CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SERPINA1	5265	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	14	PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Down-regulation	-	-

Gene Details

Chromosome: 14; NC_000014.8 (94843084..94857029, complement)
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Gene Type	protein coding
Gene Family	-
Description	The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	14
Location	14q32.1
Start	94376747
End	94390692
Strand	-
Gene Sequence	>gi\|568815584:c94390692-94376747 Homo sapiens chromosome 14, GRCh38.p2 Primary Assembly TGGGCAGGAACTGGGCACTGTGCCCAGGGCATGCACTGCCTCCACGCAGCAACCCTCAGAGTCCTGAGCT GAACCAAGAAGGAGGAGGGGGTCGGGCCTCCGAGGAAGGCCTAGCCGCTGCTGCTGCCAGGAATTCCAGG TTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGCCAGAAGAGACAGAGCTTG AGGAGAGCTTGAGGAGAGCAGGAAAGGTGGGACATTGCTGCTGCTGCTCACTCAGTTCCACAGGTGGGAG GGACAGCAGGGCTTAGAGTGGGGGTCATTGTGCAGATGGGAAAACAAAGGCCCAGAGAGGGGAAGAAATG CCCAGGAGCTACCGAGGGCAGGCGACCTCAACCACAGCCCAGTGCTGGAGCTGTGAGTGGATGTAGAGCA GCGGAATATCCATTCAGCCAGCTCAGGGGAAGGACAGGGGCCCTGAAGCCAGGGGATGGAGCTGCAGGGA AGGGAGCTCAGAGAGAAGGGGAGGGGAGTCTGAGCTCAGTTTCCCGCTGCCTGAAAGGAGGGTGGTACCT ACTCCCTTCACAGGGTAACTGAATGAGAGACTGCCTGGAGGAAAGCTCTTCAAGTGTGGCCCACCCCACC CCAGTGACACCAGCCCCTGACACGGGGGAGGGAGGGCAGCATCAGGAGGGGCTTTCTGGGCACACCCAGT ACCCGTCTCTGAGCTTTCCTTGAACTGTTGCATTTTAATCCTCACAGCAGCTCAACAAGGTACATACCGT CACCATCCCCATTTTACAGATAGGGAAATTGAGGCTCGGAGCGGTTAAACAACTCACCTGAGGCCTCACA GCCAGTAAGTGGGTTCCCTGGTCTGAATGTGTGTGCTGGAGGATCCTGTGGGTCACTCGCCTGGTAGAGC CCCAAGGTGGAGGCATAAATGGGACTGGTGAATGACAGAAGGGGCAAAAATGCACTCATCCATTCACTCT GCAAGTATCTACGGCACGTACGCCAGCTCCCAAGCAGGTTTGCGGGTTGCACAGCGGGCGATGCAATCTG ATTTAGGCTTTTAAAGGGATTGCAATCAAGTGGGGCCCCACTAGCCTCAACCCTGTACCTCCCCTCCCCT CCACCCCCAGCAGTCTCCAAAGGCCTCCAACAACCCCAGAGTGGGGGCCATGTATCCAAAGAAACTCCAA GCTGTATACGGATCACACTGGTTTTCCAGGAGCAAAAACAGAAACAGGCCTGAGGCTGGTCAAAATTGAA CCTCCTCCTGCTCTGAGCAGCCTGGGGGGCAGACTAAGCAGAGGGCTGTGCAGACCCACATAAAGAGCCT ACTGTGTGCCAGGCACTTCACCCGAGGCACTTCACAAGCATGCTTGGGAATGAAACTTCCAACTCTTTGG GATGCAGGTGAAACAGTTCCTGGTTCAGAGAGGTGAAGCGGCCTGCCTGAGGCAGCACAGCTCTTCTTTA CAGATGTGCTTCCCCACCTCTACCCTGTCTCACGGCCCCCCATGCCAGCCTGACGGTTGTGTCTGCCTCA GTCATGCTCCATTTTTCCATCGGGACCATCAAGAGGGTGTTTGTGTCTAAGGCTGACTGGGTAACTTTGG ATGAGCGGTCTCTCCGCTCTGAGCCTGTTTCCTCATCTGTCAAATGGGCTCTAACCCACTCTGATCTCCC AGGGCGGCAGTAAGTCTTCAGCATCAGGCATTTTGGGGTGACTCAGTAAATGGTAGATCTTGCTACCAGT GGAACAGCCACTAAGGATTCTGCAGTGAGAGCAGAGGGCCAGCTAAGTGGTACTCTCCCAGAGACTGTCT GACTCACGCCACCCCCTCCACCTTGGACACAGGACGCTGTGGTTTCTGAGCCAGGTACAATGACTCCTTT CGGTAAGTGCAGTGGAAGCTGTACACTGCCCAGGCAAAGCGTCCGGGCAGCGTAGGCGGGCGACTCAGAT CCCAGCCAGTGGACTTAGCCCCTGTTTGCTCCTCCGATAACTGGGGTGACCTTGGTTAATATTCACCAGC AGCCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGGGCCCTGTCTCCTCAGCT TCAGGCACCACCACTGACCTGGGACAGTGAATCGTAAGTATGCCTTTCACTGCGAGAGGTTCTGGAGAGG CTTCTGAGCTCCCCATGGCCCAGGCAGGCAGCAGGTCTGGGGCAGGAGGGGGGTTGTGGAGTGGGTATCC GCCTGCTGAGGTGCAGGGCAGATGGAGAGGCTGCAGCTGAGCTCCTATTTTCATAATAACAGCAGCCATG AGGGTTGTGTCCTGTTTCCCAGTCCTGCCCGGTCCCCCCTCGGTACCTCCTGGTGGATACACTGGTTCCT GTAAGCAGAAGTGGATGAGGGTGTCTAGGTCTGCAGTCCTGGCACCCCAGGATGGGGGACACCAGCCAAG ATACAGCAACAGCAACAAAGCGCAGCCATTTCTTTCTGTTTGCACAGCTCCTCTGTCTGTCGGGGGCTCC TGTCTGTTGTCTCCTATAAGCCTCACCACCTCTCCTACTGCTTGGGCATGCATCTTTCTCCCCTTCTATA GATGAGGAGGTTAAGGTCCAGAGAGGGGTGGGGAGGAACGCCGGCTCACATTCTCCATCCCCTCCAGATA TGACCAGGAACAGACCTGTGCCAGGCCTCAGCCTTACATCAAAATGGGCCTCCCCATGCACCGTGGACCT CTGGGCCCTCCTGTCCCAGTGGAGGACAGGAAGCTGTGAGGGGCACTGTCACCCAGGGCTCAAGCTGGCA TTCCTGAATAATCGCTCTGCACCAGGCCACGGCTAAGCTCAGTGCGTGATTAAGCCTCATAACCCTCCAA GGCAGTTACTAGTGTGATTCCCATTTTACAGATGAGGAAGATGGGGACAGAGAGGTGAATAACTGGCCCC AAATCACACACCATCCATAATTCGGGCTCAGGCACCTGGCTCCAGTCCCCAAACTCTTGAACCTGGCCCT AGTGTCACTGTTTCTCTTGGGTCTCAGGCGCTGGATGGGGAACAGGAAACCTGGGCTGGACTTGAGGCCT CTCTGATGCTCGGTGACTTCAGACAGTTGCTCAACCTCTCTGTTCTCTTGGGCAAAACATGATAACCTTT GACTTCTGTCCCCTCCCCTCACCCCACCCGACCTTGATCTCTGAAGTGTTGGAAGGATTTAATTTTTCCT GCACTGAGTTTTGGAGACAGGTCAAAAAGATGACCAAGGCCAAGGTGGCCAGTTTCCTATAGAACGCCTC TAAAAGACCTGCAGCAATAGCAGCAAGAACTGGTATTCTCGAGAACTTGCTGCGCAGCAGGCACTTCTTG GCATTTTATGTGTATTTAATTTCACAATAGCTCTATGACAAAGTCCACCTTTCTCATCTCCAGGAAACTG AGGTTCAGAGAGGTTAAGTAACTTGTCCAAGGTCACACAGCTAATAGCAAGTTGACGTGGAGCAATCTGG CCTCAGAGCCTTTAATTTTAGCCACAGACTGATGCTCCCCTCTTCATTTAGCCAGGCTGCCTCTGAAGTT TTCTGATTCAAGACTTCTGGCTTCAGCTTTGTACACAGAGATGATTCAATGTCAGGTTTTGGAGTGAAAT CTGTTTAATCCCAGACAAAACATTTAGGATTACATCTCAGTTTTGTAAGCAAGTAGCTCTGTGATTTTTA GTGAGTTATTTAATGCTCTTTGGGGCTCAATTTTTCTATCTATAAAATAGGGCTAATAATTTGCACCTTA TAGGGTAAGCTTTGAGGACAGATTAGATGATACGGTGCCTGTAAAACACCAGGTGTTAGTAAGTGTGGCA ATGATGGTGACGCTGAGGCTGATGTTTGCTTAGCATAGGGTTAGGCAGCTGGCAGGCAGTAAACAGTTGG ATAATTTAATGGAAAATTTGCCAAACTCAGATGCTGTTCACTGCTGAGCAGGAGCCCCTTCCTGCTGAAA TGGTCCTGGGGAGTGCAGCAGGCTCTCCGGGAAGAAATCTACCATCTCTCGGGCAGGAGCTCAACCTGTG TGCAGGTACAGGGAGGGCTTCCTCACCTGGTGCCCACTCATGCATTACGTCAGTTATTCCTCATCCCTGT CCAAAGGATTCTTTTCTCCATTGTACAGCTATGAAGCTAGTGCTCAAAGAAGTGAAGTCATTTACCCCAG GCCCCCTGCCAGTAAGTGACAGGGCCTGGTCACACTTGGGTTTATTTATTGCCCAGTTCAACAGGTTGTT TGACCATAGGCGAGATTCTCTTCCCTGCACCCTGCCGGGTTGCTCTTGGTCCCTTATTTTATGCTCCCGG GTAGAAATGGTGTGAGATTAGGCAGGGAGTGGCTCGCTTCCCTGTCCCTGGCCCCGCAAAGAGTGCTCCC ACCTGCCCCGATCCCAGAAATGTCACCATGAAGCCTTCATTCTTTTGGTTTAAAGCTTGGCCTCAGTGTC CGTACACCATGGGGTACTTGGCCAGATGGCGACTTTCTCCTCTCCAGTCGCCCTCCCAGGCACTAGCTTT TAGGAGTGCAGGGTGCTGCCTCTGATAGAAGGGCCAGGAGAGAGCAGGTTTTGGAGTCCTGATGTTATAA GGAACAGCTTGGGAGGCATAATGAACCCAACATGATGCTTGAGACCAATGTCACAGCCCAATTCTGACAT TCATCATCTGAGATCTGAGGACACAGCTGTCTCAGTTCATGATCTGAGTGCTGGGAAAGCCAAGACTTGT TCCAGCTTTGTCACTGACTTGCTGTATAGCCTCAACAAGGCCCTGACCCTCTCTGGGCTTCAAACTCTTC ACTGTGAAAGGAGGAAACCAGAGTAGGTGATGTGACACCAGGAAAGATGGATGGGTGTGGGGGAATGTGC TCCTCCCAGCTGTCACCCCCTCGCCACCCTCCCTGCACCAGCCTCTCCACCTCCTTTGAGCCCAGAATTC CCCTGTCTAGGAGGGCACCTGTCTCATGCCTAGCCATGGGAATTCTCCATCTGTTTTGCTACATTGAACC CAGATGCCATTCTAACCAAGAATCCTGGCTGGGTGCAGGGGCTCTCGCCTGTAACCCCAGCACTTTGGGA GGCCAAGGCAGGCGGATCAAGAGGTCAGGAGTTCAAGACCTGCCTGGCCAACACGGTGAAACCTCAGCTC TACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCACACGCCTGTAATCCCAGCTATTTGGGAAGCTGAG ACAGAAGAATTTCTTGAACCCGGGAGGTGGAGGTTTCAGTGAGCCGAGATCACGCCACTGCACTCCACCC TGGCAGATAAAGCGAGACTCTGTCTCAAAAAAAACCCAAAAACCTATGTTAGTGTACAGAGGGCCCCAGT GAAGTCTTCTCCCAGCCCCACTTTGCACAACTGGGGAGAGTGAGGCCCCAGGACCAGAGGATTCTTGCTA AAGGCCAAGTGGATAGTGATGGCCCTGCCAGGGCTAGAAGCCACAACCTCTGGCCCTGAGGCCACTCAGC ATATTTAGTGTCCCCACCCTGCAGAGGCCCAACTCCCTCCTGACCACTGAGCCCTGTAATGATGGGGGAA TTTCCATAAGCCATGAAGGACTGCACAAAGTTCAGTTGGGAAGTGAAAGAGAAATTAAAGGGAGATGGAA ATATACAGCACTAATTTTAGCACCGTCTTTAGTTCTAACAACACTAGCTAGCTGAAGAAAAATACAAACA TGTATTATGTAATGTGTGGTCTGTTCCATTTGGATTACTTAGAGGCACGAGGGCCAGGAGAAAGGTGGTG GAGAGAAACCAGCTTTGCACTTCATTTGTTGCTTTATTGGAAGGAAACTTTTAAAAGTCCAAGGGGGTTG AAGAATCTCAATATTTGTTATTTCCAGCTTTTTTTCTCCAGTTTTTCATTTCCCAAATTCAAGGACACCT TTTTCTTTGTATTTTGTTAAGATGATGGTTTTGGTTTTGTGACTAGTAGTTAACAATGTGGCTGCCGGGC ATATTCTCCTCAGCTAGGACCTCAGTTTTCCCATCTGTGAAGACGGCAGGTTCTACCTAGGGGGCTGCAG GCTGGTGGTCCGAAGCCTGGGCATATCTGGAGTAGAAGGATCACTGTGGGGCAGGGCAGGTTCTGTGTTG CTGTGGATGACGTTGACTTTGACCATTGCTCGGCAGAGCCTGCTCTCGCTGGTTCAGCCACAGGCCCCAC CACTCCCTATTGTCTCAGCCCCGGGTATGAAACATGTATTCCTCACTGGCCTATCACCTGAAGCCTTTGA ATTTGCAACACCTGCCAACCCCTCCCTCAAAAGAGTTGCCCTCTCAGATCCTTTTGATGTAAGGTTTGGT GTTGAGACTTATTTCACTAAATTCTCATACATAAACATCACTTTATGTATGAGGCAAAATGAGGACCAGG GAGATGAATGACTTGTCCTGGCTCATACACCTGGAAAGTGACAGAGTCAGATTAGATCCCAGGTCTATCT GAAGTTAAAAGAGGTGTCTTTTCACTTCCCACCTCCTCCATCTACTTTAAAGCAGCACAAACCCCTGCTT TCAAGGAGAGATGAGCGTCTCTAAAGCCCCTGACAGCAAGAGCCCAGAACTGGGACACCATTAGTGACCC AGACGGCAGGTAAGCTGACTGCAGGAGCATCAGCCTATTCTTGTGTCTGGGACCACAGAGCATTGTGGGG ACAGCCCCGTCTCTTGGGAAAAAAACCCTAAGGGCTGAGGATCCTTGTGAGTGTTGGGTGGGAACAGCTC CCAGGAGGTTTAATCACAGCCCCTCCATGCTCTCTAGCTGTTGCCATTGTGCAAGATGCATTTCCCTTCT GTGCAGCAGTTTCCCTGGCCACTAAATAGTGGGATTAGATAGAAGCCCTCCAAGGGCTTCCAGCTTGACA TGATTCTTGATTCTGATCTGGCCCGATTCCTGGATAATCGTGGGCAGGCCCATTCCTCTTCTTGTGCCTC ATTTTCTTCTTTTGTAAAACAATGGCTGTACCATTTGCATCTTAGGGTCATTGCAGATGTAAGTGTTGCT GTCCAGAGCCTGGGTGCAGGACCTAGATGTAGGATTCTGGTTCTGCTACTTCCTCAGTGACATTGAATAG CTGACCTAATCTCTCTGGCTTTGGTTTCTTCATCTGTAAAAGAAGGATATTAGCATTAGCACCTCACGGG ATTGTTACAAGAAAGCAATGAATTAACACATGTGAGCACGGAGAACAGTGCTTGGCATATGGTAAGCACT ACGTACATTTTGCTATTCTTCTGATTCTTTCAGTGTTACTGATGTCGGCAAGTACTTGGCACAGGCTGGT TTAATAATCCCTAGGCACTTCCACGTGGTGTCAATCCCTGATCACTGGGAGTCATCATGTGCCTTGACTC GGGGCCTGGCCCCCCCATCTCTGTCTTGCAGGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCT GGCAGGCCTGTGCTGCCTGGTCCCTGTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACA GATACATCCCACCATGATCAGGATCACCCAACCTTCAACAAGATCACCCCCAACCTGGCTGAGTTCGCCT TCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGAGCATCGC TACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAAT TTCAACCTCACGGAGATTCCGGAGGCTCAGATCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACC AGCCAGACAGCCAGCTCCAGCTGACCACCGGCAATGGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGA TAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAA GAGGCCAAGAAACAGATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGG AGCTTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGTAAGGTTGCTCAACCAGC CTGAGCTGTTCCCATAGAAACAAGCAAAAATATTCTCAAACCATCAGTTCTTGAACTCTCCTTGGCAATG CATTATGGGCCATAGCAATGCTTTTCAGCGTGGATTCTTCAGTTTTCTACACACAAACACTAAAATGTTT TCCATCATTGAGTAATTTGAGGAAATAATAGATTAAACTGTCAAAACTACTGACAGCTCTGCAGAACTTT TCAGAGCCTTTAATGTCCTTGTGTATACTGTATATGTAGAATATATAATGCTTAGAACTATAGAACAAAT TGTAATACACTGCATAAAGGGATAGTTTCATGGAACATACTTTACACGACTCTAGTGTCCCAGAATCAGT ATCAGTTTTGCAATCTGAAAGACCTGGGTTCAAATCCTGCCTCTAACACAATTAGCTTTTGACAAAAACA ATGCATTCTACCTCTTTGAGGTGCTAATTTCTCATCTTAGCATGGACAAAATACCATTCTTGCTGTCAGG TTTTTTTAGGATTAAACAAATGACAAAGACTGTGGGGATGGTGTGTGGCATACAGCAGGTGATGGACTCT TCTGTATCTCAGGCTGCCTTCCTGCCCCTGAGGGGTTAAAATGCCAGGGTCCTGGGGGCCCCAGGGCATT CTAAGCCAGCTCCCACTGTCCCAGGAAAACAGCATAGGGGAGGGGAGGTGGGAGGCAAGGCCAGGGGCTG CTTCCTCCACTCTGAGGCTCCCTTGCTCTTGAGGCAAAGGAGGGCAGTGGAGAGCAGCCAGGCTGCAGTC AGCACAGCTAAAGTCCTGGCTCTGCTGTGGCCTTAGTGGGGGCCCAGGTCCCTCTCCAGCCCCAGTCTCC TCCTTCTGTCCAATGAGAAAGCTGGGATCAGGGGTCCCTGAGGCCCCTGTCCACTCTGCATGCCTCGATG GTGAAGCTCTGTTGGTATGGCAGAGGGGAGGCTGCTCAGGCATCTGCATTTCCCCTGCCAATCTAGAGGA TGAGGAAAGCTCTCAGGAATAGTAAGCAGAATGTTTGCCCTGGATGAATAACTGAGCTGCCAATTAACAA GGGGCAGGGAGCCTTAGACAGAAGGTACCAAATATGCCTGATGCTCCAACATTTTATTTGTAATATCCAA GACACCCTCAAATAAACATATGATTCCAATAAAAATGCACAGCCACGATGGCATCTCTTAGCCTGACATC GCCACGATGTAGAAATTCTGCATCTTCCTCTAGTTTTGAATTATCCCCACACAATCTTTTTCGGCAGCTT GGATGGTCAGTTTCAGCACCTTTTACAGATGATGAAGCTGAGCCTCGAGGGATGTGTGTCGTCAAGGGGG CTCAGGGCTTCTCAGGGAGGGGACTCATGGTTTCTTTATTCTGCTACACTCTTCCAAACCTTCACTCACC CCTGGTGATGCCCACCTTCCCCTCTCTCCAGGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGG AAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAA CATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATC TTCTTCCTGCCTGATGAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGT TCCTGGAAAATGAAGACAGAAGGTGATTCCCCAACCTGAGGGTGACCAAGAAGCTGCCCACACCTCTTAG CCATGTTGGGACTGAGGCCCATCAGGACTGGCCAGAGGGCTGAGGAGGGTGAACCCCACATCCCTGGGTC ACTGCTACTCTGTATAAACTTGGCTTCCAGAATGAGGCCACCACTGAGTTCAGGCAGCGCCATCCATGCT CCATGAGGAGGACAGTACCCAGGGGTGAGGAGGTAAAGGTCTCGTCCCTGGGGACTTCCCACTCCAGTGT GGACACTGTCCCTTCCCAATATCCAGTGCCCAGGGCAGGGACAGCAGCACCACCACACGTTCTGGCAGAA CCAAAAAGGAACAGATGGGCTTCCTGGCAAAGGCAGCAGTGGAGTGTGGAGTTCAAGGGTAGAATGTCCC TGGGGGGACGGGGGAAGAGCCTGTGTGGCAAGGCCCAGAAAAGCAAGGTTCGGAATTGGAACAGCCAGGC CATGTTCGCAGAAGGCTTGCGTTTCTCTGTCACTTTATCGGTGCTGTTAGATTGGGTGTCCTGTAGTAAG TGATACTTAAACATGAGCCACACATTAGTGTATGTGTGTGCATTCGTGATTATGCCCATGCCCTGCTGAT CTAGTTCGTTTTGTACACTGTAAAACCAAGATGAAAATACAAAAGGTGTCGGGTTCATAATAGGAATCGA GGCTGGAATTTCTCTGTTCCATGCCAGCACCTCCTGAGGTCTCTGCTCCAGGGGTTGAGAAAGAACAAAG AGGCTGAGAGGGTAACGGATCAGAGAGCCCAGAGCCAAGCTGCCCGCTCACACCAGACCCTGCTCAGGGT GGCATTGTCTCCCCATGGAAAACCAGAGAGGAGCACTCAGCCTGGTGTGGTCACTCTTCTCTTATCCACT AAACGGTTGTCACTGGGCACTGCCACCAGCCCCGTGTTTCTCTGGGTGTAGGGCCCTGGGGATGTTACAG GCTGGGGGCCAGGTGACCCAACACTACAGGGCAAGATGAGACAGGCTTCCAGGACACCTAGAATATCAGA GGAGGTGGCATTTCAAGCTTTTGTGATTCATTCGATGTTAACATTCTTTGACTCAATGTAGAAGAGCTAA AAGTAGAACAAACCAAAGCCGAGTTCCCATCTTAGTGTGGGTGGAGGACACAGGAGTAAGTGGCAGAAAT AATCAGAAAAGAAAACACTTGCACTGTGGTGGGTCCCAGAAGAACAAGAGGAATGCTGTGCCATGCCTTG AATTTCTTTTCTGCACGACAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGAT CTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCA CAGAGGAGGCACCCCTGAAGCTCTCCAAGGTGAGATCACCCTGACGACCTTGTTGCACCCTGGTATCTGT AGGGAAGAATGTGTGGGGGCTGCAGCTCTGTCCTGAGGCTGAGGAAGGGGCCGAGGGAAACAAATGAAGA CCCAGGCTGAGCTCCTGAAGATGCCCGTGATTCACTGACACGGGACGTGGTCAAACAGCAAAGCCAGGCA GGGGACTGCTGTGCAGCTGGCACTTTCGGGGCCTCCCTTGAGGTTGTGTCACTGACCCTGAATTTCAACT TTGCCCAAGACCTTCTAGACATTGGGCCTTGATTTATCCATACTGACACAGAAAGGTTTGGGCTAAGTTG TTTCAAAGGAATTTCTGACTCCTTCGATCTGTGAGATTTGGTGTCTGAATTAATGAATGATTTCAGCTAA AGATGACACTTATTTTGGAAAACTAAAGGCGACCAATGAACAACTGCAGTTCCATGAATGGCTGCATTAT CTTGGGGTCTGGGCACTGTGAAGGTCACTGCCAGGGTCCGTGTCCTCAAGGAGCTTCAAGCCGTGTACTA GAAAGGAGAGAGCCCTGGAGGCAGACGTGGAGTGACGATGCTCTTCCCTGTTCTGAGTTGTGGGTGCACC TGAGCAGGGGGAGAGGCGCTTGTCAGGAAGATGGACAGAGGGGAGCCAGCCCCATCAGCCAAAGCCTTGA GGAGGAGCAAGGCCTATGTGACAGGGAGGGAGAGGATGTGCAGGGCCAGGGCCGTCCAGGGGGAGTGAGC GCTTCCTGGGAGGTGTCCACGTGAGCCTTGCTCGAGGCCTGGGATCAGCCTTACAACGTGTCTCTGCTTC TCTCCCCTCCAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCA TGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAAT GATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTGCCT CTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACATTAAAGAAGGGTTGAGCTGG TCCCTGCCTGCATGTGACTGTAAATCCCTCCCATGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGT ATGTGGGCTCCAGGTAACAGTGCTGTCTTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTA GGCACATGCTGGGCTTGAATCCAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTG GAGGGCTCCAGTCTTCCTTGTCCTGTCTTGGAGTCCCCAAGAAGGAATCACAGGGGAGGAACCAGATACC AGCCATGACCCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCCCCACCCAGA GTTGCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGCCTG ATCGTGCCGTGGCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTCCTCTTGACC CGCTGTCACCTAACCAGACTCGGGCCCTGCACCTCTCAGGCACTTCTGGAAAATGACTGAGGCAGATTCT TCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTTGTCCTTCCATCGCTGCCCCAG AAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCCAGATGAAGAGGAGGGTCTCTGCTTTGT TTTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGCAGGCCCCAGAAGACCATTACCCTATATCCCTTC TCCTCCCTAGTCACATGGCCATAGGCCTGCTGATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTAT GGGAGAGGAAGCACATCACCCATTGACCCCCGCAACCCCTCCCTTTCCTCCTCTGAGTCCCGACTGGGGC CACATGCAGCCTGACTTCTTTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGCAGCTCCAGT GCCACGGCAGGAGGCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGG CCCTGCTAAAGGACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGT CTCTACCAGGAATGGCCTTGTCCTATGGAAGGCACTGCCCCATCCCAAACTAATCTAGGAATCACTGTCT AACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACCAAATAGTGATTTCGATAGT TCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACCGACTGTTTCCCACACAA GTCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCACAAATACATTAAAGATATGGCCA TCACCAAGCCCCCTAGGATGACACCAGACCTGAGAGTCTGAAGACCTGGATCCAAGTTCTGACTTTTCCC CCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAACCTCTCTGAGCCCCAGTCATTGCTAGTAAGACCTG CCTTTGAGTTGGTATGATGTTCAAGTTAGATAACAAAATGTTTATACCCATTAGAACAGAGAATAAATAG AACTACATTTCTTGCA Download Select all
Length	13946
OMIM ID	107400
HGNC ID	HGNC:8941
Unigene ID	Hs.525557
Ensembl ID	ENSG00000197249
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001002235.2
Exon	join(1..236,7452..8101,9552..9822,11082..11229, 12053..13946)
mRNA Sequence	>5265 TGGGCAGGAACTGGGCACTGTGCCCAGGGCATGCACTGCCTCCACGCAGCAACCCTCAGAGTCC TGAGCTGAACCAAGAAGGAGGAGGGGGTCGGGCCTCCGAGGAAGGCCTAGCCGCTGCTGCTGCC AGGAATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGC CAGAAGAGACAGAGCTTGAGGAGAGCTTGAGGAGAGCAGGAAAGGGCGGCAGTAAGTCTTCAGC ATCAGGCATTTTGGGGTGACTCAGTAAATGGTAGATCTTGCTACCAGTGGAACAGCCACTAAGG ATTCTGCAGTGAGAGCAGAGGGCCAGCTAAGTGGTACTCTCCCAGAGACTGTCTGACTCACGCC ACCCCCTCCACCTTGGACACAGGACGCTGTGGTTTCTGAGCCAGGTACAATGACTCCTTTCGCA GCCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGGGCCCTGTCTCCT CAGCTTCAGGCACCACCACTGACCTGGGACAGTGAATCGACAATGCCGTCTTCTGTCTCGTGGG GCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCCCTGTCTCCCTGGCTGAGGATCCCCAGGG AGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTTCAACAAGATC ACCCCCAACCTGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCA CCAATATCTTCTTCTCCCCAGTGAGCATCGCTACAGCCTTTGCAATGCTCTCCCTGGGGACCAA GGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCT CAGATCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGC TGACCACCGGCAATGGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGA TGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAAGAGGCCAAG AAACAGATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGC TTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAATGGGAGAGACC CTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTG CCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGC TGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACA GCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGG TCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCTGG GTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGC ACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAA GCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACA AACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGT GAATCCCACCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTC CCTGGATGACATTAAAGAAGGGTTGAGCTGGTCCCTGCCTGCATGTGACTGTAAATCCCTCCCA TGTTTTCTCTGAGTCTCCCTTTGCCTGCTGAGGCTGTATGTGGGCTCCAGGTAACAGTGCTGTC TTCGGGCCCCCTGAACTGTGTTCATGGAGCATCTGGCTGGGTAGGCACATGCTGGGCTTGAATC CAGGGGGGACTGAATCCTCAGCTTACGGACCTGGGCCCATCTGTTTCTGGAGGGCTCCAGTCTT CCTTGTCCTGTCTTGGAGTCCCCAAGAAGGAATCACAGGGGAGGAACCAGATACCAGCCATGAC CCCAGGCTCCACCAAGCATCTTCATGTCCCCCTGCTCATCCCCCACTCCCCCCCACCCAGAGTT GCTCATCCTGCCAGGGCTGGCTGTGCCCACCCCAAGGCTGCCCTCCTGGGGGCCCCAGAACTGC CTGATCGTGCCGTGGCCCAGTTTTGTGGCATCTGCAGCAACACAAGAGAGAGGACAATGTCCTC CTCTTGACCCGCTGTCACCTAACCAGACTCGGGCCCTGCACCTCTCAGGCACTTCTGGAAAATG ACTGAGGCAGATTCTTCCTGAAGCCCATTCTCCATGGGGCAACAAGGACACCTATTCTGTCCTT GTCCTTCCATCGCTGCCCCAGAAAGCCTCACATATCTCCGTTTAGAATCAGGTCCCTTCTCCCC AGATGAAGAGGAGGGTCTCTGCTTTGTTTTCTCTATCTCCTCCTCAGACTTGACCAGGCCCAGC AGGCCCCAGAAGACCATTACCCTATATCCCTTCTCCTCCCTAGTCACATGGCCATAGGCCTGCT GATGGCTCAGGAAGGCCATTGCAAGGACTCCTCAGCTATGGGAGAGGAAGCACATCACCCATTG ACCCCCGCAACCCCTCCCTTTCCTCCTCTGAGTCCCGACTGGGGCCACATGCAGCCTGACTTCT TTGTGCCTGTTGCTGTCCCTGCAGTCTTCAGAGGGCCACCGCAGCTCCAGTGCCACGGCAGGAG GCTGTTCCTGAATAGCCCCTGTGGTAAGGGCCAGGAGAGTCCTTCCATCCTCCAAGGCCCTGCT AAAGGACACAGCAGCCAGGAAGTCCCCTGGGCCCCTAGCTGAAGGACAGCCTGCTCCCTCCGTC TCTACCAGGAATGGCCTTGTCCTATGGAAGGCACTGCCCCATCCCAAACTAATCTAGGAATCAC TGTCTAACCACTCACTGTCATGAATGTGTACTTAAAGGATGAGGTTGAGTCATACCAAATAGTG ATTTCGATAGTTCAAAATGGTGAAATTAGCAATTCTACATGATTCAGTCTAATCAATGGATACC GACTGTTTCCCACACAAGTCTCCTGTTCTCTTAAGCTTACTCACTGACAGCCTTTCACTCTCCA CAAATACATTAAAGATATGGCCATCACCAAGCCCCCTAGGATGACACCAGACCTGAGAGTCTGA AGACCTGGATCCAAGTTCTGACTTTTCCCCCTGACAGCTGTGTGACCTTCGTGAAGTCGCCAAA CCTCTCTGAGCCCCAGTCATTGCTAGTAAGACCTGCCTTTGAGTTGGTATGATGTTCAAGTTAG ATAACAAAATGTTTATACCCATTAGAACAGAGAATAAATAGAACTACATTTCTTGCA Download Select all
Length	3513

CDS Information

Location	join(7456..8101,9552..9822,11082..11229,12053..12244)
CDS Sequence	>gi\|189163526:555-1811 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 2, mRNA ATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCCCTGTCTCCCTGG CTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTT CAACAAGATCACCCCCAACCTGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAAC AGCACCAATATCTTCTTCTCCCCAGTGAGCATCGCTACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGG CTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCTCAGATCCA TGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCAAT GGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACT CAGAAGCCTTCACTGTCAACTTCGGGGACACCGAAGAGGCCAAGAAACAGATCAACGATTACGTGGAGAA GGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGCTTGACAGAGACACAGTTTTTGCTCTGGTGAAT TACATCTTCTTTAAAGGCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACG TGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAA GAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGAT GAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAG ACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACCTATGATCTGAAGAGCGTCCT GGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCC CTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGG CCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTT AATGATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGTGAATCCCACCCAAAAATAA Download Select all
CCDS ID	CCDS9925.1

Protein Information

Protein ID	NP_000286.3
Protein Name	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Molecular Wt. (Da)	44325
Protein Sequence	>5265 MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQ LAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLN QPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGK IVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHC KKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGT YDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSI PPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK Download Select all
Length	418
Uniprot ID	P02462
Ensembl Protein ID	ENSP00000364979

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	107
C	S-Nitrosylation	256
N	Glycosylation	271
N	Glycosylation	70
N	Glycosylation	107
C	S-Nitrosylation	256
N	Glycosylation	271
N	Glycosylation	70
N	Glycosylation	107
C	S-Nitrosylation	256
N	Glycosylation	271
N	Glycosylation	70
F	Proteolytic Cleavage	376
F	Proteolytic Cleavage	376
F	Proteolytic Cleavage	376
A	Proteolytic Cleavage	24
A	Proteolytic Cleavage	24
A	Proteolytic Cleavage	24
A	Proteolytic Cleavage	374
T	Phosphorylation	333
T	Phosphorylation	333
T	Phosphorylation	333
S	Phosphorylation	383
S	Phosphorylation	383
S	Phosphorylation	383

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1504	CTRB1	345	NP_001897.4	in vitro	6983488
1511	CTSG	289	NP_001902.1	in vitro	15131125
1990	CELA1	553	NP_001962.3	in vitro;in vivo	619 197 961 536 321 000 000
1991	ELANE	554	NP_001963.1	in vitro	1 086 701 416 321 980
5644	PRSS1	2039	NP_002760.1	in vitro	11057674
5657	PRTN3	1512	NP_002768.3	in vitro	12114510

Pathway Information

Pathway Name	Pathway ID
Complement and coagulation cascades	hsa04610

Structure Information

PDB ID	1ATU
Resolution	2.7
Method	X-RAY DIFFRACTION
Chains	A
Molecule	ALPHA-1-ANTITRYPSIN
Model	View

Domain Information

ID	Location	Description
cd02056	55-412	alpha-1-antitrypsin_like
cl00137	55-412	SERPIN superfamily
smart00093	59-415	SERPIN
pfam00079	52-415	Serpin
cd00172	53-412	SERPIN
cd02058	57-415	PAI-2
cd02059	55-415	ovalbumin_like
cd02044	56-415	ov-serpin
cd02055	49-412	PZI
cd02049	53-412	bacterial_SERPIN
cd02048	54-415	neuroserpin
COG4826	57-415	SERPIN
cd02047	55-416	HCII
cd02052	48-415	PEDF
cd02051	55-415	PAI-1_nexin-1
cd02045	55-412	antithrombin-III_like
cd02046	55-412	hsp47
cd02057	57-415	maspin_like
cd02054	54-415	angiotensinogen
cd02043	63-415	plant_SERPIN
cd02050	54-412	C1_inh
cd02053	57-412	alpha2AP
PHA02948	62-415	PHA02948
PHA02660	48-415	PHA02660

Ontology Information

HPRD ID	2364
Molecular Class	Protease inhibitor
Molecular Function	Extracellular matrix structural constituent (GO:0005201)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO