CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SLC3A2	6520	Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	11	4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
17192196	2006	Cell line : - Source : Biochain Institute, Inc. (Hayward, CA). Sample Type : CRC tumor and normal tissue, Blood sample No. of Sample : 10 matched-pairs primary colon tumor and adjascent tissue Stage : -	Microarray, Exon-centric array (GeneChip Human Exon 1.0 ST), RT-PCR.	Differential splicing	-	Transcripts for SLC3A2 are shifted to a higher molecular weight, indicating the inclusion of various combinations of exons 2, 3 and 4 in tumor samples that are much less prevalent in normal tissue.
20522643	2010	Cell line : HCT 116 Source : Jackson Laboratory Sample Type : Mouse model No. of Sample : - Stage : -	Polyamine transport assay in cells, Western blot analysis and Bicinchoninic acid (BCA) protein assay	Up-regulation	-	-
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue, Blood sample No. of Sample : 63 CRC patient samples Stage : -	Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.	Up-regulation	7.3	-

Gene Details

Chromosome: 11; NC_000011.9 (62623484..62656355)
View Larger Image

Gene Type	protein coding
Gene Family	Solute carriers
Description	This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Chromosome	11
Location	11q13
Start	62856012
End	62888883
Strand	+
Gene Sequence	>gi\|568815587:62856012-62888883 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly AGTTCCAGGGAAGGAGGGCGTAGACAAAGCGCCACCTGAACTTGCGGCGCGAAAAAGGCGCGCATGCGTC CTACGGGAGCGTGCTGGCTCACCGACCGCATTGCGGCTTGGTTTTCTCACCCAGTGCATGTGGCAGGAGC GGTGAGATCACTGCCTCACGGCGATCCTGGACTGACGGTCACGACTGCCTACCCTCTAACCCTGTTCTGA GCTGCCCCTTGCCCACACACCCCAAACCTGTGTGCAGGATCCGCCTCCATGGAGCTACAGCCTCCTGAAG CCTCGATCGCCGTCGTGTCGATTCCGCGCCAGTTGCCTGGCTCACATTCGGAGGCTGGTGTCCAGGGTCT CAGCGCGGGGGACGACTCAGGTACTGGATCCCGGGCTAAGCTCGGGAGGAGGTCCCCTTTGGTGGGGCCA TTTCGGGAAAGTATGTCAGGACGTAAGTGCTTCACTGAAGACAGGATCTGATTTTTTCCTAACTGGTTCC CTATGTCCTGCCTTCTGGTGCGTTTTCTTTAGATCTTGGACTACTACGGGCCAACATTAGCTAACATTTA TGGAGCACCGTTTTAAGCACACTATATGAATCGATTAATCCACCAAAATCCCAAGAGCTAGGTAGGATGA CAACCCCCATTTTATTGATGGGGAACCCTAAAGAGCTCCGGCGGTGCTGCCTGCTGCAACTCCTGCCTGA TCAATATGGTTGCAGTCAGCTATAGACTGTTTTACTGAGACCGGACAACATTAGTTCAGTCGTTTGTGGT AAACATCTACGTGTACAAGCACACTTTATAAACATTTTTTTCTTTCTTTTTTTTTTTTTTTGAGACGGAG TTTCGCTCTTGTTGCCCAGGCTGGAATGCAATGGCCCGATCTCAGCTCACTGCATTCCACCTCCCGGGTT CAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACTGTGACCGGCTAAT TTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCCGGTCTTGAACTCCTGACCTCGGGTG ATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAAACATTTT TTTCTTTCAAGACGGAGGCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATGTCTGTTCACTGCA ACCTCCGCTTCCCAGGTTCAAGCGATTCTCCTTCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCTCCCG CCATCATCATGCCACACTAATTTTTGTGTTTTTCGGAGAGACGGGGTTTCATCATGTTGGCCAGGCTGCT CTCGAACTACTGACCTCAGGTGACCTCCTGCCTCAGCCTCCCAAACTGCTGGGATTACAGGGGTGGGCCA CCACACCCGGCCTGGCTCAGCATTTTGGGAGGCCAAGGCGGGAGGATCTCTTGAGCCCAAGAGTTCAAGA CCAGTCTAAGCAACATAGTGAGAAACCCATACCGATCTCTACAAAAAAAATAGAAAAAATTAGCCAGGAG CGGTGGTGCATGCCTGTAGCCCCAGCTGCTTGGGAGGCTAAGGTGGGAGGATTGCTTGAGCCCAGGAGGT TGAGACTGCAAATGAGCTGTGATCAAGCCACTGCACTGCACTCCAGCCTGGATGACTGAGATTGACCCTG TCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAATGTGGGACAGATAAACTGGAAAATCAAGATGGCCCAGA GTAGACAGACAAGGCTGGGGAGGTTGTGTGTGGGAATGGCAGTCGGGAAATGCTTTATAGAGTGTCTGGG CCTGAAAGGGTAGAAAGACTTGGGAGGGGAATTCCAGTTAAAGGAACAACTGGAGCACAAGCTTGGTGCT AGAAAAAGAAGGAAGTGTGTAGCTACAATTCATGAAAGATGGGCAAAAGGGGAGTATTAGAATATAAAAC TGGAAAGTATTTCCTGGGGAAAGCCAGATAAGCAGGACCTTGAATGCAAAGCTAAATCATTTGAATTATA CATAGAAAAGAAAAAAAAACCGGGGAGAGTTTTTAAGTAGGAAAGTGATAAGACATTGGGGGATAAGATG GAGACAAGGGCATTAATTAGATTGCCATAGTAGTTTAGGCAAGAGGATTCAATGCTAACAAGTATAATGG CAGTGGAAGTGGAAAAGAGGGGATTTAGGTTAGGGGTCTCCAACTCACGTACAGAAATCAGCTAAGTAAT GTAGGTAAGTGAAATGAACTGAGTTGGGACTCTGGTGAACTGGGCAGCCCTTTCACAGCTCCAGCTGATT GTTGCCTTGCGACAATATTGTCTCTGTGTGATCAGATAGTCAGTTTTCAAAAGAATCCAGAAGTCCAGAA TTGTGTATTTACTCACGTTGAAATGTTGAATTTAAAATTTTTTGGCCGGGCGTGGTGGCTCATGCCTGTA ATCCTAGCACCTTGGGAGGCCAAAGTGGGCGGATCACCTGAGGTCAGGAGTTAGAGTGAAGGGGTGGGTT GCCCCTCCACACCTGTGGATGTTTCTCCTAAGGTGGAACGAGAGACTTAGGAAAGAAAAAGACAGAGACA AAGTATAGAGAAAGAAATAAGGGGACCCGGGGAACCAGCGTTCAGCATATGGAGGATCCCGCCAGCCTCT GAGTTCCCTTAGTATTTATTGATCATTCGTGGGTGTTTCTCGAAGAGGGGGTTGTGTCAGGGCCACAAGA CAATAGTGGGGAGAGGGTCAGCAGACAAACACGTGAACAAAGGTCTTTGCATCATAGACAAGGTAAAGGA TTAAGTGCTGTGCTTTTAGATATGCATACACATAAACATCTCAATGCTTTACAAAGCAGTATTGCTGCCC GCAGATCCCACCTCCAGCCCTAAGGCGGTTTTTCCCTATCTCAGTAGATGGAACGTACAATCGGGTTTTA TACCGAGACATTCCATTGCCCAGGGACGGGCAGGAGACAGATGCCTTCCTCTTGTCTCAACTGCAAGAGG CATGCCTTCCTCTTATACTAATCCTCCTCAGCACAGACGCTTTACGGGTGTCGGGCTGGGGGACAGTCAG GTCTTTCCCTTCCCACGAGGCCATATTTCAGACTATCACATGGGGAGAAACCTTGGACAATACCTGGCTT TCCTAGGCAGAGGTCCCTGCGGCCTTCCGCAGTTTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTG ATGACTCTTAAGGAGCATGCTGCCTTCAAGCATCTGTTTAACAAAGCACATCTCGCACCGCCCTTAATCC ATTGAACCCTGAGTTTGACACAGCACATGTTTCAGAGAGCACGGGGTTGGGGGTAAGGTCACAGAATCTC AAGGCAGAAGAATTTTTCTTAGTACATAACAAAATGGAGTCTCCCATGTCTATTTCTTTCTACACAGACA CAGTAACAATCTGATCTCTCTTGCTTTTCCCCACATTAGAGACCAGCATGGCCAACATGGTGAAAACCCT TCTCTACTAAAAATTCAAAAATAAGCCGGGCGTGGTGTGGGTGCGGTGGCAGGCGATTGTAATCCTAGCT ACTTAGGAGGCTGAGGCAGGAGAAGTGGTTGAACCCGGGAGGTGGAAGTTGCAGTGAGCCAAGATCACCC CACTGCACTCCAGCCTGGGGGACAAGAGTGAGTCTCAAAAACAAACAAAAAACCAAAATATGCCCGTGGG CCAAAGGTGGCCTTTGATTGTGAGTTTGCAACCTCTTGTGAGTGACATAGAATCTACTAGAAAAGAGGGC ATTTTAAAAAAAGTAGGCTGGGTGGAGCGGCTCACGCCTGTAATCCTGAAGGGGGCCAGCCCCTCCACAC CTGTGGGTATTTCTCGTCAGGTGGGACGAGAGACTGAGAAAAGAAATAAGACACAGAGACAAAGTATAGA GGAAGAAAAGTGGACCCGGGGACTGGCGCTCAGCATACGGAGGACCCGCACCAGCACTGGTCTCTGAGTT CCCTCAGTATTTATTGATCACTATCTCTACCATCTCAGCCAGAGGGATGTGGCAGGACTATAGGGTAATG GTGGGGAGAGGGTCAGCAGGAAAACATGTGAGCAAAGGACTCTGTGTCATAAATAAGTTTAAGGAAAGGT GCTGTGCCTTGATGTGCACGTAGGCCACATTTATGATTGACTTTACACAAACATCTCAGCGCAGTAAAGA GCAGTATTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATC ACGAGGTCAGGAGTTCGAGACCATCCTGGTTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAA AAAATTAGCCGGGTGTGATGGCGTGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGT GTGAAACCTGGGCGACAAGGCGAGACTCTGTCTCAAAAAAAAAAAAAAAGCAGTATTGCCGCCAGCATGT CTAACCTCCAGCCATAAGGCGGTTTTCTCCTATCTCAGTAAATAGAATGTACAATCGGGTTTTATACAGA GATATTCCATTCCCAGGGACTAGCAGGAGACAGATGCCTTCCTCTTATCTCAACTGCAAAGAGGCCTTCC TCTTTCACTAATCCTTCTCAGCACAGACCCTTTATGGGTGTCTGGGGGACGGTCAGGTCTTTCCATTCCC ATGAGGCCATATCTCAGGCTGTCTCAGTGGAGAGAAACCTTGGACGATACCCAGGCTTTCTTGGGCAGAG GTCCCTGCGGCCTTCCGCAGTGCACTGTGTCCCTGGGTACTCGAGACTGGAGAATGGCGATGACTTTTAC CAAGCATACTGCCTGCAAACACATTTTTAACAAAGCACATCCTGCACAGCCCTAAATCCATTAAACCTTG AGTCAATACAGTGCATGTTTCTGCGAGCACAGGGTTGGGGCTAGGGTTACAGATTAACGGTGTTTCAAGG CAGAATAATTTTTCTTAGTACAGATCAAAATGGAGTTTCTTATGTCTTCCTTTTTCCACATAGACACAGT AACAGTGTGATCTCTCTTTCTTTCCCCCACATAATCCCAGCACTTTGGGAGGCCAAGGCAAGCAGACTAC TTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATATGGAGCCCGTCTCTACAAAAATAAAAATTAGCT GCGTGTGGTGGTGCATGTGTATAGTCCCAGTTCTGGGGGAGGCTGAGGTGGGGAGGATTGCTTGAGCCCA GGAGTTCAAGGCTGCAGTGAGCTTTAATTGTGCAACAAATAGAGGCCCTGTCTCAAAAAAAAAAGAGGGT TTCACTCTTGGTCACTGTAACCTCAAACTCCTGCACACAAGCAATCCTCTGGGCTGAGCTGGGACTACAG GCATGGGCCACCGTGCCCAGCTAATCTATTTTGCTTTTTGAATAGACAGAGGTCTTGCTGTGTTGCCCAG GCTGGTCTCAAACTCCTGGGCTCAAGTGATTCTCCAGCCTTGGCCTCCCAAAGCAATCCCTAGGTAACAG ACTCAGTCTGGCTTCCTGGCTCTGGCTTCTTCCCTTCTAGTTCATTCTCCACACTGTAGTCAGAGTGATC TTTACGAATAAAAACTCTGGTCGGTCGGGCACAGTGGCTCATGCCTGTAATTCCAGCACGTTGGGAGGCC TAGGCGTGTGGATCACTTGAGGTTGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTA CTAAAAATACAAAATCAGCCAGGCGTGGTGGCATATGCCTGTAATTCGAGCTACTCAGGAGGCTGAGGCA GGAGAGTCGCTTGAGAAAGGCGGAGGATGCGGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGCCAA CAAGAGCAAAACCTCTCTCAAAAAAAAAAAAAAAAAAAAAAAGTCTGGTCAGGTCCCACTTCAGCTCACA ATCAGTTCAGTGCCTCTCCATTGTCTTTAAGCTATAGCCCAAATTGATCAATACAGCCATTAAGAAGTGC TGCTAGGCCAGGCGCGGTGGCTTACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATTACCTG AGGTCAGGAGTTCAAGACCAGCCTGGGCAACATGGTGAAATCCCGTCTCTACTAAAAATACAAAAATTAG CTGGACATGTTGGAGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCATAAGAATTGCTTGAACCT GGGAGGTGGAGGCAACGATGAGCTCATCGCAACGATGAGCTGAGATCACGCCATTGCACTCCAGCCTGGG CGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGCCCTGCTTCTAACAGGGCCAATG GCTCACACCTGTAATCCCAGCACTTTGGGAGGCGAAGGTGAGAGGGTCCCTTGAGGCCAGAGGTTTGAGA CCAGCCTGGGCAACATAGTAAGATGAAACCCCCATCTCTACAGGAAAAAAGCCCTTCCTCCCTATCGCCA CCCCTCCCCCAAGCCTAAACTACCCCTTCTCACCCACAGTCAACTCCCTGGGGTTTGATTTTATCTAGGT AAATCATCCTGCTATCTCTATTGTCTAGCAGAATACAATTCACAAATAGGACTCAATATACATTTATTAG TTACCTCTATAAGTTTTTTTCAGTTTGCCTCTTTATGTTGGGAATGCTGTAAATTTTTAAATGATCTTTT CTCAGCCAATTCATTGACTGTCCTACCTTACCAAATGATTTTGCTCTTAGAGAGGTCTGGAGAGTGTTTG TTCAAGGAGCAACCCTGCCCCCACCTGGCAGCAAGAGGCACTGCCTCAATTAATAGAGGAGAAGGATATG CAAATGACCAGTGCTTGTCAGGGAACTGGCAGAGACGTGACAGTGGAGAAAAGGCTCAAATTCTTTTTGA GATGGGGTCTCATTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGTTCACTGCAACCTCTGCCT CCCAGGTTCAAGCGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCTGCAACCACTCCC AGCTGATTTTTATGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTAGTCTCGAACCCCTGAC CTTAAGTGATCAGCCTGGCTTAGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCACTCTGGGCCT CAATTTCTTTTCTTTTTGAACCAGGATCTCACTCTGTCACCTAGGCTGGAATGCAGTGTGTGATCACGGC TCACTGCAGTGTTGAACTCCTGGGCTCAGAGGATCCTCCCACCTCAGCCTCCTGAGTAACTGGGACTGTA GGCATGTGCCATCACACCCAGCTAATTCTTTAATTTTTTGGAGTGTGACAGTGCCTCACTATGGTGCCTA GGCGGGTCTCCAACTCCTGGGCTCAAGCGACCAAATTGCTGGGAAACAGGCATGAGCCACTATACCTGGC CCAACATAAATAGAATTTCCTGGGTTGTGGAGGAGTGTGACATTGAGGTGGTCTTCCAGGGAAGAGGTGC TTTTACAACTGCAGTGGGTAACATGGGTATCTGGGCTACCTGCTCATGCAATGTACTAATGTTTTCTGGT TCTGCTTTCAGCTTCATCATGAATATACCATTTCCATCTTTATATCTGACTAAAGGGTCTGTCTGACTTT ATGACTTGATAGGTCTGACAAGACCCAATTCATAATGGGGCAGTTCTGGATGCTTCATAGTCAAGCTTTC CAGTAACAGCCCTGATGCTGTTTCTCAAAAGGCACCTACTTCCCTGCTTTGGACAGCTTGGCCTTGCTCC AGAATCTCAGGGACTTGCATTGTGCTTTTGCCATAGGAGCTTGCCATAAGTTCTACACTGAATCTTTTTT TCGCTACTGATACTTTGAACCCCCAGGATCTGCTGGATTGCATGGCTTAAGTGTGCATTGCATCCTAGAC TTGATGCAGAGCCCTTTCCTGCTCAGAGTTTGAGTCAAAGTTGGCAGCTTAGCCGGTATGTGGGCTGGAG ATATATTTCTAAGTCTGGATGTGACAGACACCACACCCGTGCATTCTTTTTGTCTTTAATGGTGGCACTA ATCTCTGTCCCTCCCCAGGATGTGATACTGCTTTTGATTTACTATCATAGCTGAAGAGAGGGAGGGGTTT TAGAGATCTCTTTGTCTGTCCCACTATGATAGGTCTTACCTCTTAGGCCAAGGACCCAATGCGATTACTT CAACTCCTAAGTATATCAATCCTGTTAAATACTTGGTTTTTTTTTTTTTTGAGATGGAATGTGCTGGCTT GCAGTGGTGCCATCTGGGCTCACTGCAACTTCCACCTTCCGAGTTCAAGCAATTCTTGGTCCTCAGCCTC CCAAGCAGCTGAGGCTATAGGCGCGCACCAGCACGCCTGGCTAATTATTTTTTTTATTTTTATTTTTATT TTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTC CACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTTGCGAGTAGCTGGGATTACAGGCGCCCACCACC AAGTCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTGTCGACC TCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCC GGCCGCTAATTTTTTTTTTTGTTTTGAGACAGAGTCCCACTCTGTCGCCTAGGCTGGAGTGCAGTGGTGC AATCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCATGCCCAG TCCCCGTTTAAACACTTGGAACTGAGGAAATATCTAGTGATGGGTCCATGGACAAGCAGACTTACTATGA GCTAGTAAGTTTTGGCTAGGACTTCAGTTACTGCCTGACACCTGTAAGTCCCCACTGTAATGTGGGAATC ATGATGAAGCTTTGGGTTTCCAGGTCTCAATGTCAGCTCAGATCTTGTGCCCAAAATCCTCAAAGTGTTT AGGCATTTCCCTTTACCCAGTGTACCGTTATCTGAGTAAGTGATATGTTGACATTCTCCCTTTTAGGAGG AACTGGCAGAACCGTTACAGTTTTAGCATCCTTTCGTAGGGATTTGTGTACCTCTTCAGTAATTGAGTTT TGGATGTGAAAGTTGTTTCAGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTAAG GCAGTCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTGGCGAAACCCCATCTCTACTA AAAATACAAAAATTAGCTGGGCATGGTGGCGTGTGCCCGTAATCCCAGCTACTAGGGAGGCTGAGGCAGG AGAGTCCCTTGAACCCTGGAGGTGGAGGATGTTGCAGTGAGCCTAGATTGCACCACTGCACTCCAGCCTG GGCAACAGAGCAAGACTCTGTCTCCCCCACAAAAAAAAAAAAAAAAAAAAAAGTTGGCTTAGATCCAGGA GCTGAATCAAGGATTTTGCCTGTTTATTGTGGTGATTGCCCTTAGCTGCCTCTTCCTCCTCTATTCTTGC CTTTTTCTGTTTGTAGATGCTTAGTAGCATCCTTTTTGGCTATCCGCATATTTTTCCCCTAAGGATGCCA TGCTCTATTGTATCCACAACTCTGTGAATCAAACGCCTCATGGCTACCCCTGCAACATTGACAGTTTTAT GGTAGTTGCATATTTCTGGCTTTTGGCAGCTAAGCAATGCTACCCAGCCTCTGTTACGTGTTGGGAGATA CTTCCCCGTATATCTTGAGTAGCTCAGCTCTGACTGCTTCTCCTGTCATCAGCTGTGGACTGCTCAGAAG CCACCACTGAATTTCTAAGTGATGCTGATGTCCACCGATGTCACCAGTATATTCTTGATGGTCTTGTAAA TGTGTCCTTCGGGTCCTTTCTTGGAACACCATTCTCTGGTCTCACATAGTACAGTATAGTACGTATATCT ATTCCAGCATGCCCACTTTTTTCAGCCACTTTTTTTTTTTTTTTGGATGGAGTTTTGCTCTTGTCGCCCA GGCTGGAGTGCAATGGTACGATCTTGGCTCATTGCAACCTCTGCCTCCTGGGTTCAAGAGATTCTTCTGC CTCGGCCTCCCAAGTAGCTGGGATTACAGGTGCCTGCCGCCATCCCCAGCTAATTTTTGTATTTTTAGTA GAGACGGGGTTTCACCATGTTGGCCATGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCCTGATGGG AATGTTAATTGTGGTAGTTTCTTTGCTTTTTTTTGGCAGGTGGGGGGGTGGTCTCACTCTATTGCCCAGG CTGGAGTGCAGTGGCACGATCTTGGCTCACTGTAAACTCTATCTCCTGGGTCCAAGCTACTCTCGTGCCT CAGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGCCACCAAACCTGGCTAATTTTTGTATTTTTAATAGA GATGGGCCTTCACCATGTTGGCCAGGTTGATTGCAAGCTCCTGACCTCAGGTGATCCGCCCTCCGCAGCC TCCCAAAGTGCTGAGATTACAAGGTGAGCCACCGCATCTGGCCCTGCTTTTTTGGTCTGTGAGCCAGAAT AGTATCTGTTCTTATCCTCTAACATCTCATCAGTTCTGTACTTGAGGATACTTTATCAGATAGATTTTTG GAACAGGGAGATTGAATAAAAACTTAAACTTGCTCATCCTTTTTACAAGTCAATATAGTATTGCATTACC TCCATGAATGCTGTGGTTCTACCTTTTGGGGCAGATGTCAGTTAAAATTCAGACTGTCACATTCCACCGT ATCTTTTGGTTTCTGGAAAAAACTTTAAGGTGAATCTGCTATTTCTTTTTTCTTCTTTTTCTTTTTCTTT CTGTTTTTTTGAGATGGAGTTTCTTGTTGTGCAGGCTGGAGTGCGATGGACTGATCTCGGCTCGCCGCAA CCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGCGC TACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGATCTT GAACTCCTGACCTCAGGTGTTGCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACC GTGCCTGGCCTATTTCCCTTTATTCTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTGATACAG AGTCTCGCTCTGTCTCCAGGCTGGAGTGCAGTGGCCCGACCTTGGCTCACTGCACTCTCCGCCTCCCGGG TTCAAGCTATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGCACCATCACACCCAGCTA ATTTTTGTGTTTTTAGTAGAGACGTGGTTTCACCATGTTGGCCAGGATGGTCTCGATCCCCTGACCTTTT GATCTGCCTATCTCTGCCTCCCAAACTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCTGCTTCCCT CTTTCTTTAAATTTAATTTAATTTTTAAAATTAAGATGTTTATCTCACTATGTTGCCCAGGCTGGTCTCA AACTCTTGGCCACAAACAATCCTCCCACCTCAGCCTTTCAAAGTGCTGGGATTATAGGCATGAGCCACCA TGCCTGACCCCTTTTTTCTTTAACATTATGTTTTTGACACATTTTTGCCTATCTTTTATGTCCTGGTTCT TTCAAATTTAGTCATTTCTAGTATTCTAGTTAGAAATTTTCTACAAATTATTTTACAAATGTTCTACAAA TTATTTTTCAAAAAAAATTTTTTTTTTTTGAGACAGTCTCACTCTTGTCGCCCAGGCTGGAGTGCAATAG CATGATCTTGGCTCACTGCAACCTCTTCCACCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTA GCTGCGATTACAGCCTCCTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACA GTGTGGTCCAGGCTGGTCTCAAACTCCTGACTTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTAG GATTACAGGTGTGAGCCACCACGCCTGGCCTATTTTTCAAATTTCCAAATTTTTACTACTATAACCAGTG CTGCAGTGAAATCTTTTATATATTGTTTTGTGTACATGTGTGAGAGTTTCTCTAGGGTATGAATCTAGCT AGGACTGTTGGTGGGTAAAAGGGTATTTTCATTCTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCT CTTGCCCAGGCTGGAGTGCAGTGGCACGATCTCCACTCACTGCAACCTCTGCCTCCTGGGTTCACGCCAT TCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCTGGCTAATTTTTTGTA TTTTTAGTGGAGACGGGGTTTCACCATGTTAGCCAGGATGGTGTTGATCTCCTCACCTCGTGATCTGCCC GCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCAAGGGTATTTTCATTCT ATAGGCGGTTGCAAATTGCTCTCCTAGAACGGATGTACCAACTAATGTTGCCACTTATGCAATTTGTATC CTCCTAATCACTTGGTTTAGTCAGATGTTTTCATATTGCCAATCTGACGGACATGAAATTCTATTTTCTT GCCATTTTAATTTGCACTTTCCAGATTACTAATGAGGTTTTGTAATCTTTACCATTCTTTTGTATATCTA ATTTTGTGAATTGGCTTTTTTGTTTTTGAGACGGTCTCATTCTGTCGCCCAGGCTGGAGTGCAGTGGTGT GATTTCAGTTCACTGCAACTTCTGCCTCCCGTGTTCAAGTGATTCTCCCACCTCAGCCTCCCGAATAGCT GGGACGACAGGCTTGCACCACCACGCCCCGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATG TTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGAT TACAGGTGTGAGACACCACGCCTGGCCTGAATTGGCTATTTCTATTATGTGATTAGAATAGAATTTCTAT TTGGTGGGTGCCGTGGCTTACATCTGTAATCCCTGCACTTTGGGAGGCCGAGATGGGCGGATCACAAGGT CAGGAGATCGAGACCATCCTGGCTAATACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCA GGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGG AGGCGGAGGTTGCAGTGAGGCGAGATTGCACCACTGCACTCCAGCCTGGGTGATAGAGCGAGACTCCATC TCAAAAAAAAAAAAAAAAAAAAAAAGAATAGAATTTCTATTTGGTGATTTTTTTTCTTGATGATTATTGG TTTTTTTCGTACTGGTTTTTAGTGATAATTTATATGTTTCATCTACTTTGTTAGCTATATTAGTTTCAGA TAGTATGTCTTCTATTTGTGGCTTGTCTTTTCAGTTTGTTATGGCAAATTGTGATGCATAATTTTTTCTC TTTTAATGTTGCACAATTTATTTGTCTTTTTCTTCATGATTTATTCTTTTGTGTATTTTTTTTTTTTTTG AGTTGGAGTCTTGCTCTGTCGCCCAGGTTGGAGTGCAGTGGCGCGATCTCGGCTCATTGCAACCTCTGCC TCCCGGGTTCAAGCTATTCTCCTGCCTCAGCCTCTTGAGTAGCTGAGATTACAGGTGCCTGCCACCACGC CCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGCTAGGCTGCTCTCTGGCCAGGC TTGTCTCGAACTCCTGACCTTGTGATCTGCCCGCCCTGGTCTCCCAAAGTGCTGGGATTACAGACGTGAG CCACCGCACCTGGCCTCTTTTGTTTCTTCTTTAAAACTCTTTTCTTATCCTGAGGTCAGAAAGATATTCT TATTTTTTTCTGAAATTTTATTTATTTACTTATTTATTTATTTTTTTTTGAGACAGAGTCTCACTTTGTT GCCAGCCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCTATTCTC CTGCCTCAGCCTCCCAGGTAGATGGGACTACAGGTGTGCGTCACCACGCCCAGCTAATTTTTGTATTTTT AGTAGAGATGGGGTTTTTTTTACCATGTTGGCCAGGATGGTCTTGATCTCGTGACCTTGTGATCCGCCCG CCTTGGCTTCCCAAAGTACTGGGATTACAGGTGTGAGCCACCGCGCCTGGCCTATTTGATTACTTAGAAT ATAATTTTGTGATTGGTGTGAAGTAGTGATCTAATTTTATTTTTTTATAGTACCATTTGGTAAATAGTTC ATTCTTTCCCCACTGATTATATTATCTCTGTCGTATATTGTTTCAAGTATGCATGAGTTATTTTTAGGCT CGTTTTCTGTTCCGTTGGACACTTGCCCATCCCTGTGTCTTTAGCATACTATGATTGTTACTTTATACAT TATTATTATTATTATTTTTTTTTTTTTTTGTAGAGTTGGGGTCTCACTGTGTTGCCCAGACTGGTCTCGA ACTCTTGGCCTCAGGTGATCCTCTTCCCTCAGCTTCCCAGAATGCCGAGATGATAGGTAATAATAATAAT AATAATTATTATTATTATTATTATTATTATTATTATTATTATTTGAGATGGAGTCTTGCTCTGTTGCCCA GGCTGGAGTGCACTGGCGCGATCTCCACTTACTGCAAGCTCCGCCTCCTGGGTTCAAGGTTCAGGTGTTT CTCCTGCCTCAGCTTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCTGGCTAATTTTTGTATT TTTAGTAGAGACGAGTTTCAGCATATTGGCCAGGCTGGTCTTAAACTCCTGACCTTGTGATCCGCCTGCC TTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATTGCGCCCGGCCTGATTACAGGTAATTATTCC TTTAGCAAATAACATGCCTGCTGCCTGGTAGGGCTTATCTTTTTTTTTTTTTTTTGGTGTGAAGTCTTGC TCTGTTGCCCAGGCTGCAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGC AATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTTCAGGCACCCGCCACCATGCCTGACTAATTTTTT GTATTTTTAGTAGAGACGGAGTTTTGCCTCATTGGCCAGCCTGGTCTCGAACTCCTGATCTCAGGTTATC CGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAACCATACTTTATATA ATATTATTATTATTATTATTTGTAGAGACGGGGTCTGACTGTGTTACCCAGGCTGGTCTTCAACTCTTGG CCTCAAGTGATCCTCCTGCCTTAGCTTCCAAGAATGCTGAGGTTACAGGTAATTATTATTTTAGCAAATA ACATGCTTGCTATCTGGTAGAATTTGTCTTTAAAAATACGATTTTTTTTCTTTAAAGATATCTTTACTAT TCTCTGCCCTTTTCTCTTGCACATGAATTATAGAGTCATCTTACAAAGTTCTCACCACCAGATATTAAGA TTTGTATTAGAATTGCATTTGGATTTTTAGATTGTTTGGGGAGCACTAATTTCTTTATGACATCAAATCT TTATTTTATTATTATTATTATTATTTTTTGAGATGGAATCTTGCTCTGTCGCCCAGGCTGGAGTGCGGTG GCGTGATCACAGCTCACTGCAACCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGT GGCTGGGACTACAGGCACACACCGCCACGCCTGGCTAAATTTTTTTTGTATTTTTAGTAGAGACGGGGTT TCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGTCTGCCTGGCCTCCCAAAGTGCT GGGATTACAGGCGTAAGCCACTGCACCTGGCCCTCTGCTTTTTTAAAAAAAGAATTCATTAGCTGAGTGC AGTGGCTCACGCCTCTAATGCTAGCACTTTGGGAGGCAGATCACTTGAACCCGGGAGTTCGAGACCAGCT TGGACAACATGACAAAACCCTGTCTCTACCAAAAAATACAAAAATTAGCCAGGCATGGTTGCATGCTCCT GTAATACCAGCTGTTCAGGAGGCTGAGGTGGGAGGATTGCTTAAGCTGAGGAAGTCAAGGCTGTAGTAAG CCAAGATCACATTACTGCACTCCAGCCTGGGCAACAGAGAGAGACCCTGTCTCAAAAAAACCCAAGAAAC AGAAAACAGAATTTGTCTTTAGTTTCTCTATAGTCCAGCCTCCTTTTAAGAGACTTGGTGTTGAAATTAA CCAATTTTTTCTTTCTTTGAGACGGAGTTTCACTCTTCTTGGCCAGGCTAGAGTGCAATGGCTCGATCTC GGCTCACTGCAACCTCTGCCTCCCCGGTTCAAGTGATTCTCCTGCCTTATTCTCCTGAGTAGCTAGGATT ACAGGCATGTGCCACCACACCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCA GGCTGGTGTTTAACTCCTGCCCTCAGGTGATCCGCCCGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGC GTGAGCCACTGTGCCTGGCCTAACCAATTTTTTAGTTGCAGAATGAGTGATATTTCAAATTCAATTTTCT GTTACAGCATACCATACTCTAAATATCTACTTCTCAATATTTTATATTCTCTTTCACCTTATTGATTATA AAATATATATATATTTTTCAGACAGGGTCTCGCTCTGTGGCCTTGGCTGGAGTGCAGTGGTGTGATCTCA GCTTACTGCACCCTCAACTTCCCAGGCTCAAGTGATACCTCCCACCTCAGCCTCCCGAGTAGCTGGGACT ACAGGCATGTGCAACCACACTCAGCTAATTTAAAAAATTTTTTGTGGCCGGGCCTGGTGGCTCACGTCTG TAATCCTAGCATTTTGGGAGGCCAAGTCGGGCAGATCATGAGGTCAGGAGTTCGAGAACAGCCTGGCCAA CATTAGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGTGGGCCCCTGTAGTCC CAGGTACTCTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGA TCGCACCACTGCACACCAGCCAGGGTGACAGTGCGAAACTCTGTCTCAAAAAAAAAAAAAAATTTTGTAC AGACAAGGTCTCACTATATTGCCCAATCTGGTCTTGAACTCCTGGGATCAAGTAATCCTCCTACCTTGGC CTTGCAAAGTGCTGGGAGTACTAGGTGTGAGCCACCACACCCGGCCAGCTAATTAAAATCAAACTTTTTT TTATAGAGACACGGGGTCTTGCTACGTGGCCCTGTCTGGTCTCAAACTTCTGGGCTCTAATGATTCTCCC ATTTTGGCCTCCCAAATTACAGGCGTGAGCCATGGCACCTGGCCAGGCTCATCAGTTATTTGTTTTTTTG TTTATTTCTAATTTTTATTTTAATTATTTTAGACCAGTTCTAGCTCTGTTGCCCAGGCTAGAGTGCAGTG GTGCAATCATAACTCACTGTAGCTTCAACCTCCTGGGCTCAAGTGGTCCCTCCCACCTCAGCTTCCCAAG TAGCTGGGACCCCAGGTACTTGCACCATGCCCAGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTGGAGAAAGAGTCTCAAATAATTTATGTAGATCTTCCCTCTGCCCAGAGATACAGAGTTTAACTCT GTACATCTTGAGTGCAGGCTGCGCTTAGTGATTCTCTTCCTCAGAGTGTGATGACAAAGTTTTGGAGGGC CAGGGGAGGGAGAAAATGAGGATGCAGTATTGTGTGATCATGACTGCAGAAATAGCTGCTGTTGGAGGGC CTCAGTGATCATTTTAAGGTCTCTTATTGCTACTTATCTTTTTTGATGAGATTAAGTATTCTGTCTCTGA TCAGTTGAATATCTGATGTCATTAATCCAAGGATAATATGTTAAAAGTACTACCCCATATTTTCCACATA CTGACCTGCTATTTCTCTGGTGTTTATCTTTTAGTATTTGGTTTCATTTGAGAGAATGGCTTGCTGCAAT GTTTTTCATTTGTCTAACTTACTTGAATACTGGATACTTTTCAGATGGTGCATTTATTTCTCTTCTCCTA AGAGATGACTTTGGTTCTATTTCTTTCACTCTTTCTGGCTTTTATCCCCACTTTGCATTCTTCACCCTTT AGTAAGACAACCCTGACAGGTCTCTTCTTTAGCAGCCAGTGTCCCTCCTATAGGATTCATAGTAACAATT AATAGTATTCTGACATGGGTTCTTCAGATAGTAGCTGCGAAGTGAACTGCTTTAGTTGGAGTCTTTTTCT CTGCTTTAATTTCAGCCACGCTTTGACTTCCAAATGCTCAATTCCTCACCCATCTTTCCTTTTTCTTTTT CTTTTTTTTTTTTTTGGAGACAGAGTCTTGCTCTGTCACCGAGGCTGGAGTGCAGTGTAATCTCAGCTTA CTGCAACCTCCGCCTCCCAGGTTGAAGGGATTCTCCTGCCTCAGCCAAGTAGCTGGGATTACAGGCACCC GCCATCGTGTGCGACTAATTTTTGTATTTTTAGTAGAGATGGGGATTTGCCATGTTGGCCAAGCTGGTCT CGAATTCCTGACTTCAAATGATCTGCCCGCCTCATTCTTCCAAAATGCTGGGATTACAGGCATGAGCCAC CACACTGGCCTCATTTTTCAAATGGCTAAAATCTTCAAGATTTCTGGCTGATTGGTATTTTAGAGGCAGC TTTGATGTTTTGTTTCTGGGTCTTTGGAATAGAGTCTTGGGCTTTCGAAGATTTATGGAGGCTGTTGGAC AGAGACAGTCTCCTGAAGAGTTTCTAGCTGTCCTCCCATCTTCTCTCTGCCTTTAGAAATCCTTCTTAGA TGTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATCACGAG ATCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACACAAAAAAATC AAAATTAGCTGGGCGTGGTGGTGGGCACCTGGAGTCCGCAGGAGAATAGTGTGAACCTTGGAAGGCAGAG CTTGTAGTGAGCTGAGATCGCACCACTGTACTCCAGCCTGGGCGACAGAGCGAGACTTCATCTCAAAAAA AAAAGTCCTTCTTAGATGTTTTTAGTTGTTTGTTTATTTTTCGAGATGGAGTTTTGCTCTTGTTGCCCAG GCTGAAGTGCAATGGCACGATCTGGGCCCATTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCC TCAGCCTCCTGAGTAGCTGGGATTACAGGCAGCCACCACCATGCCCAGCTCATTTTTGTATTTTTAGTAG AGATGGGGTTTCACCACGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTCAGC CTCTCAAAGTGCTGGGATTGCAGGCATGAGCCACTGCGCCCAGCCTGTTTGTTTGTTTTCAGATAGGGTC ACCCTGTCAGCCAGGCTGGAATGCAATGGTGTGATTGTGATCACAGCTCACTGCTGCCTCAACCTGAGGG CTCAAGTGATCCTCCCACTTCAGCCTCCTTAGTAACTGGGACCACAGGGGTGAGCCACCATGCCTGGCTA ATTTGTTAATTTTTGTAGAGATGGGGTCTCCCTATGTTGCCGAGGCTGGTCTCAAACTACTGGGCTTAAG TGATCCTCCTGCCTTAGCTTCCCAGAGCGCTGGGATTAAAGGCATGAGCTGCTGTGCCTGGTCAATCCTT TTTACATGTTTGAGGAAAAATAAATGTCCTGTTTTCAGGCTAAGATCAAGTAATAATCCTCATGTGTTAG GAAGCATGTGACATGGATTTTTGCAGCAGAGGGTTAGAAAGGAACTTTCTTTATATACTTGGCCCCCTGC ATTTCAGGGCTCCACCGCCATCTGTCTGTCTGAGTGTAAAGTGGACCTTATTGGCATCTGGGCTGCCAAA CTGCTTTTTTTCCTTTGCTTTGCCCAGCCTTCTCTTGAAGGCTAAATTCTTGAAAAATTATATTCTTTGT GTTCCTATAGTAAATATTAAGCTTTATATCAACACATATGGCAGGATCTGAGGCTCTTTACTCACCTCTG GTCCATTTCTCTAGTCTTTTCTCTGTAGTCTTTTTGTTTTCCTGTCCTCCATCTCCTAATTTATTAGTTT TATTATTATATTTTATATTATTTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGG CGCGATCTTGGCTCACTGCAATCCCTGCCTCATGGGTTCAAGTGATTTGTCTGCCACAGCCTCCTGAGTA GCTGAAATTACAGGCACGCACCACCATACCTGGCTAATTTTTGTATTTTTAGTAGAAACGGGGTTTCACC ATGTTAGCCAGGCTGATATTGAATTCCTGACCTCAATTGATCCGACTGCCTCGGCCTCCGGAAGTGCTGG GATTACAGGTGAGCCACAGTGCCTGGCAGTTTGTTTTATTTTGGTTGAACAGTTACAAGTCTTGGTTTGT TTTCCTGCAGCAACAGGTTTATCTTGATATGATACAGCGTTATTTAAATTCCTTTTCATTTTCCTGCCTT TGTCTTCACATGCTAGTTTTTTTCAGTTGTTTCTTTTTTCTTCTTCCTTTTCTTTTTTTTTTTTTTTGAG AGATAGTCTTGCTGTGTTGTCCAGGTTGCAGTACAGTGGTGCGATCTGGGCTCACTGCAACCTCTGCCTC CTGGGTTCAAGTGATTCTCTCACCTCAGCCTCCGGAGTAGCTGGGATTACAGGTGCCCACCACCACGCCT GGCTAATTTTTGTATTTTTAGTAGAGACAGCGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGAC CTCAATTGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGATTACAGGTGTGATCCACCGTGCCTAGCCTGT TTAGTTGTTTCTAAGAAGGGAGATATTGGTTTTGATTGACATAGTTCATCCACTTATTTACCAAACACTT GCGAAGTGCCTACTATATGCTGCCTCCGAATAGGCAGGTTCGTCCACAATAGCACAAGGCTCCTGCCACT TGTCTTCAAGGACAAAGAGACATCCAGACAAACAAATGTAATAAACAAATGGGACATGATTGTAGCAGAG GCAGATGCATGGTGGAGGGAAAGTAATTTTGTCTGGGGAGTTGAGAAAAGCTGTCACTTGAGCTAGATCT TGAATGAATAGGAACTCATGAGGTTGAGTGGACAAACAGGAAGGGCCAACAGCAGAGGTATGGCATGTAC AAGATGCAGAGCTCTGCCTGAAAAAGCCTGGTGTGTTGTGAGTCTGGCAGGTGTTTGAAGGCTGATGTGG CTGGAGGCTAGTGCCTGTGAAGCAGGTGGTGGCTGATAAGATTGGAGAGGCAAGCTGTTATCCTCTTTAT GCATGCAGAAGGAATTGACTTCAGGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGC TGAGGCGGGCAGATCACCTGAAGTTAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCT CCTAAAAATACAAAATTAGCCGGGTGTGGCGGTGCACGCCTCCTATAATCTCAACTACTGGGGAGGCTCA GGAAGAAGAATCGCTTGAACCTGAGAGGCACAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCATG CTGGGTGACAGTGTGAGACCCTGTCTCAAAAAAAAAAAAACAAAAAACAAAAGGAATTGACTTCAGCCAT TTGGAGCCATGAGGATCTGTGAGTGAGATACTGTGTCATGTTGGACCATCTCAAAGACAGCTTCTGACCC CACAGTTCTCAACCTTGTTCTTACTTATTTTTAGAGACAGGGTCTCGCTCTGTCTCCTAGGCTGGTATGC AGTGGTGCCACCATGGCTCACTGCAGCCTCACAAACTCCTGGACTCAAGTGATCCTCCTGCTTTTGCTTC CCTTGAGTGTTGGCATCTCATGGGACTCCAGGGGCACATCACCAATTACAGATGATAATTTTTTTTTTTT TTGAGACGGAGTCTTGCTCTGTATCCCAGGCTGGAGTGCAGTGGCGCGATTTTGGCTCACTGCAAGCTCC GCCTCCCAGGTTCACGTCATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCA CGCCTGGCTGATTTTTTTTTTTTTTTTTTGCATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGA TGGTCTCGGTCTCCTGACCTCTTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGTATTACAGGTGTGAG ACACCACGCCTGGCCTTTTTTTTTCTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAG CCGCGCAATCTTGGCTCACTGCAACCTCTGCCTCTCGGGTTCAAGCGATTCTCATGCCTCACCCCTCCAA GTCTGGGACTACAGGCGTGTGCTACTATGTCCAGTTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCAC CATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTTATCCGCCACCCTCAGCCTCCCAAAGTGCTG GGATTACAGGTGTCAGCCACCACACCTGGCCTGTTAGTTTTTTTGAGGCAGAGTCTTGCTCTATCACCCA GACTGGAGTGCAGTGGCCCATTCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCAAGCGATTCTCATGC CACAGCATGAGAAGTGGGATTACAGGGATTAGTAGGTGGGATTACAGGTGTGAGCCACCACACCCAGCCA GGCCCAGATAATTTTAAAATTTATTTTTTTATTTATTTAGAAATGGAGTCTCACTATGTTGCCCCGTCTG GTCTTAAACTCCTGGCCTCAAGGAATCCTCCCTCCTTGGCCTCCTAAAGGGCTAGGTGACAGGCATGAGT CACACTGCGCCCAGCCTTGAGCTTTTGTGCTCGAGATATAGTCCATTCAGAACCTCTGGTTGGCACTTCT TATCTGGCACATGCAGGGCACCTTGGATCTCTTATTATCTTTGAGCACTGGTCTGAACCCACTTGCTTGC CTTCTCCCAGGGGCTGCCCCGTGCACCCCTTGTTCCTAGGGTGGGGATGGGGTTGGATGCCTGGGGTTGC AGAGGGGACTAGCAGAGGGTGACCCTTTTCTCTATGCTATTACTTCAGATCTTGGCTTTTGCTTTCTTCC AAATACACAGCAATCTTGGCTTCCAGCCTAGGTGGGAAAGGGAGAAAGAACCGATTTCCTCCAGCTCCTC TCTGAAAGTAGCCCAACTGGCACTGTTTAGGAACAAGGAGTTCCTGAGAGTGTTGGCACCCCACGGTGTT GATGTCCGGTAGTTCCCTGCTGTGAACCCTGTCTCTGCCCCACTTCAATCCAAGGACCCTGTGGAGGGAA TTCTAGGCTTCTTCAAAGCCTCTGCAGTACCAGCTGCCTCCAAGGCCTAACATAGTGAAGTGATAGGGAG ACAGGACCTTGGGGGAGTTTGGGGATAACTGTGGGAGTTCCTGCAAGGTGGGTAAGAGTCTGGCCATGGC ATCTTCTGGTCTATTCCACAAAAAAGGTGGATGCCTCTGAGACCTAGCTCTGTTATGTTCATTACAGCCC TATCAGTCTCTTCTGGATGTCTGATTCCTAGCTGCCAAACATCCAGGTGCTAGCAGCTGGGGGTGGGGTA GGATAAGAAGGGGGGTGTCTACCTCAACCTTCCTGCCCAAACCATTCATTTTAAAGTACTGTGAAGAAGG CTGGATTAGTGTTAAATTCAATAAAGTTAACAAAGCAAAGTATTGTAGTGAGTACACAATAAATAGTTGC TGCATGAGGAATTTCTTGAAATGAATTCAAGATGAGTCTTGAAAAACGAGTGGGAGTAAGCCGTGCACGG AAGCAGAGGTCTAGCAGAGGTCTAGCGCCAAGTCCCAGAGGCCTGAGAGGGCAAGCCTTGGTGGGGGAAA AGGCAGAAGTTGTGACTGGCTGCCTCTGAGAGTGCAAGTAGCCATGCAAAGTTGGGAAAACCAGACGGCG GCCGGAGCCGTGAACCAGGGGCAAATGGAGGATGGTGTTGGGGTAGTCACTAGCCTGCCGGAATGGAAGA AGAGGGGCGTTTGGGGGCGGTAAGGCCTAAAGGACACTGGAGGGGCCTCGGGATTTGGGGCAGGATCACA GGCCTAGTCCACTTAAAGGTGGCTCCGTGCCAGGCCTTCCCAGAATCAGGTTGAAAAGAACTTTAGGGTT AGACAGGTTGGAGATGAGAAATTGGACCATGCAGGAAGTACTGTCGGAGGCGTGTTCCTGACTTTACTAC CCTGAGCCGCCCACGGCTGGGGCAGTCCCCGAGGTTCCACCTTAAGGGGCGGGCCGGGGCGGGGCTCCGC TGCCCCTTCCCAGAGGCCGCGCCTGCTGCTGAGCAGATGCAGTAGCCGAAACTGCGCGGAGGCACAGAGG CCGGGGAGAGCGTTCTGGGTCCGAGGGTCCAGGTAGGGGTTGAGCCACCATCTGACCGCAAGCTGCGTCG TGTCGCCGGTTCTGCAGGCACCATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAG TTAGAGCCCGAGAAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGA ATGGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTCACGGGCCT GTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACCCGCTGGGCACTGCTGCTG CTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTGGTCATAATCGTGCGAGCGCCGCGTTGTC GCGAGCTACCGGCGCAGAAGTGGTGGCACACGGGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCA GGGCCACGGCGCGGGCAACCTGGCGGGTGAGTGCAGCGCGCCCCCGTCCCGGGTACCTCCGGTTGAATCT GGTGGCTTGCACCGACCCCCTCCCCTGTCCCCAGACGGATCTAGATGGTTCTTCCCTCCATCCCGTACCG ACGACTGTTCCCCCTTCCCCCACCCCCTCCCCGGCACATTGTCCTTCCCTCCTTTCTTTGAAGAAAGCCG ACCCGCCCCTCACTCCGTCACGAGGGTGGGTGACTCAGCGTCCTCCTTCCCCGCGGCGCCAGAAGCCAGT TGCAACCGGTTTCTGAAGTAATGTGCAGGACTCCTTACATCAGCTCCTCTGAGTCTCGTGATTCAGCCTT GCCTCCCTCTCTCCCCCTTTGCCCCCTCCCCGTCCCACCCTTAGGCGCTGGGAGAAGGGAGGGTGGGGAG GTCAGGGGCCTCTCAGAGGGGCCTCACTTGTTAACCCAGCCCCCATTTCAGGTCTGAAGGGGCGTCTCGA TTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTGGGTCCAATTCACAAGAACCAGAAGGATGATGTC GCTCAGACTGACTTGCTGCAGATCGACCCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAAT CGGCTAAAAAAAAGAGTGGGTATCCTGGGGTTCCCAAGGAAACAGCTAGAAAGGACTTGGCCAGAGGAAA AGTAGGCTAGAACTTTTGTCTGGTTTCCTGCTAACTGGCTCTGAGTTTTCCTAGGGCAGGTAGAGGGGAG ATTTGTTAGTCTTCAGCCTAAAATGGATTTGTCCAGTCGTCTGGGGGCTTTCTACTTGGCTGTGGAATCT TGAGCAGGTCATTTAACTTCTGGGCTTCAGTGCCCTTATTTGCAAAATATAGATATTTACTAAACCAGTG GTTTTAAACTTGTAAAACAGTAGGTTTTTTTGGGGGGGGGGAATCCCAAATATTGTTTTACGACTCGATA TAGACACATGTTTAAAAAGGTTCACTTTGGGAGTGGGGAACACAGGGGCCACTTCTCTGCACTATAAACT TTCTGCCTTCCAATATCTTTTTTTTTTTTTGAGATGGAGTCTCACTCTTGTCACCCAGGCTGCAGTGCAG TGGAACGATCTCAGCTTACTGCAGCCTCCTCCCCCAGGGTTCAAGCGATTCTCGTGCCTCAGCCTCCTGA GTAGCTGGTACTACAGCCGTGTGCCACCACACCCAGATAATTTTTTTATTTTTAGTAGAGACAATTTTCA ACATGTTGACCGGTCTGGTTTTGAACTCGCCTGGCCTGCCTTCCCATATCTTAAGGCCCTTCCTTGCTCA CATCTGTTTCAATGGAATGAATTTTGCCCGGGTTCAAATTCAAGCTTTTGTACCAAGTAATACATAGGAA ACACTCAGTGACTTGCATTTGTGATTTCCTTATTTTCCCTTAACTCATAGACTGTCTCATGATTGCGTCT TCCTCCGTTGTTTTAGGCATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGT TCTCCACTCAGGTTGACACTGTGGCCACCAAGGTGAAGGTGAGTGTTGGAGCTGATGGCTGGTGGAAGTC AGATGCTGGGGCTGGGACAGTCCTTTCACAGCAAGCCCTGTAGACCCAGCCTGACTCCAGCTGAGGGTCC CTTTGCTCCTTAGGACCAAGGAGGAATGCCTCCTCCTATAGCCAAAGGATAGGCCAATAGCACACCTGTT TTTCTTGTTCCTTTTCTGACCTCTTATTTTTCTTATTTCCTTGACTCTGAGGATGAGACAGTGCCAGGAA GGGACCTTCTCAGAAGTCAGTCTGGAAGTTTGATTTTTCTTTCTTTTGGGAGAGGAAGCCCTTTCTCTGT GAGAATCCTGTCCTGACTGGTTTCCCAGTTCTTGTTTGATGTGTTTGGAATAGAGCCCAGTCTGAAATTA TAAGCACTGGGGTACTCCTATGTGTCTGGGACTCTATGCCAAGTATTTTATAGATGTTTTCTAATTCTCT GTATAACCATACAAGGTATATAATTTGCCATAGGTTCAAATGTGTACCCAGCAGGCTAGGAGTAGGGCTT TGAATGTCACCTAGCTCCTGATGTCTGGGTCCTAGGACACTGACCTGTTCAGAATGGGTAGAACAAAAAT GGAAGCAGATACTGACACTGCTGGTAGCTGTGATTCTAAGATAGAATTCTGGACTCCCAGCATTTGGGTA GGACCCCGGGATCATCCAGTTTAGGCCTTGCCAGTTACTAGGGGACCCTTTAAAAGTTGCTGATGAGGGA ATGTTTTTGGATGGTTTGGCATGAGGGGCGGTACCCTCAGATGGAAATGGAGACCAGAGGAGAGAGTACA TGGCCCAGAGAAAGGGAAGAAAAGGAGAATGGGGGTGAAGTTCCACAGTGTGTGCAGGACTGCCAGGATT CCATTCAGCAGCACTGGCCTCTTTTCAAATCTAAACTGCCCTGGGGCTATGCTTTGAATTTCAATCTTTC ATCCTTGGCCTTGCTCTGAGCAGTTATTGTACTCACACCTTCCCCAGGCCTCAGGAAACTGGGAGAGGGG GGATCTTGACTGACATTTTAGATCCTGTCTGCTGCTCACTGATTATGACTGTGGACGCGTCTCCCTGCTT CTCTGGGTCTGTTTCTTCATCTCTAAAATAGGTATGCTAACATTCCAATGCTAAGTGTTAAACGAAGTTA TGTTTATGGACATACCTTTTCTCTGGGGCCTTTTCTGTGGCTTTCAAAGTTGAAGCTGTGTGATTTGCCA GAGGCAAGAATGAGAAGTAAAATGCTGTAGCACTAAGAAAATGAGTGGAAGGGTAGAGCTGGAGGGGTCC AAAGGCTAAGCCTTTGTAGTGCAGGTGGGGAAGACCCAGGCAAGGCACAGGACTCTCCCCAGCTCCCGGG GAAGTGTGTGGTGGGTGAGGTTTAGTGTGGGCTGGAATTTTCTGAGCCTTTTCCTGAGAACTGATGTCTG TCCTTTATTCTTCTGCCCCCTATAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGCGTGGATGGGTTCCAG GTTCGGGACATAGAGAATCTGAAGGTGAGTTCCCTTTCCACATTAGGGACAAAGCTTGGGCGAGAACAGA GGGACTCAGCTAGAGCCTCATAATATTCTCTGGTCCTTGATTCTGCTTTTTTCTTTCTAGGATGCATCCT CATTCTTGGCTGAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGTGGGTGCAGGAGCCATTCTG CTGACTCAGCTCCAATGTGGGAACCCCTCAGTGGAGTGCTAGGCCTAAGAAGGGGGGATTCCTAGTCTAG AGCATTTTCTTTACCTTTATTCTTTCTTTAGCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAG ATGGAGTTCCGCTCTTTTTGCCCAGGCTGGGGTGCGATGGCGTGATCTTGGCTCACTGCAACCTCTGCCT CCTGGGTTCAAGCGATTCTCCTGCCTCAGCATCCCAAGTAGCTGGGATTACAGACGCGGGCCACCACACC TGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAAGCCAGTCTCGAACTCCTGAC CTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGCGCCTGGCCC CATTCTTTCTTGTGCTAACCTTGAACTCCTCCCTCCCCTCTGCAGGCTCTTGATTGCGGGGACTAACTCC TCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACTAGCTCATACCTGT CTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAGTATTTGAATGCCACTGGCAATCG CTGGTGCAGCTGGAGTGTGAGTACCATGCTGGTGGGAAAGGGGGCAGATGGGAGAAGAAAGGGTTGTTGG GAGACAGAGGCAGAGGTGGGTTATGGGGCTCACTGGAGTGTCTCTCCCTGTAGTTGTCTCAGGCAAGGCT CCTGACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCAGGGACC CCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGACAGGTACTGCTTGCTG TCTTTCTGTCACAGGGAGGTTGTTTATCCATCTTACAATGATGATTCTGGGGATGGCGGCACATAGACGT GAGCCTTGGGGTGAAAACGCGTTTGATTCTTAGTCAGTAGCTGAGTGGCTATGTGGCTTTGGGCAAATTA TTTTACCTTTCTGAATTTTGGTCATCCCTTGTGTTACTGCATTTCTTGAAGGGTGGTTAGTATTAAATGA GGGCATGTTTTTAATGGTAATGCCTGGTACCTGGCAGATGTTTGCTATGGTAGCCACCATTCATTTATTC ATTCCTTTATTCTTTGGACAGTGGGTACTGTGCTAGGCTCTGTGCCCTCAGGAGCTCATAGTTTAGTGAG GGAGCCAGATAAATAAGTGGAGAAGTACATGGCAGTGGCTGGGCACGGTGGCTCATGCCTGTAATCCTAG CACTTTGGGAGTCCAAGGTGGGTGGATCACTGGAGGTAAGGAGTTCGAAACCAGCCTAGCCAACAGGGTG AAACCCAGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTGCACGCCTGTAGTCCCAGCTACT GGGGAGGCTGAGGCAAGAGAATCGCTTGAACCTGGAGGCAGAGGTTGCAGTGAACTGAGATTGTGCCACT GCACTTTAGCCTGGGCGGCAGAGGGAGACTCCTTCTCCAAAAAAAAAAAGAAAAGAAAAGAAAGAAAGAA ATACATGGTAGGGATACTACTACAAAGGCATTCACTAGCTTTAGATACAGGGTTACTGTTGATCCCCGAC TTTTTTTTTTTGTTTGTTTGTTTGTTTTTTGTTTTTGTTTTTAAGACAGCATTTCCCTATGTCGCCCAGG CTGGAGTGCAGTGGCATGATCTTGGTTCATTGCAGCCTCCGCCTCCCAGGCCGAAGTGATCATCCCACCT CAGCCTCCTGAGTAGCTGGGATATGTACCATAGATAGGTGCGTGCCATCATGCCCAGCTGATCTTTTTTT TTTTTGGAGACAGGTTCTTGCTCTGTTGATCTGGCTGGATTGCAGTGGTGCGATTATGTCTCACTGCAAC CTCTGCCTCTTGGGTTCAAGTGATACTCCTGCCTCAGCTTCCCAAGTAGCTGGGAATACAGGTGGTCTGG GAATACAGGCACACACCACCATGCCCGGCTAATTTTTGTAGAGACAGGCTTTCACTGTTGTTGCCCAGGC TGGTCTCCAACTCCTGGGCTCAATCGCTCTGCCTGCCCTGATCTCCCAAATTGCTGGGACTACAGGTGTG AGCCACTGTGCCTGGCCACAGCTAATTTTTAAAATTTGTAGAGGTGTGGTCTCACTATGTTGCCCAGGCT GTTCTCAAACTCCTGGGTGCAAATGATCCTCCCACCTTGGCCTCCCAAACTGCTATGATTACAGGTGCGA GCCACTGCACCCGGCCATCAGCATGATGTTTATAGAACCAGTTATTCATTTATTCCACAGATGTTTATAG AATAATTTCTGTCTGTTACACTGAGGATACAGCATTGCACAAGAGAGCTGGAGGTGGTTAGATAATTAGA TATGCATAAATAAAACGCCAGCTGCTGATCAGTGCTATGCAAAAGAAGGCGGGGTAAGGAGCCTAGAGAC TAGGGGATGATGGGGCTTGTTTTATAGAGAGTAGCCATAGGAGACCTGGTAAGATAACCAAGCAGATACC TGAGGGAAGTGAGAGAGCTGGCTGGCAGCCATCTGGGAGCTCTTGGCTGAGGGGCAACAGTGTATGTGTG AGGACCCTGAGGTGGGAGCCTGCCTCACTCATCCAGTAGAAGTTAGCCAGGCCGGGTGTCGTGGCTTATG CCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAAGAGTTCGAGACCAGCCT AGCCAACATGGTGAAACCCCGTCTTTACTAAAAATACAAAAAAATTAGCTGGGTGTGGTGGTGCACACCT ATGGTCAGCTACTGGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGATTGCAGTAAGCC AAGATCGTGCCATTGCACTCCAGCCTGAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGT TAGCCAGACATGAGTTGGGGAGGTTATATATTGATGAGGATGTGAATGGGAAGAGGGATACGGGACAGTG GGCCCAGGGCTTTTTTTTTGAGACAGGGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTGGAGTCAT GGCTCACTGCAAGCTCAAACTCCTGGGTTCAAGTGATCCTCCCTCCTCAGCCTCCCCAGTATCTGGGACT ATAGGGATGTAACACTACACCCAGCTAATTTTTAAAAATTTTGTAGTAGAGATGAGGGCTCATTATGTTG CTGAGGCTGGTTTCAAATGCCTGGGCTCAAGCAATCCTCTTGGCCTTGACCTCCCAGACTGCTGGAATTA CAGATGTGAGCCACCATGCCTGACCCCAGGCCTTTTTAAAGTCCTATTTTCTCTGCTTTTCAGCCTATGG AGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGGGCTGTAAGTGCCAACATGAC TGTGAAGGTAAGAGTTCTAGATGGGTAGAAACTGACCGGTGGAGGGTGGGCTGGGCTTGTAGAAGTCTGT ACCCAGGGGAGCCCCTCACACGCTTCTGCTATGTTTTTATCATTCTTAGGGCCAGAGTGAAGACCCTGGC TCCCTCCTTTCCTTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACT TCCACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAGCGTTTTCT GGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCCGACCTGCCTGCCAGCGCC AGCCTGCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCAGGCCGTGAGGAGGGCTCCCCTCTTGAGC TGGAACGCCTGAAACTGGAGCCTCACGAAGGGCTGCTGCTCCGCTTCCCCTACGCGGCCTGACTTCAGCC TGACATGGACCCACTACCCTTCTCCTTTCCTTCCCAGGCCCTTTGGCTTCTGATTTTTCTCTTTTTTAAA AACAAACAAACAAACTGTTGCAGATTATGAGTGAACCCCCAAATAGGGTGTTTTCTGCCTTCAAATAAAA GTCACCCCTGCATGGTGAAGTCTTCCCTCTGCTTCTCTCATA Download Select all
Length	32872
OMIM ID	158070
HGNC ID	HGNC:11026
Unigene ID	Hs.502769
Ensembl ID	ENSG00000168003
PharmGKB ID	-

mRNA Information

mRNA ID	NM_002394.5
Exon	join(1..370,14734..14826,15566..15658,25008..25436, 25882..26055,26897..26988,28446..28514,28621..28679, 29166..29346,29454..29597,32124..32207,32320..32872)
mRNA Sequence	>6520 AGTTCCAGGGAAGGAGGGCGTAGACAAAGCGCCACCTGAACTTGCGGCGCGAAAAAGGCGCGCA TGCGTCCTACGGGAGCGTGCTGGCTCACCGACCGCATTGCGGCTTGGTTTTCTCACCCAGTGCA TGTGGCAGGAGCGGTGAGATCACTGCCTCACGGCGATCCTGGACTGACGGTCACGACTGCCTAC CCTCTAACCCTGTTCTGAGCTGCCCCTTGCCCACACACCCCAAACCTGTGTGCAGGATCCGCCT CCATGGAGCTACAGCCTCCTGAAGCCTCGATCGCCGTCGTGTCGATTCCGCGCCAGTTGCCTGG CTCACATTCGGAGGCTGGTGTCCAGGGTCTCAGCGCGGGGGACGACTCAGAGTTGGGGTCTCAC TGTGTTGCCCAGACTGGTCTCGAACTCTTGGCCTCAGGTGATCCTCTTCCCTCAGCTTCCCAGA ATGCCGAGATGATAGAGACGGGGTCTGACTGTGTTACCCAGGCTGGTCTTCAACTCTTGGCCTC AAGTGATCCTCCTGCCTTAGCTTCCAAGAATGCTGAGGTTACAGGCACCATGAGCCAGGACACC GAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAGAAGCAGCCGATGAACGCGG CGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAATGGTCTGGTGAAGATCAAGGTGGC GGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTCACGGGCCTGTCCAAGGAGGAGCTGCTG AAGGTGGCAGGCAGCCCCGGCTGGGTACGCACCCGCTGGGCACTGCTGCTGCTCTTCTGGCTCG GCTGGCTCGGCATGCTTGCTGGTGCCGTGGTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCT ACCGGCGCAGAAGTGGTGGCACACGGGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAG GGCCACGGCGCGGGCAACCTGGCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGG TGAAGGGCCTTGTGCTGGGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTT GCTGCAGATCGACCCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAA AAAAAGAGCATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCT CCACTCAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGG CGTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCTGAG TGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAACTCCTCCG ACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACTAGCTCATACCT GTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAGTATTTGAATGCCACT GGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTGACTTCCTTCTTGCCGGCTC AACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCAGGGACCCCTGTTTTCAGCTACGG GGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGACAGCCTATGGAGGCTCCAGTCATGCTG TGGGATGAGTCCAGCTTCCCTGACATCCCAGGGGCTGTAAGTGCCAACATGACTGTGAAGGGCC AGAGTGAAGACCCTGGCTCCCTCCTTTCCTTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGA GCGCTCCCTACTGCATGGGGACTTCCACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATC CGCCACTGGGACCAGAATGAGCGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGG CTGGACTGCAGGCCTCCGACCTGCCTGCCAGCGCCAGCCTGCCAGCCAAGGCTGACCTCCTGCT CAGCACCCAGCCAGGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCT CACGAAGGGCTGCTGCTCCGCTTCCCCTACGCGGCCTGACTTCAGCCTGACATGGACCCACTAC CCTTCTCCTTTCCTTCCCAGGCCCTTTGGCTTCTGATTTTTCTCTTTTTTAAAAACAAACAAAC AAACTGTTGCAGATTATGAGTGAACCCCCAAATAGGGTGTTTTCTGCCTTCAAATAAAAGTCAC CCCTGCATGGTGAAGTCTTCCCTCTGCTTCTCTCATAAAAAAA Download Select all
Length	2347

CDS Information

Location	join(259..370,14734..14826,15566..15658,25008..25436, 25882..26055,26897..26988,28446..28514,28621..28679, 29166..29346,29454..29597,32124..32207,32320..32682)
CDS Sequence	>gi\|312032447:259-2151 Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2), transcript variant 3, mRNA ATGGAGCTACAGCCTCCTGAAGCCTCGATCGCCGTCGTGTCGATTCCGCGCCAGTTGCCTGGCTCACATT CGGAGGCTGGTGTCCAGGGTCTCAGCGCGGGGGACGACTCAGAGTTGGGGTCTCACTGTGTTGCCCAGAC TGGTCTCGAACTCTTGGCCTCAGGTGATCCTCTTCCCTCAGCTTCCCAGAATGCCGAGATGATAGAGACG GGGTCTGACTGTGTTACCCAGGCTGGTCTTCAACTCTTGGCCTCAAGTGATCCTCCTGCCTTAGCTTCCA AGAATGCTGAGGTTACAGGCACCATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGA GTTAGAGCCCGAGAAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAG AATGGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTCACGGGCC TGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACCCGCTGGGCACTGCTGCT GCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTGGTCATAATCGTGCGAGCGCCGCGTTGT CGCGAGCTACCGGCGCAGAAGTGGTGGCACACGGGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCC AGGGCCACGGCGCGGGCAACCTGGCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAA GGGCCTTGTGCTGGGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATC GACCCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGCATCCGTG TCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACTCAGGTTGACACTGTGGC CACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGCGTGGATGGGTTCCAGGTTCGGGACATA GAGAATCTGAAGGATGCATCCTCATTCTTGGCTGAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACA GGCTCTTGATTGCGGGGACTAACTCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGA CTTGCTGTTGACTAGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACA CAGTATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTGACTTCCT TCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCAGGGACCCCTGTTTTCAG CTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGACAGCCTATGGAGGCTCCAGTCATGCTG TGGGATGAGTCCAGCTTCCCTGACATCCCAGGGGCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTG AAGACCCTGGCTCCCTCCTTTCCTTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACT GCATGGGGACTTCCACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAAT GAGCGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCCGACCTGC CTGCCAGCGCCAGCCTGCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCAGGCCGTGAGGAGGGCTC CCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGGCTGCTGCTCCGCTTCCCCTACGCGGCC TGA Download Select all
CCDS ID	CCDS8039.2

Protein Information

Protein ID	NP_001012680.1
Protein Name	Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Molecular Wt. (Da)	67970
Protein Sequence	>6520 MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSETGSDCVTQAGLQLLASSDPPALASKN AEVTVETGFHHVSQADIEFLTSIDPTASASGSAGITGTMSQDTEVDMKEVELNELEPEKQPMNA ASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWL GWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLK VKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWF STQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSS DLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPA QLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKG QSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLS AGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA Download Select all
Length	631
Uniprot ID	Q07973
Ensembl Protein ID	ENSP00000216862

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	396
N	Glycosylation	412
N	Glycosylation	455
N	Glycosylation	537
N	Glycosylation	366
N	Glycosylation	334
N	Glycosylation	303
N	Glycosylation	264
N	Glycosylation	382
N	Glycosylation	350
N	Glycosylation	319
N	Glycosylation	280
N	Glycosylation	425
N	Glycosylation	393
N	Glycosylation	362
N	Glycosylation	323
N	Glycosylation	507
N	Glycosylation	475
N	Glycosylation	444
N	Glycosylation	405
C	Disulfide Bridge	241;462
C	Disulfide Bridge	211;432
C	Disulfide Bridge	179;400
C	Disulfide Bridge	148;369
C	Disulfide Bridge	109;330
S	Phosphorylation	103;-
S	Phosphorylation	134;-
S	Phosphorylation	104;-
S	Phosphorylation	72;-
S	Phosphorylation	41;-
S	Phosphorylation	2;-
T	Phosphorylation	106;-
T	Phosphorylation	137;-
T	Phosphorylation	107;-
T	Phosphorylation	75;-
T	Phosphorylation	44;-
T	Phosphorylation	5;-
S	Phosphorylation	134;-
S	Phosphorylation	165;-
S	Phosphorylation	135;-
S	Phosphorylation	103;-
S	Phosphorylation	72;-
S	Phosphorylation	33;-
T	Phosphorylation	39
S	Phosphorylation	41
T	Phosphorylation	39
S	Phosphorylation	41
S	Acetylation	103
S	Acetylation	134
S	Acetylation	104
S	Acetylation	72
S	Acetylation	41
S	Acetylation	2
S	Phosphorylation	9
S	Phosphorylation	9
S	Phosphorylation	9
S	Phosphorylation	9
S	Phosphorylation	9
N	Glycosylation	365
N	Glycosylation	381
N	Glycosylation	424
N	Glycosylation	428
N	Glycosylation	459
N	Glycosylation	429
N	Glycosylation	397
N	Glycosylation	366
N	Glycosylation	327
N	Glycosylation	506
N	Glycosylation	395
N	Glycosylation	426
N	Glycosylation	396
N	Glycosylation	364
N	Glycosylation	333
N	Glycosylation	294
S	Phosphorylation	301
Y	Phosphorylation	312
S	Phosphorylation	332
Y	Phosphorylation	343
S	Phosphorylation	302
Y	Phosphorylation	313
S	Phosphorylation	270
Y	Phosphorylation	281
S	Phosphorylation	239
Y	Phosphorylation	250
S	Phosphorylation	200
Y	Phosphorylation	211
S	Phosphorylation	607
S	Phosphorylation	638
S	Phosphorylation	608
S	Phosphorylation	576
S	Phosphorylation	545
S	Phosphorylation	506

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
3688	ITGB1	628	NP_391987.1	in vitro;in vivo	12181350

Pathway Information

Pathway Name	Pathway ID
Protein digestion and absorption	hsa04974

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd11345	207-536	AmyAc_SLC3A2
cl07893	207-536	AmyAc_family superfamily
cd11331	217-540	AmyAc_OligoGlu_like
cd11359	218-539	AmyAc_SLC3A1
cd11329	161-600	AmyAc_maltase-like
cd11316	235-539	AmyAc_bac2_AmyA
cd00551	225-468	AmyAc_family
cd11328	218-542	AmyAc_maltase
cd11334	218-530	AmyAc_TreS
cd11333	233-526	AmyAc_SI_OligoGlu_DGase
cd11330	217-541	AmyAc_OligoGlu
cd11338	208-541	AmyAc_CMD
cd11348	231-526	AmyAc_2
cd11339	236-487	AmyAc_bac_CMD_like_2
cd11332	218-319	AmyAc_OligoGlu_TS
smart00642	235-318	Aamy
cd11313	237-475	AmyAc_arch_bac_AmyA
cd11352	230-319	AmyAc_5
cd11340	236-319	AmyAc_bac_CMD_like_3
cd11337	218-474	AmyAc_CMD_like
cd11320	229-471	AmyAc_AmyMalt_CGTase_like
cd11354	218-307	AmyAc_bac_CMD_like
cd11324	238-311	AmyAc_Amylosucrase
cd11336	225-318	AmyAc_MTSase
cd11350	237-345	AmyAc_4
cd11344	239-347	AmyAc_GlgE_like
cd11353	241-318	AmyAc_euk_bac_CMD_like
cd11314	276-371	AmyAc_arch_bac_plant_AmyA
pfam11941	519-624	DUF3459
cl02706	519-624	Alpha-amylase_C superfamily
cd11323	236-309	AmyAc_AGS
COG0366	237-596	AmyA
TIGR02456	218-587	treS_nterm
pfam00128	239-474	Alpha-amylase
TIGR02403	218-570	trehalose_treC
PRK10933	218-622	PRK10933
PRK10785	239-611	PRK10785
PRK09505	233-315	malS
COG3280	223-337	TreY
TIGR02401	223-318	trehalose_TreY
PRK14507	223-318	PRK14507
PRK14511	247-318	PRK14511
PRK14510	232-316	PRK14510

Ontology Information

HPRD ID	16031
Molecular Class	Membrane transport protein
Molecular Function	Transcription regulator activity (GO:0030528)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO