Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC39A14 | 23516 | solute carrier family 39 (zinc transporter), member 14 | 8 | KIAA0062, NET34, ZIP14 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22173985 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 244 Stage : - | Exon-specific quantitative RT-PCR | Splicing alteration | - | SLC39A14-exon4B transcript variant is a CRC biomarker with high sensitivity and organ-confined specificity. Exon-specific quantitative RT-PCR analyses across 136 Stage I-IV CRC samples and 44 normal colonic mucosa samples showed complete cancer-specificity, as well as 94% sensitivity of SLC39A14-exon4B relative to SLC39A14-exon4A expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[ | Chromosome | 8 |
| Location | 8p21.2 |
| Start | 22367249 |
| End | 22434129 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 66881 |
| OMIM ID | 608736 |
| HGNC ID | HGNC:20858 |
| Unigene ID | Hs.491232 |
| Ensembl ID | ENSG00000104635 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001135154.1 |
|---|---|
| Exon | join(1..160,37448..37732,41062..41248,44789..44958, 47532..47654,48521..48709,48825..49032,50403..50587, 66643..66881) | mRNA Sequence | Download Select all |
| Length | 4699 |
CDS Information
| Location | join(25970..25984,37448..37732,41062..41248,44789..44958, 47532..47654,48521..48709,48825..49032,50403..50587, 52304..52450) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001121903.1 |
|---|---|
| Protein Name | solute carrier family 39 (zinc transporter), member 14 |
| Molecular Wt. (Da) | 50842 |
| Protein Sequence | Download Select all |
| Length | 492 |
| Uniprot ID | P35968 |
| Ensembl Protein ID | ENSP00000263923 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 76 |
| N | Glycosylation | 101 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02535 | 151-483 | Zip |
| cl00437 | 151-483 | Zip superfamily |
| COG0428 | 334-482 | ZupT |
Ontology Information
| HPRD ID | 4475 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.