAAAAGGTTTTT TTTGGCATCTTTAGGCAAACTGAGTGTGTGTTGATCCAAGGAACACTGAAATATCAGGTTGTCCATATGA ATTGAACTTATGAAAAAAAAGTTATACTTAATGTTGCCTTGGACCTATATTATATGGCCTAAAAGATTCT CACTGAAGTAGACCAAAAAATTAGCACTTTCCAAGATCACATTGTATGTTACCATTTGTCCTTGTATGTT TCTGTTTCTGTTAAGAGATCCCTGTTCGGCTCTCATTGTATGCCTTTAGTATACAGAGCTCGGTTGCTTT TGTCTAGAATTTGCTTTGTTTCTCCTCAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTT TTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGTGAGTTAC CTTCCAAATATAGGTAGGTAAGCTGTGGAACCTTACTAAGAGTAAACTGTGGAAACTTTCCATGGAAGGA ACTTCGCAGCCCATCAACTATTTGATGTTCTGTTGTTGATGACTTAGAAACAGCTAAGCTGCATCTATAA GATCCCCTAGGCTCTGACTTCTTTGTGAAGGAGAACTGAGTCTTAACATCTCAGATGCATCTTGCTCAGG AATGAGCCACATGCTGCTCTGATTTCCTGAGTGCTCCATTGTCCAAACTCATAAAAGAAAGGTGCTCTGT CAAAGCTTCAGTGAAGCAAGGTTAGGAGCAAAGATGTGCTGGTTTTAGGCCACTTGCGTATCTGTTGTAA TATCCAGGATACTTTCGTGAGTTCACAGGGTGTATGTTTTTAAAATTCTAAGGAAGTTGGATATAAGTTA TTCAGATGCTAATGAAGGACCCCAACCCAAGAAAGAAACCCTTCTACTGATCCTTTAAGATAATTAACTT CAATTATTAAGATTCAGGATGAAAGTAAAGTGACAAGACTTCATAAAGATTGGGGTCTAATGAGTAAATA TAGAAGTTCTTTTATGAGGACCGTGTCCTGGTTGCTTTTGTTCTCCTGACTTGATGCAACACAGTGTTTT TTGATACGGTATTTGGGAAGCTTCTTCTGGTGCATGTGAAGTATTACCAAAGAGCTGCTAGTACTCTGAC GAAACAATGTTGGTAACTGAGCATTGCATCATTTCTTTGTACACAGGAATGTAATTGTTTTTAGGGATGT GTATAATTCTCAATATAGCAGTTTCAAAAGCTAAGTAGGGATGTGTTTGGATTAAAATGAACTGGGTGTT CCCTTAATTTTCATCTCTCCTCTCAGGGTTTTTTTGTTTTTGTTTTTGTTTTTTCTTTTGTTTTGAGATG GAGTCATACTCTGTCTCCCAGGCTGGAGTGTCATGGCATGATCTTGGCTCAGTGCACCCTCTGCCTCCTG GGTTCAAGCAGTGTCCCACTCTAGCCTCCCCAGTAGCTGGAAGTACAGGTGCGCACCACCACGCCCAGCT AATTTTTATATTTTCAGTAGAAGCGGGGTTTTGCCATGTTAGCCAGGCTGGTCTCGAACTCCTGACTTCA AGTGATCCGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACTGTGCCTGGCCTATAG TTGCTATTTTTATCTTTTGACTTCGTGTCTTTACTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTA TATATATATTATATATTTTATATATTATGTTATATATATTTTATATAATGTTATATATTATATATTTTAT ATAATGTTATATATTATATTTTATATGTATTATGTTATATATTATATATTATATATTATGTTATATGTTA TATATTTTATATGTACTACATATTATATATAATTATATATATTTTATATATATTATATATATTTATTTTT TAGACAGAGTCTCACTCTGTTGCCAGGCTGGAGTGCAGTGGTGCGACCTCGGCTCACTGTAGCCTCCGCC TCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCATGCACCACCACGC CTAGCTAATTTTTGTAGTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGATCTCGATTTTTTG ACCTCATGATCCGCCCACCTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCGGCCT CCTTTCTTATATTTTTATTGTGCTTTTCCTATTTGAGAACAAATTATTCTTTGTGTGATTTTCTGAAACT GCATAGGCAACCTGCCTTAAGTTTACTATGTGGTGTGAATGGCCACAATTAGGAAGCTATACCTTGGATT CTAACTTAAGAGGAGATATTAGTGGAATCTTTTCTTTTTTGAACTTTTGTGGTTTTGGTTTTTGGTTTTT TGGGGTGGCGTTGGGGGGTACAGAGTCTTGCTCTATCACCCAGGCTGGAGTGCAGTGGGGCGGTCTTGGC TCACTACAACCTTCATCTCCCTGGTTCATGTGATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTAAC AGGTGTGTGCCACTATACCCAGCTAGTCTTTGTATTTTTAGTAGAAACGAGGTTTCACCATGTTTACCAG GCTGGTCTCGAAGTCCTGACCTCAAGTGATCTGCCTGCCTTGGCCTCCTAAAGTGCTGGGATTACAGGCA TGAGCCACTGCACTGCACCTTGCCTCTTTTTTGAACTTTTGATTGAATCATGTCTTCTTCCCAGTCATGA AACTCCCTTACTTTCCTGGTCTTTTATTCCATAGGTTAATTTTTGTTGATTTTGGACTTTATTTATTATT ATTTTTAATACTATGTTTTTTTTTTTTTCTGACAGAGTCTCACTCTGTTACACAGGCTGGAGCACAGTGG CACAATCTCGGCTCACTGCAACCTCCGCCTTCCAGGTTCAAGCAATTCTCCTGCCTTGGCCTCCTGAGTA GCTGGGACTACAGGCACGTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACC ATGTTGACCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACCTTAGCCTCCCAAAGTGCTGG GATTACAGGCATGAGCCACCGCGCCTGGCCGATTTTGGACTTTACATAACTGGAATCATACAGCATACAT TCTAGTTCTGTATTTTGTTCTAAATGTTTGGAATTCATTCTTTTTGGATGTAGTTGAAATTTTTTCATTC TTGTTGTGTAGTACTAAATGGAATCTTCTTCCATCTGAATCTTGTTTAACAAAGGCTATGCTGTGATGAA TGTTTGTGGAAGAGACAAAATATAAAGGTCTTATATTTTATTTCCCTGGAGTTTAAGTTCTAAAGACATT CAAGAGTAGTCAGAGGACCTTTAGAGTTAAAATGATTCTTTGGACAAAATCTTAACTAGTGCCATATTCT TTCACCAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCT TCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAAC CCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTC AGCTCAAACCACTAGTTATACAGGTGAAACTGAGGGATTTTTGGAGTAGAAAGTAGGATATTTATTGTTT AAACTTAAAGCATATCTTTATTTTTCAAAACAAAACTGTAAATTGTCATCTACAAAGATTATCTCTAGAT ACTTGTTTACTTTTAATGAGGGTAAAATATATTTCTTAGGTTTTTAATTACATAAGTCAGCATGATCCAG AGACATGTGAAAGAAGCCAAAAGAGAAAAGTCATCTTTAATTTCATTGCCCAGAAATACCACTCTTAACT CTGTATTTATCCTTGAAGCTTTTTCCTATGTGCATGTGTGTGCAACAGGCTCTTCCTGTGCAGATTGTTT TATAACTTGTTTCTTCATTTAATACTATGTTGTAAACATTTCCCAATAATTTTTTTTTGCACCTAGCACT GATTCCCCATAATTTTTAATAATGGCATTATTATTCTATTCTTTGGACAAAATGTCCTTTATGTAATGAA AATGTTCTTATGGAAATGTTGTGCTTGTTTTGCTATTACAAGTCGTGCCATTGCACTCCAGCCTGGGCAA CGAGCGAAACTCTATCTCAAAAAAAAAAAAAAGAGTTTGTTATAGTTGAGTTTAGTGCTTAAAGAATTCA GTCTTCAGTCTTTCTGGATATAGCCAGATGCCATCATAGCTGCATCCTGAGAATTCTGAGTATCTGAGTA ATTCTTTTTTTTTTTGAGGTAGGGAGGCGGGGGGATGGAGTCTTACTCTGTCACCCATGCTGGAGTGCTG AAGTGCAGTGGTGCAATCTAGGCTCACTGCAACCTCCAGCTCCCCAGCTTAAGCAATTCTCGTGCCTCAG CCCCCTGAGTAGGTGGGACTATGTGCCACCATGCCCAGCTAATTTTTGTATTCTTAGTAGAGAGACCGGG TTTCATCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAAGCAACTCCTGACCTCAAGTGATCTGCC TGCCTCAGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCATCATCATGCCCGGCCTCTATCTGAGTAA TTTATTGCAGACTACTAAAAGCATTTACACCAAATTCTTAATATAAAACTCTAAACTGGAGTTTTGAAAG ATATTTTCAAATATTTTGAAAGATGTTTCACACCATGTCCTGTAAAATTACAGAAGTATCTTGGTGACTT TTTTGAGTTAAGCCATCCATCAGTATTTCTTTCTCTGGGGTAGTAGTTAACATGAATTTTAATCTTTGTT TTGCTTTGCTAATAACTGTTATATTTTCAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTG TAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAA TGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCA AATGTGTGCTGGGTAAGGGATTTTCTTGCTGGTGAGAAAAGGAGCTTGCCTGCGCCACTGGCAAGAAAGT AGAAGGTGTGGGAGAGAAATCAATCTGCCTCACTGGAATGCTTTTTCTGATTTTCTTTCTAATTTATTCA ATTAAAATGTGGGGGAGATTCCAACTGCAAGAGCCAGTGGGAACACTTGACTTATGGTTACTGGTTCCTG AACCACTTAGAACAGTCATGGTAACCCAGTGGGGAAACTATCTGGACTTGGGTTGCTTTCTTGAATTGCT TGGGGACAAGAAGTTTTGATTAAGGTAGAGAGTTTTTGGCTGTAAGAAGTATCATTGCTGAGTAGAGGGC AAGAGGGAAGGAAGGTAGGCAGCCTAAATGCTGAGTCAGTATAGGCTAATGTAATTGGTTAAGGGGAGGA AGTTCAAATAAGGAAGGAATGGGGCTAAACGTCTTTCTGTGAAAGGAAACAGAAATGAAATGGCAGGTAT GGTTGAAAGTACTCTGCTGCTTAGAGAGTTGTCAGATTATCAAACAGGATGATGAGAGATGTCAGATTAT CAGACAGGATTTCTGTGATTGGAAACAGAAGAAATGGCAGGTATTGGTGAAAGTACTCTGCTGCTTAGAG AGTTGTCAGATTATCAGACAGGATGAACAGGAAGTACAAATCAAATAAATAAATAGTTAGTTTAAAAGAT ACCTGTAAAATGCTGTCTTGAGATGACCTTGGCAGAAAAAGTTGGAAGTTCACTGACACGGCCCAAAGTA TCTTAATGAAAAATGAGATAATCCTAAGGTGTGGGGTTCTTTCAGGATTAACATTGAACCTATGTGCATT TCAGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCA GCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGGTAAC TGATATTTCACAGAAATGAGTGACGTCTTTGCATCCAAGTTCTATTGCCTTCTGTGTGGAGGATATCTAG CTTAATCATAGAAGCATAATGAGACAGGACAAGACTCTACCTTCTCTAGAGGAATTAAAAGAAACCCGCT GGGCGCGGTGGCTCACGCCTATATTCCCAGCACTTTGGGAGGCCAAGGCGGCTGGATCACCTGAGGTCAG GAGTTCGAAAGCAGTCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGC GTGCTGGCGCATGCCTGTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGGGAATTGCTTGAACCTGGGAGA TGGAGGTTGCAGTGAGCTGAGACTGCGCCATTGCACTCCAGCCTGGACAACAAGAGTGGAACTCGTCTCA AAAAAAAGAATTCCATGATTGATTGATTGGTTTGTTTAAAGATGGAGAAAGAAATGCAGATTCCACCTAC CTTAGAATTGTTCAGTTTACAGCTGAAATCTGAATATAGTGTAATTTCTCTGCTTTCTTTGTAGAGAGTA ATAGATCTAGAGAGGTTCCTTCATTTTGCAGCATTGACAGTTAACAGGAGTATTTGGTTACAAGAGAAAT GATAGTACTCATTATGAATTTGATTGCCACACCAAATCAATAACTACCATTTTTATTTTATTTTATTAAT TAATTAATTAATTTATTTTGAGACAGAGTGTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCAATCTC AGCTCACTGCAACCTCCTCAAGCGATTCTCCTGCCTCAGCCTCCTGGGTAGCTGGGACTACAGGTGCATG CCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGACAGGATGGTCTC GATCTCCTGACCCTCGTGATCCACCTGCCTTCGCCCCCCAAAGTGCCAGGATTACAGGCATGAGCCACCA TGCCCGGCCAACTACCATATTTTTATATAGGATGAAGAACTTGGGGTAAATACAGTTGACTTAGAAACAA GCTTTTGAAATGTTGTTTAAAGGGATTATAAGTTGGAGACAACCTTTAACAATTTATGTTTTGTATGAGC TATACCTAAAGTCATGAGCAAAGTAAACCTTCAGGAAGAGAGCTGAGCACAAAATCTTCCTTTTTTTTTT TTTTGAGACAGTCTTCTCTTGTCACCCAGGCTAGAGTGCAATTGTGCAATCTTGGCTCACTGCAACCTCC TGGGTTCAAGTGATTCTCGTACTTCAGCCTCCCGAGTAGCTGGTACTAAAGGTGCCCACCAACATGCCTG GCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCACAAACTCCTGACA CCTCAGGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTGTAGGCCTGAGCCACTGTGCCCATCA AAAAAAAAATCTTCCATTTAACTAGTTCATGTCCATGCCTCTTTGAGATTATATATGAAGACATCTTTTT TAAATGAATGAAGAAAATTGGGGTATTTTTTTTTTTCTGGGACGGAGTTTCGGTCTTGTTGCTCAGGCTG GAGTGCGGTCTCGGCCCACTGCAACCTCCACCTCCCAGGTTCAAGGAATTCTCGTGCCTCAGCCTCCTGA GTAGCTAGGATTACAGGCACAAGCCACTACACCTGGCTAATTTTTATATTTTTAGTAGAGGTGGGGTTTC ACCATGTTGACCAGGCTGGTCTCAAACTGACCTCAAGTGATCCGCCTGCCTCAGCCTCCTAAATTGCTGG GATTATAGGCATGAGCCATCACGTCTAGCCAGGAAAATTGGGGTATTTTCTTCATAGCACTTCAGACAAC CTGTTAAATTGTTCACATGATTTTTTACCATTTCAAACCATTTTTTCCTCTATAATTTTAGCCCATTTCC AAAAGGGCCATTCTAAATTTTAACTGTCTGGAGACCATAATGAACATAGCCATTGGCTCAAAGGACTTGA AGATTTCATTCTTGGATATTGTGTTTTCAAACTCAAACCAGGTCTGCAGACATACCGGTTCCTGAGTTCT TATTTTTGGCAAGACATTGTCTATGTTCTTCCCTGTCCTTTTCATTTGAGGCTTTAAGATTTTCGCTGTG TTCTTTACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGT GAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAA CAGGTTCTTCAGATGGAGGTGAGACCTAAGAGTGCCCCTGACTATGGGTGGGAATTGGGTAGTACTTTTG ACACCTAGGTCTGTTTTCCAGACTGTTCTGTCTTTTTAGTGTTTAAGTATATATTTTCTCAGAAAGATAA TAAAGCTTATACAAAAAACATTGCACCTTAACGTTAGCATTGTTTGTCATGGTTTACTCATATATGTGTT ACACTATATGTATTATGGGTTTTTTGTTGCTGTTGTTTACTTTCCTATGTTAGTATTAGGGAAGATTATT AAATGGTCCCAGCAAAAGTGGAAGGTTTTCATGTAGAGTATGTTTTCTTATTTTCTTTGTAGTCACATAT CCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGGTATGG TGGTGCCTTATGACTTAATAACTCCAGGTTGGAGAATTATTAGTATCTCAGTATAACAAGTTCGTGTACA CACAGAACTCGAAAATGGTATAGATGATGCGGATCAGAAGCTGTTCTCAGAAGGCTTTGGTCTGTGATTG GTTGATTGGGAGAGGAATTCCCCACCTGCCTTACCTGTCTGTCTAGAAAGATTCAAATCCTACTTATTTA CAGATGGTCTAGATGTAATCTTGATAAAATCAAACCAACTTGACTTCTCCTAATTCAACATACACTCCTC AGACCTCTCTTCCTCACTCGTTTGTTTCAACTAATGTCACTGTGTAGAGAAGGAAACTACTTAATGTGTG ATGGTTCCTTCCAGATGTATAGCTCATTTGTGTTGGCAGCTTGAATGGTTTTGGTTTTTTTATTTTGAAA ACCAAAAAACTCTTGGTTTTTCATTAGGTTATTCAAGCCTAGCTCAGTCAGATTTGGTTCCCAGCTATAG TTCACTTGGCTAAAAATAAAGCCTTGAATTTGTACCGTCATCTTTTGAAACATTTGCTGTTTGACCTAAT GTCAGTGACATTAGTTGAAACAAACGAGTGAGGAAGGAATGTTTGATGGGAGAAGTCAGGTTGGTTTGAT TTTATCAAGTTTATTTCTAGGTCATCTGTAAATAGGTAGGATATAGGAAGGGTTGCTTTTTGTTTGTTTT ATGAATAAGAGCTCTAAGGTGATAGGGCCTTCTCTAAAGCTGAAGTAATTTAACTATCATTCCAGTAAGA CTGGACTATGGCGGCTACCAGCAGGGATTTGTCAGACAGTAAGACAAATGAAATTGAGAGGACATGACCT TCTGCACAACGGAGGATCAGCTCACGTTTGTTCTGAATTGAGAAACAGGAGAAATGTTAAAATGTATTGC TGATGATTGGTACTGTCAATGTTTTTGTGTATAAAATACATTTGGCATTCCCAAAATTAAAAAATATCAA GGGACTTAATTGATTTTAAAAAGAAAAGGTATAGTGTTCTGATTGGGAGATTTGGAATCAACTGATCTTG AACTCTTACTCATTTCACAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGT GGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTG ATGGCAGTTAGCACACTGGTGGAAGGTCGGTGAGAAATACTGTCTGGTCAGGGAATGTCTTTGGAATGTA GGCATTTCAGTGGCCTTAAATAATTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTTGGCGCACTGCAG CCTTGAAATCGTGGGCTCACATGATCCTTCCACTTCAGTGCCCCCACAGTAGCTGGGACTAACAGATGCA CACCACCATGCCCAGCTAATTTTTATATTTTTGGTAGAGATGGAGTTTCGCCATGTTGCCCAGACTGGTC TTGAACTCCTGAGTCAAGTGATCCTCCTGCCTCAGCCTCCCAGAGTGCTAGGATTATAGATGTGAGCCAC TGGGCCCAGCTTAATTTTGTTTGTGTGTGAAGATAGGGTCTCACTATATTGCTCAGGCTGGTCTCAAACT CCTGGGCCTCCTTGTCAGAGCATTAAAGAATTTTTGACTATAGAAAGCATAGTCCTTTTACTGGGGCATG AGTCACTTCAAAGTTAGATTGAACTTAAGTGCACACCACTTAAATTTGTATAACTGCCTTGTCAGTCCAT TTAAATGGGGAGCCAGTTTGCAACGGAGATTGGCAGAGGTGTTGTTTTTTTTTTGTTTTTTTTTTTTGTT TGTTTTTTTTTTGAGACTTGTTCTGTTGCCCAGGATGGAGTGCAGTGGCACCATCTTGGCTCACCACAGC CTCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTATAGGCATGAGCC ACTGTGCCCTGCTAAAAGTTTCTATTTTCTTTCCTGGTACTTGTCATCACCTGGTTTGGTTTGTAGTGCT TTGGACTAAGATTGACACATCATGGTGCCTGGTATGGGATGAAATGAAACATTGAGCGAGTTCTAGGAAT TGATTTTCTGATTTTTACATGTCTGACTGCAAAATTGGTTTGGGGAAGCCATATCTGACTTAAGACTCTT TGAAGGGGCATTACGAAGCACTTTAGGAATCTGATATGCCTTTTCAGGGGTGGCCTGTAAGTACATTGCT AAGGCCATTTACCTGAGGACCACTCTCCTGAGGACTAGACCTATTTTTGGCATAAACAGCCTATGTCCAA CTGGTCTGTCAACATGTGACCACTCCTCTGAAAGGGCAAAGAAGTTAATTTTGGCTCCTGGAGTGGCTGA TTTGGATCTGAAGCCCAGTGCTGCTTTTCCTGGCTGTGGCTTGTTTAGCCCTTGATGGAATTGCCTAAGG ACCCTGTTTTGAAGCTGGCTTGCAGAAAGGACATGCTATTATCAGATGAGGAGGTGGACAAGAGTCAGTA TTGCTGGTTCAGCCCATTTAAAATTAACCTTGACATTCCTTGAGGGTCATACCACTTGGTTGTATTAGTC AGAGTAAAGCCCTATTCTGTGGACAGTGGGCATTGTCTCTGTGGCGTATGAATTAGGGCCCTTCCAGCAG TAATAAATTTGGCTTATGCAAGCCTTTAATGTCTTCATGATGGAATCGGTAACTAAAGCACATTTCACCC AACCTGTTGAGTGGAGCGAGTACATTTTGGGAGAGGTAGGATGGGTTATTTCTGCCTGCCTCTGTGTTAA CCCGTGGTGCTGTCATTGGCTAATAGCTTATTTCATTACAGTGTTGGGTGGTGAATTCCTCAAGTACATG GAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTAGGATGTGCTTTTC AAAATAGTATGTTCCCATTTATATCTGACAGTCACTGTAGTGCACGCAAAACCAGGTTCTTATAGCTTAA GTAGTTTTTCCTGATACATTGTCCTAAAAGGCAAGCTACTTTATTCATTGCCTGAACGTTTGAACTGGAA GTAGTCCATGAAAAACAGGATATTAGATGTACCAGATAACGGTGGACAAGATATTAGATGTAACAGATAA TGGTGGACAAGATGACTGTTTATTTGCTTAGACAGTACTAATGCAGGAGCAGCTATAAAGTTGAGCTATT AGCACCCTGGAGAGCAAGGCTTTTTTTTTTTTTTTTTTTTTAACTTTATCAGTGATCTCTCTCGGATAGT CTTTGTTCCCTGCCTGCCATGTTGGTTGTTGAAAAATTAATCTCGGCAGAGGGATTTAACTCTAGGTTCA AGTGATAAAAGCTCAGCAGCTAGTTAAAAATAATATCTTGCCCCAGCAGGCAGCCTTTTCTGTTAGAAGA TTATTTCCTTGATTCTTGGCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTG CAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGGTGAGTATCT ACACACAATCTAATTAACCAGTCTTCTTTGAAGAAAACAACAGTTGGAAAGATAGTTAAATATCGACCAG GCTGGGCGCAGTGGCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCAGGCCAGGAGTTCGAGACCAACCT GGACAACATGGTGAAACCCCGTCTGTACTGTAGATACAAAAAAAATTAGCCGGGCGTGATGGCAGGCGCT TGTAATCCCAGCTACTCGGAAGGCTGAGGCAGGATAATCGCTTGTACCCGGGAGGTGGACGTTGCAGTGA GCCAAGATCACGCCATTGCACTCCAGCCTGGGCAAGAAGAGCCAAACTCCGTCTCAAAAAAAAAAAAAAA AAAAAAAAATCAGTGACAGGGAGCTGTAAGTTTCTAGAACATTGGCTTTGGGCTTATAAAGAGGGGAGTT GTTCATTTCACAGATGACTCTGAAGAAAGATTGTAAAGTTAAAGGAATGTGTGCTCTATTAGAGATTTTT AAAACAAAACAGTAAAATGCAAAGGAAAAGTAAATACAGTTGTTCCTTGACTTATGATGGAGTTAGGTCC CAATAAACACATTGTAAAGTGGAGAAATCATCAAACCATCATGAGCAGGGGACCATTTGTATATTATACC TCTCTCCAGAGATAGCCATCATTAATTATTGTACATGTGTGTTCTCAGACAAGTCACTTGATTCTTAAGT CAGTCTCCTCATGTGTAAAGTGGGAATACCAATACCTGGGCTAGCTTCTTAGAGTTGGTGTGAGGTGCAA ATGGGAAAGGTTTTGTAAGCTATAAAGGACCATCCAAATATTTAAAATCAATAGTTGCTTGTTAGAAATG AAATTTTCATGAATCTTTGGACCAAACAAGTTTTGACTTAATTCACTTTTCCTTTTGTTCCTTGTCAGAA TGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGA GGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACA AGGTAAGCTTAAAGCTATCTTGGCTGTTCTTTAAGTCTAGCTCTAATTGGAGGGACTATTGACAAACATG CAGCTAAAAGTGATCAGTGTGATGTAGGTTCTGTTCTTTGTGTCTTACAGTCAGACTATGACATGGTGGA TTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGAT CAGGAGAACGTACACCGTTGAGTATACAACCCAGTTCCCTTCGTCCGCTCGCCAATGTGCACTTAGCCAA GTGGGCTATGTCTGTCATTCTGTAGCTCGCTTGTGAACCTAGTGCCTGTTGCTTAAAAGGCTGGGAGAAG GGGGAGCAGTGCCCTAATGAAGAGAGTGGCTTGGGGAAAACTGTAGACTACTGTTTTTGCTCTGCTTCTT CTTTCTTTTTTTTGTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTCGTGCAATCTCG GCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAACTA TACACATCTGCCACTATGCCTGGCTAATTTTTATATTTTTAGTAGAGGCAAGCTTTCACCTTGTTGGTCA GGCTGGTCTTGAACTCCTGATCTCAATTGATCCACCCGCCTTGGTCTCCCAAAGTGCTGGGATTACAGGC TTGAGCCACTGTGCCCAGCCTTTTAAATTTATTTTATTTTATTTTTATTTTTTGGAGACAGTCTCACTCT CACCCAAGCTGGAGTGCAGTGGAGCGATCACAGCTCACTGCAGTCTTCACTTCCTGGGTTCAAGTGATTC TTATGCCTCAGCTTCCTGAGTAGCTGGGACTACAGGCACACACCACCATGCCCAGCTATTTTTTTTTTTT TTGTATTTTAGTAGAGATGGGATTTCACCATGTTTTGCAGGCTGCTCTCGAACTCCTGAGCTCAGGCAAT CTCCCACCTTGGGCTCCCAAAGTGATGGGATTTCAGGCGTGAGCCACTGCACCCAGCCCTCTGCTTCTTT TTCTCATATTTCTTGAGTATTACAAGGGATGGGATTCAGCAAAAATGTTGGGGGGAAGAAACCCAACATA AATGCTTCCTGTATCAACCATGAGTGGCAGGTCCCCTACCCCTTTCCCATCCCCACAAGCTAAATTGGAG GACTGGGGAGTCATAATTCCCGTTACGTGTTCTTGTTGCTGATTGGGGAAATTTTTTACTTCACCCCCCT TGGTATCATTAGCTCAGGAAAAAGTTAAATTTGTTTCTTCTATATTTGCCTATAGGAAGAGGAATATTTG TCTCTTCTGTCGACTTGAGGAACGACACATTAATCAAAGGAAGAATAATTTGATATAACTATATGCATCT AGTTATCCAGCTTGGACCTTGTATGATAGGGGTATAATAGTTGGAAATTTTGAAAAAGGATGTAGTCCTG CCATATGAGGGACAGCTGCATCAGACCTTCTCTCTCTTTTTTTTTTCTTTTTTTTTTGAGATGGAATCTT GCTCTGTCGCCTAGGCTGGAGCGCAGTGGCGCAATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCAC GCCATTTTCCTACCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTT TTTGTATTTTTAGTAGAGACGGGGTTTCACCGAGTTAGCCAGGATGGTCTCGATCTTCTGACCTTGTGAT CCACCCGCCTGGGCCTCCTAAAGTGCTGGGTTTACAGGCATGAGCCACCGCACCCGACCAATACCTTCTC TCTCTTTTATAGCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACAT TGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGTAAGTTATACCC TGCTTCTAAGAGCTGAATAGAACTTCTCACAGAAAATGAGAAAACATGGAGTAAGGAGTTTTGAGAGTAT CGCGGATGGCAACAGTTCACTTTTTTGGCACAGAGATTTCTTTGCAGAACGCTTCATGTCCTGTTTTGAG TGTTCACATGATAGTTTATTCCAGACCCTCAAGGTGTCTGTATTACACCCCATTAAACTCTGATGTTGGT CAACAATTGCCTCTGTCTAGTGACCTCTACTGAGGGTTTTATTTATCTTTGAAATTTGCTAAGAAACCCA TAGCACTGGTTTGGAAGGCTCAAAACATTATACTGGTATGGGGCTAGGAGCTCATTCTCAGCTGTGTTTG TTTTGCACAGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGAT CCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACA AAAGAACTGAGGAAACTGAAGAACCAAGCTTGGTAAGATCTTGCCTCCACTGTCCTCTTTCTTCTACTTC CTGGAGGAGGGGGGTATGTTTTCTTTAGGCCATTCTGGCAAGCACTGCCTTCTGGCATTTTTTTTGTTTG TACTTTTTCCCATGTAGGTGCTTCTGAGTCAGGCAGCCTCAGTTTTTCCTTGAGCCAAATGTTTGACTCC TCATAGTGATGGAGAGCAGAACTTTTAAAACTGGAATTCACTGAAATTCCCTGAGTATTTTGGGTCCTAA TAAAATCATCAGTAATGCCATTTCCCCCTAATTCTCTTCTGTTTTCTATTCCTTTCCTCATGCCCTATTC TTTCTTTACAGCAGTGCTTTTAGACGTTGCCTAGCTCTAGAGAAGATTTCCAAAGTCAAATGTTTTTTTG TGTGTGTGTGTGTGTGTGTGTGTTTTCTTTTTGAGACAGAGTCTCACTGTCGCCCAGGCTGGAGTGCAAT GGCACAATCTCGGTTCACTGCAACTGCTGCCTCCTGGGTTTGAGCAATTCTCCTGTCTCAGCCTCCCGAG TAGCTGGGATTACAGTCACATGCCACCACACCCGACTAATTTTCTTTTTTTCTTTTCTTTTCTTCTTCTT TTTTTTTTTTTTTTTCTTTTGGAGACAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTC AGCTTATTGCAACCTCTGCCTCCCGGGTTCAAGCAGTTCTCTGCCTCAGCCTCCTGAGTAGCTAGGATTA CAGGTGCCCTACCACCACCACACCTGGCTAATTTTTTTGTATTTTTAGTAGAAACAGGATTTCACCATCT TGGCCAGGCTGGTCTTGACCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTACTGGGATTAC AGGCGTAAGCTACCATGCCTGGCCCAGTTTTTGTATTTTTAGTAAAGATGGGGTTTCACCATGTTTGCCA GGCTGGTCTTGAACTCCTGATTTTAGGTGATCCACCCACCTCAGCCTCCTAAATTGCTGGAATTATAGGT TTTTTTTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGATGGGTTTTCACCATGTTGGCCAGACTGGTC CTGACCTCAGGTGATCCACCTTTGTCGGTCTCCCAGGTGTGCACCACCACACCAGGCCTTGGCTCCTACT TTGAAATGCAATCTTGTTTGTTTGGAGACAGAGTCTCCTCTGTCACCCAGGCTGGAGTGCAGTGGTACAA TCACACCTCATAGAAGCCTCCAGCTCCTGGGCTTAAGTGGCCCTCCTGCCTCAGCCTCCCAGGTGGTTGG GACTGCAGGCAAGCACCTCCATGACTGGCTAATTTTTTTTTATTTTTAGAGACAAGATCTCCTGTTGCCC AGGCTGGGTTTGAACTCCTGACCTCAAGAAGTTCTCCCTCCTTGGCCTCCCAAAGTGCTGAGATTAAAGG CTTGAGCCACTGCACCCAGACTGAAATACAGTTTTAATTTCTTTCACTCTTAATTAGTTATCTTACTCCA CAGATCTCAGTAAAATTGGCTCTTTGAGTTTCCCTCGCACCCTCTGATGTAGGTGTTAATAAGAGCAGGT CAATGGCACATAGGACAAGAAGAAAGAGTGTCAATCCTTGAAATGTTGACAAATTCCATTCAGGCCTAGG AGCATGTAATTGTAGGAGTCAGCATTATTGGCTCTGTTGGGTATATGTGATCTCAAAGATTGACCTTTTT TTCCATCTGTTTTCAGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCT TTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGA GGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTA GTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATG GAGTTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGT CTTTTGGCCAGTGCCGAGTGGAATGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTT TGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCG CTGTACCTTTGCCACATGGTACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGA GAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTCTCAACTTCAAGTCATTGCAGTTTCTTTTTCCCAG AAAACAAGGGGTTAGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGA TGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACACACACAGAGGAAAGACGCTCTTTAGGTTTTGTTT TGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAACACTGACGAATGGTCAGAGCT CCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATGGTTCAACTGTGAATGTAGAAGTGGGGG GGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATATAAGTACAATTGTTACAAATA ACGCAGACTTCAAAAACAAAAAAATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCA CAAAGAAAACGCCCTCTCCTGACTTGTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGT TTAGAAAAATAAATATACAATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTAACTATTTTG GATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTG Download Select all
Length	33801
OMIM ID	602738
HGNC ID	HGNC:6400
Unigene ID	Hs.532793
Ensembl ID	ENSG00000108424
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002265.5
Exon	join(1..447,549..607,2857..3039,7023..7223,8671..8823, 11282..11341,13252..13341,14322..14432,15220..15321, 18349..18573,19841..20032,20865..20995,23181..23328, 23653..23724,24801..24945,26572..26654,27183..27290, 28209..28352,28471..28576,30183..30297,30671..30832, 32567..33801)
mRNA Sequence	>3837 AACGGCCAATCGTCGTGGAGCGCGGCGCCTCCGCGGAGAGGTCCGGTCCGAATATCCCTCCGCC TTCCTCCCTCCCTCGCTCCCTCCCTGCGCGCCGCCTCTCACTCACAGCCTCCCTTCCTTCTTTC TCCCTCCGCCTCCCGAGCACCAGCGCGCTCTGAGCTGCCCCCAGGGTCCCTCCCCCGCCGCCAG CAGCCCATTTGGAGGGAGGAAGTAAGGGAAGAGGAGAGGAAGGGGAGCCGGACCGACTACCCAG ACAGAGCCGGTGAATGGGTTTGTGGTGACCCCCGCCCCCCACCCCACCCTCCCTTCCCACCCGA CCCCCAACCCCCATCCCCAGTTCGAGCCGCCGCCCGAAAGGCCGGGCCGTCGTCTTAGGAGGAG TCGCCGCCGCCGCCACCTCCGCCATGGAGCTGATCACCATTCTCGAGAAGACCGTGTCTCCCGA TCGGCTGGAGCTGGAAGCGGCGCAGAAGTTCCTGGAGCGTGCGGCCGTGGAGAACCTGCCCACT TTCCTTGTGGAACTGTCCAGAGTGCTGGCAAATCCAGGAAACAGTCAGGTTGCCAGAGTTGCAG CTGGTCTACAAATCAAGAACTCTTTGACATCTAAAGATCCAGATATCAAGGCACAATATCAGCA GAGGTGGCTTGCTATTGATGCTAATGCTCGACGAGAAGTCAAGAACTATGTTTTGCAGACATTG GGTACAGAAACTTACCGGCCTAGTTCTGCCTCACAGTGTGTGGCTGGTATTGCTTGTGCAGAGA TCCCAGTAAACCAGTGGCCAGAACTCATTCCTCAGCTGGTGGCCAATGTCACAAACCCCAACAG CACAGAGCACATGAAGGAGTCGACATTGGAAGCCATCGGTTATATTTGCCAAGATATAGACCCA GAGCAGCTACAAGATAAATCCAATGAGATTCTGACTGCCATAATCCAGGGGATGAGGAAAGAAG AGCCTAGTAATAATGTGAAGCTAGCTGCTACGAATGCACTCCTGAACTCATTGGAGTTCACCAA AGCAAACTTTGATAAAGAGTCTGAAAGGCACTTTATTATGCAGGTGGTCTGTGAAGCCACACAG TGTCCAGATACGAGGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATT ATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAG TGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATG GATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGT TTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGA CGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTG GCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGA ACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGA GCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGAC CCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTG AAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGC TGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAA GCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAAC TCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAG TTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTC CAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCC AGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAA TGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTG TTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTA GCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCT GGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGA GACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTC TGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGG TGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTT CAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGC TAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAA CGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCAC ATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACT TATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATT GTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAA GAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCC CACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTT TGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTGCCACAGCA GCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAAC CATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAGTTACTTATTTAAAAAAAAAGAAAG AAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGTCTTTTGGCCAGTGCCGAGTGG AATGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAG CCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTT TGCCACATGGTACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGAGAA TGAGTGTGTGTGAGTGAGGCGGTATCCACATTCTCAACTTCAAGTCATTGCAGTTTCTTTTTCC CAGAAAACAAGGGGTTAGATGTTGCATTTCATAAAACTAACCGAAGTTCTGTCTACTGATGCAG CACAAGAGATGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACACACACAGAGGAAAGACGCT CTTTAGGTTTTGTTTTGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAA CACTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATG GTTCAACTGTGAATGTAGAAGTGGGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGA TATAGAAAAATATAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAAAAATCACAAC CCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGACTT GTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGTTTAGAAAAATAAATATACA ATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTAACTATTTTGGATTGCAAACAGG ATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGAAAA Download Select all
Length	4276

CDS Information

Location	join(408..447,549..607,2857..3039,7023..7223,8671..8823, 11282..11341,13252..13341,14322..14432,15220..15321, 18349..18573,19841..20032,20865..20995,23181..23328, 23653..23724,24801..24945,26572..26654,27183..27290, 28209..28352,28471..28576,30183..30297,30671..30832,32567)
CDS Sequence	>gi\|449784877:408-3038 Homo sapiens karyopherin (importin) beta 1 (KPNB1), transcript variant 1, mRNA ATGGAGCTGATCACCATTCTCGAGAAGACCGTGTCTCCCGATCGGCTGGAGCTGGAAGCGGCGCAGAAGT TCCTGGAGCGTGCGGCCGTGGAGAACCTGCCCACTTTCCTTGTGGAACTGTCCAGAGTGCTGGCAAATCC AGGAAACAGTCAGGTTGCCAGAGTTGCAGCTGGTCTACAAATCAAGAACTCTTTGACATCTAAAGATCCA GATATCAAGGCACAATATCAGCAGAGGTGGCTTGCTATTGATGCTAATGCTCGACGAGAAGTCAAGAACT ATGTTTTGCAGACATTGGGTACAGAAACTTACCGGCCTAGTTCTGCCTCACAGTGTGTGGCTGGTATTGC TTGTGCAGAGATCCCAGTAAACCAGTGGCCAGAACTCATTCCTCAGCTGGTGGCCAATGTCACAAACCCC AACAGCACAGAGCACATGAAGGAGTCGACATTGGAAGCCATCGGTTATATTTGCCAAGATATAGACCCAG AGCAGCTACAAGATAAATCCAATGAGATTCTGACTGCCATAATCCAGGGGATGAGGAAAGAAGAGCCTAG TAATAATGTGAAGCTAGCTGCTACGAATGCACTCCTGAACTCATTGGAGTTCACCAAAGCAAACTTTGAT AAAGAGTCTGAAAGGCACTTTATTATGCAGGTGGTCTGTGAAGCCACACAGTGTCCAGATACGAGGGTAC GAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGG TCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATA GAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAG GACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCAC ACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTG TGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAAC ACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACC AGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCC AGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCA TCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGC TTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGAT CAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTA CAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAA AAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAG GTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTAC TCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGT TATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATG GCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCC TGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTT GTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTG GGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTA TTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGT GGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACT GGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAG TAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTG TGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGG CCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACAT GGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGA Download Select all
CCDS ID	CCDS11513.1

Protein Information

Protein ID	NP_001263382.1
Protein Name	Karyopherin (importin) beta 1
Molecular Wt. (Da)	81048
Protein Sequence	>3837 MKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANF DKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDID EVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDEND DDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQ LKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPR VASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAY ESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLR KVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIG LKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIA LAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHP DVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTE GRRSKTNKAKTLATWATKELRKLKNQA Download Select all
Length	731
Uniprot ID	P10747
Ensembl Protein ID	ENSP00000324890

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	12
K	Acetylation	867
K	Acetylation	835
K	Acetylation	211
S	Phosphorylation	853
T	Phosphorylation	855
T	Phosphorylation	5
T	Phosphorylation	10
S	Phosphorylation	170

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
862	RUNX1T1	590	NP_783552.1	in vitro	10951564
1434	CSE1L	3217	NP_001307.2	in vitro	9323134
1452	CSNK1A1	2739	NP_001020276.1	in vitro	12062430
2260	FGFR1	634	NP_000595.1	in vivo	11257130
3005	H1F0	819	NP_005309.1	in vitro	10228156
3486	IGFBP3	899	NP_001013416.1	in vitro	10811646
3488	IGFBP5	901	NP_000590.1	in vitro	10811646
3838	KPNA2	2818	NP_002257.1	in vitro;yeast 2-hybrid	86 172 261 538 327 600 000 000
3839	KPNA3	3536	NP_002258.2	in vitro	9435235
4928	NUP98	3012	NP_057404.2	in vitro	91 441 899 275 187
5744	PTHLH	1348	NP_945316.1	in vitro	1 250 401 011 401 500
5757	PTMA	1778	NP_001092755.1	in vitro	11310559
5764	PTN	1199	NP_002816.1	yeast 2-hybrid	15383276
5901	RAN	3109	NP_006316.1	in vitro	91 351 328 576 188 100 000 000 000 000
5903	RANBP2	3111	NP_006258.3	in vitro;in vivo	104 736 109 398 662
6606	SMN1	2646	NP_000335.1	in vitro;in vivo	12095920
6721	SREBF2	2726	NP_004590.2	in vitro;in vivo	10397761
7013	TERF1	2975	NP_059523.2	in vitro	12135354
7157	TP53	1859	NP_000537.3	in vivo	11297531

Pathway Information

Pathway Name	Pathway ID
RNA transport	hsa03013

Structure Information

PDB ID	1F59
Resolution	2.8
Method	X-RAY DIFFRACTION
Chains	A,B
Molecule	IMPORTIN BETA-1
Model	View

Domain Information

ID	Location	Description
cd00020	365-479	ARM
cl22454	365-479	ARM superfamily
pfam03810	21-101	IBN_N
cl04271	21-101	IBN_N superfamily
pfam13513	380-435	HEAT_EZ
smart00913	21-101	IBN_N
pfam02985	410-439	HEAT
cl03819	410-439	HEAT superfamily
pfam13513	424-477	HEAT_EZ
COG5215	2-871	KAP95
pfam13646	376-435	HEAT_2

Ontology Information

HPRD ID	1430
Molecular Class	Transport/cargo protein
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Metabolism (GO:0008152)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO