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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MNDA | 4332 | Myeloid cell nuclear differentiation antigen | 1 | PYHIN3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q22 |
| Start | 158831378 |
| End | 158849480 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18103 |
| OMIM ID | 159553 |
| HGNC ID | HGNC:7183 |
| Unigene ID | Hs.153837 |
| Ensembl ID | ENSG00000163563 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002432.1 |
|---|---|
| Exon | join(1..180,10757..11041,11902..12038,12578..12745, 14210..14626,16351..16539,17813..18103) | mRNA Sequence | Download Select all |
| Length | 1670 |
CDS Information
| Location | join(10777..11041,11902..12038,12578..12745,14210..14626, 16351..16539,17813..17860) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS1177.1 |
Protein Information
| Protein ID | NP_002423.1 |
|---|---|
| Protein Name | Myeloid cell nuclear differentiation antigen |
| Molecular Wt. (Da) | 45705 |
| Protein Sequence | Download Select all |
| Length | 407 |
| Uniprot ID | P06731 |
| Ensembl Protein ID | ENSP00000221992 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 | CDK1 | 302 | NP_001777.1 | in vitro | 16458891 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro | 16458891 |
| 3212 | HOXB2 | 854 | NP_002136.1 | in vitro | 16458891 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 16458891 |
| 5934 | RBL2 | 1576 | NP_005602.3 | in vitro | 16458891 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro | 16458891 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2DBG |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | Myeloid cell nuclear differentiation antigen |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08305 | Oct-83 | Pyrin |
| cl14633 | Oct-83 | DD superfamily |
| pfam02760 | 208-375 | HIN |
| cl08357 | 208-375 | HIN superfamily |
| pfam02758 | Jun-84 | PYRIN |
Ontology Information
| HPRD ID | 16450 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.