CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
LTBP4	8425	Latent transforming growth factor beta binding protein 4	19	ARCL1C; LTBP-4; LTBP4L; LTBP4S

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.

Gene Details

Chromosome: 19; NC_000019.9 (41099072..41135725)
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Gene Type	protein coding
Gene Family	Latent transforming growth factor, beta binding proteins
Description	The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Chromosome	19
Location	19q13.1-q1
Start	40592888
End	40629820
Strand	+
Gene Sequence	>gi\|568815579:40592888-40629820 Homo sapiens chromosome 19, GRCh38.p2 Primary Assembly TGACAAAAAGGACCTGAAAAATCACTGATTCTAGAATAGGGGAGTGTCAAGGGGAGTTCATACCCATGAA TCTCCACCGGTAGGAATATCTTGCATGCCAGGATGTCTGGAATGCTGAGAATTATAGGATACAGAAAGGA ACCTGGATTACTAGGAAATCTAGAGAATGGGAGAGATCCTGGACTATCCGCCCTTCCAGAGCACTGGAAG GTTTGTTTGCGTTCCAAGAAATCCATAATGGCAGGAGATTCCGGATTATCAGAGAATCTGGAACACAAAT GGGAGACGTAAAAGGTGAGTGCCTCTGAAACCGGGGTGTTCTGAAATAGCTGTGCACCTCAAACCCTAAT TTTGTTTTTGTTTGTTTGTTTTTGAGACAGGGTCTTGCTTTGTTGCCCGGGCTAGGGTGCAGTGGTGCAA TCATGGCTCACTGCAGCCTCGGCCTTCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCCTGAGTATTTGG GACTACAGGTGTGTGCCACCACAGCCAGCTACTTTTTAAGTTTTTTTGTAGAGACATTGTCTCACTATGT TGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCCATTCTCCTGCCTTAGCCTCCCAAAGTGCTGGGATT ACAGGTGTGAGCTACCATGCCCAGCCTCACACTCTAGAAAATTTTTTACATGCCAGGATATTCAGAATAT TGGGGGATATTGGCATGTTAGGAAATCTAGTATGTAGGGGGAGGGCCTGGAAGGTCAGGAAATCTAGAAT ATGGTGGTGTTTTGTAATGCTCACAGATCTAGAATATTAGAGTCATTTTTTTTTCCAGGCCGGAGAATCC AGAACGCTCGTGTTGCTGAAATGCTGGTCATTCTATTCTTATTTCATGTTTAAATTTTTATTATTTTCTT TATTTCTTTTTTTTGAGACAGGGTCTTTCTCTGTTGCCCGGGTTGGAGTGCAGTGGTGTGATCTCAGCTC ACCTCAACCTCTGCCTCCCGGGTTCAAGTGATCCTCCCACCTTAGCCTCTTGAGTAGCCGGGATTACAGG CGTGCGCCACCATGCCTGGATAATTTTTGTATTCTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCT GGCCTGAAACTCCTGACCTCAAGTGATCTGCCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGAC GTGAGCCGGCCTTATTCTGGGGGAGGGGGTGGGGGGGGAGAGAGAGAGAGGGAGAGAGAGAGGAGAATTT GGGATGTTAGCAAATCTAGAACACTGAAGAGCTGGGTTTTTTAAATGCTAGAGATAGTATTATCCTAGTA TAGTATTAACTCTGTGTGTTTTTGTGCGTGAGAGGGCATGGGGGGAGGGGTGGAAGATTCTGGAATGCGG GGGGACTAGAACTCTGAGGGATTCTGAAGGGTTGAGATGAGTTAGGATTCAAGAGGTGACATAGACACGA TCCTGGGAGATAGTGACACTGATGGGAGGGATGGGGAGCTGGGGACTCCAAATTCTAGGGGGAGGGGAGG CTAACGCCGGAAGTTGCAGTGGTGAGCCAGAGGATGTTGCCTAGCAACAAGCATTGAAGATGCGCTGGAT CCCGGACAGAAGGGAGAAATTTCAGCAGCGCCCCCAGCAAATGCTCCAGCCACAGGGTAGGAGGTGGTGA GGGGGGAAGCGGGTAGGGATATGCTGTCCTGCAGGGTCATGTGAGCAGGGGTCTTGGGGGTTATACAAAA ACAGGGTCATGGAGTACAGTCATGGGGCAGAGCCGGGCTCTGGGACAGCCCACGAATAGCTGTGAATGGA GTGTGAGTGCCGTCGTCACCTGCCCCAGGGACTGTGTGTCCCTGGACGGTGCTGGACCCAGATTTCTGGG TGTCAGTGTGGGATGGAGGCATGGATTGCTGTAGGTGGCAGTAATGGTGTGTAGCCGTGTGAGTCAGCCT GTGTGTCTCACAGTGAGCGGGGGTGAAGGGCTTCCCCGTCAGTCCTGCACACCCTCCTGGATTGGAAGAA GGAGCAGGAGTGGGGGGTGGGGGGTGCAACTGGATCAGTTGCCATTCTTGGTCTGGGGTGGGCTCTGTGG TCACGGCGTGTGGCCTAGTACCCTGTGTGGGTGGAGCCTGGGATCCACGAGGTGGGGGCGGGGCTAACGC TACAGAACTGGGAAGCTTAAGAATCCAACTGCTTTGGGATATGGGGCCTGGAACCCCAAAGCGAAGCAAA CATGAAAGGGGTGGGCTTGGGATCCTACATGTGGTCACGTCCCAGTTTTCTGTGGGAAAGGGTGTGGCCT GAAACTCTGGAAAAAGAGGTGATTAGGGGCAGAGTGAAGCTCTGAGGGTGGTGCCTTAGGGAGAGAAGGG GCTTGTATTTCAGAGAATATAGGGTGGAGCCTTGAATTTATAATGATCTTCTCAAAGAATTGATCCCTTC TCAAGGCCCTAGGCTTCAGGGGTTCCAGGCTCACCATCTGCAAAAGCTTGCTCCCCGAAGCTCTGTCCCT CAGTGAACCCAGCCAGGCTCTGCCCCTGACCCACAGGATCTGCTCCCAGGGGGTCCTGGGGGCTCCTGGC TCTGCCCCCTCCTGCACCTCACTTATTGCCATCCCCAGAGGGTATCAGACCCCCTTCCTTGCCTGAGTCT TTGAATGCTCCCAAGAGCTTTGAGTCTCAAGCTGGGCTTGAGACCCTGAGTTTGAAGGCTTGAAGCCTGG AACCCCGGTGTGGACGGGGTTTAAGGGCCCCTGTGGCTTGCAGCTCCTAGTGGTGGAGACTCTTAGGCAA GGAAGGGATCGGTACTCTCTTTTATATAGTTTTATGTATTTATTTATTATTGAGATAGGGTCTCACTCTA TCGTCCAGGCTGGAGTGCAGTGCAGTGCAGTGGTGCCATCTCAACTCACTGCAGCCTCCACTTACCAGGC TCAAGTGATCCTCCTACCTCATCCTCCCGAGTAGCTGGGACTACTGGCTCATGCCACCATACCCGGCTAA TTTTTGGATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGC TAGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAACGATTCTCCTGCCTC AGCCTCCCGAGTCGCTGGGATTACAGGCGCCCACCACTGCACCCAGCTAATTTTTGTATTTTTTAGTAGA GATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTCCTGACCTCATGATCCACCCGCCTCGGCCTC CCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCTAATTTTTGGATTTTTAATAGAGATGGG GTCCTATGTTGTACTATGTTGCTCAGGCTCACCTCAAACTCCTGGACTCAAGCGATCCACCTCGGCCTTC CAAAGTGCTGGGATTACAGGCCCGCGCCAGGGCACCTAGCCGGAACTGGGAACTCTCTAAGGAGAAAGTC TGCAATTCTGGGTGGTGGGAGGCTGCTCTTGGGAGCATTCAAAGACTCAGGCAAGGAAGGGGGTCTGATA CCCTCTGGGGGCGGCGATAAGTGGGGTGCAGGAGGGGGCAGAGCCAGGAGCACCCTGGGAGCAGAGTTTG TGGATCAGGGGCAGAGCCTGGCTGGGTTCACTGAGGGACAGAGCTTCGGGGAGCAAGCTTTTGCAGATGG TGAGCCTGGAATCCCTGAAGCCCAGGGTCTTGAGAAGAGATCAATTCTTTGAGAAGATCCAATGTGAACT TGGGACCCTCAGAGGGGCAGGACCTGGGGGCTGGTGCAGGGTTGGTGCTCCATTTGCAGAATCCTCAGTC TCTCTCGTGGAAAGGGGTACCCGTGGGGGGCTTCCAGCTTCTACGCCAGCGAGGGAGCTAAATTCTGACC GAATTCTCCCAGAACTGGGAGCAGAGAGCTGAGGACTGCCAGATGGAGTCCAGCTTAGGGGACCCTGCCC CCAACCCCGCTCCCGTATCCCTCCCATTTTTAAGCACCCCTACGCCTGGGACCTCTGTTCCACGAGAAGG TTCACGGAGCCAGTATCCGAGTCCTAATTTCCCCCCACCGCGTGGGGAACTCGAGGTCCCCCGCGCCCCT AGTCCGGCACCTGTCCCTGCTGCCTCCTGATTGGCCGCGCGGCGAGCGCTGGCGGCGCCGGGCTGTGATT GGCGGGAAGTTCGCAGCCCGTGGCTGGACTGTGGAGAAAGTGAGTCGGCCTCGGGCGGGGGCGGGGGCGG GGGCAGGGGCGGGGCCGGGGCTAGCCTGACCCGCTGGACAGACCGCCCGCCCGGAGCGGGACTCGGCGCC CGACACGATGCCGAGGCCTGGCACCAGCGGCCGCCGCCCCCTCCTGCTGGTGCTGTTGCTGCCGCTCTTC GCAGCCGCCACCTCCGCCGCCAGCCCCAGCCCCAGCCCCAGCCAGGTCGTCGAGGTCCCGGGGGTCCCCA GCCGCCCGGCCAGGTAAGCCCCCTGCTTCCTTGTGCCCCTTCCACCCAATAAGTCTGGTGGTCCAGGAGG ACCACGGCTTTCGGATTCAGGGGAAACTCGAACCCACTGCTTCGATGTGGAGATGCAAAGAGGGCCCTTG GATTTATTAGGCGCCCTCAATTTGTAGGGGTTAGATTCGGGGAGTACTGAGATTTTTAGGGGAAAGAGTC CCCTTTATTGTGGTGGAGAAGGCTAAGTCTCCAGAGAATCCTGGGGTTAGTTCGGGGAAAGGTCTCTAGT TTATTGGGGCAGGGGGTGGGGGGCTGAGCTCTCCTAGAATGATAGAGACGTGTGGGGTCTTCGAGCTAGG ATGGAGCGCCCCAAGTTTCTTGGGCGCGTAAGGAGGAAAGGTGTTGGGGGATTCTGGAGGGACTTTATGA GGCCGCTGAGTTGTCCTGGTTTTCTAGGATTTGGGGGCTCTGTGTTCATGAAAAGCGACCTTTGGGTTTT TCGAATTGGTCAGGAAGACATAGACTCTTGCGTTGATGGTGGAGGGGCTTGTGGGGAGTGGGGTCGGGTG GGGGAGTCCTCAGGCTTCAGAACGGTTGGGGATGCTCAAGTTTCCTAGAATTAGAGGACTCTGGGATTGA ATGAGGCTCCAGTGATTTCACCGCGAGAGATCCAGGATTCCCTATAGATCTGGGGGCTATAGGCGCCCTT CCTGTCTGCGGGTGACGGGACTGAAGGAAGCCGTCTGCCCAGCACCCCCACCCACCCTCCCCGCCTGGCG GCCCAGCGCTCCGTTACAAAGGCCCCGGGCTCCTCTCCCGCCTGGGTCTCTGCGAATGCGTTTAGTAACC CGAGCCGCGGCGGGGGCGGGGCCGGGAAGGGGTTAACCTGGAGAAAAGGCGGGAGGGATGACGGCAAGAT CGGGGATCCCCGAGGCTCCCCACCAGATGGCCTCATCCTCCACTCGGCCCCACCCACCTGAGAGGGGCCC ACGCGCTGGACACCCCCCTCTCTGCACCCCCCCACTGCTCTCCTCTCGGGGTCTGGGCGCGCGCCCTCGT CTCTAGACCCCCTTAGCCTGGGGATAATGGACTTGTCTGGGGGGCCCCTTCATTGCGACGCACTTGAACC GGAGCTGGAAGCTCCGCCACTGAGACCCTCTGGGCTGGGAGATGTCTGCAAGAACGGCACCTTTCTCCTG GTCAGGCGGGAAACTGAGGCCCAAAGACCAAGAAACGCTGGCTTCTGGACACACATCGTGGAAGGGCAAG AACGGGCTAGAACTCAGGCTCTGGGATTCTCAGTCCTGGACTGTGACTCCCGTTATCCCCCTCCACCTCA GCACCCTGCTGGACCCACAGTCAGAGGGAAGAGCCTTCCCTCCCCAGCTGCCGAGGCCTGTGAAAATGGC GCCACCTGTCGGCCAGGCTCAGGATGGCGTCTGAGTCCCGGACCGGGATGTGCGGGAGGGCGGGGTTCTA GATTCCCAGACAGTGCGGGCTTAGAAATGCTCTTAGAAATCGAGTCTTTTGTTTTTGTTTTTGTTTTTTA ATCACTTTTAAAAGGCTTTAAAATAACGTATTTTTTCAATAAAATCGTACGCCAAAATCTCTTCATAAGA CAAAAGTACGGTTTCTGTGCCCTTCAGCCCGAAGTCTAAGCCAATTTGCCTCCCATTGTACAGATGGAGA AACTGAGGCGTGGGGAGAAGAACCTCGTTAGTCATATACCTGTTTCAAGCCCCCTCAGGATGCGTCTTGG TTTCCCCTCCCCGATTGCCCTCCTTTGCAGAGTTCTGGGGTGCTAGGGGCCTGAGTGACTTCCACTCCAC TATTTATAGCGTTGCTGTTTGTCGCTGCTGCCCGGGCCAGACGTCTAGGAGGAGCCGCTGCATCCGAGGT GGGTTCTGGAAGATGGAGTATGAGTAGGGGGCAAAAGGGAATAGGAGGAGAGGGGCAGGGAGCTCCCCAT CCCTCCCCTCATCCCAGTGGGAGAGCTGGATGCATTTGGTAGAGAAGTACTTGGTCCCCTCCTTCCCCAC TTAGTCCCTGGCTGTCTCCGAAGCCTTCTGCAGGGTCCGAAGCTGCCAGCCCAAAAAGTGTGCAGGCCCC CAGCGGTGCCTGAACCCAGTGCCTGCAGTGCCCAGTCCCAGCCCCAGCGTGAGGAAGAGACAGGTGTCCC TCAACTGGCAGCCACTGACGTGAGTGGGCAGTCCCTCCCCTACCAAATCCTCCCTCAGGAACTCCTAGCT TTGCCCCCGTTTCCGCTCCTCCTCCCTTCCCCTCTCCCTCTCTCTCCCCCCTCCCTCCCCGGCTCTTTCT TTTGCTATCAGCCTGTCTGTCCGTTTCTATTTCATCCCTTGCCTGCCTATCTCAGGCTCTTCCCATCTCT GCATTATTTCTGTCTCTTTCTGTTTCTTTCTAGTTACCTGTCTCTTTTCCTCTCTCTCTTTCTCCCTGTG TCTCACTGCCTGCCTCTATGTCTAAGTCTCTCTGCCCCTTCTCTCTTTCTCTCCCCCAACCCCCATCATC TCTCTTTCTCTCAGGGTCTTTGTTTCTCTCCCACTAGAGGCCTGGTCCCCATAAATAGGTGTTGTGGGGG GAGGGTTGGGCAGAGCCGCTACTGAAAGACATTTTCCTGGCATGGAGGCCCTTTGGTGGGGAGGTCAGTT TAACCCGGTGACAGCAGCTTTTCCGTCCTCTCCCACCCAGGCTCCAGGAGGCCAGAGCTCTACTGAAGCG GCGGCGGCCCCGGGGGCCAGGGGGCCGGGGACTACTGAGAAGGAGGCCCCCACAGCGTGCCCCCGCTGGC AAGGCCCCGGGTAAGCACATCCGCCTTTCCTCCGCCTGGGGCGAGGGGGGTTCCGGGCCAGATAAAGCCG TCTGGTTCCCACGGTCCAGCCGCCGCCTACCCGCCCCCCGTTGTAGCTCAGCACCCACCCCCAGGACGAG GCCCCCTCTAGGGACCCCAGCGTCCGGCCGTGCGAGGTGAGCCCGGGACAGGACCAGACACAGGCCAGAG GCACTGACCCGCGGGGGTGGGGCCGGGAAGCCAGGCGTCCGGGCTCCCCGCGGCCGAAGAGGGAGGGCGC TGGCCCGTTAGAAAGCTCCGCCGAACCAGCCCAGACAACAAAAGCGATTGTGCGGGTTGGCGCCTGCCTG GGCACCAAATGCTCAAGATTGTGGGGCGGCTGGGGGCCAAAGGCCTCCTCCTGTTTCCCGAATCTTCCCC CTGCCCTCCTCCCGCTCCAGCTCTTGACCCCTAGTCTAGAACACCCCTCATCTCAAACACCCTCAAAACC CTCCTCTTGCTGTAGCCTTCAGCCCAGATGTGACCCCTCCCCCTAAAGTCTTCCAGATGTGAGCCTCGGG CCAGATGTTAGTACCCCCGCCCACAGCCTCCCTTTATCCATTGTGACTTCTCCCGCCAGGTGTGGCGTTC TGGCCAGATGTGGCTACATCTTCACATGTATCCCCCCCACCTCCAGCCTCCTGCCCAGGATCTAGACGCC CAATTCCTTTATGTGCCCAGGTGTAGCGACCCTTCTCCCATCCCTCAGATGTCCCACCTGGCTGTCCAGA TGTACCATGATAGCCCCCTATCAAGATGAAGCCCCTTTCTCTGTGCCCCGGGCAGAAGAGGATCAACTCT TAGCTGTCTCCCCAAATGTGGCCCCCACTACTCTTAATGGATTTCCTCTTTATGGATTCAGCTCTGTCTG GGGGGAAACCCGCCCGCCCCCACCTGTTCCCTTCCCCGCCGCTCCCCTACAGGCCCGGTCCACTTGTTGG TGCGCGGATGGGGACAGAGGGGGCGCCCCGCTCACCCCTGCGAGTCTAGCGCCCAGCCTGCGAGCCTCTG GCTAAGCGCCCAGCCCCACGCGCCCCCGCGCGGCCGCCGGGGAGGGAGTGGTGAGGAGGGGGGGCCTGAG CGGGGGCGCGGGCGACCTCCCCCGCGGGCGGGCGGGCGGGTGCGGCCGGGCCCCTCGGGCGGGCTGGGGC GGCGGCGCGGCGGAGCGCGGCGCTGCAGCCATGGCGGGCGGCGTGCGGCTGCTCTGGGTGTCGCTATTGG TGCTGCTGGCGCAGCTAGGGCCGCAGCCTGGACTGGGCCGGCTCGGAGAGCGTCTCCGCGTGCGCTTCAC CCCGGTCGTGTGCGGCCTGCGCTGCGTCCATGGGCCGACCGGCTCCCGCTGTACCCCGACCTGCGCGCCC CGCAACGCCACCAGCGTGGACAGCGGCGCTCCCGGCGGGGCGGCCCCGGGGGGACCCGGCTTCCGCGCCT GTGAGTGCGGGGTGGTGGTCCCGAGAGAGCGGCTCCGGGGGGGAGGAGGATCCCTGGGGATGGAGGAGAC AGTCCTCCAGGGAGAGGGAGCCCAGATTCCATATGCAATAGTGCAAGGGAATATCAGGGGCTATTTGAGG AAGGGGGCCCCAAATTCCTGGCTTTTGGGGTTGGGTCCTGAGGGTTCCGATTTTGCAAGCAATGAGGGTT CTTAGAGGCCTGTGATGTCCCACGTGAGGGAATTGGCGCCAGCTTTCATGCTTTGCGTCAAAATGGGGAT CTCAGAATTGAGGGGCCTGAGAACTTTTGGGAGGGGGGCTCGAATTCTGAGACGCTGAGTAAGGAGTCCC CGGGGACCAAGCAAGAGTCTCAGGACCGCATGGGGGACGTCTCAGTTTCTGTGTGTTTGGGTGGGAAGGT TCTGTATGGGAATGCCTGTGAGGTGGGGTACTAGAGAGAAGAAAGTTAATCCGAAGAACTAAGAGGGAGA GGGGACAGAGACGGGGGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGCGGCGGGGGTGGG GTGGGGGTGTCTCCGCAGGACCTGAGTTGCAGGGGTCCCACGTGCGACAGAAATCCAGATAAGAGGGCTT ACGGAAGGGGCGCCCCCTGGGGGCGGAGGGGACAGGAGGTGTATGCACCAGGCACTCCTAGAGATGGGGA GCCTTGGGGGTTCAGGTGAGGTGGGGGAGGGCGCACCACCTGTTGTTCCAGGATGCAAAAGTGGGCAGAC TCTCTGGGATCGGGCCTTCCTGCCCCCTACCCCGCAGACCCTATGGAGTGGGGAGTGGGGGCCCCTGGAG CGGAGAACTCGCCCAGCCTGGCCCCCAGCCAGCCCAGCCCGGCCGGCGTGAGCTCATCTCCCGCCTGAGC CCCCGCCCGCTGCCACTCCCTCTCTCCTCCCCTTCCTCCCTCTTTCTTTCACTCTTTCCCGGCCCAGCCC CAACGTGCCTGTGCCAGGCGCCATGCCCAGGCGGGTGCCAAGCCCTTGGGGGTGCAAGGAGTGGCATGTG AAGTGGGGGCTGACCTCAAAGGGACCCCTATGTCCTCAACTCCCCGCTTGGCCAGGGCTGTGGGGCATGA CGTTGGCTGTGGCCATCTAGTGGCCCACCCTGGGTGTAGGCACCCCCAGGGAGCTGGCCTGCGGGCCTGC ATTCAGGCCAAGAGAAGGCAGAGAAATGCCTCTGGAGCCTGGGAAATACCCTCAGACCTGGCTGGTTTCC CACCCCCTCCATCAGAGACCCTTACCATTCTGCAATTTTGATTCCTAGTTAAGCCTCTCCTAGGCCCCAC TACTCAATTAAAAGCCCCCATTAGACCACCCTGGAGTCATGGCCCCACACTCCTACCTAAGGGAGCTGAG TTTTTGCTCCAGGCCCTAGACCCGCTCTCCAACCATGGCAACAGACTTTAGAGACCACTCCTCCAGTGAA ATTCCCTCTCATTCTTCCCTCCCACCTCCCAAACTGTGCCTTTCCCCAGATAACTCTGTAGTATTGTCCA GAAGTCCTGTTCTTCTAGCTCACCCCCTTCCCCAGGAACTTCTGATCCCATTTATCTTCAGAGAACCCCA GGGTTGGTCTTGATAAGTGGGTTCTCGCAAGAGGACTCCAGACATTGTGCTCCTTACAGGCAGCCATTAA TAAAAAGCCTTTGGCACTTAATCCTTAGCTGGGAGGGGAGGGGATTCCACAGAGGGACTCGGCCAATTGA GCCTCTTAAGTGCTGATGACTTCCAGGAATTCCACTTCACTATCTAAACCCTGTTTTCAGCACCGTCAAA CTGGTTGTCTCCTAGGCGGCACTAGAGTCCTGTTTTCTAGGTAACTGTCCACAAAAGGACTCCTGCTGAA AGGACGCCTCAGTTTCCTCTGAGCTAGGTTCCTCCATCCCAGAAACCTCCAGCCGTCTTTGAACTCGAGA GGACTGCCCTTTAGTCGATCTCCTCCCAGGACTCCAGTCCCTTTATCCTTCTAAACGGAGGTGGCTCTCT GCGTCCTTTCCTCTCTACAGTTGTGGCTCAGAATCCCACACGCGCCTCCCCCGGCCGCCTGCCTCCTCCC TCCCCTCCGCACAGCTGTCTCCAGCTGTTCTCTGCAGCCCCGGGAGAGAGAGGGAGGGGGTGCCCTCGCA GGACAGCCCGGCCTCCTTTGGCTCAAAGGTCCCGGGGCTCCCCAAGGGTCCGGAATGTGGAGCCTCCGCC CTGCCCCCGCCGCACCTCTCTCTTTGTTTACCCCGCCGCACAGCTGGCAGTGCCCCGCCCAGAGGTGGCC TGGGGCCCAGCGAGGGCGCGCAGAGGGGAGTGGAGGCGCGTTCCCGCTCGTGGCTCCGCCCCGGTGCTAC TGGAGGCTGTAAGGCCGAGCTAGAACTCTAAAGCCCCAGCCAGAAAGAAGTTGGGCGGAGACACAGCGCG GTGGGCGGAACTAGGGCACCCGGACAGCCTGGAGGTGGGGTGGGAGGGGCGTGAACAAGTGAGCCGGGCG AATCAGAGTGCGGAAAGGAAGGTGGGAGGGGCTAGAGGCAGCAGGTTAAGCTCCTGGATAGGCGGGGTTT AGAATCCCGCGGGTAGAAGGTAATGTGAGAGGGGCTACAAAGGGGGCACAGCCAGGGGGCGGAGGTAGGA CTTCGTGGACCAAGCAGAGGGAGTGTGGGCGGGCATAGAATGCGAAGGAGACAGAGTTGGGCGGGGAGTT ATGCCAGGGAGTGGTTAAAATGTGGTTTGAGTCAATGGAAGGGATCAGCATTGGGTCGGAGGGGCTGGAA CAGCAAAGGGTTCCGTCGGACTACGGAATGGGCGGGGTCAGCGCCGTCTGGGCTGGTCTGGAACTCCGTG GACTCAGCCAGAAATTGGGATCCGAGAGGTTGACATGAAAGTGAATAAACAGCCTGAGGGCTGGCTGGGC TCACGCCTGTAATCCCAGCACTTTGGGAGACTGAGGCAGAAGGATTGCCTGAGCCCAGGAGTTCAAGACC AGCCTGGCCAACATAGTGAGACCCCGCCTCTACCAAATTTTTAAAAAACGTAGCCCGATGTGGTGCACGC CTGTCGTCTCAGCTACTTAGGAGGCTCAGATGGGAGGATCACTTCAGCTTAGGAGGTCGAGGCTGCAGAG CCATAATCACGCTACTGCATTCCAGCCTGGGCAATAGAGCGAGATCCTGCCGACTTAGTGGGTGGGACCG TACCTCTGATGGCTGAACAACTGGACTGGGCCAATGCTGATGCCAGAATTGGGGCGGGGCCACATGACAG CTAAGGGCGGAGCGACTTAGAAATGAATGATACCTTGAGGGAGTAGGGACCCCAGGAGAACCTGCCAGGA ATGGTGGCGCCCCTGAGTGTCCTCGTTCTCCTCCCAGTCCTGTGTCCCTTGATCTGTCACAATGGCGGTG TGTGCGTGAAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGCCAGTTGCACTCCTC GGGCGCCCGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGCCAAC CACCGCGACGACGAGCACGGTGAGGAAAGGGTGGCCAGAGTCCCCTCCGACCCCTGTCAAGCATTTCACT TTGCCCCTGACCCTCATATTTCCCGCCTTCCCGAGCACCTTTGCCCAGCTCGCCCTCCCCGCCTTGTCTA GCCCCACCCCGTAAGAACCCGTGTAGACATCCGTTTGCCCGGCCGTGCCTCCCCTAGGCGTGGCATCTAT GGTGAGCGTCCACGTGGAGCACCCGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTGGC CCTTGGGAGGAGGCGGACGCTGAGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGC CCTACACGGTGTTGGCACAGAGCGCGCCGCGGGAGGACGGCTACTCAGATGCCTCGGGCTTCGGTTACTG CTTTCGGGAGCTGCGCGGAGGCGAAGTGAGAGGAGGCCCGTGGGGAGGGGCCCGGAGCTTGCCTCCGCGC GGGGGCGCGCTCACCCAACACTTCCCCGCAGTGCGCGTCCCCGCTGCCCGGGCTCCGGACGCAGGAGGTC TGCTGCCGAGGGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGGGTAAGC CCCAGGACGTCCCCGAAGTGCTCGGAGCTGGGGAGTGGTGACAACCTCACCGTTCCTCCTACTCTGCCCT AGATAAACCCAGTTCACAAATTGTAGCCACGCCTACCCCATTGTGGAGGCGACTTCCAGTCCTGAGCTTT TCATACCGCTCTGGGACCACCCACCCCATTTTCTGACTTTGGCCACTCTGTTCTCACCCTGCCTTTGTGC CTTGGCCCCCCACCATATACTTTGGGAGTCTCCAATGTTGCCATTTCAACTGCCAACCTAAGGCTGTCCC TGCACTTAAACTACAGCCAACATCTTTTAGTCCCTCCCACCCCGTCTTCGTCTCTGCCCACTCCATTCTC GCTCTGCCCACCTGTCCCTGGCCCACCCCTCTCCTCTCGCCACAGGGAACTCCGAAAGAGTGAGCGCCCC AGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGGTGCAACGGGGCAGGGGTGG GAGGGGCTTGGTTCTGGGGGCGGGATTTGCAGGGATCAAGTTCCTGACTCCACGGTGACCTCCCCAACCC TGGCAGATGTGGATGAGTGCGCGACTGGCGGGCGCTGCCAGCACGGCGAGTGTGCAAACACGCGCGGCGG GTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGACTCGTCCCGCAGCAGCTGCATCTGTGAGCAACCA GCAGGGAGCTGAGGCTGGGTCCCGCCCTCCCTGCCCTCAGAAGTCCCAGAGCATCCTGGGGCCTTTAATT CCCTCGGACCCCCCCAGACTCCCGGGTTCCTCTGTCAGCCTTAGAGCCCCCTCAGAACTTCTCAGATTCT TATACAGCTTCAGCATCCCTGGACCACCTTTAGACCTTTCAAGCCTTTTGGATCCAGATCCCTCCAGACT CCCAGACTTTTTTTTTTGGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCG GCTCACTGCAATCTCTGCCTCCTGGTTTCAAGTGATTCTCCTGCCTCGGCCTCCCGAGTAGCTAGAACTA CAGGCGGGCACCACCATGCCCGGCTAAATTTTTTTGTATTTTTGGTAGAGACAGGGTTTCGCCACGTTGG CCAGGCTGGCCTCAAACCCCTGGCTTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACA GGCGTAAGCCACTGCGCCCAGCTCTCCCAGACTTTCTGGAATCCTTCTCAGACCCCCAAATCCTCTCGTC CCCCTCAACGACTCGACTATCTTCAGATCTTGAGATCCTTCTCAGAGTCTCTCATTCACCACTGACACCC CATTGAGGCTCCAAGCCCTTCTCAGACCTCCAGAGCCCACTGCTCTCCTTCAGACCCTCTCAGACCTCTC CCAAATGCCCCTCGCACCCACCAACCCCCCACCCCCAACCCCAGAACCATTCCCCTCTCTCCCAAATCCC TCAGTGCTACAGCATTCCCAGCCCCGCCCTGAAGGATTTCCTCCCTGCTCCTCGCAGCCCAACACGTGAT CTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTGCCCATTCTGCGGAAC ATCACTAAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCAC CCTTCGGCTCAGGTGAGCCCCTGCGGCAGTGCCTAGCCCTACGCGCAACACATGTGGCGCTCATTCTACG CCCCACCCTCCAACCCTGAGTTCACTGCCCCAACCTGACTGGCTGGGCTCCAGCCTTGGCCACGCAGCAG CCTCTGAGACCCGCAGGCCTCAGACTGGACAGCATCCATGGCTCCACCTCCATCTGTAGCCACAGCCACC CCTCCATTCGTAGCCACAGCTACCCCGGAGCTCCCAAGTTAGTTTTTGTCTCCTGAGCGTCAACGCCCAG TCCCACCCTGTCCCTGAACTTTGACCAAGTCCTTGGCTTCTGAGACACTGCCTTCAGCTTAGCCCCACCC CAGGCATGCCCCTCCCTGAGACACCTCCCTGGCATTCTATCTTCTGCTTAAAACTAAATCTCACAAGGGA GCTATTTCCTAGCCTCCAACTCTGTCCCTGTAGACCCAACCGGACCCTGCCCTCAACCCTGTTCCTACCA CCATCCCAAATGTGGGAAAACGCTCTTGGCCCCACCTGTAGCCTCTAAGACATTCTACTCTTTGGCCAGG ACACCACCCCATCCCAGCCTCCAGCTCAAACCCCTGACACTCTCCAGCCAAGCCCTGCCCCTAGCCAAGG CCAGAGTCTGGGCTGGCCATCGTTTTCTTCCCGCTCTCTTGTCCTCTCTCTGTCTCTCTTACCTATTCCC AGAGGGTTTCCGGGAGATCTGCCCGGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAAC ACCAGACCCCTGGGCCAGGAGCCACCCCGAGTGTCACTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTC GGCCATCTGCAGGTGAGCTGGCTCTGGCAGAAGTGGGTGCCATCTTCAAGGGGCTGCCCCAGCCCCATAG TGAAAGGAGGCAAGAGAGGATTTGGGCTCCACTCGTTGATACCCCTTCTTTATCAGGCTTTCTGCCCACC CATCGCCTGGAGCCCCGGCCTGAACCCCGGCCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAGCA TCCCTGCCTGGACTGGTCCTGAGATTCCTGAATCAGGTTTGCTAGAAAGAACTGAGGGCATTGGGCCTGC AGCAGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCTGAGGAGGGTGGATCACCAGGTCAGGAGTT CGAGACCAGCCTGGCCAACATGGCGAAACCCTGTCTCTACTAAAACTACAAAAATTAACTGGGCGTGGTG GCAGATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGG TTGCAGTGAGCTGAGATCGTGCCATTGCACTCCAGCTTGAGCGACACTCCATCTCAAAAAAAAAAAAAAA AAAAGAATTCAGGGCATTGATGGGGGTATTACAGGTGGGATTCTGGGGTAAAAGACTCCAAGGTGAAGAT TCCAGGTTACAGCAAATAGGAATGGTATGGGCAGAGATAAGCGTTTGAAGGGTTGGGTGGTAGTTAGATC AGGAGCTGGAGTCACAGTTGGGCTCTTCTGTGTCAATCGAGCAAGCCATTTAACCTCTGAGACTCAGTTT TCTCATTGGTAAAATGGGGATGGTTGTTGAGATGCCTCTGAAGTGTCTGACACCTAGTAAGTGCTCAGAT AAATACTTATGGTAGATAATTATTTTTCATTATCTAATATTAGATAATTATTTCTCAGGTAGGGCACTAA GAATGTATCTCAGGCGGAGGGTTGGAGAGCAAACTATTCAAAGCCAGAGACCTTGGGGTGGCATGATGAG GGGATTCGGCCAAGGATCTGATGAGAACGTTCCAGGATAAAAAAGATGGAGATCAGAAGAAGACTGGGCT TGCTTGGGGAGGAGACATCCATGAAGGTGTTTTATGGATGTCTCCGGGGGTGGGGGTTTTACTGGGATGA AAGGAACGGAGGATTCAGAGATGGGGGAACCCTGGCTGACTGGACCCCCCAGGTCCCTCCTCCGGCATGT GTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGCGCTTG CGACTCTGGCTTCCGGCTCAGCCCCCAGGGCACCCGATGCATTGGTGAGCAAGACGGAGGGCGCGGAAGG AGGCGGGGCGGGGGGCTTTGCCTGGTCACCTTGTCACCAGCCCCCTCCGTGTCCTCAGATGTGGACGAAT GTCGCCGCGTGCCCCCGCCCTGTGCTCCCGGGCGCTGCGAGAACTCACCAGGCAGCTTCCGCTGCGTGTG CGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGGTGAGAAATTTGCCCCACCCGGCTCC AGGCCCACCCCAGGGTCTCGCTCCTGCTCTCACTCCAGAGCCTCTCCAGCCCTCCCACGCTTCCCCTCTC GGGTCCCGCCCCAGGACTGCTCTGCCCTGGCCCTTGGCCCTGCCCTTCCCTGACCCGCCTCCACCCAGCT CCAGCCTCCCTTTGACCCCACCCCTACCCAGCTCCCAAACTGCCAGTTTCTATCGGGGCCTGGTCGCAAC TCGTATTGCTCCGCCCCCACGCCCAGGCCCCGCCCTTATTGGCCACGCCCCTCCCTGACTAACTCCCTCC CCCAGGCCCCGCCACTGTCCTGCAACTGCGGCAACCAATCTCCTGACCGCGACCCCGATTCCAACCCTGC CACACCAGAGCCCTATCCCCAAACTGCTCCTTTCTTCTCTAGCCCCTACCCCACCTTCCCTTAGCTTGGT CCCCAAAGCTCTCCTTTCTGCCCTTGCGCTACCAAACCCTGCCCTCCACAATTGCCTCTCTCACTGTGCC CCTCTCCGGCTGTCCTGGCCGGGTCCCCATCCTGGCTCTGGCCCAAGCTTGGTCCCGCTCCCGCTTCCCT CTACCCCTGCCTCCTTGCGTCGCTTCTCCCGGGGCTGTCTGCCCCAGTCCCAGCCGCCTGGTCTGTGCCT ACAGATGTGGACGAGTGCCACCGCGTGCCGCCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCA GCTTCCTGTGCGTGTGCCCCGCCGGGTACCAGGCTGCACCGCACGGAGCCAGCTGCCAGGGTGAGGGCCT GGGAGGGGCAGCTGGGAAGGGGTGTGAGCGGTTGGGTAGAGCGCAGTGATGAGGGCCAGAGAGACTGAAC AATAGGGCAAAGCGAGTTGATTTGGAGACAGAGGCCAGGCTCTCGAGCAGACGTGTGGCCTGATGGCAGT AGAGAGAGACCTGGGATGCAGAGGCCAAGTGATGGGAAACAGAAAGGCTGAGTCATGAAAGATGGAGAAG CAGAATGAGGAGGGATGGAGATGTCAGTAATCGGGTAAGGGGAGCAGAGTTATGGAGGAAAGGGGAGAAG GAGGCCTTCTCATGGGGACTACAGAGACAGAACCAGCCAGGCAGCTTAGTAGGGATTGGTGGAGGATGCA GAGTCAGATGATGGTGACAAGGAGGAATAGAGATGGGGTCACGGGGACAGAATGTTGGAGGGTGGAAAGC CAAAGTGACAGAGGTCAGGGAGGCAGAGGGGAACAAGTGACCCCGGGCCCCCTGCCCTGTGCAGATGTGG ATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTGGCTCTTTCCGCTG TGTTTGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCCG CCCTGTGGGCCCGGCCGCTGTGACAACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGCTTCCGCT CCCGAGGGCCCGGGGCCCCCTGCCAAGGTGAGGGTGCTGAGCCCAGCCCTACTCCATCACTGTTTGCTGT GGAGACTGGAGAGAGATTATTGAGGGGCAGAGAGGCAGAGTGATGGGGCTCAGGGATGGAGAACAGGGGC TGAGGGATGGGGACCTCACTCCAGAGTCTTCTCTCCTTTCAACAAAATAAGGCAGTCCTCCCCACCCCTC CTCCCTTTTTGAAAGATACTCTTGTGCTTATGGGAACCCTGAGGAGGGGGTCACCTGAGGCAGGGCAGGC AACATGGAGTTGGTGCCTTAGCCCCCACCTTAGTAGCTGGAGAGACCATTGAATGGGGACACGAGGAAGG TGTCTGTCTTCCTGGGAAGAGGGAGCAGCCTGAGGCAAGTCCAGAAGGCAGGCTCAAGACTGGAATGCTG GGGTGGGTGGTGATGGCCATGGGAATGGATTCAGGCCCCTTCCTCAGCCTCATTGGTCCCCTCTGCCCCA GATGTGGATGAGTGTGCCCGAAGCCCCCCACCCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCT TCCAGTGTGTCTGCCCCATGGGCTTCCAACCCAACACTGCTGGCTCCGAGTGCGAGGGTGAGGCCGGGGA GGGAGGGAGGAGTGTGGATGGGTGAGGGGGGAGTTGGACCACTTCTTCAAGGCCACCCTCTCCCCTGCCC CCCAGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGTGAACTCGCCCGGCTCC TTCCAGTGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACTGGTGAGACCAGGCCCT GGCTGTGACCTTGGGCCTGCATCATGACCCCCGACCCTTGACCCAGATCACAACTATGACCTGGCCGTAA CCTCCTGACCTGGACCTCAGTCCCTCAGTCCCCAGAGCCTGTGACTCCTGACCCTGACCTGGACCACAAC TCTTGACCCTGAATGTGACTCCTGAGACCCAACTTGACAGTAACATTTGACCCTAACCATCACCCTTGAT GATAGTCCCTGCCCATACCCTGATAGCAATTGTGACCCTCATGACTCTGGCCCTGAATGTGACCTATAAC TCCTGAATTTGACTGTGACATTTGACCCTAATCATAACCACTAACCATAGCACTGACCATAACCTTGACT GTGTGACTCTTGGTCCTATCTCTTTCACAGCCCCTGCCTCTTCTCAGAATCCCTTCTCTGGAACCTGGTT GGGTTCATAATCCCTGACCCTGGCCCCTGACTTGAGGCAGAATTCTGGACCCTGACTATAACTTCTGATC CTAACTGGATTCAGATTCCAGTCACTAACTCTGACCCATGGCTCAGCCGAATCCCATCCAATGATCCTAG TTTATAATACTTGACTGGTCCCTTGCCCTAGTTGATTTCTGATCCCTGTCTGATCCCTCTCCTGACTCCA AAATCCTGGCACAGGTAGTTCCTAGAAACCTAGACCCACAGGACTTGCAACCATGGTCCCCGGAACCCGA GAACCTTGGTCAGCCCTACCCACCTCTGCCATAGAGCCCTCCCCCAGCCTCCAACTCATGAGACTTCCCA CCACCTCCCCCAGACACCCTACTCCAAGGGGATTGGTCGGGTGTGTCCCGAGACTGGACCCTTTCTGAAC ACCCCCACCCCCCACAGATGTGGACGAATGCAGTTCGGGTGCCCCTCCCTGTGGTCCCCACGGCCACTGC ACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCGGGTCGGCCCGGGC CCTGCGCAGGTGAGCAGCATAGGGACCCGCCAGAGAGTCTGGGAGTAGGGCCTGGGTTCCAGGGCAAAGC CGGCTGGAAAGGTGGAGGCGGGACCAAGGCGCTGTGGGAGGAGCTTAGAAACCTGGCATTGGTGGGGGCG GGGTTACTGCGATGTGGGCGGAGCTTGTCTGGGAGGCCGGGTCCCGTGACTCCGCCCAATCTCCCGCGTA CCCTAGACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGG CTCCTTTGCCTGTACTTGTGCCCCTGGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGGTTCGTAC CCGGGCTGATCCTGGCCCCGGAAAGGGTGGGCTTAGGGCAGGAAAAGGCGGGACGGGGAGAAGAGGGCGA AAAGGGGAAAACGAGTTTTTAGCCGGGGTATTCCAGCAGGATCAGGGGGCAGCTGGTGGGAGTCTCGAGG CAGTGAGGGGGGGCGGGGCGTGGAGATGAAAGGGCCGAGTCTGGGTATTTGGACCGTGATTGTAAAGAAG CTGTTCTAAACCCGTCGGGGGGCGGTGTTTGCAGGGAGGGAAGTAGCGTGAGGCAGGTTGGGGAAGGCGT GAGAGGCCTAGGAGAGCCGAGGGGCGGTGGAGGGGTGTGGCCTAGAATGTTAGGCGGAGCGGGAGGTGGG CCGGGCCTTCGGACGCCCTGTCCCGCAGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGAGCGGCA TCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGC CTCCTGCCTCGGTGAGAGGCCCCGCCCCGGCCTGATCCCTCCTCCCTTCGACTCCCCGACTCGCCGATTG GCCTCCCACCTCTGTCTTTCCTCCTCCGCTTCTCCCCTCCCCTTACCTCTTTCCCCCGCCTCCTCTCCTA GCCTCCCCAACTCTCCTCTACCCCAATCTTCTCCTGCCCTCTCCTCTGCTTCCCCGGCCTCCCCCTTCTG ACTCTCCTCTCCCCTCTTTGTATCCCCCATCTTGCCTCCCTGCTTCCCACATCCGACCACCCGACCTCTC TCCTCAGACGTGGACGAATGTCGCGAGCGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTC CCGGCTCCTACCGCTGTGTCCGGGACTGCGATCCTGGGTACCACGCGGGCCCCGAGGGCACCTGTGACGG TGAGCCTGCCCCCACCCGCCTTCGCTAGCGCTTGCAACGCGGTGCTGGAGGCTGCTCCCTTGGGGACTGA GGAGGGGCGCCCTGCTTCCCAGACTTAGGCGGAGGGAAAGAACACCCTCTCACCGTATCTCTGTAGTGGA AATAAGCCGCCACCGTGTCCATGTATTTTCTTGTGTCAGGATCACGGCCAAGCCTCCCTTCCAGCCGCAG TCCATTCCCCCTCTGCAGCTGAAGCCCGGTCCACATTTTAGGCTATGCCCCCAGTAAGACACCGCCCCAA AACTGTTAGGCCCCGCCCCTTCCAATCGGCCTCTGGATTAAAACCCCCTCTTCAGGCCCCTTCTCTTCCT AACAGAAGTTTGGACGTGCCCTTTCCGCGCCCTCCACCAGTCCTACTTCCAGCCTTCCCTCCAAAGAGGC CCAATCCCGGTGGCCCTAGGCCCCATTCTTTCCCAATGAGAAATTCCCAAGGTGAAATTCTCCTAGCATT GGCCCCCGCCCGTTTAAGCTCTGCCCTTCCTTGGTCTCTCTAGACAGGGCTTTCCATTCGCTCGGATGGC TCCAGTCTCTCGAACACTTAGGCCCTCCCTTCCTATCTTTGCTCCGCCCACAGACCCGCCCCTTGCCTTT TCTTACTTTCCAGGCCTTCCCTCCCGCCCCGCTCTTTCACCCCTCCCGGGTCAGGCTCCAGCGAGGCAGG AGGGTGGGGCTAATCTTCCATACAGTATATATTTTTTTGTGTCGGCGGGGGGGGGGGGGCGGTGATGGTG TGTGAGTCCGCATCTTGTGGAACACATGAAACAAAACATCTGTGGGCTGCCGTTGACTCTGCTAGACCTC TGACTCATGGAAATCTAGCTTCATAAGATCTCATTCATTAATTCCACAAGAATTCACTAAGCACCTACTC TATGCCAGCGTCTGGAAAAGGTAATAAGAGCAACAGGAAATAAGTCATATAAAAACCCCTGCCTTCCTGG AGTTATTGTGGGGTAATAAATATGTAAATAAATTCAAGATTTATACAGCAGGCCAGGAGCTGTGGCTCAT GCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGATGGATCACGAGGTCAGGAGATCGAGACTAGCCTG GCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCATGCGCCTGTA GTCCCAGCTACTCAGGAGACTGAGGCAGGATACTCGCTTGAACCCGGGAGGCGGAGGTGGCAGTTGAGCC GAGATCGCGCCACTGCACTGCAGCCTCGGCGACAGAGTGAGATTGTCTCAAAAAAAAAATTTATACAACA AAAAACTGGGGGGCACCTTACTATATGTTGGGCACTGGAGATGTAGCAAGGAACAAAATAGACACAAATC CCTGCTATTGTAGAGTTTGTATTCTAGAGAGGCGACAGTTGGCATACCAATAAATACATACGTATAACAT CAGGTTTAGGAAGGAAAACAAAGCAAGACAAATGGGACAGAGATGACAGAGCAGTGGATGGAGGAGTGCT AGGAGGGCTTGACCTAGACACCAGACAGAAGCGAGGGAGGCAGCCATGCAGAGAGCTGAGGGGAGACTGT TCCTGGCAGAGGGAAGAGCCAGTGCAAAGGCTCTGAGGCAGGACCATGCTTTTGAGAAATGGCAGTGAGG ACTTGAGAGTTATCAACTATGCTAGGTGTGGTGGCACAAGCTTGTAATCCCAGCTACTCAGGAGGCTAAG GTGGGAGAACTGCCTGAACCCGGGAGGTTGAAGCTCCAGTGAGCCATGATCCTGTCACTACACTCCAGCC TGAGCAACAGAGCAAGACCCCATTTAAAAAAAAGAAAAAAAAGCTGGATGGGGTGGCTCATGCCTATAAT CCCAGCACTTTGGAAGGCTGAGGCAGCTAGATTGCCTGAGGTCAGAAGTTCATCACCAGCCTGGCCAATA TGATGAAACCCCATCTCTACTAAAGAAAAAAAAAAAAGATAGTGGCTGGGCGTGGTGGCTCACACCTGTA ATCCTAGGACTTGAGGAGGCCGAGGTGGACAGATCGCTTGAGGTCAGGAGTTCGAGACCATTCTGGTCAA CATGGTGAAATCTCATCTCTACTAAAAATACAAAAATTAGCTAGGCATGATGGTGCATGCCTGTAGTCCC AGCTGCTCTAGAAGCTGAGGTAGAATTGCTTGAACCTAGGAGGCAAAAGTTGCAGTGAGCTGAGATTGAG CCACTGCACTCCAGCCTGAGTGAAAGAGCGAGACTCCGTCTCAAAGAAAAAACAAAGTTTTCAACATTGT TGATCTTCAGAAGCTCAGGCTCCTAGAATACCAGATTGCTAAAGACTTCTTAGTCTTGGGCACCGGAAGT GGTGTTAGAACTTCTGAATTCAGGCCTTTGACTCCCCTTTCATCTCCTCCACACTCTGCAGATGTGGATG AGTGCCAAGAATATGGTCCCGAGATTTGTGGAGCCCAGCGTTGTGAGAACACCCCTGGCTCCTACCGCTG CACACCAGCCTGTGACCCTGGCTATCAGCCCACGCCAGGGGGCGGATGCCAGGGTGGGTGTCCATCAGGC ATCGGGTGAGATGTGGAGATGGTAGAAGGTCCAGAAATGGCCTGACTGTCTGGTGGTTGCAGATGTGGAC GAATGCCGGAACCGGTCCTTCTGCGGTGCCCACGCCGTGTGCCAGAACCTGCCCGGCTCCTTCCAGTGCC TCTGTGACCAGGGTTACGAGGGGGCACGGGATGGGCGTCACTGCGTGGGTACGGGACTTCAGGAGGTGGA TGGGACCAAAGGGGGTGGGGGAGGTTGGTCAGGCCCTGTCCCTCCCCATATATCTGAACAAATGGGAATT TTCGGGTTGTGGAATTTAGACTTTGGAATATAAGATCATCTTCATGCCAGGCACGGTGGCTCACGCCTGT AATCCCAGTACTTTGGGAGGCCGAGGCGGGCAGATCACTTGAAGTCAGGAGTTTGAAACCAGCCTGGTCA ACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGATCTGGTGGCAAATGCCTGTAATCC CAGCTACTCAGGAAGCTGAGGCACAAGAATTGCCTGAACCCAAGAGGTGGAGGTTGCAGTGAGCCAAGAT TGTGCAATTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAA ATCAGAACTGTTGTAGTGGCTGGTGACAGAAACCTGACTTAATCAGGTTTTATTTTTGTGTGTGTTCTTT TAAAAATGTATAAAGTATAAATGTATAAAGTACTAATCTTAAGTGTTCATAAACATTAATCTTTCCTAAC ATTTTATGAGGAAAATTTCTAAACACAAAGCAAATTGAGAGAATCATAGAATGAACACCTACCTACTCAT GATCTAGATTATATTATCATTTTATTACACTTGCTTCCTCACATATCTATCCATTAATCCATCTAATTTT TTGGACAGAGTTAAAAGTAAATTGCAGGCACCAGTCTGCTTCCCCATAAATTCTTCAATATGCATATCAC TAACCAGAATTCAATATGTGTTTACCAATGTATTCTTCTCTTCTCTCTTTTTTTTTTTTACTTTGAGGTG GGGTCTTGCTCTGTTGCCCAGGCTGGAGTGTGGTTGTTTGATCATAGCTTACTGCAGCCTCTAACTCCTG GGCTCAAGCCATCCTCCCTCCAGAACTGAGCTTCCGAGTAGCTGCTACCACAGGCACACGCAACCACGCC CAGCTAATGTTTTTAATTTTTGTAGAGATGAGTTTTTTTTTTTTTTTTGGAGACAGAGTTTTGCTCTAGT TGTCCAGGCTGGAGTGCAATGGCATGATCTTGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCAATTC TCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGTGCCCACCACTATGCCCAGCTAATTTTTTGTACT TTGAGTAGAGATGGAGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTTAGGTGATCCGCCC ACCGTGGCCTCCTAAAGTGCTGGGATTATAAGCATGAGCCACCACGCCTGGCCTGTAGAGATGAGTTATT GCTCTGTTGCCCAGACTGGTCTCAAACTCCTGGCTTTAAGCAACCCTCCCTCCTTGGCCTCCCAAAGCAC TGGGATTACAGGCATGAGCCATTGTACCCTACAGATATTTTCATTCAACGTTCAATTTATATACAGTGAA ATGCAGCAATCTTAATTATACATTCTGTAAATTTTCACAAATGCAAACACAACAGGTTTTATTTCTTTAA AGGGAATTAAAACTATAAAGTCTTGGGATATATTTGAACTCCAGGCATAACTGGATCCAGGAATTTTAAC AAGGCTATTTCTATCTTCTCTGAGTTCTGCTTTCTTCTATTGCATGATTTTCAGGCAGATTATTTTTCAC AATGATGAAGGTGGCCCTAGAACCTCTGGGCTAACATCTCCAGTGGGCCACCCGAGAGCTAAAAAGGGAG GTTTTTTTTTCAATATTTCTAGCAAAAGCGCCAGGCCTGGCTTTGATTGACCCAGCATGATCACTGCCTA TGTCTGAACCAGAGAAATGCCGTCATCTGTTTGGTCATTCCTGGAACTTGTGCCCACCTCTCAGAGTAGA TATAGCCCTACTCAAAGAACAGGATTGAAAATAGAGGAGCACAGGGTTCCCAAGGGAAATTCAAGGTTTC TCACTAGAAGAAAAACAGATGATGGGATCTGGGCCATTAAATATACACATTATATTTGAAAGCTGAGACT TTCGGACCTTTGGAATCATAGAAGCTTATAACCACTGAGTCCCTCTCCCCTGTTGTCTCCTGCTTACAGA TGTGAACGAGTGTGAAACACTACAGGGTGTATGTGGAGCTGCCCTGTGTGAAAATGTCGAAGGCTCCTTC CTCTGTGTCTGCCCCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTT CTGCTGGTGAGACTGATGTGTCTATTTAACTGATGGCGGCTGGCCCCATGGGAAAATCACGTGGTCTAAT CATTCCTGATGTGGACAGCTACCATCAGCTAAATACTGTTGTTTTAAACATCAACAAAAGACACATAAGT TAACATGGGTAGTGAGACTGTGTCAGGAGAATTAGACCCTGGTCCTGACTCTACCAGATTCTTTCATTCA ACAAATGTTCACAGGGTGTGCACTGTGTTCAGGCCATCTTCTGGGCACTGAGAACATAGTAGTGACCAGA AGGGATCACTGTCTGTCCTCAAGGGGCTCACAAGCCAATGGGGCAGACAGAGATATCACCAGATAGTGAC AACCCAGAGAAATCAACAAGACTGTGACGGGGAAAGCCCAGGGGGGTTTTGGAGGAGGCGCCTGGCCCAG CATGAGAAGAGGATTAGGGAGTTCTTCCTGTAGGAGACGACATCTGAACTGAGAGCTGTGGGATGAATAG AAATGAGCCAGGCCCGATGAGTGAGGAGGGCATTCTGGGCAGAGGACACAGCAAGGGCAAAGGCCTGGCA AAGCCAGAGAGCATCTGGCATGTGAGAAGAACTGAAACAGGTTCAACATGGCATGATTTAGAGAGCAAAG GAAGGGGTAGGGAGAGATGGGGCCAGGGAAAGAGTCAGGTGCCCGATCACACTGACTTATCACAGTAAGA GAGCACTGCGGTACCGTGGAAGGGGTTTCGGCGTTTTTTTTTTGAAAATTTTTTTTAAATGTTTTTTTTT TAAGACAGGGTCGTACTTTCACCCAGGCCGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAACCTCCACC TCCTGTGCTCAAGGAATCCTCCAACCTCAGCCTGCTGAGTAACTGGGACTACAGGCACATATCACCACAA CAGCTAATTTTTGTATTTTTTGTAGAGATGTGGTTTTGTCATGTTGCCCAGGCTGCAGTATTTTTTTTTT TTTAATTTTTAAATGTTACATATTTAGGCTAGGATTGGTGGCTGAAGGCCATAATCCCAGCTCTCTGGGA GGCCAAGGCGGGAGGATCACCTGAGGTCAGGAGTTCGAGACCAGCATGGCCAACATGGCAAAACCCTGTC TCTACTAAAAATACAAAAATTAGCTGGGTGTAGTGGTGCACGCCTGTAATCCCAGCTATTCGAAAGGCTG AGGCAGGAAAATCGCTTGAATCCAGGAGGCGGAGGTTGTGGGATTGCACCACTGCACTCCAGCCTGGGTG AGAGAGGAAGACTCCGTCCCAAAAAAAAAAAAAAAAAAAAAGCTATGTATTTATTTATTTTTAATAATTT CCATCTTTACTTTAGATTCAGGGGATACATGTGCAGGCTTTTTACCTGGGTATATTTCGTGATGCTGAGC TTTGGGATACAAATGATCCCGTCACCCAGATAGTAAGCACAGTACCCAACAGCCAGTTTTTTTTTTTCTT TGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTAGAGTGCAGTGGCGTGATCTCAGCTCACTGTAACCTCC ACCTCCCTGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTCCGCCACCA CGCCCAGCTAATTTTTTGTATTTTTAGTACAGACGGGGTTTCATCATATTGGTCAGGCTGGTCTCGAACT CCTGACCTCAGGTCATCCACCTGCCTCGGCTTCCCAAAGTGCAGGGATTACAGGCGTGAGCCACCATGCT CGGCCCAACAGCCAGTTTTTCAACCCTTGTACCTCTGTCCCTCCCCCATCTAGTGGTCCCCAGCAACTAT TGTGGGCATCTTTACATCCATGAGTACCCACTGTTTAGCTCTCACTTGTAAGTGAGAACATGTGGTATTT GGTCTTCTGTTTCTGCATTAATTTGCTTAGGATAATGGCCTCCAGCTGCATCCATGTTGCTGCTAAGGAC ATGATTTCATTCTTTTTCATGGCTGTGTAGTATTCATGGAAGGGTTCTAAGCAGGAAAGATAGAATCAGA TTTTGAAACCTCCCTCTGGCCGCCATGTGAAGGTGATTGAAGCGGGTGATATGGAGGCTGGGAGCTCAGG GAACAGGCTGGGGCAGGGGCCTGGACAGGAGAGAACAGGGCTGGACCAAGGCAGGGGCTGTGGAAGGGGA GGAGAAGGTGGTGGGAGAAAAACCCAAGAGGCCATGTGGACAAGCTGTGGATGTCTGGGTGGGGAAGCTG TGTCCAAGACAAGGCATAGGTTTTTTGTTTGTTTGTTTTGTGACAGAGTCTCGCTCTGTCGCCCAGGCTA GAATGCAGTGGTGTGATCTCGGCTCACTGCAACTTCCGCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGC CTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTTTCTATTTTTAGTAGAGAC CGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAAGTAATCCAACCGCGTCGGCCTCC TGAAGTGCTGGGAGGACAGGCAGGAGCCACTGCACCTGGCGACAAATTGTAGGTTTTGAGATGAAGACTC AGCCAGTTTGCCACACACTGGATAAGAGACCCAGAGAGGCATCCAGGAAGCCAGGGAAGTTCCCTCACCA CCCACCCAAGCTGTTAGCTGCAGTGACGGGAAAGTGTGAGGTGGGGAGGCAAGAGATGCAGAAATGACAG GAGGTGACAGTGGGAGAAAGAGAAACAGTGACAGAGGAGCGTGAGAGGTGTGGAGTCTGGTTCTGCCACT GATGGCTGCCACCCTCTGTTTCCCTATCTATGCCAGCCTCAGTTTCCCCATCTATGATAGTGGCGGGGCT GGGGATTCAGCCCACACTGGGCTAAAGCTCCTTGTCTCCCCAGGCACGTTCCCAGGCTCGCAGCCCCAGG CACCTGCTAGCCCCGTTCTGCCCGCCAGGCCACCTCCGCCACCCCTGCCCCGCCGACCCAGCACACCTAG GCAGGGCCCTGTGGGGAGTGGGCGCCGGGAGTGCTACTTTGACACAGCGGCCCCGGATGCATGTGACAAC ATCCTGGCTCGGAATGTGACATGGCAGGAGTGCTGCTGTACTGTGGGTGAGGGCTGGGGCAGCGGCTGCC GCATCCAGCAGTGCCCGGGCACCGAGACAGGTGGGCATGGGCTGATGGGGACACAGGGCTGAGGGCTTGG GTGGAAATACTGGGTGGGGTGTGGGCCTGGGACAGGGGACACTTTTGGACAGGGCCTTGAGGTACTAGTA CTGTCAGGGCAAGGGCGAGCTGCCAGGCAGGTGGGCATGGGCAGACATAAGGCTGAGAGGTGGGCACTAA CAGGCACAGGGCCAGAGGGACTTTTGTGACAAGTGGGCACGAGCAGGTCAGGGCTGGGGCTGGGGCTCTG GTGTCCTGGCTCAGGCTTGTCTCTGTGTGTAGCTGAGTACCAGTCATTGTGCCCTCACGGCCGGGGCTAC CTGGCGCCCAGTGGAGACCTGAGCCTCCGGAGAGGTGAGGCCAGCCTTTGACCCTCCACCCCACTCAGCT CTGAGGCCCAGCTTCGTCTCTTCCTGTTTTCTTTGCCTCTGTCTCTCACCCTTTCTGTTTCTCTGTATCT GTCTCCCCGACCCCACCCATACTCTGTCTCTTTCTTTCTTTTCTTTCTTTTTTTTTTTTTTCTTAAGATA GAGTTTTGTTCTTGTCGCCCAGGCTGGAGAGCAATGGCGAGATCTTGGCTCACTGCAACCTTTGTCTCCT GGGTTCAAGCGATTCTCTTGCCTCAGCCTCTGGCGTAGCTGGCTACAGACACTAGCCACTACGCCTGGCT AATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGATTGGTCTCGAACTCCTGACCT CAAGTGATCCGCCCACCTTAGCCTCCTGAAGTGCTGGGATTTCAGGCATGAGCCACCGCTCCTGGCCTCT CCATCTTTCTTTCCCTGTCTCTACTTCTTGGTCTATCACCAGCTCTGTCTCTGTCTTCCCACGTCATGCC CTCACACACTCCACCCATCCAGCCCGCCCCCATCTCTCTCTCTGCTTTTCGCACAGACGTGGACGAATGT CAGCTCTTCCGAGACCAGGTGTGCAAGAGTGGCGTGTGTGTGAACACGGCCCCGGGCTACTCATGCTATT GCAGCAACGGCTACTACTACCACACACAGCGGCTGGAGTGCATCGGTACAAGCCCCACCTCCCCCAACCC CCGGCAACTCTCTCCAACCCCTAGCCTTGCCAGCTCCCCTCTGGAATGTGGCCACCACCAGCGGGAAGTC TTTCCTGGAGTCTAGACTCCATCCATCACACTGCCAATGTGCTGGGAAGAGAAATGGGAAAGGGTGGGGA GAGTTGAAGGGGATGCCTCTTAATCATCCTCTCCCTAGACAATGACGAGTGCGCCGATGAGGAACCGGCC TGTGAGGGCGGCCGCTGTGTCAACACTGTGGGCTCTTATCACTGTACCTGCGAGCCCCCACTGGTGCTGG ATGGCTCGCAGCGCCGCTGCGTCTCCAACGAGAGCCAGAGCCTCGGTAACCCCGCCCACGCCATCCAGGC CCTCCTTCCCTTGGCTCGGCCTCACACCCGCACCCGGGCCACACCTTTGCGACGGCCACGCCCTCCGAAG GCCACGCCCCATGCTCCTGGCTCGACCACGCCCCACTGAGCCCTCACTCAGTCTCTGTCCCACTGTCTGT CTCTCTGAGGCGAGCTGGCTAGGTGGTTAAAGGCAAAAGTTTTAGGGCAACCTTTGCATGTTGCCTCTTG GACTCCAGGTTTCTTTCTGCACACTGGGTGAATAGCCCCTACCTTATAGGGTGGCTGTGAGGAATTTTAT TTAATTTTATTTATTTATTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAGGCTAGAGCGCAGTGGCGCC ATCTCAGCTCACTGCAACCTCCACCTCCGGGGTTCAAACGATTCTCCTGCCTCAGGCTCCCGAGTAGCTG GGATTACAGGCATGTGCTACCACGCCCAGCTAATTTTGTATTTTTTTCTTTAGTAGAGACAGGGTTTCTC CATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTA GGATTACAGGTGTGAGCCACCACACCTGGCTGATGAATTTTATTTTATTTTATTTTATTTTTAATTTTTA ATTTTTAGTTTTATTATTTATTTTTTACTAAGTACCACATGAGTGCTGCCTGTTATTATTTATCTGCATC TCTAGGTCTCTGTCTCTTTCCAGCTGTTTGTGGATTTCTGTCTTTGGGGTTTTCTCTGAATTTCTGACAC CCTCTGGATCTTTGTTTTCAGGTCCCTTTCTCCTGCCTCTGTATCTTTGTTTTCCTGTTTTGAGTCTTTG ACTCTTTGGATGTGTTTCTCTCTCTCTCTTTGGGTCTTTTTTCTCCCTTTTCGTTTCTGACTATTTTCCT ATCTCTAGGCCCCTAACAACTTCTGCTGAAGCTCTGTCTCTTGAACACTCTACTTGTCGTTGTTTGTTTT CATTTTTGAGACAAGATCTCGCTCTGTCATCCAAGCTGAAGTACAGTGGCACAATCACAGCTCACTGCAG CTTCCACCTCTCATGCCCAAATGATCCTCCCACCTCAGACTTGCAGTAGCTGGGAGTCCAGGAGCCCGCC ACCAAGCCTGGCTAATTTTTGTATTTATATATATATATATATATATATATATATATATATATATATATAT ATATATATATATATATATATTTTTTTTTTTAAAGATGGGTTTTTGCCATGTTGCCCAGGCTGGTCTTGAA CTCATGGGCTCAAGCAACCCCCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTCCAACACACTCT CTCTGTGCTTCTTGCCACCTCTCTTTTTGCCCACTGTCCCAACCACTCTTCTCTCATTTCCTGTGCCTTC AGCACTTACCCCCATACAGTGAGATGTCAGACAATGCTCAGAGAAGCAAAGCAACTGCCCCGAGGCCACA CAGCCCTCCAGAGGCCAGACTTGGGTAGACCCCTCTCAGGCCCTACCTCCCAGTCATTGGACACCTTCTT CTGCCCTCTCCTCCTATATGACAGTCTCCTTGTTCCTCAATCCAGAACCCTGGAGTGACCTCAGAGAACT TCCAGAGTTAGATCACAGCTGATGAGAAGGATTTGCTGATAGGCAGAGGGTGCCTGGGCTGCTCAGCAGG GGAAGGGTCCAGCCCCTGGGAGGACCTGAGTGCCAGGCCCACTCTGACACATGCTGTCTCCACCTACAGA TGACAATCTGGGAGTGTGCTGGCAGGAAGTGGGGGCTGACCTCGTGTGCAGCCACCCTCGGCTGGACCGT CAGGCCACCTACACAGAGTGCTGCTGCCTGTATGGAGAGGCCTGGGGCATGGACTGCGCCCTCTGCCCTG CGCAGGACTCAGGTGCTGGCACTGGCCTAGGCTGAACTCAGAGGCCTTGCCCCATGGGCTCCAAATCTAG GCCCTCAGATCCCCAGTCGCAGAACCCCCAGACTCTATCCAAACTCTGTCCCCTAGACCAACCCCTATGT CGCAGCCCATCCCAAAATCTTGGTCCCCGATTCACACTCCAAAGACTTCCAAGTCTCAGCCACAGACATC CCAAGGCCTGACCCAGCAGATCCCATAGTACCAGACCCACAGGCCCCTGAGGTCTGGTCTCTCATATGCT CAGCTCCTGGTCTCTAGAACCACCAGACACAGCCTATGAGATGTCCTCCCCTAAATCCTGGGCCCTTAGA CCTGAAATGCCAGTTGCTCAGACCTCACCATCCTGGCCCCAGACCCCCTGGTCACAGCCCCACAGACCTC CAAGTCCCATTGCCTTAGACACCCTCCAAGTCCCATTGCCTTACACACCACATCCGGGTGCCTAAGACCC CAACACACAGCCCCAGAGATTCCCAAGTCTTGGTTTCTACAACCTCTGAGTCCCTCAGTCCTCAGCCCTT AGGAACCCAGTTCCAAAGCCCCAGTCCTGGGTCCTCAGACCTCCAGGTCCCAGTGCCTCAGACTGTCTCC CATGCATCCTGCCCCCTCAGGTCCCCAGCAGCAATCCCTGGGATTCCCCAGTCCTGGTCCACAGAACACC CCCATCTAATTTCTTCAGGTCCCTAGTCCTAGCTCCCATGGGTCGCTCCAATTCCAGCCTCTCAGACCCT GATTCTTAGCAGGCTTCATTACCCTTGATCTCAGCACGTCCGAATCCCAGTCTCAGCCTTCAGATTCTCA GCGCTGGCTCCAGAAACCCCGGGGCCACCCAGGACCCTCCCCATCCAGTCCTCTGCCTCCTCTCCCAAGG GGGGTATGTGAGTGGTGGGTGTGGGGGCCAGCAGGGGCTGATTGTTTGCCTTGGCTCCTGTTCCCAGATG ACTTCGAGGCCCTGTGCAATGTGCTACGCCCCCCCGCATATAGCCCCCCGCGACCAGGTGGCTTTGGACT CCCCTACGAGTACGGCCCAGACTTAGGTCCACCTTACCAGGGCCTCCCATATGGGCCTGAGTTGTACCCA CCACCTGCGCTACCCTACGACCCCTACCCACCGCCACCTGGGCCCTTCGCCCGCCGGGAGGCTCCTTATG GGGCACCCCGCTTCGACATGCCAGACTTTGAGGACGATGGTGGCCCCTATGGCGAATCTGAGGCTCCTGC GCCACCTGGCCCGGGCACCCGCTGGCCCTATCGGTCCCGGGACACCCGCCGCTCCTTCCCAGAGCCCGAG GAGCCTCCTGAAGGTGGAAGCTATGCTGGTGAGCACTGCCAGCGCATGATGAGACTGAGATGAGGGGTGA GGTGTGCACGGAGAGAGGAGGGAGGGAAACAGAAGGCGGGAGGAGAGACGGAACACAGGTGCAACTGGAG AGAGCCACAGAAAGGGACAGAGAAGTGTCTATAGCCCGGCAAAGAAAGAGAAGGTGGCAGAGGGAAAGCT GGCGAGAGAATGAGGTAAGCTTACTGGCCCCGCAGCACCCGCCACAGCCCTGGAGCGGGATGGACAGTTT ACAGCGAGAAAGATGGAGCCAAGGACGCGCACCCACCGTTGTGGGTAAGGGGTGAAGGCAGGGACCTCAA GTCATAGGGTCCCCGCATTTCCCACAGGTTCCCTGGCTGAGCCCTACGAGGAGCTGGAGGCGGAGGAGTG CGGGATCCTGGACGGCTGCACCAACGGCCGCTGCGTGCGCGTCCCCGAAGGCTTCACCTGCCGTTGCTTC GACGGCTACCGCCTGGACATGACCCGCATGGCCTGCGTTGGTGAGGGCGGGCCCGGGGCCAGCATGCGCA GGGAGAGGCGAGGCTTGTCCAGGGAGGGTGGAAGCCCTGACTAGGGGGTGCTGGTCAGGGACGGGAAAGG ACCTCACTACAGGGGACGGGCCAGCGCAAAAGGGAGGAGTAATTCTTCCACCTGGGTGGGGCTTGACTGA AGAAGGCGGAGTCAGGGTGCCAGCAGGGCAGGGCTTAACCACGGGGCTGGAGCCGGGCCTTGAAGCAGGA TAGAGGAATAGAATAGTGCTGGTGTGACTTGCAGTGCTACCTTGGGCAGTCTGCAGGACCTCTTTGGAGA GCCTCAGTCTTCCCACCTGTAAAATGGGAATATTAATCAAGTCTGCCTAATTTGGATGGCAGTAAAGCCA AGTGATTAAAATCAAGAACATAGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG AGGCGGGCGGATCATTAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTAAAA ATACAAAATTAGCCGGGTGTGGTGGTGCATGCGTGTAATCCCAGCTACTCGGGAGGAACCCAGGAGGCAG AGGTTGTGGTGAGCCAAGATCGCGCCATTGCACTCCAGCCTGGGCAATAAGAGCAAAACTCCGTCTCAAA AAACAAACAAAACTCGAGGAGGTCACATAGACCTCAGACTCAGTCCAGCAACTTGCTGTGTGACGCTGGA CAGGTCACTGTCCCTTACCTAATTTTTCTGATATGAAAAATGGCTACAGTCAAAGATCCCATTTCATAGA ATTGCGAATATTATTAACACTGATTTACAATAACATTGAGAGTCATGTGCAAATGGAGGCACATGCGTAA AACGAATTACAGTACCTACCTAATAGGGGTATTAGAAGGACAAAGTTAATACTTGTAATGTGCTTAAAAC AATGCATGAACATTTATTGTTGTTGACACCATCATCAGTATTTTTTTCTTCTTTTTTTTTTCTTTTCTTG GCGACAGAGACTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCCTGATCTCGGCTCACAGCAACCTCCTC CTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGATTACAGGCGCCCGCCACCATG CCTGGCTAATTTTTGTATTCTTAGTAGAGACGGGGTCTCACCATGTTGGCCAGGTTCGTCTCGAACTCCG GCCTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCGCGCCCGGC CATTATTATTTTCTTAACAAAATCCTAGTGCGGTATGGGCCACCATATCCATCTTACAGAACACGAAACT GAAGCACAGTGAGGTTAAGCCACCTGGCCGGGCTCACACAGTTAGCAGATGGCAGAGGCCAGATTGGACT CCAAACTGCTCAGCATCTGTGCTCCTCTGTTCCAAGAACTTAAGGGGCCAAGGAGGCGAGCTTCTGGGGC CCCAGCCTTCAGCAGCGATCGTTGTCTCCCCTCCGCAGACATCAACGAGTGTGATGAGGCCGAGGCTGCC TCCCCGCTGTGCGTCAACGCGCGTTGCCTCAACACGGATGGCTCCTTCCGCTGCATCTGCCGCCCGGGAT TCGCACCCACGCACCAGCCGCACCACTGTGCGCCCGCACGGCCCCGGGCCTGAGCCCTGGCACCCGCTGG CCGCCCACCCGCGCCCGCCACTCGGGGCCCCTGCCGCGCATCCTGCAGCCCGCTTATGCGTATGTGCACG GGGCCGCCCGCCTGGACCTGGAGAAGGGACCTACGGACGCCTGGAAGCTGCGACGCCCTGCACTGCTCCC GCCTCCACCAGCGCCTCCCACTGATGTCGTGGTCCCGGGCCTGGCCCAGGGGCCCCTTTACATGCCCTCT CCCTTTTATAAAATTTTCCATTAAAAACCACCTATTTTCTATC Download Select all
Length	36933
OMIM ID	604710
HGNC ID	HGNC:6717
Unigene ID	Hs.466766
Ensembl ID	ENSG00000090006
PharmGKB ID	PA30480

mRNA Information

mRNA ID	XM_011527387.1
Exon	join(1..294,6310..6368,6534..6669,7181..7290,12148..12339, 12518..12765,12842..12944,13346..13420,13517..13639, 14478..14642,15333..15482,15597..15716,16643..16774, 16859..16984,17645..17770,18265..18507,18972..19097, 19186..19305,20178..20309,20517..20642,21029..21151, 21428..21559,24002..24133,24213..24338,26460..26606, 29514..29780,30063..30134,30717..30845,31049..31195, 32970..33122,34088..34468,34818..34970,36509..36931)
mRNA Sequence	>8425 TGACAAAAAGGACCTGAAAAATCACTGATTCTAGAATAGGGGAGTGTCAAGGGGAGTTCATACC CATGAATCTCCACCGGTAGGAATATCTTGCATGCCAGGATGTCTGGAATGCTGAGAATTATAGG ATACAGAAAGGAACCTGGATTACTAGGAAATCTAGAGAATGGGAGAGATCCTGGACTATCCGCC CTTCCAGAGCACTGGAAGGTTTGTTTGCGTTCCAAGAAATCCATAATGGCAGGAGATTCCGGAT TATCAGAGAATCTGGAACACAAATGGGAGACGTAAAAGCGTTGCTGTTTGTCGCTGCTGCCCGG GCCAGACGTCTAGGAGGAGCCGCTGCATCCGAGCCTTCTGCAGGGTCCGAAGCTGCCAGCCCAA AAAGTGTGCAGGCCCCCAGCGGTGCCTGAACCCAGTGCCTGCAGTGCCCAGTCCCAGCCCCAGC GTGAGGAAGAGACAGGTGTCCCTCAACTGGCAGCCACTGACGCTCCAGGAGGCCAGAGCTCTAC TGAAGCGGCGGCGGCCCCGGGGGCCAGGGGGCCGGGGACTACTGAGAAGGAGGCCCCCACAGCG TGCCCCCGCTGGCAAGGCCCCGGTCCTGTGTCCCTTGATCTGTCACAATGGCGGTGTGTGCGTG AAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGCCAGTTGCACTCCTCGG GCGCCCGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGC CAACCACCGCGACGACGAGCACGGCGTGGCATCTATGGTGAGCGTCCACGTGGAGCACCCGCAG GAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTGGCCCTTGGGAGGAGGCGGACGCTG AGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTGGC ACAGAGCGCGCCGCGGGAGGACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAG CTGCGCGGAGGCGAATGCGCGTCCCCGCTGCCCGGGCTCCGGACGCAGGAGGTCTGCTGCCGAG GGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGGGGAACTCCGA AAGAGTGAGCGCCCCAGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAA GATGTGGATGAGTGCGCGACTGGCGGGCGCTGCCAGCACGGCGAGTGTGCAAACACGCGCGGCG GGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGACTCGTCCCGCAGCAGCTGCATCTCCCA ACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTG CCCATTCTGCGGAACATCACTAAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCC GGGGCTGCCAGCTCTGCCCACCCTTCGGCTCAGAGGGTTTCCGGGAGATCTGCCCGGCTGGTCC TGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGCCAGGAGCCACCC CGAGTGTCACTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGC CCACCCATCGCCTGGAGCCCCGGCCTGAACCCCGGCCCGATCCCCGGCCCGGCCCTGAGCTTCC CTTGCCCAGCATCCCTGCCTGGACTGGTCCTGAGATTCCTGAATCAGGTCCCTCCTCCGGCATG TGTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCT GCGCTTGCGACTCTGGCTTCCGGCTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATG TCGCCGCGTGCCCCCGCCCTGTGCTCCCGGGCGCTGCGAGAACTCACCAGGCAGCTTCCGCTGC GTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGATGTGGACGAGTGCC ACCGCGTGCCGCCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCAGCTTCCTGTGCGT GTGCCCCGCCGGGTACCAGGCTGCACCGCACGGAGCCAGCTGCCAGGATGTGGATGAATGCACC CAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTGGCTCTTTCCGCTGTGTTT GCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCC GCCCTGTGGGCCCGGCCGCTGTGACAACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGC TTCCGCTCCCGAGGGCCCGGGGCCCCCTGCCAAGATGTGGATGAGTGTGCCCGAAGCCCCCCAC CCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCCATGGGCTT CCAACCCAACACTGCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGC CCTGGGCAGGAGTGTGTGAACTCGCCCGGCTCCTTCCAGTGCAGGACCTGTCCTTCTGGCCACC ACCTGCACCGTGGCAGATGCACTGATGTGGACGAATGCAGTTCGGGTGCCCCTCCCTGTGGTCC CCACGGCCACTGCACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCG CCGTCGGGTCGGCCCGGGCCCTGCGCAGACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCC CTCACGGCGAGTGCCTCAACACTGACGGCTCCTTTGCCTGTACTTGTGCCCCTGGCTACCGACC CGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGAGC GGCATCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCC CGGACCTCGCCTCCTGCCTCGACGTGGACGAATGTCGCGAGCGAGGCCCAGCCCTGTGCGGGTC GCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCGATCCTGGGTACCAC GCGGGCCCCGAGGGCACCTGTGACGATGTGGATGAGTGCCAAGAATATGGTCCCGAGATTTGTG GAGCCCAGCGTTGTGAGAACACCCCTGGCTCCTACCGCTGCACACCAGCCTGTGACCCTGGCTA TCAGCCCACGCCAGGGGGCGGATGCCAGGATGTGGACGAATGCCGGAACCGGTCCTTCTGCGGT GCCCACGCCGTGTGCCAGAACCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGGGTTACGAGG GGGCACGGGATGGGCGTCACTGCGTGGATGTGAACGAGTGTGAAACACTACAGGGTGTATGTGG AGCTGCCCTGTGTGAAAATGTCGAAGGCTCCTTCCTCTGTGTCTGCCCCAACAGCCCGGAAGAG TTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTGGCACGTTCCCAGGCTCGC AGCCCCAGGCACCTGCTAGCCCCGTTCTGCCCGCCAGGCCACCTCCGCCACCCCTGCCCCGCCG ACCCAGCACACCTAGGCAGGGCCCTGTGGGGAGTGGGCGCCGGGAGTGCTACTTTGACACAGCG GCCCCGGATGCATGTGACAACATCCTGGCTCGGAATGTGACATGGCAGGAGTGCTGCTGTACTG TGGGTGAGGGCTGGGGCAGCGGCTGCCGCATCCAGCAGTGCCCGGGCACCGAGACAGCTGAGTA CCAGTCATTGTGCCCTCACGGCCGGGGCTACCTGGCGCCCAGTGGAGACCTGAGCCTCCGGAGA GACGTGGACGAATGTCAGCTCTTCCGAGACCAGGTGTGCAAGAGTGGCGTGTGTGTGAACACGG CCCCGGGCTACTCATGCTATTGCAGCAACGGCTACTACTACCACACACAGCGGCTGGAGTGCAT CGACAATGACGAGTGCGCCGATGAGGAACCGGCCTGTGAGGGCGGCCGCTGTGTCAACACTGTG GGCTCTTATCACTGTACCTGCGAGCCCCCACTGGTGCTGGATGGCTCGCAGCGCCGCTGCGTCT CCAACGAGAGCCAGAGCCTCGATGACAATCTGGGAGTGTGCTGGCAGGAAGTGGGGGCTGACCT CGTGTGCAGCCACCCTCGGCTGGACCGTCAGGCCACCTACACAGAGTGCTGCTGCCTGTATGGA GAGGCCTGGGGCATGGACTGCGCCCTCTGCCCTGCGCAGGACTCAGATGACTTCGAGGCCCTGT GCAATGTGCTACGCCCCCCCGCATATAGCCCCCCGCGACCAGGTGGCTTTGGACTCCCCTACGA GTACGGCCCAGACTTAGGTCCACCTTACCAGGGCCTCCCATATGGGCCTGAGTTGTACCCACCA CCTGCGCTACCCTACGACCCCTACCCACCGCCACCTGGGCCCTTCGCCCGCCGGGAGGCTCCTT ATGGGGCACCCCGCTTCGACATGCCAGACTTTGAGGACGATGGTGGCCCCTATGGCGAATCTGA GGCTCCTGCGCCACCTGGCCCGGGCACCCGCTGGCCCTATCGGTCCCGGGACACCCGCCGCTCC TTCCCAGAGCCCGAGGAGCCTCCTGAAGGTGGAAGCTATGCTGGTTCCCTGGCTGAGCCCTACG AGGAGCTGGAGGCGGAGGAGTGCGGGATCCTGGACGGCTGCACCAACGGCCGCTGCGTGCGCGT CCCCGAAGGCTTCACCTGCCGTTGCTTCGACGGCTACCGCCTGGACATGACCCGCATGGCCTGC GTTGACATCAACGAGTGTGATGAGGCCGAGGCTGCCTCCCCGCTGTGCGTCAACGCGCGTTGCC TCAACACGGATGGCTCCTTCCGCTGCATCTGCCGCCCGGGATTCGCACCCACGCACCAGCCGCA CCACTGTGCGCCCGCACGGCCCCGGGCCTGAGCCCTGGCACCCGCTGGCCGCCCACCCGCGCCC GCCACTCGGGGCCCCTGCCGCGCATCCTGCAGCCCGCTTATGCGTATGTGCACGGGGCCGCCCG CCTGGACCTGGAGAAGGGACCTACGGACGCCTGGAAGCTGCGACGCCCTGCACTGCTCCCGCCT CCACCAGCGCCTCCCACTGATGTCGTGGTCCCGGGCCTGGCCCAGGGGCCCCTTTACATGCCCT CTCCCTTTTATAAAATTTTCCATTAAAAACCACCTATTTTCTA Download Select all
Length	5291

CDS Information

Location	join(279..294,6310..6368,6515..6669,7181..7290, 12148..12339,12518..12765,12842..12944,13346..13420, 13517..13639,14478..14642,15333..15482,15597..15716, 16643..16774,16859..16984,17645..17770,18265..18507, 18972..19097,19186..19305,20178..20309,20517..20642, 21029..21151,21428..21559,24002..24133,24213..24338, 26460..26606,29514..29780,30063..30134,30717..30845,
CDS Sequence	>lcl\|XM_011527387.1_cds_XP_011525689.1_1 [gene=LTBP4] [protein=latent-transforming growth factor beta-binding protein 4 isoform X12] [protein_id=XP_011525689.1] [location=758..5023] ATGCCACTGGCCAACCACCGCGACGACGAGCACGGCGTGGCATCTATGGTGAGCGTCCACGTGGAGCACC CGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTGGCCCTTGGGAGGAGGCGGACGCTGA GGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTGGCACAGAGC GCGCCGCGGGAGGACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAGCTGCGCGGAGGCG AATGCGCGTCCCCGCTGCCCGGGCTCCGGACGCAGGAGGTCTGCTGCCGAGGGGCCGGCTTGGCCTGGGG CGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGGGGAACTCCGAAAGAGTGAGCGCCCCAGATGGACCT TGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGATGTGGATGAGTGCGCGACTGGCGGGCGCT GCCAGCACGGCGAGTGTGCAAACACGCGCGGCGGGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGA CTCGTCCCGCAGCAGCTGCATCTCCCAACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTC CGCGACGGCGGCTGTTCGCTGCCCATTCTGCGGAACATCACTAAACAGATCTGCTGCTGCAGCCGCGTAG GCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCACCCTTCGGCTCAGAGGGTTTCCGGGAGATCTGCCC GGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGCCAGGAGCCA CCCCGAGTGTCACTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGCCCA CCCATCGCCTGGAGCCCCGGCCTGAACCCCGGCCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAG CATCCCTGCCTGGACTGGTCCTGAGATTCCTGAATCAGGTCCCTCCTCCGGCATGTGTCAGCGCAACCCC CAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGCGCTTGCGACTCTGGCTTCC GGCTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATGTCGCCGCGTGCCCCCGCCCTGTGCTCC CGGGCGCTGCGAGAACTCACCAGGCAGCTTCCGCTGCGTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGG GCTGCGGAATGCCTGGATGTGGACGAGTGCCACCGCGTGCCGCCGCCGTGTGACCTCGGGCGCTGCGAGA ACACGCCAGGCAGCTTCCTGTGCGTGTGCCCCGCCGGGTACCAGGCTGCACCGCACGGAGCCAGCTGCCA GGATGTGGATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTGGCTCT TTCCGCTGTGTTTGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGG AGCCGCCGCCCTGTGGGCCCGGCCGCTGTGACAACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGG CTTCCGCTCCCGAGGGCCCGGGGCCCCCTGCCAAGATGTGGATGAGTGTGCCCGAAGCCCCCCACCCTGC ACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCCATGGGCTTCCAACCCAACA CTGCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGT GAACTCGCCCGGCTCCTTCCAGTGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACT GATGTGGACGAATGCAGTTCGGGTGCCCCTCCCTGTGGTCCCCACGGCCACTGCACTAACACCGAAGGCT CCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCGGGTCGGCCCGGGCCCTGCGCAGACGTGAA CGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGGCTCCTTTGCCTGT ACTTGTGCCCCTGGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGG AGGACCTTTGCCAGAGCGGCATCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACA CCGCGCTGGCCCGGACCTCGCCTCCTGCCTCGACGTGGACGAATGTCGCGAGCGAGGCCCAGCCCTGTGC GGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCGATCCTGGGTACCACG CGGGCCCCGAGGGCACCTGTGACGATGTGGATGAGTGCCAAGAATATGGTCCCGAGATTTGTGGAGCCCA GCGTTGTGAGAACACCCCTGGCTCCTACCGCTGCACACCAGCCTGTGACCCTGGCTATCAGCCCACGCCA GGGGGCGGATGCCAGGATGTGGACGAATGCCGGAACCGGTCCTTCTGCGGTGCCCACGCCGTGTGCCAGA ACCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGGGTTACGAGGGGGCACGGGATGGGCGTCACTGCGT GGATGTGAACGAGTGTGAAACACTACAGGGTGTATGTGGAGCTGCCCTGTGTGAAAATGTCGAAGGCTCC TTCCTCTGTGTCTGCCCCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAA CTTCTGCTGGCACGTTCCCAGGCTCGCAGCCCCAGGCACCTGCTAGCCCCGTTCTGCCCGCCAGGCCACC TCCGCCACCCCTGCCCCGCCGACCCAGCACACCTAGGCAGGGCCCTGTGGGGAGTGGGCGCCGGGAGTGC TACTTTGACACAGCGGCCCCGGATGCATGTGACAACATCCTGGCTCGGAATGTGACATGGCAGGAGTGCT GCTGTACTGTGGGTGAGGGCTGGGGCAGCGGCTGCCGCATCCAGCAGTGCCCGGGCACCGAGACAGCTGA GTACCAGTCATTGTGCCCTCACGGCCGGGGCTACCTGGCGCCCAGTGGAGACCTGAGCCTCCGGAGAGAC GTGGACGAATGTCAGCTCTTCCGAGACCAGGTGTGCAAGAGTGGCGTGTGTGTGAACACGGCCCCGGGCT ACTCATGCTATTGCAGCAACGGCTACTACTACCACACACAGCGGCTGGAGTGCATCGACAATGACGAGTG CGCCGATGAGGAACCGGCCTGTGAGGGCGGCCGCTGTGTCAACACTGTGGGCTCTTATCACTGTACCTGC GAGCCCCCACTGGTGCTGGATGGCTCGCAGCGCCGCTGCGTCTCCAACGAGAGCCAGAGCCTCGATGACA ATCTGGGAGTGTGCTGGCAGGAAGTGGGGGCTGACCTCGTGTGCAGCCACCCTCGGCTGGACCGTCAGGC CACCTACACAGAGTGCTGCTGCCTGTATGGAGAGGCCTGGGGCATGGACTGCGCCCTCTGCCCTGCGCAG GACTCAGATGACTTCGAGGCCCTGTGCAATGTGCTACGCCCCCCCGCATATAGCCCCCCGCGACCAGGTG GCTTTGGACTCCCCTACGAGTACGGCCCAGACTTAGGTCCACCTTACCAGGGCCTCCCATATGGGCCTGA GTTGTACCCACCACCTGCGCTACCCTACGACCCCTACCCACCGCCACCTGGGCCCTTCGCCCGCCGGGAG GCTCCTTATGGGGCACCCCGCTTCGACATGCCAGACTTTGAGGACGATGGTGGCCCCTATGGCGAATCTG AGGCTCCTGCGCCACCTGGCCCGGGCACCCGCTGGCCCTATCGGTCCCGGGACACCCGCCGCTCCTTCCC AGAGCCCGAGGAGCCTCCTGAAGGTGGAAGCTATGCTGGTTCCCTGGCTGAGCCCTACGAGGAGCTGGAG GCGGAGGAGTGCGGGATCCTGGACGGCTGCACCAACGGCCGCTGCGTGCGCGTCCCCGAAGGCTTCACCT GCCGTTGCTTCGACGGCTACCGCCTGGACATGACCCGCATGGCCTGCGTTGACATCAACGAGTGTGATGA GGCCGAGGCTGCCTCCCCGCTGTGCGTCAACGCGCGTTGCCTCAACACGGATGGCTCCTTCCGCTGCATC TGCCGCCCGGGATTCGCACCCACGCACCAGCCGCACCACTGTGCGCCCGCACGGCCCCGGGCCTGA Download Select all
CCDS ID	CCDS74368.1

Protein Information

Protein ID	NP_001036009.1
Protein Name	Latent transforming growth factor beta binding protein 4
Molecular Wt. (Da)	170635
Protein Sequence	>8425 MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRS RCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPR GPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAP AVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAE AAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWG VHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCP DGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCP PFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEP RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGF RLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC DLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRC TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLN TDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCL DVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN TPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH CVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPAS PVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGS GCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCY CSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSL DDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPP AYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFD MPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEE CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSF RCICRPGFAPTHQPHHCAPARPRA Download Select all
Length	1624
Uniprot ID	Q9H8V3
Ensembl Protein ID	ENSP00000232458

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
7040	TGFB1	1821	NP_000651.3	in vivo	9660815

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00054	834-867	EGF_CA
cl21504	834-867	EGF_CA superfamily
cd00054	1049-1084	EGF_CA
cl21504	1049-1084	EGF_CA superfamily
cd00054	878-910	EGF_CA
cl21504	878-910	EGF_CA superfamily
cd00054	671-708	EGF_CA
cl21504	671-708	EGF_CA superfamily
cd00054	920-951	EGF_CA
cl21504	920-951	EGF_CA superfamily
cd00054	357-391	EGF_CA
cl21504	357-391	EGF_CA superfamily
cd00054	752-787	EGF_CA
cl21504	752-787	EGF_CA superfamily
cd00054	710-744	EGF_CA
cl21504	710-744	EGF_CA superfamily
cd00054	1296-1325	EGF_CA
cl21504	1296-1325	EGF_CA superfamily
cd00054	587-619	EGF_CA
cl21504	587-619	EGF_CA superfamily
cd00054	629-670	EGF_CA
cl21504	629-670	EGF_CA superfamily
cd00054	1574-1612	EGF_CA
cl21504	1574-1612	EGF_CA superfamily
smart00179	878-914	EGF_CA
smart00179	834-867	EGF_CA
smart00179	1049-1090	EGF_CA
smart00179	920-955	EGF_CA
pfam00683	418-458	TB
cl02926	418-458	TB superfamily
smart00179	357-387	EGF_CA
pfam00683	1360-1401	TB
cl02926	1360-1401	TB superfamily
pfam07645	834-868	EGF_CA
smart00179	671-708	EGF_CA
smart00179	752-793	EGF_CA
pfam07645	752-792	EGF_CA
pfam00683	1193-1234	TB
cl02926	1193-1234	TB superfamily
smart00179	587-623	EGF_CA
smart00179	629-670	EGF_CA
pfam07645	878-918	EGF_CA
pfam12662	1071-1094	cEGF
pfam12662	567-590	cEGF
cl21504	567-590	EGF_CA superfamily
smart00179	710-744	EGF_CA
pfam07645	1049-1089	EGF_CA
pfam07645	920-959	EGF_CA
smart00181	360-392	EGF
pfam12947	1059-1089	EGF_3
smart00179	1296-1325	EGF_CA
smart00179	1574-1608	EGF_CA
pfam07645	710-750	EGF_CA
pfam12947	838-866	EGF_3
smart00179	961-999	EGF_CA
cl21504	961-999	EGF_CA superfamily
smart00179	1005-1048	EGF_CA
cl21504	1005-1048	EGF_CA superfamily
pfam12662	651-674	cEGF

Ontology Information

HPRD ID	570
Molecular Class	Extracellular matrix protein
Molecular Function	Peptide hormone (GO:0005180)
Biological Process	Cell development (GO:0048468)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

CoReCG

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General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information