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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAPTM4B 55353 lysosomal protein transmembrane 4 beta  8LC27 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22578410   2012Cell line : -

Source : Tumor Hospital of Harbin Medical University, Harbin, China

Sample Type : CRC tumor and normal tissue

No. of Sample : 161

Stage : -

Immunohistochemistry, Western blottingUp-regulation-LAPTM4B overexpression is an independent factor in colorectal cancer prognosis, and it may be an important potential biomarker.

Among the 136 patients with colorectal cancer, 51 patients had low LAPTM4B expression, and 85 patients had high LAPTM4B expression. The sensitivity and specificity of LAPTM4B overexpression were 62.5% and 100%, respectively.


Gene Details



Chromosome 8 - NC_000008.11 (97775581..97852602)

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Gene Type protein coding
Gene Family
Description -  
Chromosome 8
Location 8q22.1
Start 97775581  
End 97852602  
Strand +  
Gene Sequence

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Length 77022  
OMIM ID 613296   
HGNC ID HGNC:13646   
Unigene ID Hs.492314   
Ensembl ID ENSG00000104341   
PharmGKB ID -   

mRNA Information


mRNA ID NM_018407.4
Exon join(1..528,29773..29884,39748..39821,40478..40600, 43560..43658,49478..49573,75817..77022)  
mRNA Sequence

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Length 2242  



CDS Information


   
Location join(157..528,29773..29884,39748..39821,40478..40600, 43560..43658,49478..49573,75817..75894)
CDS Sequence

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CCDS ID CCDS6275.1



Protein Information


      
Protein IDNP_060877.3
Protein Namelysosomal protein transmembrane 4 beta
Molecular Wt. (Da)34992
Protein Sequence

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Length 317  
Uniprot IDP55268
Ensembl Protein ID ENSP00000307156  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Lysosome hsa04142


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam03821164-370  Mtp
cl04276164-370  Mtp superfamily
TIGR00799153-370  mtp


Ontology Information


   
HPRD ID1032
Molecular ClassUnclassified
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO